Substancedefinition-chemical-ponatinib-example

FHIR CI-Build

This is the Continuous Integration Build of FHIR (will be incorrect/inconsistent at times).
See the Directory of published versions

Example SubstanceDefinition/ponatinib-hcl (Narrative)

Responsible Owner: Biomedical Research and Regulation Work Group

Standards Status: Informative

Compartments: No defined compartments

This is the narrative for the resource. See also the XML, JSON or Turtle format. This example conforms to the profile SubstanceDefinition.

Generated Narrative: SubstanceDefinition ponatinib-hcl

identifier: http://example.europa.eu/fhir/SMSId/PONA4321C

status: Active

classification: Chemical

domain: Human use

description:

Ponatinib hydrochloride — a small-molecule tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Hydrochloride salt of ponatinib.

Codes

Code

PONA4321C

name
name: Ponatinib Hydrochloride
preferred: true
language: English
Officials

- Authority Status

* USAN Active

MolecularWeights

Type

Amount

Exact

569.04 g/mol (Details: UCUM codeg/mol = 'g/mol')

moiety
role: Active moiety
name: Ponatinib
molecularFormula: C29H27F3N6O

moiety
role: Counter-ion (salt)
name: Hydrochloride
molecularFormula: HCl

Relationships

SubstanceDefinition[x]

Type

Amount[x]

MeasurementType

Interaction

BCR-ABL1 fusion kinase

Therapeutic target

0.37 nM (Details: UCUM codenmol/L = 'nmol/L')

IC50

Inhibition

Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.