Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot - ballot International flag

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

Resource Profile: NetEffectContribution - Detailed Descriptions

Page standards status: Draft Maturity Level: 1

Definitions for the net-effect-contribution resource profile.

Guidance on how to interpret the contents of this table can be found here

0. Evidence
2. Evidence.relatedArtifact
Control1..?
SlicingThis element introduces a set of slices on Evidence.relatedArtifact. The slices areUnordered and Open, and can be differentiated using the following discriminators:
  • value @ type
  • 4. Evidence.relatedArtifact:amendedWith
    Slice NameamendedWith
    Control1..*
    Must Supporttrue
    6. Evidence.relatedArtifact:amendedWith.type
    Pattern Valueamended-with
    8. Evidence.relatedArtifact:amendedWith.resourceReference
    TypeReference(OutcomeImportance)
    10. Evidence.relatedArtifact:citeAs
    Slice NameciteAs
    Control0..1
    12. Evidence.relatedArtifact:citeAs.type
    Pattern Valuecite-as
    14. Evidence.variableDefinition
    Control4..?
    16. Evidence.variableDefinition:covariate
    Slice Namecovariate
    Control1..*
    18. Evidence.variableDefinition:covariate.extension:variableRoleCode
    Slice NamevariableRoleCode
    20. Evidence.variableDefinition:covariate.extension:variableRoleCode.value[x]
    [x] NoteSee Choice of Data Types for further information about how to use [x]
    Pattern Valuecovariate
    22. Evidence.variableDefinition:covariate.extension:roleSubtype
    Slice NameroleSubtype
    24. Evidence.variableDefinition:covariate.extension:roleSubtype.value[x]
    [x] NoteSee Choice of Data Types for further information about how to use [x]
    26. Evidence.variableDefinition:covariate.extension:roleSubtype.value[x].text
    Pattern ValueRelative Value Multiplier
    28. Evidence.variableDefinition:covariate.extension:comparatorCategory
    Slice NamecomparatorCategory
    30. Evidence.variableDefinition:covariate.note
    32. Evidence.variableDefinition:covariate.note.text
    Pattern Valuecovariate
    34. Evidence.variableDefinition:covariate.observed
    36. Evidence.variableDefinition:covariate.observed.display
    Pattern ValueRelative Importance Multiplier
    38. Evidence.variableDefinition:covariate.intended
    Control0..0
    40. Evidence.statistic
    Control1..?
    SlicingThis element introduces a set of slices on Evidence.statistic. The slices areUnordered and Open, and can be differentiated using the following discriminators:
    • value @ statisticType.coding
    • 42. Evidence.statistic:netEffect
      Slice NamenetEffect
      Control1..1
      Must Supporttrue
      44. Evidence.statistic:netEffect.extension:modelExpression
      Slice NamemodelExpression
      46. Evidence.statistic:netEffect.statisticType
      48. Evidence.statistic:netEffect.statisticType.coding
      Control1..1
      Pattern Value{
        "system" : "https://fevir.net/resources/CodeSystem/181513",
        "code" : "STATO:0000424",
        "display" : "Risk Difference"
      }
      50. Evidence.statistic:netEffect.attributeEstimate
      Control1..?
      SlicingThis element introduces a set of slices on Evidence.statistic.attributeEstimate. The slices areUnordered and Open, and can be differentiated using the following discriminators:
      • value @ type.coding
      • 52. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval
        Slice NameconfidenceInterval
        Control1..1
        Must Supporttrue
        54. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type
        56. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type.coding
        Control1..1
        Pattern Value{
          "system" : "https://fevir.net/resources/CodeSystem/181513",
          "code" : "STATO:0000196",
          "display" : "confidence interval"
        }
        58. Evidence.statistic:netEffect.modelCharacteristic
        Control1..?
        SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic. The slices areUnordered and Open, and can be differentiated using the following discriminators:
        • value @ code.coding
        • 60. Evidence.statistic:netEffect.modelCharacteristic.extension:valueQuantity
          Slice NamevalueQuantity
          62. Evidence.statistic:netEffect.modelCharacteristic.extension:valueRange
          Slice NamevalueRange
          64. Evidence.statistic:netEffect.modelCharacteristic.extension:valueCodeableConcept
          Slice NamevalueCodeableConcept
          66. Evidence.statistic:netEffect.modelCharacteristic.extension:intended
          Slice Nameintended
          68. Evidence.statistic:netEffect.modelCharacteristic.extension:applied
          Slice Nameapplied
          70. Evidence.statistic:netEffect.modelCharacteristic.extension:includeIf
          Slice NameincludeIf
          72. Evidence.statistic:netEffect.modelCharacteristic.variable
          74. Evidence.statistic:netEffect.modelCharacteristic.variable.extension:includeIf
          Slice NameincludeIf
          76. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis
          Slice NamenetEffectContributionAnalysis
          Control1..1
          Must Supporttrue
          78. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:valueQuantity
          Slice NamevalueQuantity
          80. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:valueRange
          Slice NamevalueRange
          82. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:valueCodeableConcept
          Slice NamevalueCodeableConcept
          84. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:intended
          Slice Nameintended
          86. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:applied
          Slice Nameapplied
          88. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:includeIf
          Slice NameincludeIf
          90. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.code
          92. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.code.coding
          Control1..1
          Pattern Value{
            "system" : "https://fevir.net/resources/CodeSystem/181513",
            "code" : "TBD:net-effect-contribution-analysis",
            "display" : "Net effect contribution analysis"
          }
          94. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable
          96. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable.extension:includeIf
          Slice NameincludeIf

          Guidance on how to interpret the contents of this table can be found here

          0. Evidence
          Definition

          The Evidence Resource provides a machine-interpretable expression of an evidence concept including the evidence variables (e.g., population, exposures/interventions, comparators, outcomes, measured variables, confounding variables), the statistics, and the certainty of this evidence.

          ShortSingle evidence bit
          Control0..*
          Is Modifierfalse
          Must Supportfalse
          Summaryfalse
          Invariantscnl-0: Name should be usable as an identifier for the module by machine processing applications such as code generation (name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$'))
          2. Evidence.implicitRules
          Definition

          A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.

          ShortA set of rules under which this content was created
          Comments

          Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of its narrative along with other profiles, value sets, etc.

          Control0..1
          Typeuri
          Is Modifiertrue because This element is labeled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies its meaning or interpretation
          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
          Must Supportfalse
          Summarytrue
          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
          4. Evidence.contained
          Definition

          These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, nor can they have their own independent transaction scope. This is allowed to be a Parameters resource if and only if it is referenced by a resource that provides context/meaning.

          ShortContained, inline Resources
          Comments

          This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags in their meta elements, but SHALL NOT have security labels.

          Control0..*
          This element is affected by the following invariants: dom-2, dom-4, dom-3, dom-5
          TypeResource
          Is Modifierfalse
          Must Supportfalse
          Summaryfalse
          Alternate Namesinline resources, anonymous resources, contained resources
          6. Evidence.modifierExtension
          Definition

          May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

          Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

          ShortExtensions that cannot be ignored
          Comments

          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

          Control0..*
          TypeExtension
          Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the resource that contains them
          Must Supportfalse
          Summarytrue
          Requirements

          Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

          Alternate Namesextensions, user content
          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
          ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
          8. Evidence.status
          Definition

          The status of this summary. Enables tracking the life-cycle of the content.

          Shortdraft | active | retired | unknown
          Comments

          Allows filtering of summarys s that are appropriate for use versus not.

          See guidance around (not) making local changes to elements here.

          Control1..1
          BindingThe codes SHALL be taken from PublicationStatushttp://hl7.org/fhir/ValueSet/publication-status|5.0.0
          (required to http://hl7.org/fhir/ValueSet/publication-status|5.0.0)

          The lifecycle status of an artifact.

          Typecode
          Is Modifiertrue because This is labeled as "Is Modifier" because applications should not use a retired {{title}} without due consideration
          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
          Must Supportfalse
          Summarytrue
          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
          10. Evidence.relatedArtifact
          Definition

          Link or citation to artifact associated with the summary.

          ShortLink or citation to artifact associated with the summary
          Control10..*
          TypeRelatedArtifact
          Is Modifierfalse
          Must Supportfalse
          Summaryfalse
          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
          SlicingThis element introduces a set of slices on Evidence.relatedArtifact. The slices areUnordered and Open, and can be differentiated using the following discriminators:
          • value @ type
          • 12. Evidence.relatedArtifact:amendedWith
            Slice NameamendedWith
            Definition

            Link or citation to artifact associated with the summary.

            ShortLink or citation to artifact associated with the summary
            Control10..*
            TypeRelatedArtifact
            Is Modifierfalse
            Must Supporttrue
            Summaryfalse
            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
            14. Evidence.relatedArtifact:amendedWith.type
            Definition

            The type of relationship to the related artifact.

            Shortdocumentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as
            Comments

            The presence of both sides of a relationship type (e.g. successor and predecessor) is required to support use cases where one side of a relationship is not represented in FHIR. However, this feature SHALL NOT be used to create bi-directional resource links in FHIR instances. Specifically, following the methodology of "new points to old" and "many points to one", when using related artifact elements to describe and reference FHIR resources, the type element SHALL be drawn from the fhir-related-artifact-type ValueSet.

            Control1..1
            BindingThe codes SHALL be taken from RelatedArtifactTypehttp://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0
            (required to http://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0)

            The type of relationship to the related artifact.

            Typecode
            Is Modifierfalse
            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
            Summarytrue
            Pattern Valueamended-with
            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
            16. Evidence.relatedArtifact:amendedWith.resourceReference
            Definition

            The related artifact, if the artifact is not a canonical resource, or a resource reference to a canonical resource.

            ShortWhat artifact, if not a conformance resource
            Comments

            If both resource and resourceReference are present, they SHOULD be consistent and reference the same resource. Although relatedArtifact is intended to support references to definitional resources, there are cases where non-definitional resources can be definitional (such as Location where the kind is mode). Related artifacts SHOULD be used to reference definitional resources, and profiles SHOULD be used to make that explicit for particular use cases.

            Control0..1
            TypeReference(OutcomeImportance, Resource)
            Is Modifierfalse
            Summarytrue
            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
            18. Evidence.relatedArtifact:citeAs
            Slice NameciteAs
            Definition

            Link or citation to artifact associated with the summary.

            ShortLink or citation to artifact associated with the summary
            Control0..1*
            TypeRelatedArtifact
            Is Modifierfalse
            Must Supportfalse
            Summaryfalse
            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
            20. Evidence.relatedArtifact:citeAs.type
            Definition

            The type of relationship to the related artifact.

            Shortdocumentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as
            Comments

            The presence of both sides of a relationship type (e.g. successor and predecessor) is required to support use cases where one side of a relationship is not represented in FHIR. However, this feature SHALL NOT be used to create bi-directional resource links in FHIR instances. Specifically, following the methodology of "new points to old" and "many points to one", when using related artifact elements to describe and reference FHIR resources, the type element SHALL be drawn from the fhir-related-artifact-type ValueSet.

            Control1..1
            BindingThe codes SHALL be taken from RelatedArtifactTypehttp://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0
            (required to http://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0)

            The type of relationship to the related artifact.

            Typecode
            Is Modifierfalse
            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
            Summarytrue
            Pattern Valuecite-as
            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
            22. Evidence.variableDefinition
            Definition

            Evidence variable such as population, exposure, or outcome.

            ShortEvidence variable such as population, exposure, or outcome
            Comments

            To report comparative evidence for a research question defined by Population, Intervention, Comparator, and Outcome (PICO), one would use three variableDefinition instances: the Population has variableRole of population, the Intervention and Comparator will be expressed as category values for a GroupAssignment EvidenceVariable with the variableRole of exposure, and the Outcome has variableRole of outcome. In some types of Comparative Evidence, where the groups being compared are not from the same Population (and thus not a PICO-style research question), the GroupAssignment EvidenceVariable may have the variableRole of exposure and express the populations being compared as categories, and a combination of these categories can be described in the variableDefinition with variableRole of population. This approach may be used for example to compare cats and dogs.

            Control41..*
            TypeBackboneElement
            Is Modifierfalse
            Must Supportfalse
            Summaryfalse
            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
            SlicingThis element introduces a set of slices on Evidence.variableDefinition. The slices areUnordered and Open, and can be differentiated using the following discriminators:
            • value @ note.text
            • 24. Evidence.variableDefinition.extension
              Definition

              An Extension


              May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

              ShortExtensionAdditional content defined by implementations
              Comments

              There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

              Control10..*
              TypeExtension
              Is Modifierfalse
              Summaryfalse
              Alternate Namesextensions, user content
              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
              SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
              • value @ url
              • 26. Evidence.variableDefinition.extension:variableRoleCode
                Slice NamevariableRoleCode
                Definition

                Classification of the role of the variable.

                Shortpopulation | exposure | outcome | covariate
                Control1..1
                TypeExtension(VariableDefinitionVariableRoleCode) (Extension Type: code)
                Is Modifierfalse
                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                28. Evidence.variableDefinition.extension:roleSubtype
                Slice NameroleSubtype
                Definition

                Sub-classification of the role of the variable.

                Shortsubgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier
                Control0..1
                TypeExtension(VariableDefinitionRoleSubtype) (Extension Type: CodeableConcept)
                Is Modifierfalse
                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                30. Evidence.variableDefinition.extension:comparatorCategory
                Slice NamecomparatorCategory
                Definition

                The reference value used for comparison. Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                ShortThe reference value used for comparison
                Control0..1
                TypeExtension(VariableDefinitionComparatorCategory) (Extension Type: string)
                Is Modifierfalse
                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                32. Evidence.variableDefinition.modifierExtension
                Definition

                May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                ShortExtensions that cannot be ignored even if unrecognized
                Comments

                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                Control0..*
                TypeExtension
                Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                Summarytrue
                Requirements

                Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                Alternate Namesextensions, user content, modifiers
                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                34. Evidence.variableDefinition.variableRole
                Definition

                population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.

                Shortpopulation | subpopulation | exposure | referenceExposure | measuredVariable | confounder
                Control1..1
                BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRolehttp://hl7.org/fhir/ValueSet/variable-role
                (extensible to http://hl7.org/fhir/ValueSet/variable-role)

                The role that the assertion variable plays.

                TypeCodeableConcept
                Is Modifierfalse
                Must Supportfalse
                Summarytrue
                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                36. Evidence.variableDefinition:population
                Slice Namepopulation
                Definition

                Evidence variable such as population, exposure, or outcome.

                ShortEvidence variable such as population, exposure, or outcome
                Control1..*
                TypeBackboneElement
                Is Modifierfalse
                Must Supportfalse
                Summaryfalse
                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                38. Evidence.variableDefinition:population.extension
                Definition

                An Extension


                May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                ShortExtensionAdditional content defined by implementations
                Comments

                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                Control10..*
                TypeExtension
                Is Modifierfalse
                Summaryfalse
                Alternate Namesextensions, user content
                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                • value @ url
                • 40. Evidence.variableDefinition:population.extension:variableRoleCode
                  Slice NamevariableRoleCode
                  Definition

                  Classification of the role of the variable.

                  Shortpopulation | exposure | outcome | covariate
                  Control1..1
                  TypeExtension(VariableDefinitionVariableRoleCode) (Extension Type: code)
                  Is Modifierfalse
                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                  42. Evidence.variableDefinition:population.extension:variableRoleCode.extension
                  Definition

                  An Extension


                  May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                  ShortExtensionAdditional content defined by implementations
                  Comments

                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                  Control0..0*
                  TypeExtension
                  Is Modifierfalse
                  Summaryfalse
                  Alternate Namesextensions, user content
                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                  SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                  • value @ url
                  • 44. Evidence.variableDefinition:population.extension:variableRoleCode.url
                    Definition

                    Source of the definition for the extension code - a logical name or a URL.

                    Shortidentifies the meaning of the extension
                    Comments

                    The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                    Control1..1
                    Typeuri
                    Is Modifierfalse
                    XML FormatIn the XML format, this property is represented as an attribute.
                    Summaryfalse
                    Fixed Valuehttp://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
                    46. Evidence.variableDefinition:population.extension:roleSubtype
                    Slice NameroleSubtype
                    Definition

                    Sub-classification of the role of the variable.

                    Shortsubgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier
                    Control0..1
                    TypeExtension(VariableDefinitionRoleSubtype) (Extension Type: CodeableConcept)
                    Is Modifierfalse
                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                    48. Evidence.variableDefinition:population.extension:comparatorCategory
                    Slice NamecomparatorCategory
                    Definition

                    The reference value used for comparison. Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                    ShortThe reference value used for comparison
                    Control0..1
                    TypeExtension(VariableDefinitionComparatorCategory) (Extension Type: string)
                    Is Modifierfalse
                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                    50. Evidence.variableDefinition:population.modifierExtension
                    Definition

                    May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                    Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                    ShortExtensions that cannot be ignored even if unrecognized
                    Comments

                    There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                    Control0..*
                    TypeExtension
                    Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                    Summarytrue
                    Requirements

                    Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                    Alternate Namesextensions, user content, modifiers
                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                    52. Evidence.variableDefinition:population.variableRole
                    Definition

                    population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.

                    Shortpopulation | subpopulation | exposure | referenceExposure | measuredVariable | confounder
                    Control1..1
                    BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRolehttp://hl7.org/fhir/ValueSet/variable-role
                    (extensible to http://hl7.org/fhir/ValueSet/variable-role)

                    The role that the assertion variable plays.

                    TypeCodeableConcept
                    Is Modifierfalse
                    Must Supportfalse
                    Summarytrue
                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                    54. Evidence.variableDefinition:exposure
                    Slice Nameexposure
                    Definition

                    Evidence variable such as population, exposure, or outcome.

                    ShortEvidence variable such as population, exposure, or outcome
                    Control1..1*
                    TypeBackboneElement
                    Is Modifierfalse
                    Must Supportfalse
                    Summaryfalse
                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                    56. Evidence.variableDefinition:exposure.extension
                    Definition

                    An Extension


                    May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                    ShortExtensionAdditional content defined by implementations
                    Comments

                    There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                    Control20..*
                    TypeExtension
                    Is Modifierfalse
                    Summaryfalse
                    Alternate Namesextensions, user content
                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                    SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                    • value @ url
                    • 58. Evidence.variableDefinition:exposure.extension:variableRoleCode
                      Slice NamevariableRoleCode
                      Definition

                      Classification of the role of the variable.

                      Shortpopulation | exposure | outcome | covariate
                      Control1..1
                      TypeExtension(VariableDefinitionVariableRoleCode) (Extension Type: code)
                      Is Modifierfalse
                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                      60. Evidence.variableDefinition:exposure.extension:variableRoleCode.extension
                      Definition

                      An Extension


                      May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                      ShortExtensionAdditional content defined by implementations
                      Comments

                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                      Control0..0*
                      TypeExtension
                      Is Modifierfalse
                      Summaryfalse
                      Alternate Namesextensions, user content
                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                      SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                      • value @ url
                      • 62. Evidence.variableDefinition:exposure.extension:variableRoleCode.url
                        Definition

                        Source of the definition for the extension code - a logical name or a URL.

                        Shortidentifies the meaning of the extension
                        Comments

                        The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                        Control1..1
                        Typeuri
                        Is Modifierfalse
                        XML FormatIn the XML format, this property is represented as an attribute.
                        Summaryfalse
                        Fixed Valuehttp://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
                        64. Evidence.variableDefinition:exposure.extension:roleSubtype
                        Slice NameroleSubtype
                        Definition

                        Sub-classification of the role of the variable.

                        Shortsubgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier
                        Control0..1
                        TypeExtension(VariableDefinitionRoleSubtype) (Extension Type: CodeableConcept)
                        Is Modifierfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                        66. Evidence.variableDefinition:exposure.extension:comparatorCategory
                        Slice NamecomparatorCategory
                        Definition

                        The reference value used for comparison. Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                        ShortThe reference value used for comparison
                        Control1..1
                        TypeExtension(VariableDefinitionComparatorCategory) (Extension Type: string)
                        Is Modifierfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                        68. Evidence.variableDefinition:exposure.modifierExtension
                        Definition

                        May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                        ShortExtensions that cannot be ignored even if unrecognized
                        Comments

                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                        Control0..*
                        TypeExtension
                        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                        Summarytrue
                        Requirements

                        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                        Alternate Namesextensions, user content, modifiers
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                        70. Evidence.variableDefinition:exposure.variableRole
                        Definition

                        population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.

                        Shortpopulation | subpopulation | exposure | referenceExposure | measuredVariable | confounder
                        Control1..1
                        BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRolehttp://hl7.org/fhir/ValueSet/variable-role
                        (extensible to http://hl7.org/fhir/ValueSet/variable-role)

                        The role that the assertion variable plays.

                        TypeCodeableConcept
                        Is Modifierfalse
                        Must Supportfalse
                        Summarytrue
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        72. Evidence.variableDefinition:outcome
                        Slice Nameoutcome
                        Definition

                        Evidence variable such as population, exposure, or outcome.

                        ShortEvidence variable such as population, exposure, or outcome
                        Control1..*
                        TypeBackboneElement
                        Is Modifierfalse
                        Must Supporttrue
                        Summaryfalse
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        74. Evidence.variableDefinition:outcome.extension
                        Definition

                        An Extension


                        May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                        ShortExtensionAdditional content defined by implementations
                        Comments

                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                        Control10..*
                        TypeExtension
                        Is Modifierfalse
                        Summaryfalse
                        Alternate Namesextensions, user content
                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                        SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                        • value @ url
                        • 76. Evidence.variableDefinition:outcome.extension:variableRoleCode
                          Slice NamevariableRoleCode
                          Definition

                          Classification of the role of the variable.

                          Shortpopulation | exposure | outcome | covariate
                          Control1..1
                          TypeExtension(VariableDefinitionVariableRoleCode) (Extension Type: code)
                          Is Modifierfalse
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                          78. Evidence.variableDefinition:outcome.extension:variableRoleCode.extension
                          Definition

                          An Extension


                          May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                          ShortExtensionAdditional content defined by implementations
                          Comments

                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                          Control0..0*
                          TypeExtension
                          Is Modifierfalse
                          Summaryfalse
                          Alternate Namesextensions, user content
                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                          ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                          SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                          • value @ url
                          • 80. Evidence.variableDefinition:outcome.extension:variableRoleCode.url
                            Definition

                            Source of the definition for the extension code - a logical name or a URL.

                            Shortidentifies the meaning of the extension
                            Comments

                            The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                            Control1..1
                            Typeuri
                            Is Modifierfalse
                            XML FormatIn the XML format, this property is represented as an attribute.
                            Summaryfalse
                            Fixed Valuehttp://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
                            82. Evidence.variableDefinition:outcome.extension:roleSubtype
                            Slice NameroleSubtype
                            Definition

                            Sub-classification of the role of the variable.

                            Shortsubgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier
                            Control0..1
                            TypeExtension(VariableDefinitionRoleSubtype) (Extension Type: CodeableConcept)
                            Is Modifierfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                            84. Evidence.variableDefinition:outcome.extension:comparatorCategory
                            Slice NamecomparatorCategory
                            Definition

                            The reference value used for comparison. Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                            ShortThe reference value used for comparison
                            Control0..0
                            TypeExtension(VariableDefinitionComparatorCategory) (Extension Type: string)
                            Is Modifierfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                            86. Evidence.variableDefinition:outcome.modifierExtension
                            Definition

                            May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                            Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                            ShortExtensions that cannot be ignored even if unrecognized
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control0..*
                            TypeExtension
                            Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                            Summarytrue
                            Requirements

                            Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                            Alternate Namesextensions, user content, modifiers
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                            88. Evidence.variableDefinition:outcome.variableRole
                            Definition

                            population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.

                            Shortpopulation | subpopulation | exposure | referenceExposure | measuredVariable | confounder
                            Control1..1
                            BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRolehttp://hl7.org/fhir/ValueSet/variable-role
                            (extensible to http://hl7.org/fhir/ValueSet/variable-role)

                            The role that the assertion variable plays.

                            TypeCodeableConcept
                            Is Modifierfalse
                            Must Supportfalse
                            Summarytrue
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            90. Evidence.variableDefinition:covariate
                            Slice Namecovariate
                            Definition

                            Evidence variable such as population, exposure, or outcome.

                            ShortEvidence variable such as population, exposure, or outcome
                            Comments

                            To report comparative evidence for a research question defined by Population, Intervention, Comparator, and Outcome (PICO), one would use three variableDefinition instances: the Population has variableRole of population, the Intervention and Comparator will be expressed as category values for a GroupAssignment EvidenceVariable with the variableRole of exposure, and the Outcome has variableRole of outcome. In some types of Comparative Evidence, where the groups being compared are not from the same Population (and thus not a PICO-style research question), the GroupAssignment EvidenceVariable may have the variableRole of exposure and express the populations being compared as categories, and a combination of these categories can be described in the variableDefinition with variableRole of population. This approach may be used for example to compare cats and dogs.

                            Control1..*
                            TypeBackboneElement
                            Is Modifierfalse
                            Must Supportfalse
                            Summaryfalse
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            92. Evidence.variableDefinition:covariate.extension
                            Definition

                            An Extension


                            May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                            ShortExtensionAdditional content defined by implementations
                            Comments

                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                            Control10..*
                            TypeExtension
                            Is Modifierfalse
                            Summaryfalse
                            Alternate Namesextensions, user content
                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                            ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                            SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                            • value @ url
                            • 94. Evidence.variableDefinition:covariate.extension:variableRoleCode
                              Slice NamevariableRoleCode
                              Definition

                              Classification of the role of the variable.

                              Shortpopulation | exposure | outcome | covariate
                              Control1..1
                              TypeExtension(VariableDefinitionVariableRoleCode) (Extension Type: code)
                              Is Modifierfalse
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                              96. Evidence.variableDefinition:covariate.extension:variableRoleCode.extension
                              Definition

                              An Extension


                              May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                              ShortExtensionAdditional content defined by implementations
                              Comments

                              There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                              Control0..0*
                              TypeExtension
                              Is Modifierfalse
                              Summaryfalse
                              Alternate Namesextensions, user content
                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                              SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                              • value @ url
                              • 98. Evidence.variableDefinition:covariate.extension:variableRoleCode.url
                                Definition

                                Source of the definition for the extension code - a logical name or a URL.

                                Shortidentifies the meaning of the extension
                                Comments

                                The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                                Control1..1
                                Typeuri
                                Is Modifierfalse
                                XML FormatIn the XML format, this property is represented as an attribute.
                                Summaryfalse
                                Fixed Valuehttp://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
                                100. Evidence.variableDefinition:covariate.extension:variableRoleCode.value[x]
                                Definition

                                Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                                ShortValue of extension
                                Control0..1
                                This element is affected by the following invariants: ext-1
                                Typecode, date, Meta, Address, Attachment, integer, Count, DataRequirement, Dosage, uuid, Identifier, RatioRange, Coding, SampledData, id, positiveInt, Distance, Availability, integer64, Period, Duration, canonical, Range, RelatedArtifact, base64Binary, UsageContext, Timing, decimal, ExtendedContactDetail, CodeableConcept, ParameterDefinition, dateTime, string, oid, instant, ContactPoint, HumanName, Money, markdown, Ratio, Age, Reference, TriggerDefinition, Quantity, uri, url, Annotation, ContactDetail, boolean, Expression, CodeableReference, Signature, unsignedInt, time
                                [x] NoteSee Choice of Data Types for further information about how to use [x]
                                Is Modifierfalse
                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                Summaryfalse
                                Pattern Valuecovariate
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                102. Evidence.variableDefinition:covariate.extension:roleSubtype
                                Slice NameroleSubtype
                                Definition

                                Sub-classification of the role of the variable.

                                Shortsubgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier
                                Control0..1
                                TypeExtension(VariableDefinitionRoleSubtype) (Extension Type: CodeableConcept)
                                Is Modifierfalse
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                104. Evidence.variableDefinition:covariate.extension:roleSubtype.extension
                                Definition

                                An Extension


                                May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                ShortExtensionAdditional content defined by implementations
                                Comments

                                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                Control0..0*
                                TypeExtension
                                Is Modifierfalse
                                Summaryfalse
                                Alternate Namesextensions, user content
                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                • value @ url
                                • 106. Evidence.variableDefinition:covariate.extension:roleSubtype.url
                                  Definition

                                  Source of the definition for the extension code - a logical name or a URL.

                                  Shortidentifies the meaning of the extension
                                  Comments

                                  The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                                  Control1..1
                                  Typeuri
                                  Is Modifierfalse
                                  XML FormatIn the XML format, this property is represented as an attribute.
                                  Summaryfalse
                                  Fixed Valuehttp://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype
                                  108. Evidence.variableDefinition:covariate.extension:comparatorCategory
                                  Slice NamecomparatorCategory
                                  Definition

                                  The reference value used for comparison. Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                                  ShortThe reference value used for comparison
                                  Control0..1
                                  TypeExtension(VariableDefinitionComparatorCategory) (Extension Type: string)
                                  Is Modifierfalse
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                  110. Evidence.variableDefinition:covariate.modifierExtension
                                  Definition

                                  May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                  Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                  ShortExtensions that cannot be ignored even if unrecognized
                                  Comments

                                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                  Control0..*
                                  TypeExtension
                                  Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                  Summarytrue
                                  Requirements

                                  Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                  Alternate Namesextensions, user content, modifiers
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                  112. Evidence.variableDefinition:covariate.variableRole
                                  Definition

                                  population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.

                                  Shortpopulation | subpopulation | exposure | referenceExposure | measuredVariable | confounder
                                  Control1..1
                                  BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRolehttp://hl7.org/fhir/ValueSet/variable-role
                                  (extensible to http://hl7.org/fhir/ValueSet/variable-role)

                                  The role that the assertion variable plays.

                                  TypeCodeableConcept
                                  Is Modifierfalse
                                  Must Supportfalse
                                  Summarytrue
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  114. Evidence.variableDefinition:covariate.intended
                                  Definition

                                  Definition of the intended variable related to the Evidence.

                                  ShortDefinition of the intended variable related to the Evidence
                                  Control0..01
                                  TypeReference(Group, EvidenceVariable)
                                  Is Modifierfalse
                                  Must Supportfalse
                                  Summaryfalse
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  116. Evidence.statistic
                                  Definition

                                  Values and parameters for a single statistic.

                                  ShortValues and parameters for a single statistic
                                  Control10..*
                                  TypeBackboneElement
                                  Is Modifierfalse
                                  Must Supportfalse
                                  Summaryfalse
                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                  SlicingThis element introduces a set of slices on Evidence.statistic. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                  • value @ statisticType.coding
                                  • 118. Evidence.statistic.extension:modelExpression
                                    Slice NamemodelExpression
                                    Definition

                                    The formula for analysis.

                                    ShortThe formula for analysis
                                    Control0..1
                                    TypeExtension(StatisticModelExpression) (Extension Type: Expression)
                                    Is Modifierfalse
                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                    120. Evidence.statistic.modifierExtension
                                    Definition

                                    May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                    Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                    ShortExtensions that cannot be ignored even if unrecognized
                                    Comments

                                    There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                    Control0..*
                                    TypeExtension
                                    Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                    Summarytrue
                                    Requirements

                                    Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                    Alternate Namesextensions, user content, modifiers
                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                    122. Evidence.statistic:netEffect
                                    Slice NamenetEffect
                                    Definition

                                    Values and parameters for a single statistic.

                                    ShortValues and parameters for a single statistic
                                    Control10..1*
                                    TypeBackboneElement
                                    Is Modifierfalse
                                    Must Supporttrue
                                    Summaryfalse
                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                    124. Evidence.statistic:netEffect.extension:modelExpression
                                    Slice NamemodelExpression
                                    Definition

                                    The formula for analysis.

                                    ShortThe formula for analysis
                                    Control0..1
                                    TypeExtension(StatisticModelExpression) (Extension Type: Expression)
                                    Is Modifierfalse
                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                    126. Evidence.statistic:netEffect.modifierExtension
                                    Definition

                                    May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                    Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                    ShortExtensions that cannot be ignored even if unrecognized
                                    Comments

                                    There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                    Control0..*
                                    TypeExtension
                                    Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                    Summarytrue
                                    Requirements

                                    Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                    Alternate Namesextensions, user content, modifiers
                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                    128. Evidence.statistic:netEffect.attributeEstimate
                                    Definition

                                    A statistical attribute of the statistic such as a measure of heterogeneity.

                                    ShortAn attribute of the Statistic
                                    Control10..*
                                    TypeBackboneElement
                                    Is Modifierfalse
                                    Must Supportfalse
                                    Summaryfalse
                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                    SlicingThis element introduces a set of slices on Evidence.statistic.attributeEstimate. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                    • value @ type.coding
                                    • 130. Evidence.statistic:netEffect.attributeEstimate.modifierExtension
                                      Definition

                                      May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                      Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                      ShortExtensions that cannot be ignored even if unrecognized
                                      Comments

                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                      Control0..*
                                      TypeExtension
                                      Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                      Summarytrue
                                      Requirements

                                      Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                      Alternate Namesextensions, user content, modifiers
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                      132. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval
                                      Slice NameconfidenceInterval
                                      Definition

                                      A statistical attribute of the statistic such as a measure of heterogeneity.

                                      ShortAn attribute of the Statistic
                                      Control10..1*
                                      TypeBackboneElement
                                      Is Modifierfalse
                                      Must Supporttrue
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      134. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.modifierExtension
                                      Definition

                                      May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                      Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                      ShortExtensions that cannot be ignored even if unrecognized
                                      Comments

                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                      Control0..*
                                      TypeExtension
                                      Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                      Summarytrue
                                      Requirements

                                      Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                      Alternate Namesextensions, user content, modifiers
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                      136. Evidence.statistic:netEffect.modelCharacteristic
                                      Definition

                                      A component of the method to generate the statistic.

                                      ShortAn aspect of the statistical model
                                      Control10..*
                                      TypeBackboneElement
                                      Is Modifierfalse
                                      Must Supportfalse
                                      Summaryfalse
                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                      SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                      • value @ code.coding
                                      • 138. Evidence.statistic:netEffect.modelCharacteristic.extension:valueQuantity
                                        Slice NamevalueQuantity
                                        Definition

                                        The specific value (when paired with code) as a Quantity

                                        ShortValue as Quantity
                                        Control0..1
                                        TypeExtension(StatisticModelValueQuantity) (Extension Type: Quantity(SimpleQuantity))
                                        Is Modifierfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        140. Evidence.statistic:netEffect.modelCharacteristic.extension:valueRange
                                        Slice NamevalueRange
                                        Definition

                                        The specific value (when paired with code) as a Range

                                        ShortValue as Range
                                        Control0..1
                                        TypeExtension(StatisticModelValueRange) (Extension Type: Range)
                                        Is Modifierfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        142. Evidence.statistic:netEffect.modelCharacteristic.extension:valueCodeableConcept
                                        Slice NamevalueCodeableConcept
                                        Definition

                                        The specific value (when paired with code) as a CodeableConcept

                                        ShortValue as CodeableConcept
                                        Control0..1
                                        TypeExtension(StatisticModelValueCodeableConcept) (Extension Type: CodeableConcept)
                                        Is Modifierfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        144. Evidence.statistic:netEffect.modelCharacteristic.extension:intended
                                        Slice Nameintended
                                        Definition

                                        The plan for analysis.

                                        ShortThe plan for analysis
                                        Control0..1
                                        TypeExtension(StatisticModelIntended) (Extension Type: boolean)
                                        Is Modifierfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        146. Evidence.statistic:netEffect.modelCharacteristic.extension:applied
                                        Slice Nameapplied
                                        Definition

                                        The analysis that was applied.

                                        ShortThe analysis that was applied
                                        Control0..1
                                        TypeExtension(StatisticModelApplied) (Extension Type: boolean)
                                        Is Modifierfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        148. Evidence.statistic:netEffect.modelCharacteristic.extension:includeIf
                                        Slice NameincludeIf
                                        Definition

                                        The condition upon which to include the variable or model characteristic in the analysis.

                                        ShortCondition upon which to include the variable or model characteristic in the analysis
                                        Control0..1
                                        TypeExtension(StatisticModelIncludeIf) (Complex Extension)
                                        Is Modifierfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        150. Evidence.statistic:netEffect.modelCharacteristic.modifierExtension
                                        Definition

                                        May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                        ShortExtensions that cannot be ignored even if unrecognized
                                        Comments

                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                        Control0..*
                                        TypeExtension
                                        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                        Summarytrue
                                        Requirements

                                        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                        Alternate Namesextensions, user content, modifiers
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        152. Evidence.statistic:netEffect.modelCharacteristic.code
                                        Definition

                                        Description of a component of the method to generate the statistic.

                                        ShortModel specification
                                        Control1..1
                                        BindingUnless not suitable, these codes SHALL be taken from StatisticModelCodehttp://hl7.org/fhir/ValueSet/statistic-model-code
                                        (extensible to http://hl7.org/fhir/ValueSet/statistic-model-code)
                                        TypeCodeableConcept
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        154. Evidence.statistic:netEffect.modelCharacteristic.value
                                        Definition

                                        Further specification of the quantified value of the component of the method to generate the statistic.

                                        ShortNumerical value to complete model specification
                                        Control0..01
                                        TypeQuantity(SimpleQuantity)
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        156. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis
                                        Slice NamenetEffectContributionAnalysis
                                        Definition

                                        A component of the method to generate the statistic.

                                        ShortAn aspect of the statistical model
                                        Control10..1*
                                        TypeBackboneElement
                                        Is Modifierfalse
                                        Must Supporttrue
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        158. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:valueQuantity
                                        Slice NamevalueQuantity
                                        Definition

                                        The specific value (when paired with code) as a Quantity

                                        ShortValue as Quantity
                                        Control0..1
                                        TypeExtension(StatisticModelValueQuantity) (Extension Type: Quantity(SimpleQuantity))
                                        Is Modifierfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        160. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:valueRange
                                        Slice NamevalueRange
                                        Definition

                                        The specific value (when paired with code) as a Range

                                        ShortValue as Range
                                        Control0..1
                                        TypeExtension(StatisticModelValueRange) (Extension Type: Range)
                                        Is Modifierfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        162. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:valueCodeableConcept
                                        Slice NamevalueCodeableConcept
                                        Definition

                                        The specific value (when paired with code) as a CodeableConcept

                                        ShortValue as CodeableConcept
                                        Control0..1
                                        TypeExtension(StatisticModelValueCodeableConcept) (Extension Type: CodeableConcept)
                                        Is Modifierfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        164. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:intended
                                        Slice Nameintended
                                        Definition

                                        The plan for analysis.

                                        ShortThe plan for analysis
                                        Control0..1
                                        TypeExtension(StatisticModelIntended) (Extension Type: boolean)
                                        Is Modifierfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        166. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:applied
                                        Slice Nameapplied
                                        Definition

                                        The analysis that was applied.

                                        ShortThe analysis that was applied
                                        Control0..1
                                        TypeExtension(StatisticModelApplied) (Extension Type: boolean)
                                        Is Modifierfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        168. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:includeIf
                                        Slice NameincludeIf
                                        Definition

                                        The condition upon which to include the variable or model characteristic in the analysis.

                                        ShortCondition upon which to include the variable or model characteristic in the analysis
                                        Control0..1
                                        TypeExtension(StatisticModelIncludeIf) (Complex Extension)
                                        Is Modifierfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        170. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.modifierExtension
                                        Definition

                                        May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                        ShortExtensions that cannot be ignored even if unrecognized
                                        Comments

                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                        Control0..*
                                        TypeExtension
                                        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                        Summarytrue
                                        Requirements

                                        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                        Alternate Namesextensions, user content, modifiers
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        172. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.code
                                        Definition

                                        Description of a component of the method to generate the statistic.

                                        ShortModel specification
                                        Control1..1
                                        BindingUnless not suitable, these codes SHALL be taken from StatisticModelCodehttp://hl7.org/fhir/ValueSet/statistic-model-code
                                        (extensible to http://hl7.org/fhir/ValueSet/statistic-model-code)
                                        TypeCodeableConcept
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        174. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.code.coding
                                        Definition

                                        A reference to a code defined by a terminology system.

                                        ShortCode defined by a terminology system
                                        Comments

                                        Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                                        Control10..1*
                                        TypeCoding
                                        Is Modifierfalse
                                        Summarytrue
                                        Requirements

                                        Allows for alternative encodings within a code system, and translations to other code systems.

                                        Pattern Value{
                                          "system" : "https://fevir.net/resources/CodeSystem/181513",
                                          "code" : "TBD:net-effect-contribution-analysis",
                                          "display" : "Net effect contribution analysis"
                                        }
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        176. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.value
                                        Definition

                                        Further specification of the quantified value of the component of the method to generate the statistic.

                                        ShortNumerical value to complete model specification
                                        Control0..01
                                        TypeQuantity(SimpleQuantity)
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))

                                        Guidance on how to interpret the contents of this table can be found here

                                        0. Evidence
                                        Definition

                                        The Evidence Resource provides a machine-interpretable expression of an evidence concept including the evidence variables (e.g., population, exposures/interventions, comparators, outcomes, measured variables, confounding variables), the statistics, and the certainty of this evidence.

                                        ShortSingle evidence bit
                                        Control0..*
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantscnl-0: Name should be usable as an identifier for the module by machine processing applications such as code generation (name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$'))
                                        2. Evidence.id
                                        Definition

                                        The logical id of the resource, as used in the URL for the resource. Once assigned, this value never changes.

                                        ShortLogical id of this artifact
                                        Comments

                                        Within the context of the FHIR RESTful interactions, the resource has an id except for cases like the create and conditional update. Otherwise, the use of the resouce id depends on the given use case.

                                        Control0..1
                                        Typeid
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summarytrue
                                        4. Evidence.meta
                                        Definition

                                        The metadata about the resource. This is content that is maintained by the infrastructure. Changes to the content might not always be associated with version changes to the resource.

                                        ShortMetadata about the resource
                                        Control0..1
                                        TypeMeta
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summarytrue
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        6. Evidence.implicitRules
                                        Definition

                                        A reference to a set of rules that were followed when the resource was constructed, and which must be understood when processing the content. Often, this is a reference to an implementation guide that defines the special rules along with other profiles etc.

                                        ShortA set of rules under which this content was created
                                        Comments

                                        Asserting this rule set restricts the content to be only understood by a limited set of trading partners. This inherently limits the usefulness of the data in the long term. However, the existing health eco-system is highly fractured, and not yet ready to define, collect, and exchange data in a generally computable sense. Wherever possible, implementers and/or specification writers should avoid using this element. Often, when used, the URL is a reference to an implementation guide that defines these special rules as part of its narrative along with other profiles, value sets, etc.

                                        Control0..1
                                        Typeuri
                                        Is Modifiertrue because This element is labeled as a modifier because the implicit rules may provide additional knowledge about the resource that modifies its meaning or interpretation
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summarytrue
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        8. Evidence.language
                                        Definition

                                        The base language in which the resource is written.

                                        ShortLanguage of the resource content
                                        Comments

                                        Language is provided to support indexing and accessibility (typically, services such as text to speech use the language tag). The html language tag in the narrative applies to the narrative. The language tag on the resource may be used to specify the language of other presentations generated from the data in the resource. Not all the content has to be in the base language. The Resource.language should not be assumed to apply to the narrative automatically. If a language is specified, it should it also be specified on the div element in the html (see rules in HTML5 for information about the relationship between xml:lang and the html lang attribute).

                                        Control0..1
                                        BindingThe codes SHALL be taken from AllLanguages
                                        (required to http://hl7.org/fhir/ValueSet/all-languages|5.0.0)

                                        IETF language tag for a human language

                                        Typecode
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        10. Evidence.text
                                        Definition

                                        A human-readable narrative that contains a summary of the resource and can be used to represent the content of the resource to a human. The narrative need not encode all the structured data, but is required to contain sufficient detail to make it "clinically safe" for a human to just read the narrative. Resource definitions may define what content should be represented in the narrative to ensure clinical safety.

                                        ShortText summary of the resource, for human interpretation
                                        Comments

                                        Contained resources do not have a narrative. Resources that are not contained SHOULD have a narrative. In some cases, a resource may only have text with little or no additional discrete data (as long as all minOccurs=1 elements are satisfied). This may be necessary for data from legacy systems where information is captured as a "text blob" or where text is additionally entered raw or narrated and encoded information is added later.

                                        Control0..1
                                        This element is affected by the following invariants: dom-6
                                        TypeNarrative
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Alternate Namesnarrative, html, xhtml, display
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        12. Evidence.contained
                                        Definition

                                        These resources do not have an independent existence apart from the resource that contains them - they cannot be identified independently, nor can they have their own independent transaction scope. This is allowed to be a Parameters resource if and only if it is referenced by a resource that provides context/meaning.

                                        ShortContained, inline Resources
                                        Comments

                                        This should never be done when the content can be identified properly, as once identification is lost, it is extremely difficult (and context dependent) to restore it again. Contained resources may have profiles and tags in their meta elements, but SHALL NOT have security labels.

                                        Control0..*
                                        This element is affected by the following invariants: dom-2, dom-4, dom-3, dom-5
                                        TypeResource
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Alternate Namesinline resources, anonymous resources, contained resources
                                        14. Evidence.extension
                                        Definition

                                        May be used to represent additional information that is not part of the basic definition of the resource. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                        ShortAdditional content defined by implementations
                                        Comments

                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                        Control0..*
                                        TypeExtension
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Alternate Namesextensions, user content
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        16. Evidence.modifierExtension
                                        Definition

                                        May be used to represent additional information that is not part of the basic definition of the resource and that modifies the understanding of the element that contains it and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer is allowed to define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                        ShortExtensions that cannot be ignored
                                        Comments

                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                        Control0..*
                                        TypeExtension
                                        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the resource that contains them
                                        Must Supportfalse
                                        Summarytrue
                                        Requirements

                                        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                        Alternate Namesextensions, user content
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                        18. Evidence.url
                                        Definition

                                        An absolute URI that is used to identify this evidence when it is referenced in a specification, model, design or an instance; also called its canonical identifier. This SHOULD be globally unique and SHOULD be a literal address at which an authoritative instance of this summary is (or will be) published. This URL can be the target of a canonical reference. It SHALL remain the same when the summary is stored on different servers.

                                        ShortCanonical identifier for this evidence, represented as a globally unique URI
                                        Comments

                                        In some cases, the resource can no longer be found at the stated url, but the url itself cannot change. Implementations can use the meta.source element to indicate where the current master source of the resource can be found.

                                        Control0..1
                                        Typeuri
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summarytrue
                                        Requirements

                                        Allows the evidence to be referenced by a single globally unique identifier.

                                        Invariantscnl-1: URL should not contain | or # - these characters make processing canonical references problematic (exists() implies matches('^[^|# ]+$'))
                                        ele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        20. Evidence.identifier
                                        Definition

                                        A formal identifier that is used to identify this summary when it is represented in other formats, or referenced in a specification, model, design or an instance.

                                        ShortAdditional identifier for the summary
                                        Comments

                                        Typically, this is used for identifiers that can go in an HL7 V3 II (instance identifier) data type, and can then identify this summary outside of FHIR, where it is not possible to use the logical URI.

                                        NoteThis is a business identifier, not a resource identifier (see discussion)
                                        Control0..*
                                        TypeIdentifier
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summarytrue
                                        Requirements

                                        Allows externally provided and/or usable business identifiers to be easily associated with the module.

                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        22. Evidence.version
                                        Definition

                                        The identifier that is used to identify this version of the summary when it is referenced in a specification, model, design or instance. This is an arbitrary value managed by the summary author and is not expected to be globally unique. For example, it might be a timestamp (e.g. yyyymmdd) if a managed version is not available. There is also no expectation that versions can be placed in a lexicographical sequence.

                                        ShortBusiness version of this summary
                                        Comments

                                        The determination of when to create a new version of a resource (same url, new version) vs. defining a new artifact is up to the author. Considerations for making this decision are found in Technical and Business Versions.

                                        NoteThis is a business version Id, not a resource version Id (see discussion)
                                        Control0..1
                                        Typestring
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summarytrue
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        24. Evidence.versionAlgorithm[x]
                                        Definition

                                        Indicates the mechanism used to compare versions to determine which is more current.

                                        ShortHow to compare versions
                                        Comments

                                        If set as a string, this is a FHIRPath expression that has two additional context variables passed in - %version1 and %version2 and will return a negative number if version1 is newer, a positive number if version2 is newer, and a 0 if the version ordering can't successfully be determined.

                                        Control0..1
                                        BindingUnless not suitable, these codes SHALL be taken from VersionAlgorithm
                                        (extensible to http://hl7.org/fhir/ValueSet/version-algorithm)
                                        TypeChoice of: string, Coding
                                        [x] NoteSee Choice of Data Types for further information about how to use [x]
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summarytrue
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        26. Evidence.name
                                        Definition

                                        A natural language name identifying the evidence. This name should be usable as an identifier for the module by machine processing applications such as code generation.

                                        ShortName for this summary (machine friendly)
                                        Comments

                                        The name is not expected to be globally unique. The name should be a simple alphanumeric type name to ensure that it is machine-processing friendly.

                                        Control0..1
                                        This element is affected by the following invariants: cnl-0
                                        Typestring
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        28. Evidence.title
                                        Definition

                                        A short, descriptive, user-friendly title for the summary.

                                        ShortName for this summary (human friendly)
                                        Control0..1
                                        Typestring
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summarytrue
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        30. Evidence.citeAs[x]
                                        Definition

                                        Citation Resource or display of suggested citation for this evidence.

                                        ShortCitation for this evidence
                                        Control0..1
                                        TypeChoice of: Reference(Citation), markdown
                                        [x] NoteSee Choice of Data Types for further information about how to use [x]
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        32. Evidence.status
                                        Definition

                                        The status of this summary. Enables tracking the life-cycle of the content.

                                        Shortdraft | active | retired | unknown
                                        Comments

                                        Allows filtering of summarys s that are appropriate for use versus not.

                                        See guidance around (not) making local changes to elements here.

                                        Control1..1
                                        BindingThe codes SHALL be taken from PublicationStatus
                                        (required to http://hl7.org/fhir/ValueSet/publication-status|5.0.0)

                                        The lifecycle status of an artifact.

                                        Typecode
                                        Is Modifiertrue because This is labeled as "Is Modifier" because applications should not use a retired {{title}} without due consideration
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summarytrue
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        34. Evidence.experimental
                                        Definition

                                        A Boolean value to indicate that this resource is authored for testing purposes (or education/evaluation/marketing) and is not intended to be used for genuine usage.

                                        ShortFor testing purposes, not real usage
                                        Control0..1
                                        Typeboolean
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Meaning if MissingIf absent, this resource is treated as though it is not experimental.
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        36. Evidence.date
                                        Definition

                                        The date (and optionally time) when the summary was last significantly changed. The date must change when the business version changes and it must change if the status code changes. In addition, it should change when the substantive content of the summary changes.

                                        ShortDate last changed
                                        Comments

                                        The date is often not tracked until the resource is published, but may be present on draft content. Note that this is not the same as the resource last-modified-date, since the resource may be a secondary representation of the summary. Additional specific dates may be added as extensions or be found by consulting Provenances associated with past versions of the resource.

                                        See guidance around (not) making local changes to elements here.

                                        Control0..1
                                        TypedateTime
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summarytrue
                                        Alternate NamesRevision Date
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        38. Evidence.approvalDate
                                        Definition

                                        The date on which the resource content was approved by the publisher. Approval happens once when the content is officially approved for usage.

                                        ShortWhen the summary was approved by publisher
                                        Comments

                                        The 'date' element may be more recent than the approval date because of minor changes or editorial corrections.

                                        See guidance around (not) making local changes to elements here.

                                        Control0..1
                                        Typedate
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        40. Evidence.lastReviewDate
                                        Definition

                                        The date on which the resource content was last reviewed. Review happens periodically after approval but does not change the original approval date.

                                        ShortWhen the summary was last reviewed by the publisher
                                        Comments

                                        If specified, this date follows the original approval date.

                                        See guidance around (not) making local changes to elements here.

                                        Control0..1
                                        Typedate
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Requirements

                                        Gives a sense of how "current" the content is. Resources that have not been reviewed in a long time may have a risk of being less appropriate/relevant.

                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        42. Evidence.publisher
                                        Definition

                                        The name of the organization or individual responsible for the release and ongoing maintenance of the evidence.

                                        ShortName of the publisher/steward (organization or individual)
                                        Comments

                                        Usually an organization but may be an individual. The publisher (or steward) of the evidence is the organization or individual primarily responsible for the maintenance and upkeep of the evidence. This is not necessarily the same individual or organization that developed and initially authored the content. The publisher is the primary point of contact for questions or issues with the evidence. This item SHOULD be populated unless the information is available from context.

                                        Control0..1
                                        Typestring
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summarytrue
                                        Requirements

                                        Helps establish the "authority/credibility" of the evidence. May also allow for contact.

                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        44. Evidence.contact
                                        Definition

                                        Contact details to assist a user in finding and communicating with the publisher.

                                        ShortContact details for the publisher
                                        Comments

                                        Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see Clinical Reasoning Module).

                                        See guidance around (not) making local changes to elements here.

                                        Control0..*
                                        TypeContactDetail
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summarytrue
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        46. Evidence.author
                                        Definition

                                        An individiual, organization, or device primarily involved in the creation and maintenance of the content.

                                        ShortWho authored the content
                                        Comments

                                        Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see Clinical Reasoning Module).

                                        Control0..*
                                        TypeContactDetail
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summarytrue
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        48. Evidence.editor
                                        Definition

                                        An individiual, organization, or device primarily responsible for internal coherence of the content.

                                        ShortWho edited the content
                                        Comments

                                        Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see Clinical Reasoning Module).

                                        Control0..*
                                        TypeContactDetail
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        50. Evidence.reviewer
                                        Definition

                                        An individiual, organization, or device primarily responsible for review of some aspect of the content.

                                        ShortWho reviewed the content
                                        Comments

                                        Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see Clinical Reasoning Module).

                                        See guidance around (not) making local changes to elements here.

                                        Control0..*
                                        TypeContactDetail
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        52. Evidence.endorser
                                        Definition

                                        An individiual, organization, or device responsible for officially endorsing the content for use in some setting.

                                        ShortWho endorsed the content
                                        Comments

                                        Extensions to ContactDetail include: contactReference, contactAddress, and contributionTime (see Clinical Reasoning Module).

                                        See guidance around (not) making local changes to elements here.

                                        Control0..*
                                        TypeContactDetail
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summarytrue
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        54. Evidence.useContext
                                        Definition

                                        The content was developed with a focus and intent of supporting the contexts that are listed. These contexts may be general categories (gender, age, ...) or may be references to specific programs (insurance plans, studies, ...) and may be used to assist with indexing and searching for appropriate evidence instances.

                                        ShortThe context that the content is intended to support
                                        Comments

                                        When multiple useContexts are specified, there is no expectation that all or any of the contexts apply.

                                        Control0..*
                                        TypeUsageContext
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summarytrue
                                        Requirements

                                        Assist in searching for appropriate content.

                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        56. Evidence.purpose
                                        Definition

                                        Explanation of why this Evidence is needed and why it has been designed as it has.

                                        ShortWhy this Evidence is defined
                                        Comments

                                        This element does not describe the usage of the Evidence. Instead, it provides traceability of ''why'' the resource is either needed or ''why'' it is defined as it is. This may be used to point to source materials or specifications that drove the structure of this Evidence.

                                        Control0..1
                                        Typemarkdown
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        58. Evidence.copyright
                                        Definition

                                        A copyright statement relating to the Evidence and/or its contents. Copyright statements are generally legal restrictions on the use and publishing of the Evidence.

                                        ShortUse and/or publishing restrictions
                                        Comments

                                        The short copyright declaration (e.g. (c) '2015+ xyz organization' should be sent in the copyrightLabel element.

                                        Control0..1
                                        Typemarkdown
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Requirements

                                        Consumers must be able to determine any legal restrictions on the use of the Evidence and/or its content.

                                        Alternate NamesLicense, Restrictions
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        60. Evidence.copyrightLabel
                                        Definition

                                        A short string (<50 characters), suitable for inclusion in a page footer that identifies the copyright holder, effective period, and optionally whether rights are resctricted. (e.g. 'All rights reserved', 'Some rights reserved').

                                        ShortCopyright holder and year(s)
                                        Comments

                                        The (c) symbol should NOT be included in this string. It will be added by software when rendering the notation. Full details about licensing, restrictions, warrantees, etc. goes in the more general 'copyright' element.

                                        Control0..1
                                        Typestring
                                        Is Modifierfalse
                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                        Must Supportfalse
                                        Summaryfalse
                                        Requirements

                                        Defines the content expected to be rendered in all representations of the artifact.

                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        62. Evidence.relatedArtifact
                                        Definition

                                        Link or citation to artifact associated with the summary.

                                        ShortLink or citation to artifact associated with the summary
                                        Control1..*
                                        TypeRelatedArtifact
                                        Is Modifierfalse
                                        Must Supportfalse
                                        Summaryfalse
                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                        SlicingThis element introduces a set of slices on Evidence.relatedArtifact. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                        • value @ type
                                        • 64. Evidence.relatedArtifact:amendedWith
                                          Slice NameamendedWith
                                          Definition

                                          Link or citation to artifact associated with the summary.

                                          ShortLink or citation to artifact associated with the summary
                                          Control1..*
                                          TypeRelatedArtifact
                                          Is Modifierfalse
                                          Must Supporttrue
                                          Summaryfalse
                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                          66. Evidence.relatedArtifact:amendedWith.id
                                          Definition

                                          Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                          ShortUnique id for inter-element referencing
                                          Control0..1
                                          This element is affected by the following invariants: ele-1
                                          Typeid
                                          Is Modifierfalse
                                          XML FormatIn the XML format, this property is represented as an attribute.
                                          Summaryfalse
                                          68. Evidence.relatedArtifact:amendedWith.extension
                                          Definition

                                          May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                          ShortAdditional content defined by implementations
                                          Comments

                                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                          Control0..*
                                          TypeExtension
                                          Is Modifierfalse
                                          Summaryfalse
                                          Alternate Namesextensions, user content
                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                          ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                          SlicingThis element introduces a set of slices on Evidence.relatedArtifact.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                          • value @ url
                                          • 70. Evidence.relatedArtifact:amendedWith.type
                                            Definition

                                            The type of relationship to the related artifact.

                                            Shortdocumentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as
                                            Comments

                                            The presence of both sides of a relationship type (e.g. successor and predecessor) is required to support use cases where one side of a relationship is not represented in FHIR. However, this feature SHALL NOT be used to create bi-directional resource links in FHIR instances. Specifically, following the methodology of "new points to old" and "many points to one", when using related artifact elements to describe and reference FHIR resources, the type element SHALL be drawn from the fhir-related-artifact-type ValueSet.

                                            Control1..1
                                            BindingThe codes SHALL be taken from RelatedArtifactType
                                            (required to http://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0)

                                            The type of relationship to the related artifact.

                                            Typecode
                                            Is Modifierfalse
                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                            Summarytrue
                                            Pattern Valueamended-with
                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                            72. Evidence.relatedArtifact:amendedWith.classifier
                                            Definition

                                            Provides additional classifiers of the related artifact.

                                            ShortAdditional classifiers
                                            Control0..*
                                            BindingFor example codes, see CitationArtifactClassifier
                                            (example to http://hl7.org/fhir/ValueSet/citation-artifact-classifier)

                                            Additional classifiers for the related artifact.

                                            TypeCodeableConcept
                                            Is Modifierfalse
                                            Summarytrue
                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                            74. Evidence.relatedArtifact:amendedWith.label
                                            Definition

                                            A short label that can be used to reference the citation from elsewhere in the containing artifact, such as a footnote index.

                                            ShortShort label
                                            Control0..1
                                            Typestring
                                            Is Modifierfalse
                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                            Summarytrue
                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                            76. Evidence.relatedArtifact:amendedWith.display
                                            Definition

                                            A brief description of the document or knowledge resource being referenced, suitable for display to a consumer.

                                            ShortBrief description of the related artifact
                                            Control0..1
                                            Typestring
                                            Is Modifierfalse
                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                            Summarytrue
                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                            78. Evidence.relatedArtifact:amendedWith.citation
                                            Definition

                                            A bibliographic citation for the related artifact. This text SHOULD be formatted according to an accepted citation format.

                                            ShortBibliographic citation for the artifact
                                            Comments

                                            Additional structured information about citations should be captured as extensions.

                                            Control0..1
                                            Typemarkdown
                                            Is Modifierfalse
                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                            Summarytrue
                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                            80. Evidence.relatedArtifact:amendedWith.document
                                            Definition

                                            The document being referenced, represented as an attachment. This is exclusive with the resource element.

                                            ShortWhat document is being referenced
                                            Control0..1
                                            TypeAttachment
                                            Is Modifierfalse
                                            Summarytrue
                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                            82. Evidence.relatedArtifact:amendedWith.resource
                                            Definition

                                            The related artifact, such as a library, value set, profile, or other knowledge resource.

                                            ShortWhat artifact is being referenced
                                            Comments

                                            If the type is predecessor, this is a reference to the succeeding knowledge resource. If the type is successor, this is a reference to the prior knowledge resource.

                                            Control0..1
                                            Typecanonical(Resource)
                                            Is Modifierfalse
                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                            Summarytrue
                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                            84. Evidence.relatedArtifact:amendedWith.resourceReference
                                            Definition

                                            The related artifact, if the artifact is not a canonical resource, or a resource reference to a canonical resource.

                                            ShortWhat artifact, if not a conformance resource
                                            Comments

                                            If both resource and resourceReference are present, they SHOULD be consistent and reference the same resource. Although relatedArtifact is intended to support references to definitional resources, there are cases where non-definitional resources can be definitional (such as Location where the kind is mode). Related artifacts SHOULD be used to reference definitional resources, and profiles SHOULD be used to make that explicit for particular use cases.

                                            Control0..1
                                            TypeReference(OutcomeImportance)
                                            Is Modifierfalse
                                            Summarytrue
                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                            86. Evidence.relatedArtifact:amendedWith.publicationStatus
                                            Definition

                                            The publication status of the artifact being referred to.

                                            Shortdraft | active | retired | unknown
                                            Control0..1
                                            BindingThe codes SHALL be taken from PublicationStatus
                                            (required to http://hl7.org/fhir/ValueSet/publication-status|5.0.0)

                                            Publication status of an artifact being referred to.

                                            Typecode
                                            Is Modifierfalse
                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                            Summarytrue
                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                            88. Evidence.relatedArtifact:amendedWith.publicationDate
                                            Definition

                                            The date of publication of the artifact being referred to.

                                            ShortDate of publication of the artifact being referred to
                                            Control0..1
                                            Typedate
                                            Is Modifierfalse
                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                            Summarytrue
                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                            90. Evidence.relatedArtifact:citeAs
                                            Slice NameciteAs
                                            Definition

                                            Link or citation to artifact associated with the summary.

                                            ShortLink or citation to artifact associated with the summary
                                            Control0..1
                                            TypeRelatedArtifact
                                            Is Modifierfalse
                                            Must Supportfalse
                                            Summaryfalse
                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                            92. Evidence.relatedArtifact:citeAs.id
                                            Definition

                                            Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                            ShortUnique id for inter-element referencing
                                            Control0..1
                                            This element is affected by the following invariants: ele-1
                                            Typeid
                                            Is Modifierfalse
                                            XML FormatIn the XML format, this property is represented as an attribute.
                                            Summaryfalse
                                            94. Evidence.relatedArtifact:citeAs.extension
                                            Definition

                                            May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                            ShortAdditional content defined by implementations
                                            Comments

                                            There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                            Control0..*
                                            TypeExtension
                                            Is Modifierfalse
                                            Summaryfalse
                                            Alternate Namesextensions, user content
                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                            ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                            SlicingThis element introduces a set of slices on Evidence.relatedArtifact.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                            • value @ url
                                            • 96. Evidence.relatedArtifact:citeAs.type
                                              Definition

                                              The type of relationship to the related artifact.

                                              Shortdocumentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as
                                              Comments

                                              The presence of both sides of a relationship type (e.g. successor and predecessor) is required to support use cases where one side of a relationship is not represented in FHIR. However, this feature SHALL NOT be used to create bi-directional resource links in FHIR instances. Specifically, following the methodology of "new points to old" and "many points to one", when using related artifact elements to describe and reference FHIR resources, the type element SHALL be drawn from the fhir-related-artifact-type ValueSet.

                                              Control1..1
                                              BindingThe codes SHALL be taken from RelatedArtifactType
                                              (required to http://hl7.org/fhir/ValueSet/related-artifact-type|5.0.0)

                                              The type of relationship to the related artifact.

                                              Typecode
                                              Is Modifierfalse
                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                              Summarytrue
                                              Pattern Valuecite-as
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              98. Evidence.relatedArtifact:citeAs.classifier
                                              Definition

                                              Provides additional classifiers of the related artifact.

                                              ShortAdditional classifiers
                                              Control0..*
                                              BindingFor example codes, see CitationArtifactClassifier
                                              (example to http://hl7.org/fhir/ValueSet/citation-artifact-classifier)

                                              Additional classifiers for the related artifact.

                                              TypeCodeableConcept
                                              Is Modifierfalse
                                              Summarytrue
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              100. Evidence.relatedArtifact:citeAs.label
                                              Definition

                                              A short label that can be used to reference the citation from elsewhere in the containing artifact, such as a footnote index.

                                              ShortShort label
                                              Control0..1
                                              Typestring
                                              Is Modifierfalse
                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                              Summarytrue
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              102. Evidence.relatedArtifact:citeAs.display
                                              Definition

                                              A brief description of the document or knowledge resource being referenced, suitable for display to a consumer.

                                              ShortBrief description of the related artifact
                                              Control0..1
                                              Typestring
                                              Is Modifierfalse
                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                              Summarytrue
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              104. Evidence.relatedArtifact:citeAs.citation
                                              Definition

                                              A bibliographic citation for the related artifact. This text SHOULD be formatted according to an accepted citation format.

                                              ShortBibliographic citation for the artifact
                                              Comments

                                              Additional structured information about citations should be captured as extensions.

                                              Control0..1
                                              Typemarkdown
                                              Is Modifierfalse
                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                              Summarytrue
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              106. Evidence.relatedArtifact:citeAs.document
                                              Definition

                                              The document being referenced, represented as an attachment. This is exclusive with the resource element.

                                              ShortWhat document is being referenced
                                              Control0..1
                                              TypeAttachment
                                              Is Modifierfalse
                                              Summarytrue
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              108. Evidence.relatedArtifact:citeAs.resource
                                              Definition

                                              The related artifact, such as a library, value set, profile, or other knowledge resource.

                                              ShortWhat artifact is being referenced
                                              Comments

                                              If the type is predecessor, this is a reference to the succeeding knowledge resource. If the type is successor, this is a reference to the prior knowledge resource.

                                              Control0..1
                                              Typecanonical(Resource)
                                              Is Modifierfalse
                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                              Summarytrue
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              110. Evidence.relatedArtifact:citeAs.resourceReference
                                              Definition

                                              The related artifact, if the artifact is not a canonical resource, or a resource reference to a canonical resource.

                                              ShortWhat artifact, if not a conformance resource
                                              Comments

                                              If both resource and resourceReference are present, they SHOULD be consistent and reference the same resource. Although relatedArtifact is intended to support references to definitional resources, there are cases where non-definitional resources can be definitional (such as Location where the kind is mode). Related artifacts SHOULD be used to reference definitional resources, and profiles SHOULD be used to make that explicit for particular use cases.

                                              Control0..1
                                              TypeReference(Resource)
                                              Is Modifierfalse
                                              Summarytrue
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              112. Evidence.relatedArtifact:citeAs.publicationStatus
                                              Definition

                                              The publication status of the artifact being referred to.

                                              Shortdraft | active | retired | unknown
                                              Control0..1
                                              BindingThe codes SHALL be taken from PublicationStatus
                                              (required to http://hl7.org/fhir/ValueSet/publication-status|5.0.0)

                                              Publication status of an artifact being referred to.

                                              Typecode
                                              Is Modifierfalse
                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                              Summarytrue
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              114. Evidence.relatedArtifact:citeAs.publicationDate
                                              Definition

                                              The date of publication of the artifact being referred to.

                                              ShortDate of publication of the artifact being referred to
                                              Control0..1
                                              Typedate
                                              Is Modifierfalse
                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                              Summarytrue
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              116. Evidence.description
                                              Definition

                                              A free text natural language description of the evidence from a consumer's perspective.

                                              ShortDescription of the particular summary
                                              Comments

                                              This description can be used to capture details such as comments about misuse, instructions for clinical use and interpretation, literature references, examples from the paper world, etc. It is not a rendering of the evidence as conveyed in the 'text' field of the resource itself. This item SHOULD be populated unless the information is available from context (e.g. the language of the evidence is presumed to be the predominant language in the place the evidence was created).

                                              Control0..1
                                              Typemarkdown
                                              Is Modifierfalse
                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                              Must Supportfalse
                                              Summaryfalse
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              118. Evidence.assertion
                                              Definition

                                              Declarative description of the Evidence.

                                              ShortDeclarative description of the Evidence
                                              Control0..1
                                              Typemarkdown
                                              Is Modifierfalse
                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                              Must Supportfalse
                                              Summaryfalse
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              120. Evidence.note
                                              Definition

                                              Footnotes and/or explanatory notes.

                                              ShortFootnotes and/or explanatory notes
                                              Control0..*
                                              TypeAnnotation
                                              Is Modifierfalse
                                              Must Supportfalse
                                              Summaryfalse
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              122. Evidence.variableDefinition
                                              Definition

                                              Evidence variable such as population, exposure, or outcome.

                                              ShortEvidence variable such as population, exposure, or outcome
                                              Comments

                                              To report comparative evidence for a research question defined by Population, Intervention, Comparator, and Outcome (PICO), one would use three variableDefinition instances: the Population has variableRole of population, the Intervention and Comparator will be expressed as category values for a GroupAssignment EvidenceVariable with the variableRole of exposure, and the Outcome has variableRole of outcome. In some types of Comparative Evidence, where the groups being compared are not from the same Population (and thus not a PICO-style research question), the GroupAssignment EvidenceVariable may have the variableRole of exposure and express the populations being compared as categories, and a combination of these categories can be described in the variableDefinition with variableRole of population. This approach may be used for example to compare cats and dogs.

                                              Control4..*
                                              TypeBackboneElement
                                              Is Modifierfalse
                                              Must Supportfalse
                                              Summaryfalse
                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                              SlicingThis element introduces a set of slices on Evidence.variableDefinition. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                              • value @ note.text
                                              • 124. Evidence.variableDefinition.id
                                                Definition

                                                Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                ShortUnique id for inter-element referencing
                                                Control0..1
                                                This element is affected by the following invariants: ele-1
                                                Typestring
                                                Is Modifierfalse
                                                XML FormatIn the XML format, this property is represented as an attribute.
                                                Summaryfalse
                                                126. Evidence.variableDefinition.extension
                                                Definition

                                                An Extension

                                                ShortExtension
                                                Control1..*
                                                TypeExtension
                                                Is Modifierfalse
                                                Summaryfalse
                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                • value @ url
                                                • 128. Evidence.variableDefinition.extension:variableRoleCode
                                                  Slice NamevariableRoleCode
                                                  Definition

                                                  Classification of the role of the variable.

                                                  Shortpopulation | exposure | outcome | covariate
                                                  Control1..1
                                                  TypeExtension(VariableDefinitionVariableRoleCode) (Extension Type: code)
                                                  Is Modifierfalse
                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                  130. Evidence.variableDefinition.extension:roleSubtype
                                                  Slice NameroleSubtype
                                                  Definition

                                                  Sub-classification of the role of the variable.

                                                  Shortsubgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier
                                                  Control0..1
                                                  TypeExtension(VariableDefinitionRoleSubtype) (Extension Type: CodeableConcept)
                                                  Is Modifierfalse
                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                  132. Evidence.variableDefinition.extension:comparatorCategory
                                                  Slice NamecomparatorCategory
                                                  Definition

                                                  The reference value used for comparison. Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                                                  ShortThe reference value used for comparison
                                                  Control0..1
                                                  TypeExtension(VariableDefinitionComparatorCategory) (Extension Type: string)
                                                  Is Modifierfalse
                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                  134. Evidence.variableDefinition.modifierExtension
                                                  Definition

                                                  May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                  Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                  ShortExtensions that cannot be ignored even if unrecognized
                                                  Comments

                                                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                  Control0..*
                                                  TypeExtension
                                                  Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                  Summarytrue
                                                  Requirements

                                                  Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                  Alternate Namesextensions, user content, modifiers
                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                  136. Evidence.variableDefinition.description
                                                  Definition

                                                  A text description or summary of the variable.

                                                  ShortA text description or summary of the variable
                                                  Control0..1
                                                  Typemarkdown
                                                  Is Modifierfalse
                                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                  Must Supportfalse
                                                  Summaryfalse
                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                  138. Evidence.variableDefinition.note
                                                  Definition

                                                  Footnotes and/or explanatory notes.

                                                  ShortFootnotes and/or explanatory notes
                                                  Control0..*
                                                  TypeAnnotation
                                                  Is Modifierfalse
                                                  Must Supportfalse
                                                  Summaryfalse
                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                  140. Evidence.variableDefinition.variableRole
                                                  Definition

                                                  population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.

                                                  Shortpopulation | subpopulation | exposure | referenceExposure | measuredVariable | confounder
                                                  Control1..1
                                                  BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRole
                                                  (extensible to http://hl7.org/fhir/ValueSet/variable-role)

                                                  The role that the assertion variable plays.

                                                  TypeCodeableConcept
                                                  Is Modifierfalse
                                                  Must Supportfalse
                                                  Summarytrue
                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                  142. Evidence.variableDefinition.variableRole.id
                                                  Definition

                                                  Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                  ShortUnique id for inter-element referencing
                                                  Control0..1
                                                  This element is affected by the following invariants: ele-1
                                                  Typeid
                                                  Is Modifierfalse
                                                  XML FormatIn the XML format, this property is represented as an attribute.
                                                  Summaryfalse
                                                  144. Evidence.variableDefinition.variableRole.extension
                                                  Definition

                                                  May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                  ShortAdditional content defined by implementations
                                                  Comments

                                                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                  Control0..*
                                                  TypeExtension
                                                  Is Modifierfalse
                                                  Summaryfalse
                                                  Alternate Namesextensions, user content
                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                  SlicingThis element introduces a set of slices on Evidence.variableDefinition.variableRole.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                  • value @ url
                                                  • 146. Evidence.variableDefinition.variableRole.coding
                                                    Definition

                                                    A reference to a code defined by a terminology system.

                                                    ShortCode defined by a terminology system
                                                    Comments

                                                    Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                                                    Control0..*
                                                    TypeCoding
                                                    Is Modifierfalse
                                                    Summarytrue
                                                    Requirements

                                                    Allows for alternative encodings within a code system, and translations to other code systems.

                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                    148. Evidence.variableDefinition.variableRole.text
                                                    Definition

                                                    A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

                                                    ShortPlain text representation of the concept
                                                    Comments

                                                    Very often the text is the same as a displayName of one of the codings.

                                                    Control0..1
                                                    Typestring
                                                    Is Modifierfalse
                                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                    Summarytrue
                                                    Requirements

                                                    The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

                                                    Pattern ValueUse extension:variableRoleCode instead.
                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                    150. Evidence.variableDefinition.observed
                                                    Definition

                                                    Definition of the actual variable related to the statistic(s).

                                                    ShortDefinition of the actual variable related to the statistic(s)
                                                    Control0..1
                                                    TypeReference(Group, EvidenceVariable)
                                                    Is Modifierfalse
                                                    Must Supportfalse
                                                    Summarytrue
                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                    152. Evidence.variableDefinition.intended
                                                    Definition

                                                    Definition of the intended variable related to the Evidence.

                                                    ShortDefinition of the intended variable related to the Evidence
                                                    Control0..1
                                                    TypeReference(Group, EvidenceVariable)
                                                    Is Modifierfalse
                                                    Must Supportfalse
                                                    Summaryfalse
                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                    154. Evidence.variableDefinition.directnessMatch
                                                    Definition

                                                    Indication of quality of match between intended variable to actual variable.

                                                    Shortlow | moderate | high | exact
                                                    Control0..1
                                                    BindingUnless not suitable, these codes SHALL be taken from EvidenceDirectness
                                                    (extensible to http://terminology.hl7.org/ValueSet/directness)

                                                    The quality of how direct the match is.

                                                    TypeCodeableConcept
                                                    Is Modifierfalse
                                                    Must Supportfalse
                                                    Summaryfalse
                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                    156. Evidence.variableDefinition:population
                                                    Slice Namepopulation
                                                    Definition

                                                    Evidence variable such as population, exposure, or outcome.

                                                    ShortEvidence variable such as population, exposure, or outcome
                                                    Control1..*
                                                    TypeBackboneElement
                                                    Is Modifierfalse
                                                    Must Supportfalse
                                                    Summaryfalse
                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                    158. Evidence.variableDefinition:population.id
                                                    Definition

                                                    Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                    ShortUnique id for inter-element referencing
                                                    Control0..1
                                                    This element is affected by the following invariants: ele-1
                                                    Typestring
                                                    Is Modifierfalse
                                                    XML FormatIn the XML format, this property is represented as an attribute.
                                                    Summaryfalse
                                                    160. Evidence.variableDefinition:population.extension
                                                    Definition

                                                    An Extension

                                                    ShortExtension
                                                    Control1..*
                                                    TypeExtension
                                                    Is Modifierfalse
                                                    Summaryfalse
                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                    SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                    • value @ url
                                                    • 162. Evidence.variableDefinition:population.extension:variableRoleCode
                                                      Slice NamevariableRoleCode
                                                      Definition

                                                      Classification of the role of the variable.

                                                      Shortpopulation | exposure | outcome | covariate
                                                      Control1..1
                                                      TypeExtension(VariableDefinitionVariableRoleCode) (Extension Type: code)
                                                      Is Modifierfalse
                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                      164. Evidence.variableDefinition:population.extension:variableRoleCode.id
                                                      Definition

                                                      Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                      ShortUnique id for inter-element referencing
                                                      Control0..1
                                                      This element is affected by the following invariants: ele-1
                                                      Typeid
                                                      Is Modifierfalse
                                                      XML FormatIn the XML format, this property is represented as an attribute.
                                                      Summaryfalse
                                                      166. Evidence.variableDefinition:population.extension:variableRoleCode.extension
                                                      Definition

                                                      An Extension

                                                      ShortExtension
                                                      Control0..0
                                                      TypeExtension
                                                      Is Modifierfalse
                                                      Summaryfalse
                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                      SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                      • value @ url
                                                      • 168. Evidence.variableDefinition:population.extension:variableRoleCode.url
                                                        Definition

                                                        Source of the definition for the extension code - a logical name or a URL.

                                                        Shortidentifies the meaning of the extension
                                                        Comments

                                                        The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                                                        Control1..1
                                                        Typeuri
                                                        Is Modifierfalse
                                                        XML FormatIn the XML format, this property is represented as an attribute.
                                                        Summaryfalse
                                                        Fixed Valuehttp://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
                                                        170. Evidence.variableDefinition:population.extension:variableRoleCode.value[x]
                                                        Definition

                                                        Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                                                        ShortValue of extension
                                                        Control0..1
                                                        This element is affected by the following invariants: ext-1
                                                        Typecode
                                                        [x] NoteSee Choice of Data Types for further information about how to use [x]
                                                        Is Modifierfalse
                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                        Summaryfalse
                                                        Pattern Valuepopulation
                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                        172. Evidence.variableDefinition:population.extension:roleSubtype
                                                        Slice NameroleSubtype
                                                        Definition

                                                        Sub-classification of the role of the variable.

                                                        Shortsubgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier
                                                        Control0..1
                                                        TypeExtension(VariableDefinitionRoleSubtype) (Extension Type: CodeableConcept)
                                                        Is Modifierfalse
                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                        174. Evidence.variableDefinition:population.extension:comparatorCategory
                                                        Slice NamecomparatorCategory
                                                        Definition

                                                        The reference value used for comparison. Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                                                        ShortThe reference value used for comparison
                                                        Control0..1
                                                        TypeExtension(VariableDefinitionComparatorCategory) (Extension Type: string)
                                                        Is Modifierfalse
                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                        176. Evidence.variableDefinition:population.modifierExtension
                                                        Definition

                                                        May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                        ShortExtensions that cannot be ignored even if unrecognized
                                                        Comments

                                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                        Control0..*
                                                        TypeExtension
                                                        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                        Summarytrue
                                                        Requirements

                                                        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                        Alternate Namesextensions, user content, modifiers
                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                        178. Evidence.variableDefinition:population.description
                                                        Definition

                                                        A text description or summary of the variable.

                                                        ShortA text description or summary of the variable
                                                        Control0..1
                                                        Typemarkdown
                                                        Is Modifierfalse
                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                        Must Supportfalse
                                                        Summaryfalse
                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                        180. Evidence.variableDefinition:population.note
                                                        Definition

                                                        Footnotes and/or explanatory notes.

                                                        ShortFootnotes and/or explanatory notes
                                                        Control0..*
                                                        TypeAnnotation
                                                        Is Modifierfalse
                                                        Must Supportfalse
                                                        Summaryfalse
                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                        182. Evidence.variableDefinition:population.note.id
                                                        Definition

                                                        Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                        ShortUnique id for inter-element referencing
                                                        Control0..1
                                                        This element is affected by the following invariants: ele-1
                                                        Typeid
                                                        Is Modifierfalse
                                                        XML FormatIn the XML format, this property is represented as an attribute.
                                                        Summaryfalse
                                                        184. Evidence.variableDefinition:population.note.extension
                                                        Definition

                                                        May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                        ShortAdditional content defined by implementations
                                                        Comments

                                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                        Control0..*
                                                        TypeExtension
                                                        Is Modifierfalse
                                                        Summaryfalse
                                                        Alternate Namesextensions, user content
                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                        SlicingThis element introduces a set of slices on Evidence.variableDefinition.note.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                        • value @ url
                                                        • 186. Evidence.variableDefinition:population.note.author[x]
                                                          Definition

                                                          The individual responsible for making the annotation.

                                                          ShortIndividual responsible for the annotation
                                                          Comments

                                                          Organization is used when there's no need for specific attribution as to who made the comment.

                                                          Control0..1
                                                          TypeChoice of: Reference(Practitioner, PractitionerRole, Patient, RelatedPerson, Organization), string
                                                          [x] NoteSee Choice of Data Types for further information about how to use [x]
                                                          Is Modifierfalse
                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                          Summarytrue
                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                          188. Evidence.variableDefinition:population.note.time
                                                          Definition

                                                          Indicates when this particular annotation was made.

                                                          ShortWhen the annotation was made
                                                          Control0..1
                                                          TypedateTime
                                                          Is Modifierfalse
                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                          Summarytrue
                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                          190. Evidence.variableDefinition:population.note.text
                                                          Definition

                                                          The text of the annotation in markdown format.

                                                          ShortThe annotation - text content (as markdown)
                                                          Control1..1
                                                          Typemarkdown
                                                          Is Modifierfalse
                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                          Summarytrue
                                                          Pattern Valuepopulation
                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                          192. Evidence.variableDefinition:population.variableRole
                                                          Definition

                                                          population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.

                                                          Shortpopulation | subpopulation | exposure | referenceExposure | measuredVariable | confounder
                                                          Control1..1
                                                          BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRole
                                                          (extensible to http://hl7.org/fhir/ValueSet/variable-role)

                                                          The role that the assertion variable plays.

                                                          TypeCodeableConcept
                                                          Is Modifierfalse
                                                          Must Supportfalse
                                                          Summarytrue
                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                          194. Evidence.variableDefinition:population.variableRole.id
                                                          Definition

                                                          Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                          ShortUnique id for inter-element referencing
                                                          Control0..1
                                                          This element is affected by the following invariants: ele-1
                                                          Typeid
                                                          Is Modifierfalse
                                                          XML FormatIn the XML format, this property is represented as an attribute.
                                                          Summaryfalse
                                                          196. Evidence.variableDefinition:population.variableRole.extension
                                                          Definition

                                                          May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                          ShortAdditional content defined by implementations
                                                          Comments

                                                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                          Control0..*
                                                          TypeExtension
                                                          Is Modifierfalse
                                                          Summaryfalse
                                                          Alternate Namesextensions, user content
                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                          ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                          SlicingThis element introduces a set of slices on Evidence.variableDefinition.variableRole.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                          • value @ url
                                                          • 198. Evidence.variableDefinition:population.variableRole.coding
                                                            Definition

                                                            A reference to a code defined by a terminology system.

                                                            ShortCode defined by a terminology system
                                                            Comments

                                                            Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                                                            Control0..*
                                                            TypeCoding
                                                            Is Modifierfalse
                                                            Summarytrue
                                                            Requirements

                                                            Allows for alternative encodings within a code system, and translations to other code systems.

                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                            200. Evidence.variableDefinition:population.variableRole.text
                                                            Definition

                                                            A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

                                                            ShortPlain text representation of the concept
                                                            Comments

                                                            Very often the text is the same as a displayName of one of the codings.

                                                            Control0..1
                                                            Typestring
                                                            Is Modifierfalse
                                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                            Summarytrue
                                                            Requirements

                                                            The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

                                                            Pattern ValueUse extension:variableRoleCode instead.
                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                            202. Evidence.variableDefinition:population.observed
                                                            Definition

                                                            Definition of the actual variable related to the statistic(s).

                                                            ShortDefinition of the actual variable related to the statistic(s)
                                                            Control0..1
                                                            TypeReference(StudyGroup, ExposureGroup, ComparatorGroup, MetaanalysisStudyGroup)
                                                            Is Modifierfalse
                                                            Must Supportfalse
                                                            Summarytrue
                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                            204. Evidence.variableDefinition:population.intended
                                                            Definition

                                                            Definition of the intended variable related to the Evidence.

                                                            ShortDefinition of the intended variable related to the Evidence
                                                            Control0..1
                                                            TypeReference(Group)
                                                            Is Modifierfalse
                                                            Must Supportfalse
                                                            Summaryfalse
                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                            206. Evidence.variableDefinition:population.directnessMatch
                                                            Definition

                                                            Indication of quality of match between intended variable to actual variable.

                                                            Shortlow | moderate | high | exact
                                                            Control0..1
                                                            BindingUnless not suitable, these codes SHALL be taken from EvidenceDirectness
                                                            (extensible to http://terminology.hl7.org/ValueSet/directness)

                                                            The quality of how direct the match is.

                                                            TypeCodeableConcept
                                                            Is Modifierfalse
                                                            Must Supportfalse
                                                            Summaryfalse
                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                            208. Evidence.variableDefinition:exposure
                                                            Slice Nameexposure
                                                            Definition

                                                            Evidence variable such as population, exposure, or outcome.

                                                            ShortEvidence variable such as population, exposure, or outcome
                                                            Control1..1
                                                            TypeBackboneElement
                                                            Is Modifierfalse
                                                            Must Supportfalse
                                                            Summaryfalse
                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                            210. Evidence.variableDefinition:exposure.id
                                                            Definition

                                                            Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                            ShortUnique id for inter-element referencing
                                                            Control0..1
                                                            This element is affected by the following invariants: ele-1
                                                            Typestring
                                                            Is Modifierfalse
                                                            XML FormatIn the XML format, this property is represented as an attribute.
                                                            Summaryfalse
                                                            212. Evidence.variableDefinition:exposure.extension
                                                            Definition

                                                            An Extension

                                                            ShortExtension
                                                            Control2..*
                                                            TypeExtension
                                                            Is Modifierfalse
                                                            Summaryfalse
                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                            ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                            SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                            • value @ url
                                                            • 214. Evidence.variableDefinition:exposure.extension:variableRoleCode
                                                              Slice NamevariableRoleCode
                                                              Definition

                                                              Classification of the role of the variable.

                                                              Shortpopulation | exposure | outcome | covariate
                                                              Control1..1
                                                              TypeExtension(VariableDefinitionVariableRoleCode) (Extension Type: code)
                                                              Is Modifierfalse
                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                              216. Evidence.variableDefinition:exposure.extension:variableRoleCode.id
                                                              Definition

                                                              Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                              ShortUnique id for inter-element referencing
                                                              Control0..1
                                                              This element is affected by the following invariants: ele-1
                                                              Typeid
                                                              Is Modifierfalse
                                                              XML FormatIn the XML format, this property is represented as an attribute.
                                                              Summaryfalse
                                                              218. Evidence.variableDefinition:exposure.extension:variableRoleCode.extension
                                                              Definition

                                                              An Extension

                                                              ShortExtension
                                                              Control0..0
                                                              TypeExtension
                                                              Is Modifierfalse
                                                              Summaryfalse
                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                              SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                              • value @ url
                                                              • 220. Evidence.variableDefinition:exposure.extension:variableRoleCode.url
                                                                Definition

                                                                Source of the definition for the extension code - a logical name or a URL.

                                                                Shortidentifies the meaning of the extension
                                                                Comments

                                                                The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                                                                Control1..1
                                                                Typeuri
                                                                Is Modifierfalse
                                                                XML FormatIn the XML format, this property is represented as an attribute.
                                                                Summaryfalse
                                                                Fixed Valuehttp://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
                                                                222. Evidence.variableDefinition:exposure.extension:variableRoleCode.value[x]
                                                                Definition

                                                                Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                                                                ShortValue of extension
                                                                Control0..1
                                                                This element is affected by the following invariants: ext-1
                                                                Typecode
                                                                [x] NoteSee Choice of Data Types for further information about how to use [x]
                                                                Is Modifierfalse
                                                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                Summaryfalse
                                                                Pattern Valueexposure
                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                224. Evidence.variableDefinition:exposure.extension:roleSubtype
                                                                Slice NameroleSubtype
                                                                Definition

                                                                Sub-classification of the role of the variable.

                                                                Shortsubgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier
                                                                Control0..1
                                                                TypeExtension(VariableDefinitionRoleSubtype) (Extension Type: CodeableConcept)
                                                                Is Modifierfalse
                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                226. Evidence.variableDefinition:exposure.extension:comparatorCategory
                                                                Slice NamecomparatorCategory
                                                                Definition

                                                                The reference value used for comparison. Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                                                                ShortThe reference value used for comparison
                                                                Control1..1
                                                                TypeExtension(VariableDefinitionComparatorCategory) (Extension Type: string)
                                                                Is Modifierfalse
                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                228. Evidence.variableDefinition:exposure.modifierExtension
                                                                Definition

                                                                May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                ShortExtensions that cannot be ignored even if unrecognized
                                                                Comments

                                                                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                Control0..*
                                                                TypeExtension
                                                                Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                Summarytrue
                                                                Requirements

                                                                Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                Alternate Namesextensions, user content, modifiers
                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                230. Evidence.variableDefinition:exposure.description
                                                                Definition

                                                                A text description or summary of the variable.

                                                                ShortA text description or summary of the variable
                                                                Control0..1
                                                                Typemarkdown
                                                                Is Modifierfalse
                                                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                Must Supportfalse
                                                                Summaryfalse
                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                232. Evidence.variableDefinition:exposure.note
                                                                Definition

                                                                Footnotes and/or explanatory notes.

                                                                ShortFootnotes and/or explanatory notes
                                                                Control0..*
                                                                TypeAnnotation
                                                                Is Modifierfalse
                                                                Must Supportfalse
                                                                Summaryfalse
                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                234. Evidence.variableDefinition:exposure.note.id
                                                                Definition

                                                                Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                ShortUnique id for inter-element referencing
                                                                Control0..1
                                                                This element is affected by the following invariants: ele-1
                                                                Typeid
                                                                Is Modifierfalse
                                                                XML FormatIn the XML format, this property is represented as an attribute.
                                                                Summaryfalse
                                                                236. Evidence.variableDefinition:exposure.note.extension
                                                                Definition

                                                                May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                ShortAdditional content defined by implementations
                                                                Comments

                                                                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                Control0..*
                                                                TypeExtension
                                                                Is Modifierfalse
                                                                Summaryfalse
                                                                Alternate Namesextensions, user content
                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                SlicingThis element introduces a set of slices on Evidence.variableDefinition.note.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                • value @ url
                                                                • 238. Evidence.variableDefinition:exposure.note.author[x]
                                                                  Definition

                                                                  The individual responsible for making the annotation.

                                                                  ShortIndividual responsible for the annotation
                                                                  Comments

                                                                  Organization is used when there's no need for specific attribution as to who made the comment.

                                                                  Control0..1
                                                                  TypeChoice of: Reference(Practitioner, PractitionerRole, Patient, RelatedPerson, Organization), string
                                                                  [x] NoteSee Choice of Data Types for further information about how to use [x]
                                                                  Is Modifierfalse
                                                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                  Summarytrue
                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                  240. Evidence.variableDefinition:exposure.note.time
                                                                  Definition

                                                                  Indicates when this particular annotation was made.

                                                                  ShortWhen the annotation was made
                                                                  Control0..1
                                                                  TypedateTime
                                                                  Is Modifierfalse
                                                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                  Summarytrue
                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                  242. Evidence.variableDefinition:exposure.note.text
                                                                  Definition

                                                                  The text of the annotation in markdown format.

                                                                  ShortThe annotation - text content (as markdown)
                                                                  Control1..1
                                                                  Typemarkdown
                                                                  Is Modifierfalse
                                                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                  Summarytrue
                                                                  Pattern Valueexposure
                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                  244. Evidence.variableDefinition:exposure.variableRole
                                                                  Definition

                                                                  population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.

                                                                  Shortpopulation | subpopulation | exposure | referenceExposure | measuredVariable | confounder
                                                                  Control1..1
                                                                  BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRole
                                                                  (extensible to http://hl7.org/fhir/ValueSet/variable-role)

                                                                  The role that the assertion variable plays.

                                                                  TypeCodeableConcept
                                                                  Is Modifierfalse
                                                                  Must Supportfalse
                                                                  Summarytrue
                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                  246. Evidence.variableDefinition:exposure.variableRole.id
                                                                  Definition

                                                                  Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                  ShortUnique id for inter-element referencing
                                                                  Control0..1
                                                                  This element is affected by the following invariants: ele-1
                                                                  Typeid
                                                                  Is Modifierfalse
                                                                  XML FormatIn the XML format, this property is represented as an attribute.
                                                                  Summaryfalse
                                                                  248. Evidence.variableDefinition:exposure.variableRole.extension
                                                                  Definition

                                                                  May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                  ShortAdditional content defined by implementations
                                                                  Comments

                                                                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                  Control0..*
                                                                  TypeExtension
                                                                  Is Modifierfalse
                                                                  Summaryfalse
                                                                  Alternate Namesextensions, user content
                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                  SlicingThis element introduces a set of slices on Evidence.variableDefinition.variableRole.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                  • value @ url
                                                                  • 250. Evidence.variableDefinition:exposure.variableRole.coding
                                                                    Definition

                                                                    A reference to a code defined by a terminology system.

                                                                    ShortCode defined by a terminology system
                                                                    Comments

                                                                    Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                                                                    Control0..*
                                                                    TypeCoding
                                                                    Is Modifierfalse
                                                                    Summarytrue
                                                                    Requirements

                                                                    Allows for alternative encodings within a code system, and translations to other code systems.

                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                    252. Evidence.variableDefinition:exposure.variableRole.text
                                                                    Definition

                                                                    A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

                                                                    ShortPlain text representation of the concept
                                                                    Comments

                                                                    Very often the text is the same as a displayName of one of the codings.

                                                                    Control0..1
                                                                    Typestring
                                                                    Is Modifierfalse
                                                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                    Summarytrue
                                                                    Requirements

                                                                    The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

                                                                    Pattern ValueUse extension:variableRoleCode instead.
                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                    254. Evidence.variableDefinition:exposure.observed
                                                                    Definition

                                                                    Definition of the actual variable related to the statistic(s).

                                                                    ShortDefinition of the actual variable related to the statistic(s)
                                                                    Control0..1
                                                                    TypeReference(GroupAssignment)
                                                                    Is Modifierfalse
                                                                    Must Supportfalse
                                                                    Summarytrue
                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                    256. Evidence.variableDefinition:exposure.intended
                                                                    Definition

                                                                    Definition of the intended variable related to the Evidence.

                                                                    ShortDefinition of the intended variable related to the Evidence
                                                                    Control0..1
                                                                    TypeReference(VariableDefinition)
                                                                    Is Modifierfalse
                                                                    Must Supportfalse
                                                                    Summaryfalse
                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                    258. Evidence.variableDefinition:exposure.directnessMatch
                                                                    Definition

                                                                    Indication of quality of match between intended variable to actual variable.

                                                                    Shortlow | moderate | high | exact
                                                                    Control0..1
                                                                    BindingUnless not suitable, these codes SHALL be taken from EvidenceDirectness
                                                                    (extensible to http://terminology.hl7.org/ValueSet/directness)

                                                                    The quality of how direct the match is.

                                                                    TypeCodeableConcept
                                                                    Is Modifierfalse
                                                                    Must Supportfalse
                                                                    Summaryfalse
                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                    260. Evidence.variableDefinition:outcome
                                                                    Slice Nameoutcome
                                                                    Definition

                                                                    Evidence variable such as population, exposure, or outcome.

                                                                    ShortEvidence variable such as population, exposure, or outcome
                                                                    Control1..*
                                                                    TypeBackboneElement
                                                                    Is Modifierfalse
                                                                    Must Supporttrue
                                                                    Summaryfalse
                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                    262. Evidence.variableDefinition:outcome.id
                                                                    Definition

                                                                    Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                    ShortUnique id for inter-element referencing
                                                                    Control0..1
                                                                    This element is affected by the following invariants: ele-1
                                                                    Typestring
                                                                    Is Modifierfalse
                                                                    XML FormatIn the XML format, this property is represented as an attribute.
                                                                    Summaryfalse
                                                                    264. Evidence.variableDefinition:outcome.extension
                                                                    Definition

                                                                    An Extension

                                                                    ShortExtension
                                                                    Control1..*
                                                                    TypeExtension
                                                                    Is Modifierfalse
                                                                    Summaryfalse
                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                    SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                    • value @ url
                                                                    • 266. Evidence.variableDefinition:outcome.extension:variableRoleCode
                                                                      Slice NamevariableRoleCode
                                                                      Definition

                                                                      Classification of the role of the variable.

                                                                      Shortpopulation | exposure | outcome | covariate
                                                                      Control1..1
                                                                      TypeExtension(VariableDefinitionVariableRoleCode) (Extension Type: code)
                                                                      Is Modifierfalse
                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                      268. Evidence.variableDefinition:outcome.extension:variableRoleCode.id
                                                                      Definition

                                                                      Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                      ShortUnique id for inter-element referencing
                                                                      Control0..1
                                                                      This element is affected by the following invariants: ele-1
                                                                      Typeid
                                                                      Is Modifierfalse
                                                                      XML FormatIn the XML format, this property is represented as an attribute.
                                                                      Summaryfalse
                                                                      270. Evidence.variableDefinition:outcome.extension:variableRoleCode.extension
                                                                      Definition

                                                                      An Extension

                                                                      ShortExtension
                                                                      Control0..0
                                                                      TypeExtension
                                                                      Is Modifierfalse
                                                                      Summaryfalse
                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                      SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                      • value @ url
                                                                      • 272. Evidence.variableDefinition:outcome.extension:variableRoleCode.url
                                                                        Definition

                                                                        Source of the definition for the extension code - a logical name or a URL.

                                                                        Shortidentifies the meaning of the extension
                                                                        Comments

                                                                        The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                                                                        Control1..1
                                                                        Typeuri
                                                                        Is Modifierfalse
                                                                        XML FormatIn the XML format, this property is represented as an attribute.
                                                                        Summaryfalse
                                                                        Fixed Valuehttp://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
                                                                        274. Evidence.variableDefinition:outcome.extension:variableRoleCode.value[x]
                                                                        Definition

                                                                        Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                                                                        ShortValue of extension
                                                                        Control0..1
                                                                        This element is affected by the following invariants: ext-1
                                                                        Typecode
                                                                        [x] NoteSee Choice of Data Types for further information about how to use [x]
                                                                        Is Modifierfalse
                                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                        Summaryfalse
                                                                        Pattern Valueoutcome
                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                        276. Evidence.variableDefinition:outcome.extension:roleSubtype
                                                                        Slice NameroleSubtype
                                                                        Definition

                                                                        Sub-classification of the role of the variable.

                                                                        Shortsubgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier
                                                                        Control0..1
                                                                        TypeExtension(VariableDefinitionRoleSubtype) (Extension Type: CodeableConcept)
                                                                        Is Modifierfalse
                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                        278. Evidence.variableDefinition:outcome.extension:comparatorCategory
                                                                        Slice NamecomparatorCategory
                                                                        Definition

                                                                        The reference value used for comparison. Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                                                                        ShortThe reference value used for comparison
                                                                        Control0..0
                                                                        TypeExtension(VariableDefinitionComparatorCategory) (Extension Type: string)
                                                                        Is Modifierfalse
                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                        280. Evidence.variableDefinition:outcome.modifierExtension
                                                                        Definition

                                                                        May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                        ShortExtensions that cannot be ignored even if unrecognized
                                                                        Comments

                                                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                        Control0..*
                                                                        TypeExtension
                                                                        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                        Summarytrue
                                                                        Requirements

                                                                        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                        Alternate Namesextensions, user content, modifiers
                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                        282. Evidence.variableDefinition:outcome.description
                                                                        Definition

                                                                        A text description or summary of the variable.

                                                                        ShortA text description or summary of the variable
                                                                        Control0..1
                                                                        Typemarkdown
                                                                        Is Modifierfalse
                                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                        Must Supportfalse
                                                                        Summaryfalse
                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                        284. Evidence.variableDefinition:outcome.note
                                                                        Definition

                                                                        Footnotes and/or explanatory notes.

                                                                        ShortFootnotes and/or explanatory notes
                                                                        Control0..*
                                                                        TypeAnnotation
                                                                        Is Modifierfalse
                                                                        Must Supportfalse
                                                                        Summaryfalse
                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                        286. Evidence.variableDefinition:outcome.note.id
                                                                        Definition

                                                                        Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                        ShortUnique id for inter-element referencing
                                                                        Control0..1
                                                                        This element is affected by the following invariants: ele-1
                                                                        Typeid
                                                                        Is Modifierfalse
                                                                        XML FormatIn the XML format, this property is represented as an attribute.
                                                                        Summaryfalse
                                                                        288. Evidence.variableDefinition:outcome.note.extension
                                                                        Definition

                                                                        May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                        ShortAdditional content defined by implementations
                                                                        Comments

                                                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                        Control0..*
                                                                        TypeExtension
                                                                        Is Modifierfalse
                                                                        Summaryfalse
                                                                        Alternate Namesextensions, user content
                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                        SlicingThis element introduces a set of slices on Evidence.variableDefinition.note.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                        • value @ url
                                                                        • 290. Evidence.variableDefinition:outcome.note.author[x]
                                                                          Definition

                                                                          The individual responsible for making the annotation.

                                                                          ShortIndividual responsible for the annotation
                                                                          Comments

                                                                          Organization is used when there's no need for specific attribution as to who made the comment.

                                                                          Control0..1
                                                                          TypeChoice of: Reference(Practitioner, PractitionerRole, Patient, RelatedPerson, Organization), string
                                                                          [x] NoteSee Choice of Data Types for further information about how to use [x]
                                                                          Is Modifierfalse
                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                          Summarytrue
                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                          292. Evidence.variableDefinition:outcome.note.time
                                                                          Definition

                                                                          Indicates when this particular annotation was made.

                                                                          ShortWhen the annotation was made
                                                                          Control0..1
                                                                          TypedateTime
                                                                          Is Modifierfalse
                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                          Summarytrue
                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                          294. Evidence.variableDefinition:outcome.note.text
                                                                          Definition

                                                                          The text of the annotation in markdown format.

                                                                          ShortThe annotation - text content (as markdown)
                                                                          Control1..1
                                                                          Typemarkdown
                                                                          Is Modifierfalse
                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                          Summarytrue
                                                                          Pattern Valueoutcome
                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                          296. Evidence.variableDefinition:outcome.variableRole
                                                                          Definition

                                                                          population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.

                                                                          Shortpopulation | subpopulation | exposure | referenceExposure | measuredVariable | confounder
                                                                          Control1..1
                                                                          BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRole
                                                                          (extensible to http://hl7.org/fhir/ValueSet/variable-role)

                                                                          The role that the assertion variable plays.

                                                                          TypeCodeableConcept
                                                                          Is Modifierfalse
                                                                          Must Supportfalse
                                                                          Summarytrue
                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                          298. Evidence.variableDefinition:outcome.variableRole.id
                                                                          Definition

                                                                          Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                          ShortUnique id for inter-element referencing
                                                                          Control0..1
                                                                          This element is affected by the following invariants: ele-1
                                                                          Typeid
                                                                          Is Modifierfalse
                                                                          XML FormatIn the XML format, this property is represented as an attribute.
                                                                          Summaryfalse
                                                                          300. Evidence.variableDefinition:outcome.variableRole.extension
                                                                          Definition

                                                                          May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                          ShortAdditional content defined by implementations
                                                                          Comments

                                                                          There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                          Control0..*
                                                                          TypeExtension
                                                                          Is Modifierfalse
                                                                          Summaryfalse
                                                                          Alternate Namesextensions, user content
                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                          ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                          SlicingThis element introduces a set of slices on Evidence.variableDefinition.variableRole.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                          • value @ url
                                                                          • 302. Evidence.variableDefinition:outcome.variableRole.coding
                                                                            Definition

                                                                            A reference to a code defined by a terminology system.

                                                                            ShortCode defined by a terminology system
                                                                            Comments

                                                                            Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                                                                            Control0..*
                                                                            TypeCoding
                                                                            Is Modifierfalse
                                                                            Summarytrue
                                                                            Requirements

                                                                            Allows for alternative encodings within a code system, and translations to other code systems.

                                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                            304. Evidence.variableDefinition:outcome.variableRole.text
                                                                            Definition

                                                                            A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

                                                                            ShortPlain text representation of the concept
                                                                            Comments

                                                                            Very often the text is the same as a displayName of one of the codings.

                                                                            Control0..1
                                                                            Typestring
                                                                            Is Modifierfalse
                                                                            Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                            Summarytrue
                                                                            Requirements

                                                                            The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

                                                                            Pattern ValueUse extension:variableRoleCode instead.
                                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                            306. Evidence.variableDefinition:outcome.observed
                                                                            Definition

                                                                            Definition of the actual variable related to the statistic(s).

                                                                            ShortDefinition of the actual variable related to the statistic(s)
                                                                            Control0..1
                                                                            TypeReference(VariableDefinition)
                                                                            Is Modifierfalse
                                                                            Must Supportfalse
                                                                            Summarytrue
                                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                            308. Evidence.variableDefinition:outcome.intended
                                                                            Definition

                                                                            Definition of the intended variable related to the Evidence.

                                                                            ShortDefinition of the intended variable related to the Evidence
                                                                            Control0..1
                                                                            TypeReference(EvidenceVariable)
                                                                            Is Modifierfalse
                                                                            Must Supportfalse
                                                                            Summaryfalse
                                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                            310. Evidence.variableDefinition:outcome.directnessMatch
                                                                            Definition

                                                                            Indication of quality of match between intended variable to actual variable.

                                                                            Shortlow | moderate | high | exact
                                                                            Control0..1
                                                                            BindingUnless not suitable, these codes SHALL be taken from EvidenceDirectness
                                                                            (extensible to http://terminology.hl7.org/ValueSet/directness)

                                                                            The quality of how direct the match is.

                                                                            TypeCodeableConcept
                                                                            Is Modifierfalse
                                                                            Must Supportfalse
                                                                            Summaryfalse
                                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                            312. Evidence.variableDefinition:covariate
                                                                            Slice Namecovariate
                                                                            Definition

                                                                            Evidence variable such as population, exposure, or outcome.

                                                                            ShortEvidence variable such as population, exposure, or outcome
                                                                            Comments

                                                                            To report comparative evidence for a research question defined by Population, Intervention, Comparator, and Outcome (PICO), one would use three variableDefinition instances: the Population has variableRole of population, the Intervention and Comparator will be expressed as category values for a GroupAssignment EvidenceVariable with the variableRole of exposure, and the Outcome has variableRole of outcome. In some types of Comparative Evidence, where the groups being compared are not from the same Population (and thus not a PICO-style research question), the GroupAssignment EvidenceVariable may have the variableRole of exposure and express the populations being compared as categories, and a combination of these categories can be described in the variableDefinition with variableRole of population. This approach may be used for example to compare cats and dogs.

                                                                            Control1..*
                                                                            TypeBackboneElement
                                                                            Is Modifierfalse
                                                                            Must Supportfalse
                                                                            Summaryfalse
                                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                            314. Evidence.variableDefinition:covariate.id
                                                                            Definition

                                                                            Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                            ShortUnique id for inter-element referencing
                                                                            Control0..1
                                                                            This element is affected by the following invariants: ele-1
                                                                            Typestring
                                                                            Is Modifierfalse
                                                                            XML FormatIn the XML format, this property is represented as an attribute.
                                                                            Summaryfalse
                                                                            316. Evidence.variableDefinition:covariate.extension
                                                                            Definition

                                                                            An Extension

                                                                            ShortExtension
                                                                            Control1..*
                                                                            TypeExtension
                                                                            Is Modifierfalse
                                                                            Summaryfalse
                                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                            ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                            SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                            • value @ url
                                                                            • 318. Evidence.variableDefinition:covariate.extension:variableRoleCode
                                                                              Slice NamevariableRoleCode
                                                                              Definition

                                                                              Classification of the role of the variable.

                                                                              Shortpopulation | exposure | outcome | covariate
                                                                              Control1..1
                                                                              TypeExtension(VariableDefinitionVariableRoleCode) (Extension Type: code)
                                                                              Is Modifierfalse
                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                              320. Evidence.variableDefinition:covariate.extension:variableRoleCode.id
                                                                              Definition

                                                                              Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                              ShortUnique id for inter-element referencing
                                                                              Control0..1
                                                                              This element is affected by the following invariants: ele-1
                                                                              Typeid
                                                                              Is Modifierfalse
                                                                              XML FormatIn the XML format, this property is represented as an attribute.
                                                                              Summaryfalse
                                                                              322. Evidence.variableDefinition:covariate.extension:variableRoleCode.extension
                                                                              Definition

                                                                              An Extension

                                                                              ShortExtension
                                                                              Control0..0
                                                                              TypeExtension
                                                                              Is Modifierfalse
                                                                              Summaryfalse
                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                              SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                              • value @ url
                                                                              • 324. Evidence.variableDefinition:covariate.extension:variableRoleCode.url
                                                                                Definition

                                                                                Source of the definition for the extension code - a logical name or a URL.

                                                                                Shortidentifies the meaning of the extension
                                                                                Comments

                                                                                The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                                                                                Control1..1
                                                                                Typeuri
                                                                                Is Modifierfalse
                                                                                XML FormatIn the XML format, this property is represented as an attribute.
                                                                                Summaryfalse
                                                                                Fixed Valuehttp://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code
                                                                                326. Evidence.variableDefinition:covariate.extension:variableRoleCode.value[x]
                                                                                Definition

                                                                                Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                                                                                ShortValue of extension
                                                                                Control0..1
                                                                                This element is affected by the following invariants: ext-1
                                                                                Typecode
                                                                                [x] NoteSee Choice of Data Types for further information about how to use [x]
                                                                                Is Modifierfalse
                                                                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                Summaryfalse
                                                                                Pattern Valuecovariate
                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                328. Evidence.variableDefinition:covariate.extension:roleSubtype
                                                                                Slice NameroleSubtype
                                                                                Definition

                                                                                Sub-classification of the role of the variable.

                                                                                Shortsubgroup | variable-A | variable-B | variable-AB | confounder | collider | mediator | effect-modifier
                                                                                Control0..1
                                                                                TypeExtension(VariableDefinitionRoleSubtype) (Extension Type: CodeableConcept)
                                                                                Is Modifierfalse
                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                330. Evidence.variableDefinition:covariate.extension:roleSubtype.id
                                                                                Definition

                                                                                Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                ShortUnique id for inter-element referencing
                                                                                Control0..1
                                                                                This element is affected by the following invariants: ele-1
                                                                                Typeid
                                                                                Is Modifierfalse
                                                                                XML FormatIn the XML format, this property is represented as an attribute.
                                                                                Summaryfalse
                                                                                332. Evidence.variableDefinition:covariate.extension:roleSubtype.extension
                                                                                Definition

                                                                                An Extension

                                                                                ShortExtension
                                                                                Control0..0
                                                                                TypeExtension
                                                                                Is Modifierfalse
                                                                                Summaryfalse
                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                • value @ url
                                                                                • 334. Evidence.variableDefinition:covariate.extension:roleSubtype.url
                                                                                  Definition

                                                                                  Source of the definition for the extension code - a logical name or a URL.

                                                                                  Shortidentifies the meaning of the extension
                                                                                  Comments

                                                                                  The definition may point directly to a computable or human-readable definition of the extensibility codes, or it may be a logical URI as declared in some other specification. The definition SHALL be a URI for the Structure Definition defining the extension.

                                                                                  Control1..1
                                                                                  Typeuri
                                                                                  Is Modifierfalse
                                                                                  XML FormatIn the XML format, this property is represented as an attribute.
                                                                                  Summaryfalse
                                                                                  Fixed Valuehttp://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-role-subtype
                                                                                  336. Evidence.variableDefinition:covariate.extension:roleSubtype.value[x]
                                                                                  Definition

                                                                                  Value of extension - must be one of a constrained set of the data types (see Extensibility for a list).

                                                                                  ShortValue of extension
                                                                                  Control0..1
                                                                                  This element is affected by the following invariants: ext-1
                                                                                  BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRoleSubtype Value Set
                                                                                  (extensible to https://fevir.net/resources/ValueSet/179424)
                                                                                  TypeCodeableConcept
                                                                                  [x] NoteSee Choice of Data Types for further information about how to use [x]
                                                                                  Is Modifierfalse
                                                                                  Summaryfalse
                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                  338. Evidence.variableDefinition:covariate.extension:roleSubtype.value[x].id
                                                                                  Definition

                                                                                  Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                  ShortUnique id for inter-element referencing
                                                                                  Control0..1
                                                                                  This element is affected by the following invariants: ele-1
                                                                                  Typeid
                                                                                  Is Modifierfalse
                                                                                  XML FormatIn the XML format, this property is represented as an attribute.
                                                                                  Summaryfalse
                                                                                  340. Evidence.variableDefinition:covariate.extension:roleSubtype.value[x].extension
                                                                                  Definition

                                                                                  May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                  ShortAdditional content defined by implementations
                                                                                  Comments

                                                                                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                  Control0..*
                                                                                  TypeExtension
                                                                                  Is Modifierfalse
                                                                                  Summaryfalse
                                                                                  Alternate Namesextensions, user content
                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                  SlicingThis element introduces a set of slices on Evidence.variableDefinition.extension.value[x].extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                  • value @ url
                                                                                  • 342. Evidence.variableDefinition:covariate.extension:roleSubtype.value[x].coding
                                                                                    Definition

                                                                                    A reference to a code defined by a terminology system.

                                                                                    ShortCode defined by a terminology system
                                                                                    Comments

                                                                                    Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                                                                                    Control0..*
                                                                                    TypeCoding
                                                                                    Is Modifierfalse
                                                                                    Summarytrue
                                                                                    Requirements

                                                                                    Allows for alternative encodings within a code system, and translations to other code systems.

                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                    344. Evidence.variableDefinition:covariate.extension:roleSubtype.value[x].text
                                                                                    Definition

                                                                                    A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

                                                                                    ShortPlain text representation of the concept
                                                                                    Comments

                                                                                    Very often the text is the same as a displayName of one of the codings.

                                                                                    Control0..1
                                                                                    Typestring
                                                                                    Is Modifierfalse
                                                                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                    Summarytrue
                                                                                    Requirements

                                                                                    The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

                                                                                    Pattern ValueRelative Value Multiplier
                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                    346. Evidence.variableDefinition:covariate.extension:comparatorCategory
                                                                                    Slice NamecomparatorCategory
                                                                                    Definition

                                                                                    The reference value used for comparison. Value should match EvidenceVariable.category.name in the EvidenceVariable referenced in the observed or intended element.

                                                                                    ShortThe reference value used for comparison
                                                                                    Control0..1
                                                                                    TypeExtension(VariableDefinitionComparatorCategory) (Extension Type: string)
                                                                                    Is Modifierfalse
                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                    348. Evidence.variableDefinition:covariate.modifierExtension
                                                                                    Definition

                                                                                    May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                    Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                    ShortExtensions that cannot be ignored even if unrecognized
                                                                                    Comments

                                                                                    There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                    Control0..*
                                                                                    TypeExtension
                                                                                    Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                    Summarytrue
                                                                                    Requirements

                                                                                    Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                    Alternate Namesextensions, user content, modifiers
                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                    350. Evidence.variableDefinition:covariate.description
                                                                                    Definition

                                                                                    A text description or summary of the variable.

                                                                                    ShortA text description or summary of the variable
                                                                                    Control0..1
                                                                                    Typemarkdown
                                                                                    Is Modifierfalse
                                                                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                    Must Supportfalse
                                                                                    Summaryfalse
                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                    352. Evidence.variableDefinition:covariate.note
                                                                                    Definition

                                                                                    Footnotes and/or explanatory notes.

                                                                                    ShortFootnotes and/or explanatory notes
                                                                                    Control0..*
                                                                                    TypeAnnotation
                                                                                    Is Modifierfalse
                                                                                    Must Supportfalse
                                                                                    Summaryfalse
                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                    354. Evidence.variableDefinition:covariate.note.id
                                                                                    Definition

                                                                                    Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                    ShortUnique id for inter-element referencing
                                                                                    Control0..1
                                                                                    This element is affected by the following invariants: ele-1
                                                                                    Typeid
                                                                                    Is Modifierfalse
                                                                                    XML FormatIn the XML format, this property is represented as an attribute.
                                                                                    Summaryfalse
                                                                                    356. Evidence.variableDefinition:covariate.note.extension
                                                                                    Definition

                                                                                    May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                    ShortAdditional content defined by implementations
                                                                                    Comments

                                                                                    There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                    Control0..*
                                                                                    TypeExtension
                                                                                    Is Modifierfalse
                                                                                    Summaryfalse
                                                                                    Alternate Namesextensions, user content
                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                    SlicingThis element introduces a set of slices on Evidence.variableDefinition.note.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                    • value @ url
                                                                                    • 358. Evidence.variableDefinition:covariate.note.author[x]
                                                                                      Definition

                                                                                      The individual responsible for making the annotation.

                                                                                      ShortIndividual responsible for the annotation
                                                                                      Comments

                                                                                      Organization is used when there's no need for specific attribution as to who made the comment.

                                                                                      Control0..1
                                                                                      TypeChoice of: Reference(Practitioner, PractitionerRole, Patient, RelatedPerson, Organization), string
                                                                                      [x] NoteSee Choice of Data Types for further information about how to use [x]
                                                                                      Is Modifierfalse
                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                      Summarytrue
                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                      360. Evidence.variableDefinition:covariate.note.time
                                                                                      Definition

                                                                                      Indicates when this particular annotation was made.

                                                                                      ShortWhen the annotation was made
                                                                                      Control0..1
                                                                                      TypedateTime
                                                                                      Is Modifierfalse
                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                      Summarytrue
                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                      362. Evidence.variableDefinition:covariate.note.text
                                                                                      Definition

                                                                                      The text of the annotation in markdown format.

                                                                                      ShortThe annotation - text content (as markdown)
                                                                                      Control1..1
                                                                                      Typemarkdown
                                                                                      Is Modifierfalse
                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                      Summarytrue
                                                                                      Pattern Valuecovariate
                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                      364. Evidence.variableDefinition:covariate.variableRole
                                                                                      Definition

                                                                                      population | subpopulation | exposure | referenceExposure | measuredVariable | confounder.

                                                                                      Shortpopulation | subpopulation | exposure | referenceExposure | measuredVariable | confounder
                                                                                      Control1..1
                                                                                      BindingUnless not suitable, these codes SHALL be taken from EvidenceVariableRole
                                                                                      (extensible to http://hl7.org/fhir/ValueSet/variable-role)

                                                                                      The role that the assertion variable plays.

                                                                                      TypeCodeableConcept
                                                                                      Is Modifierfalse
                                                                                      Must Supportfalse
                                                                                      Summarytrue
                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                      366. Evidence.variableDefinition:covariate.variableRole.id
                                                                                      Definition

                                                                                      Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                      ShortUnique id for inter-element referencing
                                                                                      Control0..1
                                                                                      This element is affected by the following invariants: ele-1
                                                                                      Typeid
                                                                                      Is Modifierfalse
                                                                                      XML FormatIn the XML format, this property is represented as an attribute.
                                                                                      Summaryfalse
                                                                                      368. Evidence.variableDefinition:covariate.variableRole.extension
                                                                                      Definition

                                                                                      May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                      ShortAdditional content defined by implementations
                                                                                      Comments

                                                                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                      Control0..*
                                                                                      TypeExtension
                                                                                      Is Modifierfalse
                                                                                      Summaryfalse
                                                                                      Alternate Namesextensions, user content
                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                      SlicingThis element introduces a set of slices on Evidence.variableDefinition.variableRole.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                      • value @ url
                                                                                      • 370. Evidence.variableDefinition:covariate.variableRole.coding
                                                                                        Definition

                                                                                        A reference to a code defined by a terminology system.

                                                                                        ShortCode defined by a terminology system
                                                                                        Comments

                                                                                        Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                                                                                        Control0..*
                                                                                        TypeCoding
                                                                                        Is Modifierfalse
                                                                                        Summarytrue
                                                                                        Requirements

                                                                                        Allows for alternative encodings within a code system, and translations to other code systems.

                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                        372. Evidence.variableDefinition:covariate.variableRole.text
                                                                                        Definition

                                                                                        A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

                                                                                        ShortPlain text representation of the concept
                                                                                        Comments

                                                                                        Very often the text is the same as a displayName of one of the codings.

                                                                                        Control0..1
                                                                                        Typestring
                                                                                        Is Modifierfalse
                                                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                        Summarytrue
                                                                                        Requirements

                                                                                        The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

                                                                                        Pattern ValueUse extension:variableRoleCode instead.
                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                        374. Evidence.variableDefinition:covariate.observed
                                                                                        Definition

                                                                                        Definition of the actual variable related to the statistic(s).

                                                                                        ShortDefinition of the actual variable related to the statistic(s)
                                                                                        Control0..1
                                                                                        TypeReference(Group, EvidenceVariable)
                                                                                        Is Modifierfalse
                                                                                        Must Supportfalse
                                                                                        Summarytrue
                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                        376. Evidence.variableDefinition:covariate.observed.id
                                                                                        Definition

                                                                                        Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                        ShortUnique id for inter-element referencing
                                                                                        Control0..1
                                                                                        This element is affected by the following invariants: ele-1
                                                                                        Typeid
                                                                                        Is Modifierfalse
                                                                                        XML FormatIn the XML format, this property is represented as an attribute.
                                                                                        Summaryfalse
                                                                                        378. Evidence.variableDefinition:covariate.observed.extension
                                                                                        Definition

                                                                                        May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                        ShortAdditional content defined by implementations
                                                                                        Comments

                                                                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                        Control0..*
                                                                                        TypeExtension
                                                                                        Is Modifierfalse
                                                                                        Summaryfalse
                                                                                        Alternate Namesextensions, user content
                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                        SlicingThis element introduces a set of slices on Evidence.variableDefinition.observed.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                        • value @ url
                                                                                        • 380. Evidence.variableDefinition:covariate.observed.reference
                                                                                          Definition

                                                                                          A reference to a location at which the other resource is found. The reference may be a relative reference, in which case it is relative to the service base URL, or an absolute URL that resolves to the location where the resource is found. The reference may be version specific or not. If the reference is not to a FHIR RESTful server, then it should be assumed to be version specific. Internal fragment references (start with '#') refer to contained resources.

                                                                                          ShortLiteral reference, Relative, internal or absolute URL
                                                                                          Comments

                                                                                          Using absolute URLs provides a stable scalable approach suitable for a cloud/web context, while using relative/logical references provides a flexible approach suitable for use when trading across closed eco-system boundaries. Absolute URLs do not need to point to a FHIR RESTful server, though this is the preferred approach. If the URL conforms to the structure "[type]/[id]" then it should be assumed that the reference is to a FHIR RESTful server.

                                                                                          Control0..1
                                                                                          This element is affected by the following invariants: ref-2, ref-1
                                                                                          Typestring
                                                                                          Is Modifierfalse
                                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                          Summarytrue
                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                          382. Evidence.variableDefinition:covariate.observed.type
                                                                                          Definition

                                                                                          The expected type of the target of the reference. If both Reference.type and Reference.reference are populated and Reference.reference is a FHIR URL, both SHALL be consistent.

                                                                                          The type is the Canonical URL of Resource Definition that is the type this reference refers to. References are URLs that are relative to http://hl7.org/fhir/StructureDefinition/ e.g. "Patient" is a reference to http://hl7.org/fhir/StructureDefinition/Patient. Absolute URLs are only allowed for logical models (and can only be used in references in logical models, not resources).

                                                                                          ShortType the reference refers to (e.g. "Patient") - must be a resource in resources
                                                                                          Comments

                                                                                          This element is used to indicate the type of the target of the reference. This may be used which ever of the other elements are populated (or not). In some cases, the type of the target may be determined by inspection of the reference (e.g. a known RESTful URL) or by resolving the target of the reference.

                                                                                          Control0..1
                                                                                          BindingUnless not suitable, these codes SHALL be taken from ResourceType
                                                                                          (extensible to http://hl7.org/fhir/ValueSet/resource-types)

                                                                                          Aa resource (or, for logical models, the URI of the logical model).

                                                                                          Typeuri
                                                                                          Is Modifierfalse
                                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                          Summarytrue
                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                          384. Evidence.variableDefinition:covariate.observed.identifier
                                                                                          Definition

                                                                                          An identifier for the target resource. This is used when there is no way to reference the other resource directly, either because the entity it represents is not available through a FHIR server, or because there is no way for the author of the resource to convert a known identifier to an actual location. There is no requirement that a Reference.identifier point to something that is actually exposed as a FHIR instance, but it SHALL point to a business concept that would be expected to be exposed as a FHIR instance, and that instance would need to be of a FHIR resource type allowed by the reference.

                                                                                          ShortLogical reference, when literal reference is not known
                                                                                          Comments

                                                                                          When an identifier is provided in place of a reference, any system processing the reference will only be able to resolve the identifier to a reference if it understands the business context in which the identifier is used. Sometimes this is global (e.g. a national identifier) but often it is not. For this reason, none of the useful mechanisms described for working with references (e.g. chaining, includes) are possible, nor should servers be expected to be able resolve the reference. Servers may accept an identifier based reference untouched, resolve it, and/or reject it - see CapabilityStatement.rest.resource.referencePolicy.

                                                                                          When both an identifier and a literal reference are provided, the literal reference is preferred. Applications processing the resource are allowed - but not required - to check that the identifier matches the literal reference

                                                                                          Applications converting a logical reference to a literal reference may choose to leave the logical reference present, or remove it.

                                                                                          Reference is intended to point to a structure that can potentially be expressed as a FHIR resource, though there is no need for it to exist as an actual FHIR resource instance - except in as much as an application wishes to actual find the target of the reference. The content referred to be the identifier must meet the logical constraints implied by any limitations on what resource types are permitted for the reference. For example, it would not be legitimate to send the identifier for a drug prescription if the type were Reference(Observation|DiagnosticReport). One of the use-cases for Reference.identifier is the situation where no FHIR representation exists (where the type is Reference (Any).

                                                                                          This element only allows for a single identifier. In the case where additional identifers are required, use the http://hl7.org/fhir/StructureDefinition/additionalIdentifier extension.

                                                                                          NoteThis is a business identifier, not a resource identifier (see discussion)
                                                                                          Control0..1
                                                                                          This element is affected by the following invariants: ref-2
                                                                                          TypeIdentifier
                                                                                          Is Modifierfalse
                                                                                          Summarytrue
                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                          386. Evidence.variableDefinition:covariate.observed.display
                                                                                          Definition

                                                                                          Plain text narrative that identifies the resource in addition to the resource reference.

                                                                                          ShortText alternative for the resource
                                                                                          Comments

                                                                                          This is generally not the same as the Resource.text of the referenced resource. The purpose is to identify what's being referenced, not to fully describe it.

                                                                                          Control0..1
                                                                                          This element is affected by the following invariants: ref-2
                                                                                          Typestring
                                                                                          Is Modifierfalse
                                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                          Summarytrue
                                                                                          Pattern ValueRelative Importance Multiplier
                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                          388. Evidence.variableDefinition:covariate.intended
                                                                                          Definition

                                                                                          Definition of the intended variable related to the Evidence.

                                                                                          ShortDefinition of the intended variable related to the Evidence
                                                                                          Control0..0
                                                                                          TypeReference(Group, EvidenceVariable)
                                                                                          Is Modifierfalse
                                                                                          Must Supportfalse
                                                                                          Summaryfalse
                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                          390. Evidence.variableDefinition:covariate.directnessMatch
                                                                                          Definition

                                                                                          Indication of quality of match between intended variable to actual variable.

                                                                                          Shortlow | moderate | high | exact
                                                                                          Control0..1
                                                                                          BindingUnless not suitable, these codes SHALL be taken from EvidenceDirectness
                                                                                          (extensible to http://terminology.hl7.org/ValueSet/directness)

                                                                                          The quality of how direct the match is.

                                                                                          TypeCodeableConcept
                                                                                          Is Modifierfalse
                                                                                          Must Supportfalse
                                                                                          Summaryfalse
                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                          392. Evidence.synthesisType
                                                                                          Definition

                                                                                          The method to combine studies.

                                                                                          ShortThe method to combine studies
                                                                                          Control0..1
                                                                                          BindingUnless not suitable, these codes SHALL be taken from StatisticSynthesisType
                                                                                          (extensible to http://terminology.hl7.org/ValueSet/synthesis-type)

                                                                                          Types of combining results from a body of evidence (e.g. summary data meta-analysis).

                                                                                          TypeCodeableConcept
                                                                                          Is Modifierfalse
                                                                                          Must Supportfalse
                                                                                          Summaryfalse
                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                          394. Evidence.studyDesign
                                                                                          Definition

                                                                                          The design of the study that produced this evidence. The design is described with any number of study design characteristics.

                                                                                          ShortThe design of the study that produced this evidence
                                                                                          Control0..*
                                                                                          BindingUnless not suitable, these codes SHALL be taken from StudyDesign
                                                                                          (extensible to http://hl7.org/fhir/ValueSet/study-design)

                                                                                          This is a set of terms for study design characteristics.

                                                                                          TypeCodeableConcept
                                                                                          Is Modifierfalse
                                                                                          Must Supportfalse
                                                                                          Summaryfalse
                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                          396. Evidence.statistic
                                                                                          Definition

                                                                                          Values and parameters for a single statistic.

                                                                                          ShortValues and parameters for a single statistic
                                                                                          Control1..*
                                                                                          TypeBackboneElement
                                                                                          Is Modifierfalse
                                                                                          Must Supportfalse
                                                                                          Summaryfalse
                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                          SlicingThis element introduces a set of slices on Evidence.statistic. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                          • value @ statisticType.coding
                                                                                          • 398. Evidence.statistic.id
                                                                                            Definition

                                                                                            Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                            ShortUnique id for inter-element referencing
                                                                                            Control0..1
                                                                                            This element is affected by the following invariants: ele-1
                                                                                            Typestring
                                                                                            Is Modifierfalse
                                                                                            XML FormatIn the XML format, this property is represented as an attribute.
                                                                                            Summaryfalse
                                                                                            400. Evidence.statistic.extension
                                                                                            Definition

                                                                                            An Extension

                                                                                            ShortExtension
                                                                                            Control0..*
                                                                                            TypeExtension
                                                                                            Is Modifierfalse
                                                                                            Summaryfalse
                                                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                            ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                            SlicingThis element introduces a set of slices on Evidence.statistic.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                            • value @ url
                                                                                            • 402. Evidence.statistic.extension:modelExpression
                                                                                              Slice NamemodelExpression
                                                                                              Definition

                                                                                              The formula for analysis.

                                                                                              ShortThe formula for analysis
                                                                                              Control0..1
                                                                                              TypeExtension(StatisticModelExpression) (Extension Type: Expression)
                                                                                              Is Modifierfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                              404. Evidence.statistic.modifierExtension
                                                                                              Definition

                                                                                              May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                              Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                              ShortExtensions that cannot be ignored even if unrecognized
                                                                                              Comments

                                                                                              There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                              Control0..*
                                                                                              TypeExtension
                                                                                              Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                              Summarytrue
                                                                                              Requirements

                                                                                              Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                              Alternate Namesextensions, user content, modifiers
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                              406. Evidence.statistic.description
                                                                                              Definition

                                                                                              A description of the content value of the statistic.

                                                                                              ShortDescription of content
                                                                                              Control0..1
                                                                                              Typemarkdown
                                                                                              Is Modifierfalse
                                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              408. Evidence.statistic.note
                                                                                              Definition

                                                                                              Footnotes and/or explanatory notes.

                                                                                              ShortFootnotes and/or explanatory notes
                                                                                              Control0..*
                                                                                              TypeAnnotation
                                                                                              Is Modifierfalse
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              410. Evidence.statistic.statisticType
                                                                                              Definition

                                                                                              Type of statistic, e.g., relative risk.

                                                                                              ShortType of statistic, e.g., relative risk
                                                                                              Control0..1
                                                                                              BindingUnless not suitable, these codes SHALL be taken from StatisticType
                                                                                              (extensible to http://hl7.org/fhir/ValueSet/statistic-type)
                                                                                              TypeCodeableConcept
                                                                                              Is Modifierfalse
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              412. Evidence.statistic.category
                                                                                              Definition

                                                                                              When the measured variable is handled categorically, the category element is used to define which category the statistic is reporting.

                                                                                              ShortAssociated category for categorical variable
                                                                                              Comments

                                                                                              Simple strings can be used for descriptive purposes. Exact matching to EvidenceVariable.category.name for the Evidence.variableDefinition[variableRole=measuredVariable].observed=Reference(EvidenceVariable) could facilitate validation within datasets.

                                                                                              Control0..1
                                                                                              TypeCodeableConcept
                                                                                              Is Modifierfalse
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              414. Evidence.statistic.quantity
                                                                                              Definition

                                                                                              Statistic value.

                                                                                              ShortStatistic value
                                                                                              Control0..1
                                                                                              TypeQuantity
                                                                                              Is Modifierfalse
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              416. Evidence.statistic.numberOfEvents
                                                                                              Definition

                                                                                              The number of events associated with the statistic, where the unit of analysis is different from numberAffected, sampleSize.knownDataCount and sampleSize.numberOfParticipants.

                                                                                              ShortThe number of events associated with the statistic
                                                                                              Comments

                                                                                              When the number of events is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberOfEvents to record the total number of events rather than the number of participants with events.

                                                                                              Control0..1
                                                                                              TypeunsignedInt
                                                                                              Is Modifierfalse
                                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              418. Evidence.statistic.numberAffected
                                                                                              Definition

                                                                                              The number of participants affected where the unit of analysis is the same as sampleSize.knownDataCount and sampleSize.numberOfParticipants.

                                                                                              ShortThe number of participants affected
                                                                                              Comments

                                                                                              When the number affected is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is a Proportion, use Evidence.statistic.numberAffected and enter an integer as the value. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberAffected to record the number of participants with events rather than the total number of events.

                                                                                              Control0..1
                                                                                              TypeunsignedInt
                                                                                              Is Modifierfalse
                                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              420. Evidence.statistic.sampleSize
                                                                                              Definition

                                                                                              Number of samples in the statistic.

                                                                                              ShortNumber of samples in the statistic
                                                                                              Control0..1
                                                                                              TypeBackboneElement
                                                                                              Is Modifierfalse
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              422. Evidence.statistic.sampleSize.id
                                                                                              Definition

                                                                                              Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                              ShortUnique id for inter-element referencing
                                                                                              Control0..1
                                                                                              This element is affected by the following invariants: ele-1
                                                                                              Typestring
                                                                                              Is Modifierfalse
                                                                                              XML FormatIn the XML format, this property is represented as an attribute.
                                                                                              Summaryfalse
                                                                                              424. Evidence.statistic.sampleSize.extension
                                                                                              Definition

                                                                                              May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                              ShortAdditional content defined by implementations
                                                                                              Comments

                                                                                              There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                              Control0..*
                                                                                              TypeExtension
                                                                                              Is Modifierfalse
                                                                                              Summaryfalse
                                                                                              Alternate Namesextensions, user content
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                              426. Evidence.statistic.sampleSize.modifierExtension
                                                                                              Definition

                                                                                              May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                              Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                              ShortExtensions that cannot be ignored even if unrecognized
                                                                                              Comments

                                                                                              There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                              Control0..*
                                                                                              TypeExtension
                                                                                              Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                              Summarytrue
                                                                                              Requirements

                                                                                              Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                              Alternate Namesextensions, user content, modifiers
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                              428. Evidence.statistic.sampleSize.description
                                                                                              Definition

                                                                                              Human-readable summary of population sample size.

                                                                                              ShortTextual description of sample size for statistic
                                                                                              Control0..1
                                                                                              Typemarkdown
                                                                                              Is Modifierfalse
                                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              430. Evidence.statistic.sampleSize.note
                                                                                              Definition

                                                                                              Footnote or explanatory note about the sample size.

                                                                                              ShortFootnote or explanatory note about the sample size
                                                                                              Control0..*
                                                                                              TypeAnnotation
                                                                                              Is Modifierfalse
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              432. Evidence.statistic.sampleSize.numberOfStudies
                                                                                              Definition

                                                                                              Number of participants in the population.

                                                                                              ShortNumber of contributing studies
                                                                                              Control0..1
                                                                                              TypeunsignedInt
                                                                                              Is Modifierfalse
                                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              434. Evidence.statistic.sampleSize.numberOfParticipants
                                                                                              Definition

                                                                                              A human-readable string to clarify or explain concepts about the sample size.

                                                                                              ShortCumulative number of participants
                                                                                              Control0..1
                                                                                              TypeunsignedInt
                                                                                              Is Modifierfalse
                                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              436. Evidence.statistic.sampleSize.knownDataCount
                                                                                              Definition

                                                                                              Number of participants with known results for measured variables.

                                                                                              ShortNumber of participants with known results for measured variables
                                                                                              Control0..1
                                                                                              TypeunsignedInt
                                                                                              Is Modifierfalse
                                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              438. Evidence.statistic.attributeEstimate
                                                                                              Definition

                                                                                              A statistical attribute of the statistic such as a measure of heterogeneity.

                                                                                              ShortAn attribute of the Statistic
                                                                                              Control0..*
                                                                                              TypeBackboneElement
                                                                                              Is Modifierfalse
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              440. Evidence.statistic.attributeEstimate.id
                                                                                              Definition

                                                                                              Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                              ShortUnique id for inter-element referencing
                                                                                              Control0..1
                                                                                              This element is affected by the following invariants: ele-1
                                                                                              Typestring
                                                                                              Is Modifierfalse
                                                                                              XML FormatIn the XML format, this property is represented as an attribute.
                                                                                              Summaryfalse
                                                                                              442. Evidence.statistic.attributeEstimate.extension
                                                                                              Definition

                                                                                              May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                              ShortAdditional content defined by implementations
                                                                                              Comments

                                                                                              There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                              Control0..*
                                                                                              TypeExtension
                                                                                              Is Modifierfalse
                                                                                              Summaryfalse
                                                                                              Alternate Namesextensions, user content
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                              444. Evidence.statistic.attributeEstimate.modifierExtension
                                                                                              Definition

                                                                                              May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                              Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                              ShortExtensions that cannot be ignored even if unrecognized
                                                                                              Comments

                                                                                              There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                              Control0..*
                                                                                              TypeExtension
                                                                                              Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                              Summarytrue
                                                                                              Requirements

                                                                                              Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                              Alternate Namesextensions, user content, modifiers
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                              446. Evidence.statistic.attributeEstimate.description
                                                                                              Definition

                                                                                              Human-readable summary of the estimate.

                                                                                              ShortTextual description of the attribute estimate
                                                                                              Control0..1
                                                                                              Typemarkdown
                                                                                              Is Modifierfalse
                                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              448. Evidence.statistic.attributeEstimate.note
                                                                                              Definition

                                                                                              Footnote or explanatory note about the estimate.

                                                                                              ShortFootnote or explanatory note about the estimate
                                                                                              Control0..*
                                                                                              TypeAnnotation
                                                                                              Is Modifierfalse
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              450. Evidence.statistic.attributeEstimate.type
                                                                                              Definition

                                                                                              The type of attribute estimate, e.g., confidence interval or p value.

                                                                                              ShortThe type of attribute estimate, e.g., confidence interval or p value
                                                                                              Control0..1
                                                                                              BindingUnless not suitable, these codes SHALL be taken from AttributeEstimateType
                                                                                              (extensible to http://hl7.org/fhir/ValueSet/attribute-estimate-type)
                                                                                              TypeCodeableConcept
                                                                                              Is Modifierfalse
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              452. Evidence.statistic.attributeEstimate.quantity
                                                                                              Definition

                                                                                              The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure.

                                                                                              ShortThe singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure
                                                                                              Comments

                                                                                              Often the p value

                                                                                              Control0..1
                                                                                              TypeQuantity
                                                                                              Is Modifierfalse
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              454. Evidence.statistic.attributeEstimate.level
                                                                                              Definition

                                                                                              Use 95 for a 95% confidence interval.

                                                                                              ShortLevel of confidence interval, e.g., 0.95 for 95% confidence interval
                                                                                              Control0..1
                                                                                              Typedecimal
                                                                                              Is Modifierfalse
                                                                                              Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              456. Evidence.statistic.attributeEstimate.range
                                                                                              Definition

                                                                                              Lower bound of confidence interval.

                                                                                              ShortLower and upper bound values of the attribute estimate
                                                                                              Control0..1
                                                                                              TypeRange
                                                                                              Is Modifierfalse
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              458. Evidence.statistic.attributeEstimate.attributeEstimate
                                                                                              Definition

                                                                                              A nested attribute estimate; which is the attribute estimate of an attribute estimate.

                                                                                              ShortA nested attribute estimate; which is the attribute estimate of an attribute estimate
                                                                                              Comments

                                                                                              A nested attribute estimate; which is the attribute estimate of an attribute estimate

                                                                                              Control0..*
                                                                                              TypeSee ttp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate
                                                                                              Is Modifierfalse
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              460. Evidence.statistic.modelCharacteristic
                                                                                              Definition

                                                                                              A component of the method to generate the statistic.

                                                                                              ShortAn aspect of the statistical model
                                                                                              Control0..*
                                                                                              TypeBackboneElement
                                                                                              Is Modifierfalse
                                                                                              Must Supportfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              462. Evidence.statistic.modelCharacteristic.id
                                                                                              Definition

                                                                                              Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                              ShortUnique id for inter-element referencing
                                                                                              Control0..1
                                                                                              This element is affected by the following invariants: ele-1
                                                                                              Typestring
                                                                                              Is Modifierfalse
                                                                                              XML FormatIn the XML format, this property is represented as an attribute.
                                                                                              Summaryfalse
                                                                                              464. Evidence.statistic.modelCharacteristic.extension
                                                                                              Definition

                                                                                              An Extension

                                                                                              ShortExtension
                                                                                              Control0..*
                                                                                              TypeExtension
                                                                                              Is Modifierfalse
                                                                                              Summaryfalse
                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                              SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                              • value @ url
                                                                                              • 466. Evidence.statistic.modelCharacteristic.extension:valueQuantity
                                                                                                Slice NamevalueQuantity
                                                                                                Definition

                                                                                                The specific value (when paired with code) as a Quantity

                                                                                                ShortValue as Quantity
                                                                                                Control0..1
                                                                                                TypeExtension(StatisticModelValueQuantity) (Extension Type: Quantity(SimpleQuantity))
                                                                                                Is Modifierfalse
                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                468. Evidence.statistic.modelCharacteristic.extension:valueRange
                                                                                                Slice NamevalueRange
                                                                                                Definition

                                                                                                The specific value (when paired with code) as a Range

                                                                                                ShortValue as Range
                                                                                                Control0..1
                                                                                                TypeExtension(StatisticModelValueRange) (Extension Type: Range)
                                                                                                Is Modifierfalse
                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                470. Evidence.statistic.modelCharacteristic.extension:valueCodeableConcept
                                                                                                Slice NamevalueCodeableConcept
                                                                                                Definition

                                                                                                The specific value (when paired with code) as a CodeableConcept

                                                                                                ShortValue as CodeableConcept
                                                                                                Control0..1
                                                                                                TypeExtension(StatisticModelValueCodeableConcept) (Extension Type: CodeableConcept)
                                                                                                Is Modifierfalse
                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                472. Evidence.statistic.modelCharacteristic.extension:intended
                                                                                                Slice Nameintended
                                                                                                Definition

                                                                                                The plan for analysis.

                                                                                                ShortThe plan for analysis
                                                                                                Control0..1
                                                                                                TypeExtension(StatisticModelIntended) (Extension Type: boolean)
                                                                                                Is Modifierfalse
                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                474. Evidence.statistic.modelCharacteristic.extension:applied
                                                                                                Slice Nameapplied
                                                                                                Definition

                                                                                                The analysis that was applied.

                                                                                                ShortThe analysis that was applied
                                                                                                Control0..1
                                                                                                TypeExtension(StatisticModelApplied) (Extension Type: boolean)
                                                                                                Is Modifierfalse
                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                476. Evidence.statistic.modelCharacteristic.extension:includeIf
                                                                                                Slice NameincludeIf
                                                                                                Definition

                                                                                                The condition upon which to include the variable or model characteristic in the analysis.

                                                                                                ShortCondition upon which to include the variable or model characteristic in the analysis
                                                                                                Control0..1
                                                                                                TypeExtension(StatisticModelIncludeIf) (Complex Extension)
                                                                                                Is Modifierfalse
                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                478. Evidence.statistic.modelCharacteristic.modifierExtension
                                                                                                Definition

                                                                                                May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                ShortExtensions that cannot be ignored even if unrecognized
                                                                                                Comments

                                                                                                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                Control0..*
                                                                                                TypeExtension
                                                                                                Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                Summarytrue
                                                                                                Requirements

                                                                                                Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                Alternate Namesextensions, user content, modifiers
                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                480. Evidence.statistic.modelCharacteristic.code
                                                                                                Definition

                                                                                                Description of a component of the method to generate the statistic.

                                                                                                ShortModel specification
                                                                                                Control1..1
                                                                                                BindingUnless not suitable, these codes SHALL be taken from StatisticModelCode
                                                                                                (extensible to http://hl7.org/fhir/ValueSet/statistic-model-code)
                                                                                                TypeCodeableConcept
                                                                                                Is Modifierfalse
                                                                                                Must Supportfalse
                                                                                                Summaryfalse
                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                482. Evidence.statistic.modelCharacteristic.value
                                                                                                Definition

                                                                                                Further specification of the quantified value of the component of the method to generate the statistic.

                                                                                                ShortNumerical value to complete model specification
                                                                                                Control0..0
                                                                                                TypeQuantity(SimpleQuantity)
                                                                                                Is Modifierfalse
                                                                                                Must Supportfalse
                                                                                                Summaryfalse
                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                484. Evidence.statistic.modelCharacteristic.variable
                                                                                                Definition

                                                                                                A variable adjusted for in the adjusted analysis.

                                                                                                ShortA variable adjusted for in the adjusted analysis
                                                                                                Control0..*
                                                                                                TypeBackboneElement
                                                                                                Is Modifierfalse
                                                                                                Must Supportfalse
                                                                                                Summaryfalse
                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                486. Evidence.statistic.modelCharacteristic.variable.id
                                                                                                Definition

                                                                                                Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                ShortUnique id for inter-element referencing
                                                                                                Control0..1
                                                                                                This element is affected by the following invariants: ele-1
                                                                                                Typestring
                                                                                                Is Modifierfalse
                                                                                                XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                Summaryfalse
                                                                                                488. Evidence.statistic.modelCharacteristic.variable.extension
                                                                                                Definition

                                                                                                An Extension

                                                                                                ShortExtension
                                                                                                Control0..*
                                                                                                TypeExtension
                                                                                                Is Modifierfalse
                                                                                                Summaryfalse
                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic.variable.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                • value @ url
                                                                                                • 490. Evidence.statistic.modelCharacteristic.variable.extension:includeIf
                                                                                                  Slice NameincludeIf
                                                                                                  Definition

                                                                                                  The condition upon which to include the variable or model characteristic in the analysis.

                                                                                                  ShortCondition upon which to include the variable or model characteristic in the analysis
                                                                                                  Control0..1
                                                                                                  TypeExtension(StatisticModelIncludeIf) (Complex Extension)
                                                                                                  Is Modifierfalse
                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                  492. Evidence.statistic.modelCharacteristic.variable.modifierExtension
                                                                                                  Definition

                                                                                                  May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                  Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                  ShortExtensions that cannot be ignored even if unrecognized
                                                                                                  Comments

                                                                                                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                  Control0..*
                                                                                                  TypeExtension
                                                                                                  Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                  Summarytrue
                                                                                                  Requirements

                                                                                                  Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                  Alternate Namesextensions, user content, modifiers
                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                  494. Evidence.statistic.modelCharacteristic.variable.variableDefinition
                                                                                                  Definition

                                                                                                  Description of the variable.

                                                                                                  ShortDescription of the variable
                                                                                                  Control1..1
                                                                                                  TypeReference(Group, EvidenceVariable)
                                                                                                  Is Modifierfalse
                                                                                                  Must Supportfalse
                                                                                                  Summaryfalse
                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                  496. Evidence.statistic.modelCharacteristic.variable.handling
                                                                                                  Definition

                                                                                                  How the variable is classified for use in adjusted analysis.

                                                                                                  Shortcontinuous | dichotomous | ordinal | polychotomous
                                                                                                  Control0..1
                                                                                                  BindingThe codes SHALL be taken from EvidenceVariableHandling
                                                                                                  (required to http://hl7.org/fhir/ValueSet/variable-handling|5.0.0)
                                                                                                  Typecode
                                                                                                  Is Modifierfalse
                                                                                                  Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                  Must Supportfalse
                                                                                                  Summaryfalse
                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                  498. Evidence.statistic.modelCharacteristic.variable.valueCategory
                                                                                                  Definition

                                                                                                  Description for grouping of ordinal or polychotomous variables.

                                                                                                  ShortDescription for grouping of ordinal or polychotomous variables
                                                                                                  Control0..*
                                                                                                  TypeCodeableConcept
                                                                                                  Is Modifierfalse
                                                                                                  Must Supportfalse
                                                                                                  Summaryfalse
                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                  500. Evidence.statistic.modelCharacteristic.variable.valueQuantity
                                                                                                  Definition

                                                                                                  Discrete value for grouping of ordinal or polychotomous variables.

                                                                                                  ShortDiscrete value for grouping of ordinal or polychotomous variables
                                                                                                  Control0..*
                                                                                                  TypeQuantity
                                                                                                  Is Modifierfalse
                                                                                                  Must Supportfalse
                                                                                                  Summaryfalse
                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                  502. Evidence.statistic.modelCharacteristic.variable.valueRange
                                                                                                  Definition

                                                                                                  Range of values for grouping of ordinal or polychotomous variables.

                                                                                                  ShortRange of values for grouping of ordinal or polychotomous variables
                                                                                                  Control0..*
                                                                                                  TypeRange
                                                                                                  Is Modifierfalse
                                                                                                  Must Supportfalse
                                                                                                  Summaryfalse
                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                  504. Evidence.statistic.modelCharacteristic.attributeEstimate
                                                                                                  Definition

                                                                                                  An attribute of the statistic used as a model characteristic.

                                                                                                  ShortAn attribute of the statistic used as a model characteristic
                                                                                                  Control0..*
                                                                                                  TypeSee ttp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate
                                                                                                  Is Modifierfalse
                                                                                                  Must Supportfalse
                                                                                                  Summaryfalse
                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                  506. Evidence.statistic:netEffect
                                                                                                  Slice NamenetEffect
                                                                                                  Definition

                                                                                                  Values and parameters for a single statistic.

                                                                                                  ShortValues and parameters for a single statistic
                                                                                                  Control1..1
                                                                                                  TypeBackboneElement
                                                                                                  Is Modifierfalse
                                                                                                  Must Supporttrue
                                                                                                  Summaryfalse
                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                  508. Evidence.statistic:netEffect.id
                                                                                                  Definition

                                                                                                  Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                  ShortUnique id for inter-element referencing
                                                                                                  Control0..1
                                                                                                  This element is affected by the following invariants: ele-1
                                                                                                  Typestring
                                                                                                  Is Modifierfalse
                                                                                                  XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                  Summaryfalse
                                                                                                  510. Evidence.statistic:netEffect.extension
                                                                                                  Definition

                                                                                                  An Extension

                                                                                                  ShortExtension
                                                                                                  Control0..*
                                                                                                  TypeExtension
                                                                                                  Is Modifierfalse
                                                                                                  Summaryfalse
                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                  SlicingThis element introduces a set of slices on Evidence.statistic.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                  • value @ url
                                                                                                  • 512. Evidence.statistic:netEffect.extension:modelExpression
                                                                                                    Slice NamemodelExpression
                                                                                                    Definition

                                                                                                    The formula for analysis.

                                                                                                    ShortThe formula for analysis
                                                                                                    Control0..1
                                                                                                    TypeExtension(StatisticModelExpression) (Extension Type: Expression)
                                                                                                    Is Modifierfalse
                                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                    514. Evidence.statistic:netEffect.modifierExtension
                                                                                                    Definition

                                                                                                    May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                    Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                    ShortExtensions that cannot be ignored even if unrecognized
                                                                                                    Comments

                                                                                                    There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                    Control0..*
                                                                                                    TypeExtension
                                                                                                    Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                    Summarytrue
                                                                                                    Requirements

                                                                                                    Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                    Alternate Namesextensions, user content, modifiers
                                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                    516. Evidence.statistic:netEffect.description
                                                                                                    Definition

                                                                                                    A description of the content value of the statistic.

                                                                                                    ShortDescription of content
                                                                                                    Control0..1
                                                                                                    Typemarkdown
                                                                                                    Is Modifierfalse
                                                                                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                    Must Supportfalse
                                                                                                    Summaryfalse
                                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                    518. Evidence.statistic:netEffect.note
                                                                                                    Definition

                                                                                                    Footnotes and/or explanatory notes.

                                                                                                    ShortFootnotes and/or explanatory notes
                                                                                                    Control0..*
                                                                                                    TypeAnnotation
                                                                                                    Is Modifierfalse
                                                                                                    Must Supportfalse
                                                                                                    Summaryfalse
                                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                    520. Evidence.statistic:netEffect.statisticType
                                                                                                    Definition

                                                                                                    Type of statistic, e.g., relative risk.

                                                                                                    ShortType of statistic, e.g., relative risk
                                                                                                    Control0..1
                                                                                                    BindingUnless not suitable, these codes SHALL be taken from StatisticType
                                                                                                    (extensible to http://hl7.org/fhir/ValueSet/statistic-type)
                                                                                                    TypeCodeableConcept
                                                                                                    Is Modifierfalse
                                                                                                    Must Supportfalse
                                                                                                    Summaryfalse
                                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                    522. Evidence.statistic:netEffect.statisticType.id
                                                                                                    Definition

                                                                                                    Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                    ShortUnique id for inter-element referencing
                                                                                                    Control0..1
                                                                                                    This element is affected by the following invariants: ele-1
                                                                                                    Typeid
                                                                                                    Is Modifierfalse
                                                                                                    XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                    Summaryfalse
                                                                                                    524. Evidence.statistic:netEffect.statisticType.extension
                                                                                                    Definition

                                                                                                    May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                                    ShortAdditional content defined by implementations
                                                                                                    Comments

                                                                                                    There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                    Control0..*
                                                                                                    TypeExtension
                                                                                                    Is Modifierfalse
                                                                                                    Summaryfalse
                                                                                                    Alternate Namesextensions, user content
                                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                    SlicingThis element introduces a set of slices on Evidence.statistic.statisticType.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                    • value @ url
                                                                                                    • 526. Evidence.statistic:netEffect.statisticType.coding
                                                                                                      Definition

                                                                                                      A reference to a code defined by a terminology system.

                                                                                                      ShortCode defined by a terminology system
                                                                                                      Comments

                                                                                                      Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                                                                                                      Control1..1
                                                                                                      TypeCoding
                                                                                                      Is Modifierfalse
                                                                                                      Summarytrue
                                                                                                      Requirements

                                                                                                      Allows for alternative encodings within a code system, and translations to other code systems.

                                                                                                      Pattern Value{
                                                                                                        "system" : "https://fevir.net/resources/CodeSystem/181513",
                                                                                                        "code" : "STATO:0000424",
                                                                                                        "display" : "Risk Difference"
                                                                                                      }
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      528. Evidence.statistic:netEffect.statisticType.text
                                                                                                      Definition

                                                                                                      A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

                                                                                                      ShortPlain text representation of the concept
                                                                                                      Comments

                                                                                                      Very often the text is the same as a displayName of one of the codings.

                                                                                                      Control0..1
                                                                                                      Typestring
                                                                                                      Is Modifierfalse
                                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                      Summarytrue
                                                                                                      Requirements

                                                                                                      The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      530. Evidence.statistic:netEffect.category
                                                                                                      Definition

                                                                                                      When the measured variable is handled categorically, the category element is used to define which category the statistic is reporting.

                                                                                                      ShortAssociated category for categorical variable
                                                                                                      Comments

                                                                                                      Simple strings can be used for descriptive purposes. Exact matching to EvidenceVariable.category.name for the Evidence.variableDefinition[variableRole=measuredVariable].observed=Reference(EvidenceVariable) could facilitate validation within datasets.

                                                                                                      Control0..1
                                                                                                      TypeCodeableConcept
                                                                                                      Is Modifierfalse
                                                                                                      Must Supportfalse
                                                                                                      Summaryfalse
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      532. Evidence.statistic:netEffect.quantity
                                                                                                      Definition

                                                                                                      Statistic value.

                                                                                                      ShortStatistic value
                                                                                                      Control0..1
                                                                                                      TypeQuantity
                                                                                                      Is Modifierfalse
                                                                                                      Must Supportfalse
                                                                                                      Summaryfalse
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      534. Evidence.statistic:netEffect.numberOfEvents
                                                                                                      Definition

                                                                                                      The number of events associated with the statistic, where the unit of analysis is different from numberAffected, sampleSize.knownDataCount and sampleSize.numberOfParticipants.

                                                                                                      ShortThe number of events associated with the statistic
                                                                                                      Comments

                                                                                                      When the number of events is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberOfEvents to record the total number of events rather than the number of participants with events.

                                                                                                      Control0..1
                                                                                                      TypeunsignedInt
                                                                                                      Is Modifierfalse
                                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                      Must Supportfalse
                                                                                                      Summaryfalse
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      536. Evidence.statistic:netEffect.numberAffected
                                                                                                      Definition

                                                                                                      The number of participants affected where the unit of analysis is the same as sampleSize.knownDataCount and sampleSize.numberOfParticipants.

                                                                                                      ShortThe number of participants affected
                                                                                                      Comments

                                                                                                      When the number affected is the statistic, use Evidence.statistic.quantity and set Evidence.statistic.type.coding.code=C25463 and Evidence.statistic.type.coding.display=Count. When the statistic is a Proportion, use Evidence.statistic.numberAffected and enter an integer as the value. When the statistic is an Event Rate (where individual participants may have 2 or more events), use Evidence.statistic.numberAffected to record the number of participants with events rather than the total number of events.

                                                                                                      Control0..1
                                                                                                      TypeunsignedInt
                                                                                                      Is Modifierfalse
                                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                      Must Supportfalse
                                                                                                      Summaryfalse
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      538. Evidence.statistic:netEffect.sampleSize
                                                                                                      Definition

                                                                                                      Number of samples in the statistic.

                                                                                                      ShortNumber of samples in the statistic
                                                                                                      Control0..1
                                                                                                      TypeBackboneElement
                                                                                                      Is Modifierfalse
                                                                                                      Must Supportfalse
                                                                                                      Summaryfalse
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      540. Evidence.statistic:netEffect.sampleSize.id
                                                                                                      Definition

                                                                                                      Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                      ShortUnique id for inter-element referencing
                                                                                                      Control0..1
                                                                                                      This element is affected by the following invariants: ele-1
                                                                                                      Typestring
                                                                                                      Is Modifierfalse
                                                                                                      XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                      Summaryfalse
                                                                                                      542. Evidence.statistic:netEffect.sampleSize.extension
                                                                                                      Definition

                                                                                                      May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                                      ShortAdditional content defined by implementations
                                                                                                      Comments

                                                                                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                      Control0..*
                                                                                                      TypeExtension
                                                                                                      Is Modifierfalse
                                                                                                      Summaryfalse
                                                                                                      Alternate Namesextensions, user content
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                      544. Evidence.statistic:netEffect.sampleSize.modifierExtension
                                                                                                      Definition

                                                                                                      May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                      Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                      ShortExtensions that cannot be ignored even if unrecognized
                                                                                                      Comments

                                                                                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                      Control0..*
                                                                                                      TypeExtension
                                                                                                      Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                      Summarytrue
                                                                                                      Requirements

                                                                                                      Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                      Alternate Namesextensions, user content, modifiers
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                      546. Evidence.statistic:netEffect.sampleSize.description
                                                                                                      Definition

                                                                                                      Human-readable summary of population sample size.

                                                                                                      ShortTextual description of sample size for statistic
                                                                                                      Control0..1
                                                                                                      Typemarkdown
                                                                                                      Is Modifierfalse
                                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                      Must Supportfalse
                                                                                                      Summaryfalse
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      548. Evidence.statistic:netEffect.sampleSize.note
                                                                                                      Definition

                                                                                                      Footnote or explanatory note about the sample size.

                                                                                                      ShortFootnote or explanatory note about the sample size
                                                                                                      Control0..*
                                                                                                      TypeAnnotation
                                                                                                      Is Modifierfalse
                                                                                                      Must Supportfalse
                                                                                                      Summaryfalse
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      550. Evidence.statistic:netEffect.sampleSize.numberOfStudies
                                                                                                      Definition

                                                                                                      Number of participants in the population.

                                                                                                      ShortNumber of contributing studies
                                                                                                      Control0..1
                                                                                                      TypeunsignedInt
                                                                                                      Is Modifierfalse
                                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                      Must Supportfalse
                                                                                                      Summaryfalse
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      552. Evidence.statistic:netEffect.sampleSize.numberOfParticipants
                                                                                                      Definition

                                                                                                      A human-readable string to clarify or explain concepts about the sample size.

                                                                                                      ShortCumulative number of participants
                                                                                                      Control0..1
                                                                                                      TypeunsignedInt
                                                                                                      Is Modifierfalse
                                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                      Must Supportfalse
                                                                                                      Summaryfalse
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      554. Evidence.statistic:netEffect.sampleSize.knownDataCount
                                                                                                      Definition

                                                                                                      Number of participants with known results for measured variables.

                                                                                                      ShortNumber of participants with known results for measured variables
                                                                                                      Control0..1
                                                                                                      TypeunsignedInt
                                                                                                      Is Modifierfalse
                                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                      Must Supportfalse
                                                                                                      Summaryfalse
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      556. Evidence.statistic:netEffect.attributeEstimate
                                                                                                      Definition

                                                                                                      A statistical attribute of the statistic such as a measure of heterogeneity.

                                                                                                      ShortAn attribute of the Statistic
                                                                                                      Control1..*
                                                                                                      TypeBackboneElement
                                                                                                      Is Modifierfalse
                                                                                                      Must Supportfalse
                                                                                                      Summaryfalse
                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                      SlicingThis element introduces a set of slices on Evidence.statistic.attributeEstimate. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                      • value @ type.coding
                                                                                                      • 558. Evidence.statistic:netEffect.attributeEstimate.id
                                                                                                        Definition

                                                                                                        Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                        ShortUnique id for inter-element referencing
                                                                                                        Control0..1
                                                                                                        This element is affected by the following invariants: ele-1
                                                                                                        Typestring
                                                                                                        Is Modifierfalse
                                                                                                        XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                        Summaryfalse
                                                                                                        560. Evidence.statistic:netEffect.attributeEstimate.extension
                                                                                                        Definition

                                                                                                        May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                                        ShortAdditional content defined by implementations
                                                                                                        Comments

                                                                                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                        Control0..*
                                                                                                        TypeExtension
                                                                                                        Is Modifierfalse
                                                                                                        Summaryfalse
                                                                                                        Alternate Namesextensions, user content
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                        562. Evidence.statistic:netEffect.attributeEstimate.modifierExtension
                                                                                                        Definition

                                                                                                        May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                        ShortExtensions that cannot be ignored even if unrecognized
                                                                                                        Comments

                                                                                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                        Control0..*
                                                                                                        TypeExtension
                                                                                                        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                        Summarytrue
                                                                                                        Requirements

                                                                                                        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                        Alternate Namesextensions, user content, modifiers
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                        564. Evidence.statistic:netEffect.attributeEstimate.description
                                                                                                        Definition

                                                                                                        Human-readable summary of the estimate.

                                                                                                        ShortTextual description of the attribute estimate
                                                                                                        Control0..1
                                                                                                        Typemarkdown
                                                                                                        Is Modifierfalse
                                                                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                        Must Supportfalse
                                                                                                        Summaryfalse
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        566. Evidence.statistic:netEffect.attributeEstimate.note
                                                                                                        Definition

                                                                                                        Footnote or explanatory note about the estimate.

                                                                                                        ShortFootnote or explanatory note about the estimate
                                                                                                        Control0..*
                                                                                                        TypeAnnotation
                                                                                                        Is Modifierfalse
                                                                                                        Must Supportfalse
                                                                                                        Summaryfalse
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        568. Evidence.statistic:netEffect.attributeEstimate.type
                                                                                                        Definition

                                                                                                        The type of attribute estimate, e.g., confidence interval or p value.

                                                                                                        ShortThe type of attribute estimate, e.g., confidence interval or p value
                                                                                                        Control0..1
                                                                                                        BindingUnless not suitable, these codes SHALL be taken from AttributeEstimateType
                                                                                                        (extensible to http://hl7.org/fhir/ValueSet/attribute-estimate-type)
                                                                                                        TypeCodeableConcept
                                                                                                        Is Modifierfalse
                                                                                                        Must Supportfalse
                                                                                                        Summaryfalse
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        570. Evidence.statistic:netEffect.attributeEstimate.quantity
                                                                                                        Definition

                                                                                                        The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure.

                                                                                                        ShortThe singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure
                                                                                                        Comments

                                                                                                        Often the p value

                                                                                                        Control0..1
                                                                                                        TypeQuantity
                                                                                                        Is Modifierfalse
                                                                                                        Must Supportfalse
                                                                                                        Summaryfalse
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        572. Evidence.statistic:netEffect.attributeEstimate.level
                                                                                                        Definition

                                                                                                        Use 95 for a 95% confidence interval.

                                                                                                        ShortLevel of confidence interval, e.g., 0.95 for 95% confidence interval
                                                                                                        Control0..1
                                                                                                        Typedecimal
                                                                                                        Is Modifierfalse
                                                                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                        Must Supportfalse
                                                                                                        Summaryfalse
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        574. Evidence.statistic:netEffect.attributeEstimate.range
                                                                                                        Definition

                                                                                                        Lower bound of confidence interval.

                                                                                                        ShortLower and upper bound values of the attribute estimate
                                                                                                        Control0..1
                                                                                                        TypeRange
                                                                                                        Is Modifierfalse
                                                                                                        Must Supportfalse
                                                                                                        Summaryfalse
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        576. Evidence.statistic:netEffect.attributeEstimate.attributeEstimate
                                                                                                        Definition

                                                                                                        A nested attribute estimate; which is the attribute estimate of an attribute estimate.

                                                                                                        ShortA nested attribute estimate; which is the attribute estimate of an attribute estimate
                                                                                                        Comments

                                                                                                        A nested attribute estimate; which is the attribute estimate of an attribute estimate

                                                                                                        Control0..*
                                                                                                        TypeSee ttp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate
                                                                                                        Is Modifierfalse
                                                                                                        Must Supportfalse
                                                                                                        Summaryfalse
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        578. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval
                                                                                                        Slice NameconfidenceInterval
                                                                                                        Definition

                                                                                                        A statistical attribute of the statistic such as a measure of heterogeneity.

                                                                                                        ShortAn attribute of the Statistic
                                                                                                        Control1..1
                                                                                                        TypeBackboneElement
                                                                                                        Is Modifierfalse
                                                                                                        Must Supporttrue
                                                                                                        Summaryfalse
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        580. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.id
                                                                                                        Definition

                                                                                                        Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                        ShortUnique id for inter-element referencing
                                                                                                        Control0..1
                                                                                                        This element is affected by the following invariants: ele-1
                                                                                                        Typestring
                                                                                                        Is Modifierfalse
                                                                                                        XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                        Summaryfalse
                                                                                                        582. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.extension
                                                                                                        Definition

                                                                                                        May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                                        ShortAdditional content defined by implementations
                                                                                                        Comments

                                                                                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                        Control0..*
                                                                                                        TypeExtension
                                                                                                        Is Modifierfalse
                                                                                                        Summaryfalse
                                                                                                        Alternate Namesextensions, user content
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                        584. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.modifierExtension
                                                                                                        Definition

                                                                                                        May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                        Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                        ShortExtensions that cannot be ignored even if unrecognized
                                                                                                        Comments

                                                                                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                        Control0..*
                                                                                                        TypeExtension
                                                                                                        Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                        Summarytrue
                                                                                                        Requirements

                                                                                                        Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                        Alternate Namesextensions, user content, modifiers
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                        586. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.description
                                                                                                        Definition

                                                                                                        Human-readable summary of the estimate.

                                                                                                        ShortTextual description of the attribute estimate
                                                                                                        Control0..1
                                                                                                        Typemarkdown
                                                                                                        Is Modifierfalse
                                                                                                        Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                        Must Supportfalse
                                                                                                        Summaryfalse
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        588. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.note
                                                                                                        Definition

                                                                                                        Footnote or explanatory note about the estimate.

                                                                                                        ShortFootnote or explanatory note about the estimate
                                                                                                        Control0..*
                                                                                                        TypeAnnotation
                                                                                                        Is Modifierfalse
                                                                                                        Must Supportfalse
                                                                                                        Summaryfalse
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        590. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type
                                                                                                        Definition

                                                                                                        The type of attribute estimate, e.g., confidence interval or p value.

                                                                                                        ShortThe type of attribute estimate, e.g., confidence interval or p value
                                                                                                        Control0..1
                                                                                                        BindingUnless not suitable, these codes SHALL be taken from AttributeEstimateType
                                                                                                        (extensible to http://hl7.org/fhir/ValueSet/attribute-estimate-type)
                                                                                                        TypeCodeableConcept
                                                                                                        Is Modifierfalse
                                                                                                        Must Supportfalse
                                                                                                        Summaryfalse
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        592. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type.id
                                                                                                        Definition

                                                                                                        Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                        ShortUnique id for inter-element referencing
                                                                                                        Control0..1
                                                                                                        This element is affected by the following invariants: ele-1
                                                                                                        Typeid
                                                                                                        Is Modifierfalse
                                                                                                        XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                        Summaryfalse
                                                                                                        594. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type.extension
                                                                                                        Definition

                                                                                                        May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                                        ShortAdditional content defined by implementations
                                                                                                        Comments

                                                                                                        There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                        Control0..*
                                                                                                        TypeExtension
                                                                                                        Is Modifierfalse
                                                                                                        Summaryfalse
                                                                                                        Alternate Namesextensions, user content
                                                                                                        Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                        ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                        SlicingThis element introduces a set of slices on Evidence.statistic.attributeEstimate.type.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                        • value @ url
                                                                                                        • 596. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type.coding
                                                                                                          Definition

                                                                                                          A reference to a code defined by a terminology system.

                                                                                                          ShortCode defined by a terminology system
                                                                                                          Comments

                                                                                                          Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                                                                                                          Control1..1
                                                                                                          TypeCoding
                                                                                                          Is Modifierfalse
                                                                                                          Summarytrue
                                                                                                          Requirements

                                                                                                          Allows for alternative encodings within a code system, and translations to other code systems.

                                                                                                          Pattern Value{
                                                                                                            "system" : "https://fevir.net/resources/CodeSystem/181513",
                                                                                                            "code" : "STATO:0000196",
                                                                                                            "display" : "confidence interval"
                                                                                                          }
                                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                          598. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.type.text
                                                                                                          Definition

                                                                                                          A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

                                                                                                          ShortPlain text representation of the concept
                                                                                                          Comments

                                                                                                          Very often the text is the same as a displayName of one of the codings.

                                                                                                          Control0..1
                                                                                                          Typestring
                                                                                                          Is Modifierfalse
                                                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                          Summarytrue
                                                                                                          Requirements

                                                                                                          The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

                                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                          600. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.quantity
                                                                                                          Definition

                                                                                                          The singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure.

                                                                                                          ShortThe singular quantity of the attribute estimate, for attribute estimates represented as single values; also used to report unit of measure
                                                                                                          Comments

                                                                                                          Often the p value

                                                                                                          Control0..1
                                                                                                          TypeQuantity
                                                                                                          Is Modifierfalse
                                                                                                          Must Supportfalse
                                                                                                          Summaryfalse
                                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                          602. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.level
                                                                                                          Definition

                                                                                                          Use 95 for a 95% confidence interval.

                                                                                                          ShortLevel of confidence interval, e.g., 0.95 for 95% confidence interval
                                                                                                          Control0..1
                                                                                                          Typedecimal
                                                                                                          Is Modifierfalse
                                                                                                          Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                          Must Supportfalse
                                                                                                          Summaryfalse
                                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                          604. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.range
                                                                                                          Definition

                                                                                                          Lower bound of confidence interval.

                                                                                                          ShortLower and upper bound values of the attribute estimate
                                                                                                          Control0..1
                                                                                                          TypeRange
                                                                                                          Is Modifierfalse
                                                                                                          Must Supportfalse
                                                                                                          Summaryfalse
                                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                          606. Evidence.statistic:netEffect.attributeEstimate:confidenceInterval.attributeEstimate
                                                                                                          Definition

                                                                                                          A nested attribute estimate; which is the attribute estimate of an attribute estimate.

                                                                                                          ShortA nested attribute estimate; which is the attribute estimate of an attribute estimate
                                                                                                          Comments

                                                                                                          A nested attribute estimate; which is the attribute estimate of an attribute estimate

                                                                                                          Control0..*
                                                                                                          TypeSee ttp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate
                                                                                                          Is Modifierfalse
                                                                                                          Must Supportfalse
                                                                                                          Summaryfalse
                                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                          608. Evidence.statistic:netEffect.modelCharacteristic
                                                                                                          Definition

                                                                                                          A component of the method to generate the statistic.

                                                                                                          ShortAn aspect of the statistical model
                                                                                                          Control1..*
                                                                                                          TypeBackboneElement
                                                                                                          Is Modifierfalse
                                                                                                          Must Supportfalse
                                                                                                          Summaryfalse
                                                                                                          Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                          SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                          • value @ code.coding
                                                                                                          • 610. Evidence.statistic:netEffect.modelCharacteristic.id
                                                                                                            Definition

                                                                                                            Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                            ShortUnique id for inter-element referencing
                                                                                                            Control0..1
                                                                                                            This element is affected by the following invariants: ele-1
                                                                                                            Typestring
                                                                                                            Is Modifierfalse
                                                                                                            XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                            Summaryfalse
                                                                                                            612. Evidence.statistic:netEffect.modelCharacteristic.extension
                                                                                                            Definition

                                                                                                            An Extension

                                                                                                            ShortExtension
                                                                                                            Control0..*
                                                                                                            TypeExtension
                                                                                                            Is Modifierfalse
                                                                                                            Summaryfalse
                                                                                                            Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                            ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                            SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                            • value @ url
                                                                                                            • 614. Evidence.statistic:netEffect.modelCharacteristic.extension:valueQuantity
                                                                                                              Slice NamevalueQuantity
                                                                                                              Definition

                                                                                                              The specific value (when paired with code) as a Quantity

                                                                                                              ShortValue as Quantity
                                                                                                              Control0..1
                                                                                                              TypeExtension(StatisticModelValueQuantity) (Extension Type: Quantity(SimpleQuantity))
                                                                                                              Is Modifierfalse
                                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                              616. Evidence.statistic:netEffect.modelCharacteristic.extension:valueRange
                                                                                                              Slice NamevalueRange
                                                                                                              Definition

                                                                                                              The specific value (when paired with code) as a Range

                                                                                                              ShortValue as Range
                                                                                                              Control0..1
                                                                                                              TypeExtension(StatisticModelValueRange) (Extension Type: Range)
                                                                                                              Is Modifierfalse
                                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                              618. Evidence.statistic:netEffect.modelCharacteristic.extension:valueCodeableConcept
                                                                                                              Slice NamevalueCodeableConcept
                                                                                                              Definition

                                                                                                              The specific value (when paired with code) as a CodeableConcept

                                                                                                              ShortValue as CodeableConcept
                                                                                                              Control0..1
                                                                                                              TypeExtension(StatisticModelValueCodeableConcept) (Extension Type: CodeableConcept)
                                                                                                              Is Modifierfalse
                                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                              620. Evidence.statistic:netEffect.modelCharacteristic.extension:intended
                                                                                                              Slice Nameintended
                                                                                                              Definition

                                                                                                              The plan for analysis.

                                                                                                              ShortThe plan for analysis
                                                                                                              Control0..1
                                                                                                              TypeExtension(StatisticModelIntended) (Extension Type: boolean)
                                                                                                              Is Modifierfalse
                                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                              622. Evidence.statistic:netEffect.modelCharacteristic.extension:applied
                                                                                                              Slice Nameapplied
                                                                                                              Definition

                                                                                                              The analysis that was applied.

                                                                                                              ShortThe analysis that was applied
                                                                                                              Control0..1
                                                                                                              TypeExtension(StatisticModelApplied) (Extension Type: boolean)
                                                                                                              Is Modifierfalse
                                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                              624. Evidence.statistic:netEffect.modelCharacteristic.extension:includeIf
                                                                                                              Slice NameincludeIf
                                                                                                              Definition

                                                                                                              The condition upon which to include the variable or model characteristic in the analysis.

                                                                                                              ShortCondition upon which to include the variable or model characteristic in the analysis
                                                                                                              Control0..1
                                                                                                              TypeExtension(StatisticModelIncludeIf) (Complex Extension)
                                                                                                              Is Modifierfalse
                                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                              626. Evidence.statistic:netEffect.modelCharacteristic.modifierExtension
                                                                                                              Definition

                                                                                                              May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                              Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                              ShortExtensions that cannot be ignored even if unrecognized
                                                                                                              Comments

                                                                                                              There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                              Control0..*
                                                                                                              TypeExtension
                                                                                                              Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                              Summarytrue
                                                                                                              Requirements

                                                                                                              Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                              Alternate Namesextensions, user content, modifiers
                                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                              628. Evidence.statistic:netEffect.modelCharacteristic.code
                                                                                                              Definition

                                                                                                              Description of a component of the method to generate the statistic.

                                                                                                              ShortModel specification
                                                                                                              Control1..1
                                                                                                              BindingUnless not suitable, these codes SHALL be taken from StatisticModelCode
                                                                                                              (extensible to http://hl7.org/fhir/ValueSet/statistic-model-code)
                                                                                                              TypeCodeableConcept
                                                                                                              Is Modifierfalse
                                                                                                              Must Supportfalse
                                                                                                              Summaryfalse
                                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                              630. Evidence.statistic:netEffect.modelCharacteristic.value
                                                                                                              Definition

                                                                                                              Further specification of the quantified value of the component of the method to generate the statistic.

                                                                                                              ShortNumerical value to complete model specification
                                                                                                              Control0..0
                                                                                                              TypeQuantity(SimpleQuantity)
                                                                                                              Is Modifierfalse
                                                                                                              Must Supportfalse
                                                                                                              Summaryfalse
                                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                              632. Evidence.statistic:netEffect.modelCharacteristic.variable
                                                                                                              Definition

                                                                                                              A variable adjusted for in the adjusted analysis.

                                                                                                              ShortA variable adjusted for in the adjusted analysis
                                                                                                              Control0..*
                                                                                                              TypeBackboneElement
                                                                                                              Is Modifierfalse
                                                                                                              Must Supportfalse
                                                                                                              Summaryfalse
                                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                              634. Evidence.statistic:netEffect.modelCharacteristic.variable.id
                                                                                                              Definition

                                                                                                              Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                              ShortUnique id for inter-element referencing
                                                                                                              Control0..1
                                                                                                              This element is affected by the following invariants: ele-1
                                                                                                              Typestring
                                                                                                              Is Modifierfalse
                                                                                                              XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                              Summaryfalse
                                                                                                              636. Evidence.statistic:netEffect.modelCharacteristic.variable.extension
                                                                                                              Definition

                                                                                                              An Extension

                                                                                                              ShortExtension
                                                                                                              Control0..*
                                                                                                              TypeExtension
                                                                                                              Is Modifierfalse
                                                                                                              Summaryfalse
                                                                                                              Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                              ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                              SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic.variable.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                              • value @ url
                                                                                                              • 638. Evidence.statistic:netEffect.modelCharacteristic.variable.extension:includeIf
                                                                                                                Slice NameincludeIf
                                                                                                                Definition

                                                                                                                The condition upon which to include the variable or model characteristic in the analysis.

                                                                                                                ShortCondition upon which to include the variable or model characteristic in the analysis
                                                                                                                Control0..1
                                                                                                                TypeExtension(StatisticModelIncludeIf) (Complex Extension)
                                                                                                                Is Modifierfalse
                                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                640. Evidence.statistic:netEffect.modelCharacteristic.variable.modifierExtension
                                                                                                                Definition

                                                                                                                May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                                Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                                ShortExtensions that cannot be ignored even if unrecognized
                                                                                                                Comments

                                                                                                                There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                Control0..*
                                                                                                                TypeExtension
                                                                                                                Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                                Summarytrue
                                                                                                                Requirements

                                                                                                                Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                                Alternate Namesextensions, user content, modifiers
                                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                642. Evidence.statistic:netEffect.modelCharacteristic.variable.variableDefinition
                                                                                                                Definition

                                                                                                                Description of the variable.

                                                                                                                ShortDescription of the variable
                                                                                                                Control1..1
                                                                                                                TypeReference(Group, EvidenceVariable)
                                                                                                                Is Modifierfalse
                                                                                                                Must Supportfalse
                                                                                                                Summaryfalse
                                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                644. Evidence.statistic:netEffect.modelCharacteristic.variable.handling
                                                                                                                Definition

                                                                                                                How the variable is classified for use in adjusted analysis.

                                                                                                                Shortcontinuous | dichotomous | ordinal | polychotomous
                                                                                                                Control0..1
                                                                                                                BindingThe codes SHALL be taken from EvidenceVariableHandling
                                                                                                                (required to http://hl7.org/fhir/ValueSet/variable-handling|5.0.0)
                                                                                                                Typecode
                                                                                                                Is Modifierfalse
                                                                                                                Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                Must Supportfalse
                                                                                                                Summaryfalse
                                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                646. Evidence.statistic:netEffect.modelCharacteristic.variable.valueCategory
                                                                                                                Definition

                                                                                                                Description for grouping of ordinal or polychotomous variables.

                                                                                                                ShortDescription for grouping of ordinal or polychotomous variables
                                                                                                                Control0..*
                                                                                                                TypeCodeableConcept
                                                                                                                Is Modifierfalse
                                                                                                                Must Supportfalse
                                                                                                                Summaryfalse
                                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                648. Evidence.statistic:netEffect.modelCharacteristic.variable.valueQuantity
                                                                                                                Definition

                                                                                                                Discrete value for grouping of ordinal or polychotomous variables.

                                                                                                                ShortDiscrete value for grouping of ordinal or polychotomous variables
                                                                                                                Control0..*
                                                                                                                TypeQuantity
                                                                                                                Is Modifierfalse
                                                                                                                Must Supportfalse
                                                                                                                Summaryfalse
                                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                650. Evidence.statistic:netEffect.modelCharacteristic.variable.valueRange
                                                                                                                Definition

                                                                                                                Range of values for grouping of ordinal or polychotomous variables.

                                                                                                                ShortRange of values for grouping of ordinal or polychotomous variables
                                                                                                                Control0..*
                                                                                                                TypeRange
                                                                                                                Is Modifierfalse
                                                                                                                Must Supportfalse
                                                                                                                Summaryfalse
                                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                652. Evidence.statistic:netEffect.modelCharacteristic.attributeEstimate
                                                                                                                Definition

                                                                                                                An attribute of the statistic used as a model characteristic.

                                                                                                                ShortAn attribute of the statistic used as a model characteristic
                                                                                                                Control0..*
                                                                                                                TypeSee ttp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate
                                                                                                                Is Modifierfalse
                                                                                                                Must Supportfalse
                                                                                                                Summaryfalse
                                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                654. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis
                                                                                                                Slice NamenetEffectContributionAnalysis
                                                                                                                Definition

                                                                                                                A component of the method to generate the statistic.

                                                                                                                ShortAn aspect of the statistical model
                                                                                                                Control1..1
                                                                                                                TypeBackboneElement
                                                                                                                Is Modifierfalse
                                                                                                                Must Supporttrue
                                                                                                                Summaryfalse
                                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                656. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.id
                                                                                                                Definition

                                                                                                                Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                                ShortUnique id for inter-element referencing
                                                                                                                Control0..1
                                                                                                                This element is affected by the following invariants: ele-1
                                                                                                                Typestring
                                                                                                                Is Modifierfalse
                                                                                                                XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                                Summaryfalse
                                                                                                                658. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension
                                                                                                                Definition

                                                                                                                An Extension

                                                                                                                ShortExtension
                                                                                                                Control0..*
                                                                                                                TypeExtension
                                                                                                                Is Modifierfalse
                                                                                                                Summaryfalse
                                                                                                                Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                                • value @ url
                                                                                                                • 660. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:valueQuantity
                                                                                                                  Slice NamevalueQuantity
                                                                                                                  Definition

                                                                                                                  The specific value (when paired with code) as a Quantity

                                                                                                                  ShortValue as Quantity
                                                                                                                  Control0..1
                                                                                                                  TypeExtension(StatisticModelValueQuantity) (Extension Type: Quantity(SimpleQuantity))
                                                                                                                  Is Modifierfalse
                                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                  662. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:valueRange
                                                                                                                  Slice NamevalueRange
                                                                                                                  Definition

                                                                                                                  The specific value (when paired with code) as a Range

                                                                                                                  ShortValue as Range
                                                                                                                  Control0..1
                                                                                                                  TypeExtension(StatisticModelValueRange) (Extension Type: Range)
                                                                                                                  Is Modifierfalse
                                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                  664. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:valueCodeableConcept
                                                                                                                  Slice NamevalueCodeableConcept
                                                                                                                  Definition

                                                                                                                  The specific value (when paired with code) as a CodeableConcept

                                                                                                                  ShortValue as CodeableConcept
                                                                                                                  Control0..1
                                                                                                                  TypeExtension(StatisticModelValueCodeableConcept) (Extension Type: CodeableConcept)
                                                                                                                  Is Modifierfalse
                                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                  666. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:intended
                                                                                                                  Slice Nameintended
                                                                                                                  Definition

                                                                                                                  The plan for analysis.

                                                                                                                  ShortThe plan for analysis
                                                                                                                  Control0..1
                                                                                                                  TypeExtension(StatisticModelIntended) (Extension Type: boolean)
                                                                                                                  Is Modifierfalse
                                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                  668. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:applied
                                                                                                                  Slice Nameapplied
                                                                                                                  Definition

                                                                                                                  The analysis that was applied.

                                                                                                                  ShortThe analysis that was applied
                                                                                                                  Control0..1
                                                                                                                  TypeExtension(StatisticModelApplied) (Extension Type: boolean)
                                                                                                                  Is Modifierfalse
                                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                  670. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.extension:includeIf
                                                                                                                  Slice NameincludeIf
                                                                                                                  Definition

                                                                                                                  The condition upon which to include the variable or model characteristic in the analysis.

                                                                                                                  ShortCondition upon which to include the variable or model characteristic in the analysis
                                                                                                                  Control0..1
                                                                                                                  TypeExtension(StatisticModelIncludeIf) (Complex Extension)
                                                                                                                  Is Modifierfalse
                                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                  672. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.modifierExtension
                                                                                                                  Definition

                                                                                                                  May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                                  Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                                  ShortExtensions that cannot be ignored even if unrecognized
                                                                                                                  Comments

                                                                                                                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                  Control0..*
                                                                                                                  TypeExtension
                                                                                                                  Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                                  Summarytrue
                                                                                                                  Requirements

                                                                                                                  Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                                  Alternate Namesextensions, user content, modifiers
                                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                  674. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.code
                                                                                                                  Definition

                                                                                                                  Description of a component of the method to generate the statistic.

                                                                                                                  ShortModel specification
                                                                                                                  Control1..1
                                                                                                                  BindingUnless not suitable, these codes SHALL be taken from StatisticModelCode
                                                                                                                  (extensible to http://hl7.org/fhir/ValueSet/statistic-model-code)
                                                                                                                  TypeCodeableConcept
                                                                                                                  Is Modifierfalse
                                                                                                                  Must Supportfalse
                                                                                                                  Summaryfalse
                                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                  676. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.code.id
                                                                                                                  Definition

                                                                                                                  Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                                  ShortUnique id for inter-element referencing
                                                                                                                  Control0..1
                                                                                                                  This element is affected by the following invariants: ele-1
                                                                                                                  Typeid
                                                                                                                  Is Modifierfalse
                                                                                                                  XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                                  Summaryfalse
                                                                                                                  678. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.code.extension
                                                                                                                  Definition

                                                                                                                  May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                                                  ShortAdditional content defined by implementations
                                                                                                                  Comments

                                                                                                                  There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                  Control0..*
                                                                                                                  TypeExtension
                                                                                                                  Is Modifierfalse
                                                                                                                  Summaryfalse
                                                                                                                  Alternate Namesextensions, user content
                                                                                                                  Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                  ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                  SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic.code.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                                  • value @ url
                                                                                                                  • 680. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.code.coding
                                                                                                                    Definition

                                                                                                                    A reference to a code defined by a terminology system.

                                                                                                                    ShortCode defined by a terminology system
                                                                                                                    Comments

                                                                                                                    Codes may be defined very casually in enumerations, or code lists, up to very formal definitions such as SNOMED CT - see the HL7 v3 Core Principles for more information. Ordering of codings is undefined and SHALL NOT be used to infer meaning. Generally, at most only one of the coding values will be labeled as UserSelected = true.

                                                                                                                    Control1..1
                                                                                                                    TypeCoding
                                                                                                                    Is Modifierfalse
                                                                                                                    Summarytrue
                                                                                                                    Requirements

                                                                                                                    Allows for alternative encodings within a code system, and translations to other code systems.

                                                                                                                    Pattern Value{
                                                                                                                      "system" : "https://fevir.net/resources/CodeSystem/181513",
                                                                                                                      "code" : "TBD:net-effect-contribution-analysis",
                                                                                                                      "display" : "Net effect contribution analysis"
                                                                                                                    }
                                                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                    682. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.code.text
                                                                                                                    Definition

                                                                                                                    A human language representation of the concept as seen/selected/uttered by the user who entered the data and/or which represents the intended meaning of the user.

                                                                                                                    ShortPlain text representation of the concept
                                                                                                                    Comments

                                                                                                                    Very often the text is the same as a displayName of one of the codings.

                                                                                                                    Control0..1
                                                                                                                    Typestring
                                                                                                                    Is Modifierfalse
                                                                                                                    Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                    Summarytrue
                                                                                                                    Requirements

                                                                                                                    The codes from the terminologies do not always capture the correct meaning with all the nuances of the human using them, or sometimes there is no appropriate code at all. In these cases, the text is used to capture the full meaning of the source.

                                                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                    684. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.value
                                                                                                                    Definition

                                                                                                                    Further specification of the quantified value of the component of the method to generate the statistic.

                                                                                                                    ShortNumerical value to complete model specification
                                                                                                                    Control0..0
                                                                                                                    TypeQuantity(SimpleQuantity)
                                                                                                                    Is Modifierfalse
                                                                                                                    Must Supportfalse
                                                                                                                    Summaryfalse
                                                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                    686. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable
                                                                                                                    Definition

                                                                                                                    A variable adjusted for in the adjusted analysis.

                                                                                                                    ShortA variable adjusted for in the adjusted analysis
                                                                                                                    Control0..*
                                                                                                                    TypeBackboneElement
                                                                                                                    Is Modifierfalse
                                                                                                                    Must Supportfalse
                                                                                                                    Summaryfalse
                                                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                    688. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable.id
                                                                                                                    Definition

                                                                                                                    Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                                    ShortUnique id for inter-element referencing
                                                                                                                    Control0..1
                                                                                                                    This element is affected by the following invariants: ele-1
                                                                                                                    Typestring
                                                                                                                    Is Modifierfalse
                                                                                                                    XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                                    Summaryfalse
                                                                                                                    690. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable.extension
                                                                                                                    Definition

                                                                                                                    An Extension

                                                                                                                    ShortExtension
                                                                                                                    Control0..*
                                                                                                                    TypeExtension
                                                                                                                    Is Modifierfalse
                                                                                                                    Summaryfalse
                                                                                                                    Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                    ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                    SlicingThis element introduces a set of slices on Evidence.statistic.modelCharacteristic.variable.extension. The slices areUnordered and Open, and can be differentiated using the following discriminators:
                                                                                                                    • value @ url
                                                                                                                    • 692. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable.extension:includeIf
                                                                                                                      Slice NameincludeIf
                                                                                                                      Definition

                                                                                                                      The condition upon which to include the variable or model characteristic in the analysis.

                                                                                                                      ShortCondition upon which to include the variable or model characteristic in the analysis
                                                                                                                      Control0..1
                                                                                                                      TypeExtension(StatisticModelIncludeIf) (Complex Extension)
                                                                                                                      Is Modifierfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                      694. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable.modifierExtension
                                                                                                                      Definition

                                                                                                                      May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                                      Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                                      ShortExtensions that cannot be ignored even if unrecognized
                                                                                                                      Comments

                                                                                                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                      Control0..*
                                                                                                                      TypeExtension
                                                                                                                      Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                                      Summarytrue
                                                                                                                      Requirements

                                                                                                                      Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                                      Alternate Namesextensions, user content, modifiers
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                      696. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable.variableDefinition
                                                                                                                      Definition

                                                                                                                      Description of the variable.

                                                                                                                      ShortDescription of the variable
                                                                                                                      Control1..1
                                                                                                                      TypeReference(Group, EvidenceVariable)
                                                                                                                      Is Modifierfalse
                                                                                                                      Must Supportfalse
                                                                                                                      Summaryfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      698. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable.handling
                                                                                                                      Definition

                                                                                                                      How the variable is classified for use in adjusted analysis.

                                                                                                                      Shortcontinuous | dichotomous | ordinal | polychotomous
                                                                                                                      Control0..1
                                                                                                                      BindingThe codes SHALL be taken from EvidenceVariableHandling
                                                                                                                      (required to http://hl7.org/fhir/ValueSet/variable-handling|5.0.0)
                                                                                                                      Typecode
                                                                                                                      Is Modifierfalse
                                                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                      Must Supportfalse
                                                                                                                      Summaryfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      700. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable.valueCategory
                                                                                                                      Definition

                                                                                                                      Description for grouping of ordinal or polychotomous variables.

                                                                                                                      ShortDescription for grouping of ordinal or polychotomous variables
                                                                                                                      Control0..*
                                                                                                                      TypeCodeableConcept
                                                                                                                      Is Modifierfalse
                                                                                                                      Must Supportfalse
                                                                                                                      Summaryfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      702. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable.valueQuantity
                                                                                                                      Definition

                                                                                                                      Discrete value for grouping of ordinal or polychotomous variables.

                                                                                                                      ShortDiscrete value for grouping of ordinal or polychotomous variables
                                                                                                                      Control0..*
                                                                                                                      TypeQuantity
                                                                                                                      Is Modifierfalse
                                                                                                                      Must Supportfalse
                                                                                                                      Summaryfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      704. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.variable.valueRange
                                                                                                                      Definition

                                                                                                                      Range of values for grouping of ordinal or polychotomous variables.

                                                                                                                      ShortRange of values for grouping of ordinal or polychotomous variables
                                                                                                                      Control0..*
                                                                                                                      TypeRange
                                                                                                                      Is Modifierfalse
                                                                                                                      Must Supportfalse
                                                                                                                      Summaryfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      706. Evidence.statistic:netEffect.modelCharacteristic:netEffectContributionAnalysis.attributeEstimate
                                                                                                                      Definition

                                                                                                                      An attribute of the statistic used as a model characteristic.

                                                                                                                      ShortAn attribute of the statistic used as a model characteristic
                                                                                                                      Control0..*
                                                                                                                      TypeSee ttp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.statistic.attributeEstimate
                                                                                                                      Is Modifierfalse
                                                                                                                      Must Supportfalse
                                                                                                                      Summaryfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      708. Evidence.certainty
                                                                                                                      Definition

                                                                                                                      Assessment of certainty, confidence in the estimates, or quality of the evidence.

                                                                                                                      ShortCertainty or quality of the evidence
                                                                                                                      Control0..*
                                                                                                                      TypeBackboneElement
                                                                                                                      Is Modifierfalse
                                                                                                                      Must Supportfalse
                                                                                                                      Summaryfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      710. Evidence.certainty.id
                                                                                                                      Definition

                                                                                                                      Unique id for the element within a resource (for internal references). This may be any string value that does not contain spaces.

                                                                                                                      ShortUnique id for inter-element referencing
                                                                                                                      Control0..1
                                                                                                                      This element is affected by the following invariants: ele-1
                                                                                                                      Typestring
                                                                                                                      Is Modifierfalse
                                                                                                                      XML FormatIn the XML format, this property is represented as an attribute.
                                                                                                                      Summaryfalse
                                                                                                                      712. Evidence.certainty.extension
                                                                                                                      Definition

                                                                                                                      May be used to represent additional information that is not part of the basic definition of the element. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension.

                                                                                                                      ShortAdditional content defined by implementations
                                                                                                                      Comments

                                                                                                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                      Control0..*
                                                                                                                      TypeExtension
                                                                                                                      Is Modifierfalse
                                                                                                                      Summaryfalse
                                                                                                                      Alternate Namesextensions, user content
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                      714. Evidence.certainty.modifierExtension
                                                                                                                      Definition

                                                                                                                      May be used to represent additional information that is not part of the basic definition of the element and that modifies the understanding of the element in which it is contained and/or the understanding of the containing element's descendants. Usually modifier elements provide negation or qualification. To make the use of extensions safe and managable, there is a strict set of governance applied to the definition and use of extensions. Though any implementer can define an extension, there is a set of requirements that SHALL be met as part of the definition of the extension. Applications processing a resource are required to check for modifier extensions.

                                                                                                                      Modifier extensions SHALL NOT change the meaning of any elements on Resource or DomainResource (including cannot change the meaning of modifierExtension itself).

                                                                                                                      ShortExtensions that cannot be ignored even if unrecognized
                                                                                                                      Comments

                                                                                                                      There can be no stigma associated with the use of extensions by any application, project, or standard - regardless of the institution or jurisdiction that uses or defines the extensions. The use of extensions is what allows the FHIR specification to retain a core level of simplicity for everyone.

                                                                                                                      Control0..*
                                                                                                                      TypeExtension
                                                                                                                      Is Modifiertrue because Modifier extensions are expected to modify the meaning or interpretation of the element that contains them
                                                                                                                      Summarytrue
                                                                                                                      Requirements

                                                                                                                      Modifier extensions allow for extensions that cannot be safely ignored to be clearly distinguished from the vast majority of extensions which can be safely ignored. This promotes interoperability by eliminating the need for implementers to prohibit the presence of extensions. For further information, see the definition of modifier extensions.

                                                                                                                      Alternate Namesextensions, user content, modifiers
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      ext-1: Must have either extensions or value[x], not both (extension.exists() != value.exists())
                                                                                                                      716. Evidence.certainty.description
                                                                                                                      Definition

                                                                                                                      Textual description of certainty.

                                                                                                                      ShortTextual description of certainty
                                                                                                                      Control0..1
                                                                                                                      Typemarkdown
                                                                                                                      Is Modifierfalse
                                                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                      Must Supportfalse
                                                                                                                      Summaryfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      718. Evidence.certainty.note
                                                                                                                      Definition

                                                                                                                      Footnotes and/or explanatory notes.

                                                                                                                      ShortFootnotes and/or explanatory notes
                                                                                                                      Control0..*
                                                                                                                      TypeAnnotation
                                                                                                                      Is Modifierfalse
                                                                                                                      Must Supportfalse
                                                                                                                      Summaryfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      720. Evidence.certainty.type
                                                                                                                      Definition

                                                                                                                      Aspect of certainty being rated.

                                                                                                                      ShortAspect of certainty being rated
                                                                                                                      Control0..1
                                                                                                                      BindingUnless not suitable, these codes SHALL be taken from EvidenceCertaintyType
                                                                                                                      (extensible to http://hl7.org/fhir/ValueSet/certainty-type)

                                                                                                                      The aspect of quality, confidence, or certainty.

                                                                                                                      TypeCodeableConcept
                                                                                                                      Is Modifierfalse
                                                                                                                      Must Supportfalse
                                                                                                                      Summaryfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      722. Evidence.certainty.rating
                                                                                                                      Definition

                                                                                                                      Assessment or judgement of the aspect.

                                                                                                                      ShortAssessment or judgement of the aspect
                                                                                                                      Control0..1
                                                                                                                      BindingUnless not suitable, these codes SHALL be taken from EvidenceCertaintyRating
                                                                                                                      (extensible to http://hl7.org/fhir/ValueSet/certainty-rating)

                                                                                                                      The assessment of quality, confidence, or certainty.

                                                                                                                      TypeCodeableConcept
                                                                                                                      Is Modifierfalse
                                                                                                                      Must Supportfalse
                                                                                                                      Summaryfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      724. Evidence.certainty.rater
                                                                                                                      Definition

                                                                                                                      Individual or group who did the rating.

                                                                                                                      ShortIndividual or group who did the rating
                                                                                                                      Control0..1
                                                                                                                      Typestring
                                                                                                                      Is Modifierfalse
                                                                                                                      Primitive ValueThis primitive element may be present, or absent, or replaced by an extension
                                                                                                                      Must Supportfalse
                                                                                                                      Summaryfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))
                                                                                                                      726. Evidence.certainty.subcomponent
                                                                                                                      Definition

                                                                                                                      A domain or subdomain of certainty.

                                                                                                                      ShortA domain or subdomain of certainty
                                                                                                                      Control0..*
                                                                                                                      TypeSee ttp://hl7.org/fhir/StructureDefinition/Evidence#Evidence.certainty
                                                                                                                      Is Modifierfalse
                                                                                                                      Must Supportfalse
                                                                                                                      Summaryfalse
                                                                                                                      Invariantsele-1: All FHIR elements must have a @value or children (hasValue() or (children().count() > id.count()))