Evidence Based Medicine on FHIR Implementation Guide
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Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: Health-related Quality of Life at 12 weeks - Change in Mental Health T score (PROMIS) for QUARTET LDQT in NCT03640312 - TTL Representation

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:Evidence ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "367923"] ; # 
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fhir:versionId [ fhir:v "26" ] ;
fhir:lastUpdated [ fhir:v "2025-08-18T13:22:42.074Z"^^xsd:dateTime ] ;
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/non-comparative-evidence"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/uv/ebm/StructureDefinition/non-comparative-evidence>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "extensions" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Evidence 367923</b></p><a name=\"367923\"> </a><a name=\"hc367923\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 26; Last updated: 2025-08-18 13:22:42+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-non-comparative-evidence.html\">NonComparativeEvidence</a></p></div><p><b>ArtifactPublicationStatus</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-status-type active}\">Active</span></p><p><b>url</b>: <a href=\"https://fevir.net/resources/Evidence/367923\">https://fevir.net/resources/Evidence/367923</a></p><p><b>identifier</b>: FEvIR Object Identifier/367923, FEvIR Linking Identifier/NCT03640312-secondaryOutcomeMeasure-7-Change-in-Mental-Health-T-score--OPEN---PROMIS---CLOSE--OG000</p><p><b>name</b>: NCT03640312_secondaryOutcomeMeasure_7_Change_in_Mental_Health_T_score_OPEN_PROMIS_CLOSE_OG000</p><p><b>title</b>: Health-related Quality of Life at 12 weeks - Change in Mental Health T score (PROMIS) for QUARTET LDQT in NCT03640312</p><p><b>citeAs</b>: </p><div><p>Health-related Quality of Life at 12 weeks - Change in Mental Health T score (PROMIS) for QUARTET LDQT in NCT03640312 [Database Entry: FHIR Evidence Resource]. Contributors: Computable Publishing®: ClinicalTrials.gov-to-FEvIR Converter [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 367923. Revised 2025-08-18. Available at: https://fevir.net/resources/Evidence/367923. Computable resource at: https://fevir.net/resources/Evidence/367923#json.</p>\n</div><p><b>status</b>: Active</p><p><b>author</b>: Computable Publishing®: ClinicalTrials.gov-to-FEvIR Converter: </p><p><b>publisher</b>: Computable Publishing LLC</p><p><b>contact</b>: <a href=\"mailto:support@computablepublishing.com\">support@computablepublishing.com</a></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>description</b>: </p><div><p>This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>QUARTET LDQT</p>\n</div><p><b>note</b>: , </p><blockquote><div><p>Outcome Measure Population Description: Data are available on only 28 participants in the intervention group for the mental health T score.</p>\n</div></blockquote><blockquote><div><p>Outcome Measure Denominator Units: Participants</p>\n</div></blockquote><p><b>variableRole</b>: Population</p><p><b>observed</b>: Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks. (Identifier: ClinicalTrials.gov Outcome Measurement Group Id/OG000)</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: Outcome</p><p><b>observed</b>: <a href=\"EvidenceVariable-370509.html\">Health-related Quality of Life at 12 weeks - Change in Mental Health T score (PROMIS) (NCT03640312)</a></p></blockquote><blockquote><p><b>statistic</b></p><p><b>statisticType</b>: <span title=\"Codes:\">Least Squares Mean</span></p><p><b>quantity</b>: 2.86 score on a scale</p><h3>SampleSizes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>KnownDataCount</b></td></tr><tr><td style=\"display: none\">*</td><td>28</td></tr></table><h3>AttributeEstimates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Quantity</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">Standard Deviation</span></td><td>6.25 score on a scale</td></tr></table></blockquote></div>"^^rdf:XMLLiteral
  ] ; # 
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fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status"^^xsd:anyURI ] ;
fhir:value [
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fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/cited-artifact-status-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "active" ] ;
fhir:display [ fhir:v "Active" ]       ] )     ]
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  fhir:url [ fhir:v "https://fevir.net/resources/Evidence/367923"^^xsd:anyURI] ; # 
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fhir:type [
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fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ACSN" ] ;
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fhir:assigner [
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  fhir:name [ fhir:v "NCT03640312_secondaryOutcomeMeasure_7_Change_in_Mental_Health_T_score_OPEN_PROMIS_CLOSE_OG000"] ; # 
  fhir:title [ fhir:v "Health-related Quality of Life at 12 weeks - Change in Mental Health T score (PROMIS) for QUARTET LDQT in NCT03640312"] ; # 
  fhir:citeAs [ fhir:v "Health-related Quality of Life at 12 weeks - Change in Mental Health T score (PROMIS) for QUARTET LDQT in NCT03640312 [Database Entry: FHIR Evidence Resource]. Contributors: Computable Publishing®: ClinicalTrials.gov-to-FEvIR Converter [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 367923. Revised 2025-08-18. Available at: https://fevir.net/resources/Evidence/367923. Computable resource at: https://fevir.net/resources/Evidence/367923#json."] ; # 
  fhir:status [ fhir:v "active"] ; # 
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  fhir:description [ fhir:v "This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide."] ; # 
  fhir:variableDefinition ( [
fhir:description [ fhir:v "QUARTET LDQT" ] ;
    ( fhir:note [
fhir:text [ fhir:v "Outcome Measure Population Description: Data are available on only 28 participants in the intervention group for the mental health T score." ]     ] [
fhir:text [ fhir:v "Outcome Measure Denominator Units: Participants" ]     ] ) ;
fhir:variableRole [ fhir:v "population" ] ;
fhir:observed [
fhir:identifier [
fhir:type [
fhir:text [ fhir:v "ClinicalTrials.gov Outcome Measurement Group Id" ]         ] ;
fhir:value [ fhir:v "OG000" ]       ] ;
fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ]     ]
  ] [
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fhir:system [ fhir:v "https://fevir.net/FLI"^^xsd:anyURI ] ;
fhir:value [ fhir:v "NCT03640312-secondaryOutcome-7-Change-in-Mental-Health-T-score--OPEN---PROMIS---CLOSE--" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]         ]       ] ;
fhir:display [ fhir:v "Health-related Quality of Life at 12 weeks - Change in Mental Health T score (PROMIS) (NCT03640312)" ]     ]
  ] ) ; # 
  fhir:statistic ( [
fhir:statisticType [
fhir:text [ fhir:v "Least Squares Mean" ]     ] ;
fhir:quantity [
fhir:value [ fhir:v 2.86 ] ;
fhir:unit [ fhir:v "score on a scale" ]     ] ;
fhir:sampleSize [
fhir:knownDataCount [ fhir:v "28"^^xsd:nonNegativeInteger ]     ] ;
    ( fhir:attributeEstimate [
fhir:type [
fhir:text [ fhir:v "Standard Deviation" ]       ] ;
fhir:quantity [
fhir:value [ fhir:v 6.25 ] ;
fhir:unit [ fhir:v "score on a scale" ]       ]     ] )
  ] ) . #