Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot International flag

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

Example Evidence: Health-related Quality of Life at 12 weeks - Change in Mental Health T score (PROMIS) for QUARTET LDQT in NCT03640312

version: 26; Last updated: 2025-08-18 13:22:42+0000

Profile: NonComparativeEvidence

ArtifactPublicationStatus: Active

url: https://fevir.net/resources/Evidence/367923

identifier: FEvIR Object Identifier/367923, FEvIR Linking Identifier/NCT03640312-secondaryOutcomeMeasure-7-Change-in-Mental-Health-T-score--OPEN---PROMIS---CLOSE--OG000

name: NCT03640312_secondaryOutcomeMeasure_7_Change_in_Mental_Health_T_score_OPEN_PROMIS_CLOSE_OG000

title: Health-related Quality of Life at 12 weeks - Change in Mental Health T score (PROMIS) for QUARTET LDQT in NCT03640312

citeAs:

Health-related Quality of Life at 12 weeks - Change in Mental Health T score (PROMIS) for QUARTET LDQT in NCT03640312 [Database Entry: FHIR Evidence Resource]. Contributors: Computable Publishing®: ClinicalTrials.gov-to-FEvIR Converter [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 367923. Revised 2025-08-18. Available at: https://fevir.net/resources/Evidence/367923. Computable resource at: https://fevir.net/resources/Evidence/367923#json.

status: Active

author: Computable Publishing®: ClinicalTrials.gov-to-FEvIR Converter:

publisher: Computable Publishing LLC

contact: support@computablepublishing.com

copyright:

https://creativecommons.org/licenses/by-nc-sa/4.0/

description:

This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide.

variableDefinition

description:

QUARTET LDQT

note: ,

Outcome Measure Population Description: Data are available on only 28 participants in the intervention group for the mental health T score.

Outcome Measure Denominator Units: Participants

variableRole: Population

observed: Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States. QUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks. (Identifier: ClinicalTrials.gov Outcome Measurement Group Id/OG000)

variableDefinition

variableRole: Outcome

observed: Health-related Quality of Life at 12 weeks - Change in Mental Health T score (PROMIS) (NCT03640312)

statistic

statisticType: Least Squares Mean

quantity: 2.86 score on a scale

SampleSizes

-KnownDataCount
*28

AttributeEstimates

-TypeQuantity
*Standard Deviation6.25 score on a scale