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4.4.1.407 ValueSet http://hl7.org/fhir/ValueSet/protein-modification-type

Responsible Owner: Biomedical Research and Regulation icon Work Group Informative Use Context: Country: World
Official URL: http://hl7.org/fhir/ValueSet/protein-modification-type Version: 6.0.0-ballot4
active as of 2026-06-30 Computable Name: ProteinModificationType
Flags: Immutable OID:

This value set is used in the following places:

4.4.1.407.1 Definition

A high-level summary of how a protein has been modified.

4.4.1.407.2 Content Logical Definition

Generated Narrative: ValueSet protein-modification-type

Last updated: 2026-07-04T18:53:58.933Z

 

4.4.1.407.3 Expansion

This expansion generated 04 Jul 2026

ValueSet

Expansion performed internally based on codesystem Protein Modification Type v6.0.0-ballot4 (CodeSystem)

This value set contains 11 concepts

SystemCodeDisplayDefinition
http://hl7.org/fhir/protein-modification-type   PEGylated PEGylated Conjugated to one or more polyethylene glycol (PEG) chains for half-life extension. Examples: pegfilgrastim, peginterferon, certolizumab pegol.
http://hl7.org/fhir/protein-modification-type   lipidated Lipidated Conjugated to a fatty acid chain (acylation) for half-life extension via albumin binding. Examples: semaglutide, liraglutide, insulin detemir, insulin degludec.
http://hl7.org/fhir/protein-modification-type   Fc-fused Fc fusion Fused to an immunoglobulin Fc region for half-life extension and effector function. Examples: etanercept, abatacept, aflibercept, dulaglutide.
http://hl7.org/fhir/protein-modification-type   albumin-fused Albumin fusion Fused to human serum albumin for half-life extension. Example: albiglutide.
http://hl7.org/fhir/protein-modification-type   drug-conjugated Drug-conjugated (ADC) Conjugated to a small-molecule drug payload via a linker (antibody-drug conjugate). Examples: trastuzumab emtansine, brentuximab vedotin, gemtuzumab ozogamicin.
http://hl7.org/fhir/protein-modification-type   polysaccharide-conjugated Polysaccharide-conjugated Conjugated to a polysaccharide antigen for vaccine immunogenicity. Examples: Hib, pneumococcal and meningococcal conjugate vaccines.
http://hl7.org/fhir/protein-modification-type   glycoengineered Glycoengineered Glycan structure engineered (e.g. afucosylated) to alter biological activity. Examples: obinutuzumab, mogamulizumab (enhanced ADCC).
http://hl7.org/fhir/protein-modification-type   amino-acid-substituted Amino acid substituted Sequence carries one or more amino acid substitutions relative to a natural or parent protein. Examples: insulin analogs lispro, aspart, glargine.
http://hl7.org/fhir/protein-modification-type   truncated Truncated Sequence is shortened relative to the parent protein.
http://hl7.org/fhir/protein-modification-type   biotinylated Biotinylated Covalently labelled with biotin. Typical for research or diagnostic reagents.
http://hl7.org/fhir/protein-modification-type   fluorescent-labeled Fluorescent labelled Covalently labelled with a fluorescent dye. Typical for imaging or flow-cytometry reagents.

 

See the full registry of value sets defined as part of FHIR.

Explanation of the columns that may appear on this page:

Lvl A few code lists that FHIR defines are hierarchical - each code is assigned a level. For value sets, levels are mostly used to organize codes for user convenience, but may follow code system hierarchy - see Code System for further information
Source The source of the definition of the code (when the value set draws in codes defined elsewhere)
Code The code (used as the code in the resource instance). If the code is in italics, this indicates that the code is not selectable ('Abstract')
Display The display (used in the display element of a Coding). If there is no display, implementers should not simply display the code, but map the concept into their application
Definition An explanation of the meaning of the concept
Comments Additional notes about how to use the code