minimal Common Oncology Data Elements (mCODE) Implementation Guide
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minimal Common Oncology Data Elements (mCODE) Implementation Guide, published by HL7 International / Clinical Interoperability Council. This guide is not an authorized publication; it is the continuous build for version 4.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/fhir-mCODE-ig/ and changes regularly. See the Directory of published versions

: gx-genomic-bundle-adam-anyperson - XML Representation

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<Bundle xmlns="http://hl7.org/fhir">
  <id value="gx-genomic-bundle-adam-anyperson"/>
  <type value="collection"/>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Patient/gx-cancer-patient-adam-anyperson"/>
    <resource>
      <Patient>
        <id value="gx-cancer-patient-adam-anyperson"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-patient"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Patient_gx-cancer-patient-adam-anyperson"> </a><p class="res-header-id"><b>Generated Narrative: Patient gx-cancer-patient-adam-anyperson</b></p><a name="gx-cancer-patient-adam-anyperson"> </a><a name="hcgx-cancer-patient-adam-anyperson"> </a><a name="gx-cancer-patient-adam-anyperson-en-US"> </a><p style="border: 1px #661aff solid; background-color: #e6e6ff; padding: 10px;">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</p><hr/><table class="grid"><tr><td style="background-color: #f3f5da" title="Other Id (see the one above)">Other Id:</td><td colspan="3">Patient external identifier/22ea1d1b-03a5-47d6-81e0-b9b4cbb15ccf (use: usual, )</td></tr><tr><td style="background-color: #f3f5da" title="Ways to contact the Patient">Contact Detail</td><td colspan="3">987 Main St Anytown 12345 US </td></tr><tr><td style="background-color: #f3f5da" title="A code classifying the person's sex assigned at birth  as specified by the [Office of the National Coordinator for Health IT (ONC)](https://www.healthit.gov/newsroom/about-onc). This extension aligns with the C-CDA Birth Sex Observation (LOINC 76689-9). After version 6.0.0, this extension is no longer a *USCDI Requirement*."><a href="http://hl7.org/fhir/us/core/STU6.1/StructureDefinition-us-core-birthsex.html">US Core Birth Sex Extension</a></td><td colspan="3">M</td></tr></table></div>
        </text>
        <extension
                   url="http://hl7.org/fhir/us/core/StructureDefinition/us-core-birthsex">
          <valueCode value="M"/>
        </extension>
        <identifier>
          <use value="usual"/>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="PT"/>
              <display value="Patient external identifier"/>
            </coding>
          </type>
          <system value="https://www.gensop.com"/>
          <value value="22ea1d1b-03a5-47d6-81e0-b9b4cbb15ccf"/>
        </identifier>
        <identifier>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="MR"/>
              <display value="Medical Record Number"/>
            </coding>
          </type>
          <system value="http://hospital.example.org"/>
          <value value="123456789"/>
        </identifier>
        <name>
          <family value="Anyperson"/>
          <given value="Adam"/>
        </name>
        <gender value="male"/>
        <birthDate value="1990-01-01"/>
        <address>
          <line value="987 Main St"/>
          <city value="Anytown"/>
          <postalCode value="12345"/>
          <country value="US"/>
        </address>
      </Patient>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/DiagnosticReport/gx-genomics-report-adam-anyperson"/>
    <resource>
      <DiagnosticReport>
        <id value="gx-genomics-report-adam-anyperson"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomics-report"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="DiagnosticReport_gx-genomics-report-adam-anyperson"> </a><p class="res-header-id"><b>Generated Narrative: DiagnosticReport gx-genomics-report-adam-anyperson</b></p><a name="gx-genomics-report-adam-anyperson"> </a><a name="hcgx-genomics-report-adam-anyperson"> </a><a name="gx-genomics-report-adam-anyperson-en-US"> </a><h2><span title="Codes:{http://loinc.org 51969-4}">Genetic analysis report</span> (<span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>) </h2><table class="grid"><tr><td>Subject</td><td>Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</td></tr><tr><td>When For</td><td>2022-02-15 19:28:58+0500</td></tr><tr><td>Performer</td><td> <a href="Organization-gx-us-core-organization-gensop-inc.html">Organization Gensop Labs, Inc.</a></td></tr></table><p><b>Report Details</b></p><table class="grid"><tr><td><b>Code</b></td><td><b>Value</b></td><td><b>Flags</b></td><td><b>When For</b></td></tr><tr><td><a href="Observation-gx-genomic-variant-somatic-bap1-indel.html"><span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></a></td><td><span title="Codes:{http://loinc.org LA9633-4}">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-variant-somatic-cdkn2a-cnv.html"><span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></a></td><td><span title="Codes:{http://loinc.org LA9633-4}">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-variant-somatic-cdkn2b-cnv.html"><span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></a></td><td><span title="Codes:{http://loinc.org LA9633-4}">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-variant-somatic-kdm5d.html"><span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></a></td><td><span title="Codes:{http://loinc.org LA9633-4}">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-variant-somatic-mtap.html"><span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></a></td><td><span title="Codes:{http://loinc.org LA9633-4}">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-variant-somatic-mycn.html"><span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></a></td><td><span title="Codes:{http://loinc.org LA9633-4}">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-variant-somatic-pof1b.html"><span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></a></td><td><span title="Codes:{http://loinc.org LA9633-4}">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-variant-somatic-polrmt.html"><span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></a></td><td><span title="Codes:{http://loinc.org LA9633-4}">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-diagnostic-implication-bap1.html"><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}">Diagnostic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-diagnostic-implication-pof1b.html"><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}">Diagnostic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-diagnostic-implication-polrmt.html"><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}">Diagnostic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-variant-fusion-met-alk.html"><span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></a></td><td><span title="Codes:{http://loinc.org LA9633-4}">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-variant-pertinent-negative-nras-kit-braf.html"><span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></a></td><td><span title="Codes:{http://loinc.org LA9634-2}">Absent</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-tmb.html"><span title="Codes:{http://loinc.org 94076-7}">Mutations/Megabase [# Ratio] in Tumor</span></a></td><td>57.1 1/1000000{Base}<span style="background: LightGoldenRodYellow"> (Details: UCUM  code1/1000000{Base} = '1/1000000{Base}')</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-msi.html"><span title="Codes:{http://loinc.org 81695-9}">Microsatellite instability [Interpretation] in Cancer specimen Qualitative</span></a></td><td><span title="Codes:{http://loinc.org LA26203-2}">MSI-H</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-therapeutic-implication-alectinib.html"><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-therapeutic-implication-brigatinib.html"><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-therapeutic-implication-ceritinib.html"><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-therapeutic-implication-crizotinib.html"><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href="Observation-gx-genomic-therapeutic-implication-lorlatinib.html"><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr></table></div>
        </text>
        <basedOn>🔗 
          <reference value="ServiceRequest/gx-order-tumornormal-gensop-inc"/>
        </basedOn>
        <status value="final"/>
        <category>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
            <code value="GE"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="51969-4"/>
            <display value="Genetic analysis report"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2022-02-15T19:28:58+05:00"/>
        <performer>🔗 
          <reference value="Organization/gx-us-core-organization-gensop-inc"/>
        </performer>
        <resultsInterpreter>🔗 
          <reference value="Practitioner/gx-practitioner-test-pathologist"/>
        </resultsInterpreter>
        <specimen>🔗 
          <reference value="Specimen/gx-genomic-specimen-tumornormal-tumor"/>
        </specimen>
        <specimen>🔗 
          <reference value="Specimen/gx-genomic-specimen-tumornormal-normal"/>
        </specimen>
        <result>🔗 
          <reference
                     value="Observation/gx-genomic-variant-somatic-bap1-indel"/>
        </result>
        <result>🔗 
          <reference
                     value="Observation/gx-genomic-variant-somatic-cdkn2a-cnv"/>
        </result>
        <result>🔗 
          <reference
                     value="Observation/gx-genomic-variant-somatic-cdkn2b-cnv"/>
        </result>
        <result>🔗 
          <reference value="Observation/gx-genomic-variant-somatic-kdm5d"/>
        </result>
        <result>🔗 
          <reference value="Observation/gx-genomic-variant-somatic-mtap"/>
        </result>
        <result>🔗 
          <reference value="Observation/gx-genomic-variant-somatic-mycn"/>
        </result>
        <result>🔗 
          <reference value="Observation/gx-genomic-variant-somatic-pof1b"/>
        </result>
        <result>🔗 
          <reference value="Observation/gx-genomic-variant-somatic-polrmt"/>
        </result>
        <result>🔗 
          <reference
                     value="Observation/gx-genomic-diagnostic-implication-bap1"/>
        </result>
        <result>🔗 
          <reference
                     value="Observation/gx-genomic-diagnostic-implication-pof1b"/>
        </result>
        <result>🔗 
          <reference
                     value="Observation/gx-genomic-diagnostic-implication-polrmt"/>
        </result>
        <result>🔗 
          <reference value="Observation/gx-genomic-variant-fusion-met-alk"/>
        </result>
        <result>🔗 
          <reference
                     value="Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf"/>
        </result>
        <result>🔗 
          <reference value="Observation/gx-genomic-tmb"/>
        </result>
        <result>🔗 
          <reference value="Observation/gx-genomic-msi"/>
        </result>
        <result>🔗 
          <reference
                     value="Observation/gx-genomic-therapeutic-implication-alectinib"/>
        </result>
        <result>🔗 
          <reference
                     value="Observation/gx-genomic-therapeutic-implication-brigatinib"/>
        </result>
        <result>🔗 
          <reference
                     value="Observation/gx-genomic-therapeutic-implication-ceritinib"/>
        </result>
        <result>🔗 
          <reference
                     value="Observation/gx-genomic-therapeutic-implication-crizotinib"/>
        </result>
        <result>🔗 
          <reference
                     value="Observation/gx-genomic-therapeutic-implication-lorlatinib"/>
        </result>
      </DiagnosticReport>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/ServiceRequest/gx-order-tumornormal-gensop-inc"/>
    <resource>
      <ServiceRequest>
        <id value="gx-order-tumornormal-gensop-inc"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="ServiceRequest_gx-order-tumornormal-gensop-inc"> </a><p class="res-header-id"><b>Generated Narrative: ServiceRequest gx-order-tumornormal-gensop-inc</b></p><a name="gx-order-tumornormal-gensop-inc"> </a><a name="hcgx-order-tumornormal-gensop-inc"> </a><a name="gx-order-tumornormal-gensop-inc-en-US"> </a><p><b>identifier</b>: Filler Identifier/22howe</p><p><b>status</b>: Completed</p><p><b>intent</b>: Order</p><p><b>code</b>: <span title="Codes:{https://www.gensop.com XT.V4}">xT - 648 gene panel</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>reasonCode</b>: <span title="Codes:{http://hl7.org/fhir/sid/icd-10-cm C34.9}, {http://terminology.hl7.org/CodeSystem/icd-o-3 C34.9 8140/3}">Malignant neoplasm of unspecified part of bronchus or lung</span></p></div>
        </text>
        <identifier>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="FILL"/>
              <display value="Filler Identifier"/>
            </coding>
          </type>
          <system value="https://www.gensop.com"/>
          <value value="22howe"/>
        </identifier>
        <status value="completed"/>
        <intent value="order"/>
        <code>
          <coding>
            <system value="https://www.gensop.com"/>
            <code value="XT.V4"/>
            <display value="xT - 648 gene panel"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <reasonCode>
          <coding>
            <system value="http://hl7.org/fhir/sid/icd-10-cm"/>
            <code value="C34.9"/>
            <display
                     value="Malignant neoplasm of unspecified part of bronchus or lung"/>
          </coding>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/icd-o-3"/>
            <code value="C34.9 8140/3"/>
            <display value="Lung adenocarcinoma"/>
          </coding>
        </reasonCode>
      </ServiceRequest>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Practitioner/gx-practitioner-test-pathologist"/>
    <resource>
      <Practitioner>
        <id value="gx-practitioner-test-pathologist"/>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Practitioner_gx-practitioner-test-pathologist"> </a><p class="res-header-id"><b>Generated Narrative: Practitioner gx-practitioner-test-pathologist</b></p><a name="gx-practitioner-test-pathologist"> </a><a name="hcgx-practitioner-test-pathologist"> </a><a name="gx-practitioner-test-pathologist-en-US"> </a><p><b>name</b>: Test Pathologist, MD</p></div>
        </text>
        <name>
          <text value="Test Pathologist, MD"/>
        </name>
      </Practitioner>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-tumor"/>
    <resource>
      <Specimen>
        <id value="gx-genomic-specimen-tumornormal-tumor"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-human-specimen"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Specimen_gx-genomic-specimen-tumornormal-tumor"> </a><p class="res-header-id"><b>Generated Narrative: Specimen gx-genomic-specimen-tumornormal-tumor</b></p><a name="gx-genomic-specimen-tumornormal-tumor"> </a><a name="hcgx-genomic-specimen-tumornormal-tumor"> </a><a name="gx-genomic-specimen-tumornormal-tumor-en-US"> </a><p><b>status</b>: Available</p><p><b>type</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0487 TUMOR}">Tumor</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>receivedTime</b>: 2021-02-09 21:30:50+0500</p><h3>Collections</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Collected[x]</b></td><td><b>BodySite</b></td></tr><tr><td style="display: none">*</td><td>2021-02-06 17:15:00+0500</td><td><span title="Codes:{http://snomed.info/sct 44029006}">Left lung structure (body structure)</span></td></tr></table></div>
        </text>
        <status value="available"/>
        <type>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/v2-0487"/>
            <code value="TUMOR"/>
            <display value="Tumor"/>
          </coding>
        </type>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <receivedTime value="2021-02-09T21:30:50+05:00"/>
        <collection>
          <collectedDateTime value="2021-02-06T17:15:00+05:00"/>
          <bodySite>
            <coding>
              <system value="http://snomed.info/sct"/>
              <code value="44029006"/>
              <display value="Left lung structure (body structure)"/>
            </coding>
          </bodySite>
        </collection>
      </Specimen>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-normal"/>
    <resource>
      <Specimen>
        <id value="gx-genomic-specimen-tumornormal-normal"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-human-specimen"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Specimen_gx-genomic-specimen-tumornormal-normal"> </a><p class="res-header-id"><b>Generated Narrative: Specimen gx-genomic-specimen-tumornormal-normal</b></p><a name="gx-genomic-specimen-tumornormal-normal"> </a><a name="hcgx-genomic-specimen-tumornormal-normal"> </a><a name="gx-genomic-specimen-tumornormal-normal-en-US"> </a><p><b>status</b>: Available</p><p><b>type</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0487 BLD}">Whole Blood</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>receivedTime</b>: 2021-02-09 21:30:50+0500</p><h3>Collections</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Collected[x]</b></td></tr><tr><td style="display: none">*</td><td>2021-02-06 17:15:00+0500</td></tr></table></div>
        </text>
        <status value="available"/>
        <type>
          <coding>
            <system value="http://terminology.hl7.org/CodeSystem/v2-0487"/>
            <code value="BLD"/>
            <display value="Whole Blood"/>
          </coding>
        </type>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <receivedTime value="2021-02-09T21:30:50+05:00"/>
        <collection>
          <collectedDateTime value="2021-02-06T17:15:00+05:00"/>
        </collection>
      </Specimen>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-somatic-bap1-indel"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-somatic-bap1-indel"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-variant-somatic-bap1-indel"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-variant-somatic-bap1-indel</b></p><a name="gx-genomic-variant-somatic-bap1-indel"> </a><a name="hcgx-genomic-variant-somatic-bap1-indel"> </a><a name="gx-genomic-variant-somatic-bap1-indel-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9633-4}">Present</span></p><p><b>method</b>: <span title="Codes:{http://loinc.org LA26398-0}">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:950}, {https://www.ncbi.nlm.nih.gov/gene 3815}">BAP1</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 51958-7}">Transcript reference sequence [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_004656}">NM_004656.4</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48004-6}">DNA change (c.HGVS)</span></p><p><b>value</b>: <span title="Codes:{http://varnomen.hgvs.org NM_004656.4:c.1768C&gt;T}">NM_004656.4:c.1768C&gt;T</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48005-3}">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title="Codes:{http://varnomen.hgvs.org NP_004647.1:p.(Gln590Ter)}">NP_004647.1:p.(Gln590Ter)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48002-0}">Genomic source class [Type]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA6684-0}">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 81258-6}">Sample variant allelic frequency [NFr]</span></p><p><b>value</b>: 57.4 %<span style="background: LightGoldenRodYellow"> (Details: UCUM  code% = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>value</b>: <span title="Codes:{http://www.sequenceontology.org/ SO:0001587}">stop_gained</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 62374-4}">Human reference sequence assembly version</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA14029-5}">GRCh37</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
            <display value="Present"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:950"/>
              <display value="BAP1"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="3815"/>
              <display value="BAP1"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51958-7"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.ncbi.nlm.nih.gov/refseq"/>
              <code value="NM_004656"/>
              <display value="NM_004656.4"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48004-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://varnomen.hgvs.org"/>
              <code value="NM_004656.4:c.1768C&gt;T"/>
              <display value="NM_004656.4:c.1768C&gt;T"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48005-3"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://varnomen.hgvs.org"/>
              <code value="NP_004647.1:p.(Gln590Ter)"/>
              <display value="NP_004647.1:p.(Gln590Ter)"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48002-0"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA6684-0"/>
              <display value="Somatic"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="81258-6"/>
            </coding>
          </code>
          <valueQuantity>
            <value value="57.4"/>
            <unit value="%"/>
            <system value="http://unitsofmeasure.org"/>
            <code value="%"/>
          </valueQuantity>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="molecular-consequence"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0001587"/>
              <display value="stop_gained"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="62374-4"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA14029-5"/>
              <display value="GRCh37"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2a-cnv"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-somatic-cdkn2a-cnv"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-variant-somatic-cdkn2a-cnv"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-variant-somatic-cdkn2a-cnv</b></p><a name="gx-genomic-variant-somatic-cdkn2a-cnv"> </a><a name="hcgx-genomic-variant-somatic-cdkn2a-cnv"> </a><a name="gx-genomic-variant-somatic-cdkn2a-cnv-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9633-4}">Present</span></p><p><b>method</b>: <span title="Codes:{http://loinc.org LA26398-0}">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:1787}, {https://www.ncbi.nlm.nih.gov/gene 1029}">CDKN2A</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48002-0}">Genomic source class [Type]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA6684-0}">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>value</b>: <span title="Codes:{http://www.sequenceontology.org/ SO:0001743}">copy_number_loss</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 62374-4}">Human reference sequence assembly version</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA14029-5}">GRCh37</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
            <display value="Present"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:1787"/>
              <display value="CDKN2A"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="1029"/>
              <display value="CDKN2A"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48002-0"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA6684-0"/>
              <display value="Somatic"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="molecular-consequence"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0001743"/>
              <display value="copy_number_loss"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="62374-4"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA14029-5"/>
              <display value="GRCh37"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2b-cnv"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-somatic-cdkn2b-cnv"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-variant-somatic-cdkn2b-cnv"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-variant-somatic-cdkn2b-cnv</b></p><a name="gx-genomic-variant-somatic-cdkn2b-cnv"> </a><a name="hcgx-genomic-variant-somatic-cdkn2b-cnv"> </a><a name="gx-genomic-variant-somatic-cdkn2b-cnv-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9633-4}">Present</span></p><p><b>method</b>: <span title="Codes:{http://loinc.org LA26398-0}">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:1788}, {https://www.ncbi.nlm.nih.gov/gene 1030}">CDKN2B</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48002-0}">Genomic source class [Type]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA6684-0}">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>value</b>: <span title="Codes:{http://www.sequenceontology.org/ SO:0001743}">copy_number_loss</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 62374-4}">Human reference sequence assembly version</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA14029-5}">GRCh37</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
            <display value="Present"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:1788"/>
              <display value="CDKN2B"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="1030"/>
              <display value="CDKN2B"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48002-0"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA6684-0"/>
              <display value="Somatic"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="molecular-consequence"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0001743"/>
              <display value="copy_number_loss"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="62374-4"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA14029-5"/>
              <display value="GRCh37"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-somatic-kdm5d"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-somatic-kdm5d"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-variant-somatic-kdm5d"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-variant-somatic-kdm5d</b></p><a name="gx-genomic-variant-somatic-kdm5d"> </a><a name="hcgx-genomic-variant-somatic-kdm5d"> </a><a name="gx-genomic-variant-somatic-kdm5d-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9633-4}">Present</span></p><p><b>method</b>: <span title="Codes:{http://loinc.org LA26398-0}">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:11115}, {https://www.ncbi.nlm.nih.gov/gene 8284}">KDM5D</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48002-0}">Genomic source class [Type]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA6684-0}">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>value</b>: <span title="Codes:{http://www.sequenceontology.org/ SO:0001743}">copy_number_loss</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 62374-4}">Human reference sequence assembly version</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA14029-5}">GRCh37</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
            <display value="Present"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:11115"/>
              <display value="KDM5D"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="8284"/>
              <display value="KDM5D"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48002-0"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA6684-0"/>
              <display value="Somatic"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="molecular-consequence"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0001743"/>
              <display value="copy_number_loss"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="62374-4"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA14029-5"/>
              <display value="GRCh37"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-somatic-mtap"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-somatic-mtap"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-variant-somatic-mtap"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-variant-somatic-mtap</b></p><a name="gx-genomic-variant-somatic-mtap"> </a><a name="hcgx-genomic-variant-somatic-mtap"> </a><a name="gx-genomic-variant-somatic-mtap-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9633-4}">Present</span></p><p><b>method</b>: <span title="Codes:{http://loinc.org LA26398-0}">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:7413}, {https://www.ncbi.nlm.nih.gov/gene 4507}">MTAP</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48002-0}">Genomic source class [Type]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA6684-0}">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>value</b>: <span title="Codes:{http://www.sequenceontology.org/ SO:0001743}">copy_number_loss</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 62374-4}">Human reference sequence assembly version</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA14029-5}">GRCh37</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
            <display value="Present"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:7413"/>
              <display value="MTAP"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="4507"/>
              <display value="MTAP"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48002-0"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA6684-0"/>
              <display value="Somatic"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="molecular-consequence"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0001743"/>
              <display value="copy_number_loss"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="62374-4"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA14029-5"/>
              <display value="GRCh37"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-somatic-mycn"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-somatic-mycn"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-variant-somatic-mycn"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-variant-somatic-mycn</b></p><a name="gx-genomic-variant-somatic-mycn"> </a><a name="hcgx-genomic-variant-somatic-mycn"> </a><a name="gx-genomic-variant-somatic-mycn-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9633-4}">Present</span></p><p><b>method</b>: <span title="Codes:{http://loinc.org LA26398-0}">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:7559}, {https://www.ncbi.nlm.nih.gov/gene 4613}">MYCN</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48002-0}">Genomic source class [Type]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA6684-0}">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>value</b>: <span title="Codes:{http://www.sequenceontology.org/ SO:0001742}">copy_number_gain</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 62374-4}">Human reference sequence assembly version</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA14029-5}">GRCh37</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
            <display value="Present"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:7559"/>
              <display value="MYCN"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="4613"/>
              <display value="MYCN"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48002-0"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA6684-0"/>
              <display value="Somatic"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="molecular-consequence"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0001742"/>
              <display value="copy_number_gain"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="62374-4"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA14029-5"/>
              <display value="GRCh37"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-somatic-pof1b"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-somatic-pof1b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-variant-somatic-pof1b"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-variant-somatic-pof1b</b></p><a name="gx-genomic-variant-somatic-pof1b"> </a><a name="hcgx-genomic-variant-somatic-pof1b"> </a><a name="gx-genomic-variant-somatic-pof1b-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9633-4}">Present</span></p><p><b>method</b>: <span title="Codes:{http://loinc.org LA26398-0}">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:13711}, {https://www.ncbi.nlm.nih.gov/gene 79983}">POF1B</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48002-0}">Genomic source class [Type]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA6684-0}">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>value</b>: <span title="Codes:{http://www.sequenceontology.org/ SO:0001583}">missense_variant</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 51958-7}">Transcript reference sequence [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_004656}">NM_004656</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48004-6}">DNA change (c.HGVS)</span></p><p><b>value</b>: <span title="Codes:{http://varnomen.hgvs.org NM_001307940.2:c.430C&gt;T}">NM_001307940.2:c.430C&gt;T</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48005-3}">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title="Codes:{http://varnomen.hgvs.org NP_001294869.1:p.(Pro144Ser)}">NP_001294869.1:p.(Pro144Ser)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 81258-6}">Sample variant allelic frequency [NFr]</span></p><p><b>value</b>: 78.6 %<span style="background: LightGoldenRodYellow"> (Details: UCUM  code% = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 62374-4}">Human reference sequence assembly version</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA14029-5}">GRCh37</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
            <display value="Present"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:13711"/>
              <display value="POF1B"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="79983"/>
              <display value="POF1B"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48002-0"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA6684-0"/>
              <display value="Somatic"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="molecular-consequence"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0001583"/>
              <display value="missense_variant"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51958-7"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.ncbi.nlm.nih.gov/refseq"/>
              <code value="NM_004656"/>
              <display value="NM_004656"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48004-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://varnomen.hgvs.org"/>
              <code value="NM_001307940.2:c.430C&gt;T"/>
              <display value="NM_001307940.2:c.430C&gt;T"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48005-3"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://varnomen.hgvs.org"/>
              <code value="NP_001294869.1:p.(Pro144Ser)"/>
              <display value="NP_001294869.1:p.(Pro144Ser)"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="81258-6"/>
            </coding>
          </code>
          <valueQuantity>
            <value value="78.6"/>
            <unit value="%"/>
            <system value="http://unitsofmeasure.org"/>
            <code value="%"/>
          </valueQuantity>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="62374-4"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA14029-5"/>
              <display value="GRCh37"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-somatic-polrmt"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-somatic-polrmt"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-variant-somatic-polrmt"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-variant-somatic-polrmt</b></p><a name="gx-genomic-variant-somatic-polrmt"> </a><a name="hcgx-genomic-variant-somatic-polrmt"> </a><a name="gx-genomic-variant-somatic-polrmt-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9633-4}">Present</span></p><p><b>method</b>: <span title="Codes:{http://loinc.org LA26398-0}">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{https://www.ncbi.nlm.nih.gov/gene 5442}">POLRMT</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48002-0}">Genomic source class [Type]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA6684-0}">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>value</b>: <span title="Codes:{http://www.sequenceontology.org/ SO:0001583}">missense_variant</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 51958-7}">Transcript reference sequence [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_004656}">NM_005035</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48004-6}">DNA change (c.HGVS)</span></p><p><b>value</b>: <span title="Codes:{http://varnomen.hgvs.org NM_005035.4:c.598G&gt;A}">NM_005035.4:c.598G&gt;A</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48005-3}">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title="Codes:{http://varnomen.hgvs.org NP_005026.3:p.(Gly200Arg)}">NP_005026.3:p.(Gly200Arg)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 81258-6}">Sample variant allelic frequency [NFr]</span></p><p><b>value</b>: 75.6 %<span style="background: LightGoldenRodYellow"> (Details: UCUM  code% = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 62374-4}">Human reference sequence assembly version</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA14029-5}">GRCh37</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
            <display value="Present"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="5442"/>
              <display value="POLRMT"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48002-0"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA6684-0"/>
              <display value="Somatic"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="molecular-consequence"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0001583"/>
              <display value="missense_variant"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51958-7"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.ncbi.nlm.nih.gov/refseq"/>
              <code value="NM_004656"/>
              <display value="NM_005035"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48004-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://varnomen.hgvs.org"/>
              <code value="NM_005035.4:c.598G&gt;A"/>
              <display value="NM_005035.4:c.598G&gt;A"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48005-3"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://varnomen.hgvs.org"/>
              <code value="NP_005026.3:p.(Gly200Arg)"/>
              <display value="NP_005026.3:p.(Gly200Arg)"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="81258-6"/>
            </coding>
          </code>
          <valueQuantity>
            <value value="75.6"/>
            <unit value="%"/>
            <system value="http://unitsofmeasure.org"/>
            <code value="%"/>
          </valueQuantity>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="62374-4"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA14029-5"/>
              <display value="GRCh37"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-bap1"/>
    <resource>
      <Observation>
        <id value="gx-genomic-diagnostic-implication-bap1"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-diagnostic-implication-bap1"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-diagnostic-implication-bap1</b></p><a name="gx-genomic-diagnostic-implication-bap1"> </a><a name="hcgx-genomic-diagnostic-implication-bap1"> </a><a name="gx-genomic-diagnostic-implication-bap1-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}">Diagnostic Implication</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href="Observation-gx-genomic-variant-somatic-bap1-indel.html">Observation Genetic variant assessment</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs functional-effect}">Functional Effect</span></td><td><span title="Codes:{http://www.sequenceontology.org/ SO:0002054}">loss of function variant</span></td></tr></table></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="diagnostic-implication"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>🔗 
          <reference
                     value="Observation/gx-genomic-variant-somatic-bap1-indel"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="functional-effect"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0002054"/>
              <display value="loss of function variant"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-pof1b"/>
    <resource>
      <Observation>
        <id value="gx-genomic-diagnostic-implication-pof1b"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-diagnostic-implication-pof1b"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-diagnostic-implication-pof1b</b></p><a name="gx-genomic-diagnostic-implication-pof1b"> </a><a name="hcgx-genomic-diagnostic-implication-pof1b"> </a><a name="gx-genomic-diagnostic-implication-pof1b-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}">Diagnostic Implication</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href="Observation-gx-genomic-variant-somatic-pof1b.html">Observation Genetic variant assessment</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 53037-8}">Genetic variation clinical significance [Imp]</span></td><td><span title="Codes:{http://loinc.org LA26333-7}">Uncertain significance</span></td></tr></table></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="diagnostic-implication"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>🔗 
          <reference value="Observation/gx-genomic-variant-somatic-pof1b"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="53037-8"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA26333-7"/>
              <display value="Uncertain significance"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-polrmt"/>
    <resource>
      <Observation>
        <id value="gx-genomic-diagnostic-implication-polrmt"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-diagnostic-implication-polrmt"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-diagnostic-implication-polrmt</b></p><a name="gx-genomic-diagnostic-implication-polrmt"> </a><a name="hcgx-genomic-diagnostic-implication-polrmt"> </a><a name="gx-genomic-diagnostic-implication-polrmt-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}">Diagnostic Implication</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href="Observation-gx-genomic-variant-somatic-polrmt.html">Observation Genetic variant assessment</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 53037-8}">Genetic variation clinical significance [Imp]</span></td><td><span title="Codes:{http://loinc.org LA26333-7}">Uncertain significance</span></td></tr></table></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="diagnostic-implication"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>🔗 
          <reference value="Observation/gx-genomic-variant-somatic-polrmt"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="53037-8"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA26333-7"/>
              <display value="Uncertain significance"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-fusion-met-alk"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-fusion-met-alk"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-variant-fusion-met-alk"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-variant-fusion-met-alk</b></p><a name="gx-genomic-variant-fusion-met-alk"> </a><a name="hcgx-genomic-variant-fusion-met-alk"> </a><a name="gx-genomic-variant-fusion-met-alk-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9633-4}">Present</span></p><p><b>method</b>: <span title="Codes:{http://loinc.org LA26398-0}">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:7029}, {https://www.ncbi.nlm.nih.gov/gene 4233}">MET</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:427}, {https://www.ncbi.nlm.nih.gov/gene 238}">ALK</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48019-4}">DNA change type</span></p><p><b>value</b>: <span title="Codes:{http://www.sequenceontology.org/ SO:0002062}">complex chromosomal rearrangement</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48002-0}">Genomic source class [Type]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA6684-0}">Somatic</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9633-4"/>
            <display value="Present"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:7029"/>
              <display value="MET"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="4233"/>
              <display value="MET"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:427"/>
              <display value="ALK"/>
            </coding>
            <coding>
              <system value="https://www.ncbi.nlm.nih.gov/gene"/>
              <code value="238"/>
              <display value="ALK"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48019-4"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.sequenceontology.org/"/>
              <code value="SO:0002062"/>
              <display value="complex chromosomal rearrangement"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48002-0"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA6684-0"/>
              <display value="Somatic"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf"/>
    <resource>
      <Observation>
        <id value="gx-genomic-variant-pertinent-negative-nras-kit-braf"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-variant-pertinent-negative-nras-kit-braf"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-variant-pertinent-negative-nras-kit-braf</b></p><a name="gx-genomic-variant-pertinent-negative-nras-kit-braf"> </a><a name="hcgx-genomic-variant-pertinent-negative-nras-kit-braf"> </a><a name="gx-genomic-variant-pertinent-negative-nras-kit-braf-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9634-2}">Absent</span></p><p><b>method</b>: <span title="Codes:{http://loinc.org LA26398-0}">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:6342}">NRAS</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:7989}">KIT</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:1097}">BRAF</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="69548-6"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueCodeableConcept>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA9634-2"/>
            <display value="Absent"/>
          </coding>
        </valueCodeableConcept>
        <method>
          <coding>
            <system value="http://loinc.org"/>
            <code value="LA26398-0"/>
            <display value="Sequencing"/>
          </coding>
        </method>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:6342"/>
              <display value="NRAS"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:7989"/>
              <display value="KIT"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="48018-6"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.genenames.org"/>
              <code value="HGNC:1097"/>
              <display value="BRAF"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl value="http://example.org/fhir/Observation/gx-genomic-tmb"/>
    <resource>
      <Observation>
        <id value="gx-genomic-tmb"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/tmb"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-tmb"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-tmb</b></p><a name="gx-genomic-tmb"> </a><a name="hcgx-genomic-tmb"> </a><a name="gx-genomic-tmb-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 94076-7}">Mutations/Megabase [# Ratio] in Tumor</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>value</b>: 57.1 1/1000000{Base}<span style="background: LightGoldenRodYellow"> (Details: UCUM  code1/1000000{Base} = '1/1000000{Base}')</span></p></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system value="http://loinc.org"/>
            <code value="94076-7"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <valueQuantity>
          <value value="57.1"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="1/1000000{Base}"/>
        </valueQuantity>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-alectinib"/>
    <resource>
      <Observation>
        <id value="gx-genomic-therapeutic-implication-alectinib"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-therapeutic-implication-alectinib"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-therapeutic-implication-alectinib</b></p><a name="gx-genomic-therapeutic-implication-alectinib"> </a><a name="hcgx-genomic-therapeutic-implication-alectinib"> </a><a name="gx-genomic-therapeutic-implication-alectinib-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}">Therapeutic Implication</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href="Observation-gx-genomic-variant-fusion-met-alk.html">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 51963-7}">Medication assessed [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 1727455}">alectinib</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs predicted-therapeutic-implication}">Predicted Therapeutic Implication</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9661-5}">Presumed responsive</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="therapeutic-implication"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>🔗 
          <reference value="Observation/gx-genomic-variant-fusion-met-alk"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51963-7"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
              <code value="1727455"/>
              <display value="alectinib"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="predicted-therapeutic-implication"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA9661-5"/>
              <display value="Presumed responsive"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-brigatinib"/>
    <resource>
      <Observation>
        <id value="gx-genomic-therapeutic-implication-brigatinib"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-therapeutic-implication-brigatinib"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-therapeutic-implication-brigatinib</b></p><a name="gx-genomic-therapeutic-implication-brigatinib"> </a><a name="hcgx-genomic-therapeutic-implication-brigatinib"> </a><a name="gx-genomic-therapeutic-implication-brigatinib-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}">Therapeutic Implication</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href="Observation-gx-genomic-variant-fusion-met-alk.html">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 51963-7}">Medication assessed [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 1921217}">brigatinib</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs predicted-therapeutic-implication}">Predicted Therapeutic Implication</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9661-5}">Presumed responsive</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="therapeutic-implication"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>🔗 
          <reference value="Observation/gx-genomic-variant-fusion-met-alk"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51963-7"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
              <code value="1921217"/>
              <display value="brigatinib"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="predicted-therapeutic-implication"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA9661-5"/>
              <display value="Presumed responsive"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-ceritinib"/>
    <resource>
      <Observation>
        <id value="gx-genomic-therapeutic-implication-ceritinib"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-therapeutic-implication-ceritinib"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-therapeutic-implication-ceritinib</b></p><a name="gx-genomic-therapeutic-implication-ceritinib"> </a><a name="hcgx-genomic-therapeutic-implication-ceritinib"> </a><a name="gx-genomic-therapeutic-implication-ceritinib-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}">Therapeutic Implication</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href="Observation-gx-genomic-variant-fusion-met-alk.html">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 51963-7}">Medication assessed [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 1535457}">ceritinib</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs predicted-therapeutic-implication}">Predicted Therapeutic Implication</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9661-5}">Presumed responsive</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="therapeutic-implication"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>🔗 
          <reference value="Observation/gx-genomic-variant-fusion-met-alk"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51963-7"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
              <code value="1535457"/>
              <display value="ceritinib"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="predicted-therapeutic-implication"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA9661-5"/>
              <display value="Presumed responsive"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-crizotinib"/>
    <resource>
      <Observation>
        <id value="gx-genomic-therapeutic-implication-crizotinib"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-therapeutic-implication-crizotinib"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-therapeutic-implication-crizotinib</b></p><a name="gx-genomic-therapeutic-implication-crizotinib"> </a><a name="hcgx-genomic-therapeutic-implication-crizotinib"> </a><a name="gx-genomic-therapeutic-implication-crizotinib-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}">Therapeutic Implication</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href="Observation-gx-genomic-variant-fusion-met-alk.html">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 51963-7}">Medication assessed [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 1148495}">crizotinib</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs predicted-therapeutic-implication}">Predicted Therapeutic Implication</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9661-5}">Presumed responsive</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="therapeutic-implication"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>🔗 
          <reference value="Observation/gx-genomic-variant-fusion-met-alk"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51963-7"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
              <code value="1148495"/>
              <display value="crizotinib"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="predicted-therapeutic-implication"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA9661-5"/>
              <display value="Presumed responsive"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
  <entry>
    <fullUrl
             value="http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-lorlatinib"/>
    <resource>
      <Observation>
        <id value="gx-genomic-therapeutic-implication-lorlatinib"/>
        <meta>
          <profile
                   value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"/>
        </meta>
        <text>
          <status value="generated"/>
          <div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-therapeutic-implication-lorlatinib"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-therapeutic-implication-lorlatinib</b></p><a name="gx-genomic-therapeutic-implication-lorlatinib"> </a><a name="hcgx-genomic-therapeutic-implication-lorlatinib"> </a><a name="gx-genomic-therapeutic-implication-lorlatinib-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}">Therapeutic Implication</span></p><p><b>subject</b>: <a href="Patient-gx-cancer-patient-adam-anyperson.html">Adam Anyperson  Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href="Practitioner-us-core-practitioner-owen-oncologist.html">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href="Observation-gx-genomic-variant-fusion-met-alk.html">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 51963-7}">Medication assessed [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 2103164}">lorlatinib</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs predicted-therapeutic-implication}">Predicted Therapeutic Implication</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9661-5}">Presumed responsive</span></p></blockquote></div>
        </text>
        <status value="final"/>
        <category>
          <coding>
            <system
                    value="http://terminology.hl7.org/CodeSystem/observation-category"/>
            <code value="laboratory"/>
          </coding>
        </category>
        <code>
          <coding>
            <system
                    value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
            <code value="therapeutic-implication"/>
          </coding>
        </code>
        <subject>🔗 
          <reference value="Patient/gx-cancer-patient-adam-anyperson"/>
        </subject>
        <effectiveDateTime value="2019-04-01"/>
        <performer>🔗 
          <reference
                     value="Practitioner/us-core-practitioner-owen-oncologist"/>
        </performer>
        <derivedFrom>🔗 
          <reference value="Observation/gx-genomic-variant-fusion-met-alk"/>
        </derivedFrom>
        <component>
          <code>
            <coding>
              <system value="http://loinc.org"/>
              <code value="51963-7"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
              <code value="2103164"/>
              <display value="lorlatinib"/>
            </coding>
          </valueCodeableConcept>
        </component>
        <component>
          <code>
            <coding>
              <system
                      value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
              <code value="predicted-therapeutic-implication"/>
            </coding>
          </code>
          <valueCodeableConcept>
            <coding>
              <system value="http://loinc.org"/>
              <code value="LA9661-5"/>
              <display value="Presumed responsive"/>
            </coding>
          </valueCodeableConcept>
        </component>
      </Observation>
    </resource>
  </entry>
</Bundle>