minimal Common Oncology Data Elements (mCODE) Implementation Guide
4.0.0 - STU4
minimal Common Oncology Data Elements (mCODE) Implementation Guide
4.0.0 - STU4
minimal Common Oncology Data Elements (mCODE) Implementation Guide, published by HL7 International / Clinical Interoperability Council. This guide is not an authorized publication; it is the continuous build for version 4.0.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/fhir-mCODE-ig/ and changes regularly. See the Directory of published versions
@prefix fhir: <http://hl7.org/fhir/> . @prefix loinc: <https://loinc.org/rdf/> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix sct: <http://snomed.info/id/> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . # - resource ------------------------------------------------------------------- a fhir:Bundle ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "gx-genomic-bundle-adam-anyperson"] ; # fhir:type [ fhir:v "collection"] ; # fhir:entry ( [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Patient/gx-cancer-patient-adam-anyperson"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Patient/gx-cancer-patient-adam-anyperson> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/DiagnosticReport/gx-genomics-report-adam-anyperson"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/DiagnosticReport/gx-genomics-report-adam-anyperson> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/ServiceRequest/gx-order-tumornormal-gensop-inc"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/ServiceRequest/gx-order-tumornormal-gensop-inc> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Practitioner/gx-practitioner-test-pathologist"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Practitioner/gx-practitioner-test-pathologist> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-tumor"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-tumor> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-normal"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-normal> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-bap1-indel"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-bap1-indel> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2a-cnv"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2a-cnv> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2b-cnv"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2b-cnv> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-kdm5d"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-kdm5d> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-mtap"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-mtap> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-mycn"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-mycn> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-pof1b"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-pof1b> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-somatic-polrmt"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-somatic-polrmt> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-bap1"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-bap1> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-pof1b"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-pof1b> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-polrmt"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-polrmt> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-fusion-met-alk"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-fusion-met-alk> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-tmb"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-tmb> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-alectinib"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-alectinib> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-brigatinib"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-brigatinib> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-ceritinib"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-ceritinib> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-crizotinib"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-crizotinib> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-lorlatinib"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-lorlatinib> ) ] ) . # <http://example.org/fhir/Patient/gx-cancer-patient-adam-anyperson> a fhir:Patient ; fhir:id [ fhir:v "gx-cancer-patient-adam-anyperson"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-patient"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-patient> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Patient_gx-cancer-patient-adam-anyperson\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Patient gx-cancer-patient-adam-anyperson</b></p><a name=\"gx-cancer-patient-adam-anyperson\"> </a><a name=\"hcgx-cancer-patient-adam-anyperson\"> </a><a name=\"gx-cancer-patient-adam-anyperson-en-US\"> </a><p style=\"border: 1px #661aff solid; background-color: #e6e6ff; padding: 10px;\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</p><hr/><table class=\"grid\"><tr><td style=\"background-color: #f3f5da\" title=\"Other Id (see the one above)\">Other Id:</td><td colspan=\"3\">Patient external identifier/22ea1d1b-03a5-47d6-81e0-b9b4cbb15ccf (use: usual, )</td></tr><tr><td style=\"background-color: #f3f5da\" title=\"Ways to contact the Patient\">Contact Detail</td><td colspan=\"3\">987 Main St Anytown 12345 US </td></tr><tr><td style=\"background-color: #f3f5da\" title=\"A code classifying the person's sex assigned at birth as specified by the [Office of the National Coordinator for Health IT (ONC)](https://www.healthit.gov/newsroom/about-onc). This extension aligns with the C-CDA Birth Sex Observation (LOINC 76689-9). After version 6.0.0, this extension is no longer a *USCDI Requirement*.\"><a href=\"http://hl7.org/fhir/us/core/STU6.1/StructureDefinition-us-core-birthsex.html\">US Core Birth Sex Extension</a></td><td colspan=\"3\">M</td></tr></table></div>" ] ; # fhir:extension ( [ fhir:url [ fhir:v "http://hl7.org/fhir/us/core/StructureDefinition/us-core-birthsex"^^xsd:anyURI ] ; fhir:value [ fhir:v "M" ] ] ) ; # fhir:identifier ( [ fhir:use [ fhir:v "usual" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "PT" ] ; fhir:display [ fhir:v "Patient external identifier" ] ] ) ] ; fhir:system [ fhir:v "https://www.gensop.com"^^xsd:anyURI ] ; fhir:value [ fhir:v "22ea1d1b-03a5-47d6-81e0-b9b4cbb15ccf" ] ] [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "MR" ] ; fhir:display [ fhir:v "Medical Record Number" ] ] ) ] ; fhir:system [ fhir:v "http://hospital.example.org"^^xsd:anyURI ] ; fhir:value [ fhir:v "123456789" ] ] ) ; # fhir:name ( [ fhir:family [ fhir:v "Anyperson" ] ; ( fhir:given [ fhir:v "Adam" ] ) ] ) ; # fhir:gender [ fhir:v "male"] ; # fhir:birthDate [ fhir:v "1990-01-01"^^xsd:date] ; # fhir:address ( [ ( fhir:line [ fhir:v "987 Main St" ] ) ; fhir:city [ fhir:v "Anytown" ] ; fhir:postalCode [ fhir:v "12345" ] ; fhir:country [ fhir:v "US" ] ] ) . # <http://example.org/fhir/DiagnosticReport/gx-genomics-report-adam-anyperson> a fhir:DiagnosticReport ; fhir:id [ fhir:v "gx-genomics-report-adam-anyperson"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomics-report"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomics-report> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DiagnosticReport_gx-genomics-report-adam-anyperson\"> </a><p class=\"res-header-id\"><b>Generated Narrative: DiagnosticReport gx-genomics-report-adam-anyperson</b></p><a name=\"gx-genomics-report-adam-anyperson\"> </a><a name=\"hcgx-genomics-report-adam-anyperson\"> </a><a name=\"gx-genomics-report-adam-anyperson-en-US\"> </a><h2><span title=\"Codes:{http://loinc.org 51969-4}\">Genetic analysis report</span> (<span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>) </h2><table class=\"grid\"><tr><td>Subject</td><td>Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</td></tr><tr><td>When For</td><td>2022-02-15 19:28:58+0500</td></tr><tr><td>Performer</td><td> <a href=\"Organization-gx-us-core-organization-gensop-inc.html\">Organization Gensop Labs, Inc.</a></td></tr></table><p><b>Report Details</b></p><table class=\"grid\"><tr><td><b>Code</b></td><td><b>Value</b></td><td><b>Flags</b></td><td><b>When For</b></td></tr><tr><td><a href=\"Observation-gx-genomic-variant-somatic-bap1-indel.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-variant-somatic-cdkn2a-cnv.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-variant-somatic-cdkn2b-cnv.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-variant-somatic-kdm5d.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-variant-somatic-mtap.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-variant-somatic-mycn.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-variant-somatic-pof1b.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-variant-somatic-polrmt.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-diagnostic-implication-bap1.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-diagnostic-implication-pof1b.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-diagnostic-implication-polrmt.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-variant-fusion-met-alk.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-variant-pertinent-negative-nras-kit-braf.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9634-2}\">Absent</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-tmb.html\"><span title=\"Codes:{http://loinc.org 94076-7}\">Mutations/Megabase [# Ratio] in Tumor</span></a></td><td>57.1 1/1000000{Base}<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code1/1000000{Base} = '1/1000000{Base}')</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-msi.html\"><span title=\"Codes:{http://loinc.org 81695-9}\">Microsatellite instability [Interpretation] in Cancer specimen Qualitative</span></a></td><td><span title=\"Codes:{http://loinc.org LA26203-2}\">MSI-H</span></td><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-therapeutic-implication-alectinib.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-therapeutic-implication-brigatinib.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-therapeutic-implication-ceritinib.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-therapeutic-implication-crizotinib.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr><tr><td><a href=\"Observation-gx-genomic-therapeutic-implication-lorlatinib.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td>2019-04-01</td></tr></table></div>" ] ; # fhir:basedOn ( [ fhir:reference [ fhir:v "ServiceRequest/gx-order-tumornormal-gensop-inc" ] ] ) ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ; fhir:code [ fhir:v "GE" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:51969-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51969-4" ] ; fhir:display [ fhir:v "Genetic analysis report" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2022-02-15T19:28:58+05:00"^^xsd:dateTime] ; # fhir:performer ( [ fhir:reference [ fhir:v "Organization/gx-us-core-organization-gensop-inc" ] ] ) ; # fhir:resultsInterpreter ( [ fhir:reference [ fhir:v "Practitioner/gx-practitioner-test-pathologist" ] ] ) ; # fhir:specimen ( [ fhir:reference [ fhir:v "Specimen/gx-genomic-specimen-tumornormal-tumor" ] ] [ fhir:reference [ fhir:v "Specimen/gx-genomic-specimen-tumornormal-normal" ] ] ) ; # fhir:result ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-bap1-indel" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-cdkn2a-cnv" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-cdkn2b-cnv" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-kdm5d" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-mtap" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-mycn" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-pof1b" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-polrmt" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-diagnostic-implication-bap1" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-diagnostic-implication-pof1b" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-diagnostic-implication-polrmt" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-fusion-met-alk" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-tmb" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-msi" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-therapeutic-implication-alectinib" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-therapeutic-implication-brigatinib" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-therapeutic-implication-ceritinib" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-therapeutic-implication-crizotinib" ] ] [ fhir:reference [ fhir:v "Observation/gx-genomic-therapeutic-implication-lorlatinib" ] ] ) . # <http://example.org/fhir/ServiceRequest/gx-order-tumornormal-gensop-inc> a fhir:ServiceRequest ; fhir:id [ fhir:v "gx-order-tumornormal-gensop-inc"] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ServiceRequest_gx-order-tumornormal-gensop-inc\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ServiceRequest gx-order-tumornormal-gensop-inc</b></p><a name=\"gx-order-tumornormal-gensop-inc\"> </a><a name=\"hcgx-order-tumornormal-gensop-inc\"> </a><a name=\"gx-order-tumornormal-gensop-inc-en-US\"> </a><p><b>identifier</b>: Filler Identifier/22howe</p><p><b>status</b>: Completed</p><p><b>intent</b>: Order</p><p><b>code</b>: <span title=\"Codes:{https://www.gensop.com XT.V4}\">xT - 648 gene panel</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>reasonCode</b>: <span title=\"Codes:{http://hl7.org/fhir/sid/icd-10-cm C34.9}, {http://terminology.hl7.org/CodeSystem/icd-o-3 C34.9 8140/3}\">Malignant neoplasm of unspecified part of bronchus or lung</span></p></div>" ] ; # fhir:identifier ( [ fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "FILL" ] ; fhir:display [ fhir:v "Filler Identifier" ] ] ) ] ; fhir:system [ fhir:v "https://www.gensop.com"^^xsd:anyURI ] ; fhir:value [ fhir:v "22howe" ] ] ) ; # fhir:status [ fhir:v "completed"] ; # fhir:intent [ fhir:v "order"] ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "https://www.gensop.com"^^xsd:anyURI ] ; fhir:code [ fhir:v "XT.V4" ] ; fhir:display [ fhir:v "xT - 648 gene panel" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:reasonCode ( [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/sid/icd-10-cm"^^xsd:anyURI ] ; fhir:code [ fhir:v "C34.9" ] ; fhir:display [ fhir:v "Malignant neoplasm of unspecified part of bronchus or lung" ] ] [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/icd-o-3"^^xsd:anyURI ] ; fhir:code [ fhir:v "C34.9 8140/3" ] ; fhir:display [ fhir:v "Lung adenocarcinoma" ] ] ) ] ) . # <http://example.org/fhir/Practitioner/gx-practitioner-test-pathologist> a fhir:Practitioner ; fhir:id [ fhir:v "gx-practitioner-test-pathologist"] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Practitioner_gx-practitioner-test-pathologist\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Practitioner gx-practitioner-test-pathologist</b></p><a name=\"gx-practitioner-test-pathologist\"> </a><a name=\"hcgx-practitioner-test-pathologist\"> </a><a name=\"gx-practitioner-test-pathologist-en-US\"> </a><p><b>name</b>: Test Pathologist, MD</p></div>" ] ; # fhir:name ( [ fhir:text [ fhir:v "Test Pathologist, MD" ] ] ) . # <http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-tumor> a fhir:Specimen ; fhir:id [ fhir:v "gx-genomic-specimen-tumornormal-tumor"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-human-specimen"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-human-specimen> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Specimen_gx-genomic-specimen-tumornormal-tumor\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Specimen gx-genomic-specimen-tumornormal-tumor</b></p><a name=\"gx-genomic-specimen-tumornormal-tumor\"> </a><a name=\"hcgx-genomic-specimen-tumornormal-tumor\"> </a><a name=\"gx-genomic-specimen-tumornormal-tumor-en-US\"> </a><p><b>status</b>: Available</p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0487 TUMOR}\">Tumor</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>receivedTime</b>: 2021-02-09 21:30:50+0500</p><h3>Collections</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Collected[x]</b></td><td><b>BodySite</b></td></tr><tr><td style=\"display: none\">*</td><td>2021-02-06 17:15:00+0500</td><td><span title=\"Codes:{http://snomed.info/sct 44029006}\">Left lung structure (body structure)</span></td></tr></table></div>" ] ; # fhir:status [ fhir:v "available"] ; # fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0487"^^xsd:anyURI ] ; fhir:code [ fhir:v "TUMOR" ] ; fhir:display [ fhir:v "Tumor" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:receivedTime [ fhir:v "2021-02-09T21:30:50+05:00"^^xsd:dateTime] ; # fhir:collection [ fhir:collected [ fhir:v "2021-02-06T17:15:00+05:00"^^xsd:dateTime ] ; fhir:bodySite [ ( fhir:coding [ a sct:44029006 ; fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ; fhir:code [ fhir:v "44029006" ] ; fhir:display [ fhir:v "Left lung structure (body structure)" ] ] ) ] ] . # <http://example.org/fhir/Specimen/gx-genomic-specimen-tumornormal-normal> a fhir:Specimen ; fhir:id [ fhir:v "gx-genomic-specimen-tumornormal-normal"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-human-specimen"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-human-specimen> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Specimen_gx-genomic-specimen-tumornormal-normal\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Specimen gx-genomic-specimen-tumornormal-normal</b></p><a name=\"gx-genomic-specimen-tumornormal-normal\"> </a><a name=\"hcgx-genomic-specimen-tumornormal-normal\"> </a><a name=\"gx-genomic-specimen-tumornormal-normal-en-US\"> </a><p><b>status</b>: Available</p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0487 BLD}\">Whole Blood</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>receivedTime</b>: 2021-02-09 21:30:50+0500</p><h3>Collections</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Collected[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>2021-02-06 17:15:00+0500</td></tr></table></div>" ] ; # fhir:status [ fhir:v "available"] ; # fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0487"^^xsd:anyURI ] ; fhir:code [ fhir:v "BLD" ] ; fhir:display [ fhir:v "Whole Blood" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:receivedTime [ fhir:v "2021-02-09T21:30:50+05:00"^^xsd:dateTime] ; # fhir:collection [ fhir:collected [ fhir:v "2021-02-06T17:15:00+05:00"^^xsd:dateTime ] ] . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-bap1-indel> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-bap1-indel"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-bap1-indel\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-variant-somatic-bap1-indel</b></p><a name=\"gx-genomic-variant-somatic-bap1-indel\"> </a><a name=\"hcgx-genomic-variant-somatic-bap1-indel\"> </a><a name=\"gx-genomic-variant-somatic-bap1-indel-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:950}, {https://www.ncbi.nlm.nih.gov/gene 3815}\">BAP1</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51958-7}\">Transcript reference sequence [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_004656}\">NM_004656.4</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48004-6}\">DNA change (c.HGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NM_004656.4:c.1768C>T}\">NM_004656.4:c.1768C>T</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48005-3}\">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NP_004647.1:p.(Gln590Ter)}\">NP_004647.1:p.(Gln590Ter)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81258-6}\">Sample variant allelic frequency [NFr]</span></p><p><b>value</b>: 57.4 %<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code% = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></p><p><b>value</b>: <span title=\"Codes:{http://www.sequenceontology.org/ SO:0001587}\">stop_gained</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:950" ] ; fhir:display [ fhir:v "BAP1" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "3815" ] ; fhir:display [ fhir:v "BAP1" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:51958-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51958-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.ncbi.nlm.nih.gov/refseq"^^xsd:anyURI ] ; fhir:code [ fhir:v "NM_004656" ] ; fhir:display [ fhir:v "NM_004656.4" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48004-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48004-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NM_004656.4:c.1768C>T" ] ; fhir:display [ fhir:v "NM_004656.4:c.1768C>T" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48005-3 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48005-3" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NP_004647.1:p.(Gln590Ter)" ] ; fhir:display [ fhir:v "NP_004647.1:p.(Gln590Ter)" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:81258-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81258-6" ] ] ) ] ; fhir:value [ a fhir:Quantity ; fhir:value [ fhir:v "57.4"^^xsd:decimal ] ; fhir:unit [ fhir:v "%" ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "%" ] ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001587" ] ; fhir:display [ fhir:v "stop_gained" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2a-cnv> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-cdkn2a-cnv"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-cdkn2a-cnv\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-variant-somatic-cdkn2a-cnv</b></p><a name=\"gx-genomic-variant-somatic-cdkn2a-cnv\"> </a><a name=\"hcgx-genomic-variant-somatic-cdkn2a-cnv\"> </a><a name=\"gx-genomic-variant-somatic-cdkn2a-cnv-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:1787}, {https://www.ncbi.nlm.nih.gov/gene 1029}\">CDKN2A</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></p><p><b>value</b>: <span title=\"Codes:{http://www.sequenceontology.org/ SO:0001743}\">copy_number_loss</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:1787" ] ; fhir:display [ fhir:v "CDKN2A" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "1029" ] ; fhir:display [ fhir:v "CDKN2A" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001743" ] ; fhir:display [ fhir:v "copy_number_loss" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-cdkn2b-cnv> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-cdkn2b-cnv"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-cdkn2b-cnv\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-variant-somatic-cdkn2b-cnv</b></p><a name=\"gx-genomic-variant-somatic-cdkn2b-cnv\"> </a><a name=\"hcgx-genomic-variant-somatic-cdkn2b-cnv\"> </a><a name=\"gx-genomic-variant-somatic-cdkn2b-cnv-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:1788}, {https://www.ncbi.nlm.nih.gov/gene 1030}\">CDKN2B</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></p><p><b>value</b>: <span title=\"Codes:{http://www.sequenceontology.org/ SO:0001743}\">copy_number_loss</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:1788" ] ; fhir:display [ fhir:v "CDKN2B" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "1030" ] ; fhir:display [ fhir:v "CDKN2B" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001743" ] ; fhir:display [ fhir:v "copy_number_loss" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-kdm5d> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-kdm5d"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-kdm5d\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-variant-somatic-kdm5d</b></p><a name=\"gx-genomic-variant-somatic-kdm5d\"> </a><a name=\"hcgx-genomic-variant-somatic-kdm5d\"> </a><a name=\"gx-genomic-variant-somatic-kdm5d-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:11115}, {https://www.ncbi.nlm.nih.gov/gene 8284}\">KDM5D</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></p><p><b>value</b>: <span title=\"Codes:{http://www.sequenceontology.org/ SO:0001743}\">copy_number_loss</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:11115" ] ; fhir:display [ fhir:v "KDM5D" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "8284" ] ; fhir:display [ fhir:v "KDM5D" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001743" ] ; fhir:display [ fhir:v "copy_number_loss" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-mtap> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-mtap"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-mtap\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-variant-somatic-mtap</b></p><a name=\"gx-genomic-variant-somatic-mtap\"> </a><a name=\"hcgx-genomic-variant-somatic-mtap\"> </a><a name=\"gx-genomic-variant-somatic-mtap-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:7413}, {https://www.ncbi.nlm.nih.gov/gene 4507}\">MTAP</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></p><p><b>value</b>: <span title=\"Codes:{http://www.sequenceontology.org/ SO:0001743}\">copy_number_loss</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:7413" ] ; fhir:display [ fhir:v "MTAP" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "4507" ] ; fhir:display [ fhir:v "MTAP" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001743" ] ; fhir:display [ fhir:v "copy_number_loss" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-mycn> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-mycn"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-mycn\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-variant-somatic-mycn</b></p><a name=\"gx-genomic-variant-somatic-mycn\"> </a><a name=\"hcgx-genomic-variant-somatic-mycn\"> </a><a name=\"gx-genomic-variant-somatic-mycn-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:7559}, {https://www.ncbi.nlm.nih.gov/gene 4613}\">MYCN</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></p><p><b>value</b>: <span title=\"Codes:{http://www.sequenceontology.org/ SO:0001742}\">copy_number_gain</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:7559" ] ; fhir:display [ fhir:v "MYCN" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "4613" ] ; fhir:display [ fhir:v "MYCN" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001742" ] ; fhir:display [ fhir:v "copy_number_gain" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-pof1b> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-pof1b"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-pof1b\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-variant-somatic-pof1b</b></p><a name=\"gx-genomic-variant-somatic-pof1b\"> </a><a name=\"hcgx-genomic-variant-somatic-pof1b\"> </a><a name=\"gx-genomic-variant-somatic-pof1b-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:13711}, {https://www.ncbi.nlm.nih.gov/gene 79983}\">POF1B</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></p><p><b>value</b>: <span title=\"Codes:{http://www.sequenceontology.org/ SO:0001583}\">missense_variant</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51958-7}\">Transcript reference sequence [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_004656}\">NM_004656</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48004-6}\">DNA change (c.HGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NM_001307940.2:c.430C>T}\">NM_001307940.2:c.430C>T</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48005-3}\">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NP_001294869.1:p.(Pro144Ser)}\">NP_001294869.1:p.(Pro144Ser)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81258-6}\">Sample variant allelic frequency [NFr]</span></p><p><b>value</b>: 78.6 %<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code% = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:13711" ] ; fhir:display [ fhir:v "POF1B" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "79983" ] ; fhir:display [ fhir:v "POF1B" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001583" ] ; fhir:display [ fhir:v "missense_variant" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:51958-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51958-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.ncbi.nlm.nih.gov/refseq"^^xsd:anyURI ] ; fhir:code [ fhir:v "NM_004656" ] ; fhir:display [ fhir:v "NM_004656" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48004-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48004-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NM_001307940.2:c.430C>T" ] ; fhir:display [ fhir:v "NM_001307940.2:c.430C>T" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48005-3 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48005-3" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NP_001294869.1:p.(Pro144Ser)" ] ; fhir:display [ fhir:v "NP_001294869.1:p.(Pro144Ser)" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:81258-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81258-6" ] ] ) ] ; fhir:value [ a fhir:Quantity ; fhir:value [ fhir:v "78.6"^^xsd:decimal ] ; fhir:unit [ fhir:v "%" ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "%" ] ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-somatic-polrmt> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-somatic-polrmt"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-somatic-polrmt\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-variant-somatic-polrmt</b></p><a name=\"gx-genomic-variant-somatic-polrmt\"> </a><a name=\"hcgx-genomic-variant-somatic-polrmt\"> </a><a name=\"gx-genomic-variant-somatic-polrmt-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{https://www.ncbi.nlm.nih.gov/gene 5442}\">POLRMT</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></p><p><b>value</b>: <span title=\"Codes:{http://www.sequenceontology.org/ SO:0001583}\">missense_variant</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51958-7}\">Transcript reference sequence [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_004656}\">NM_005035</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48004-6}\">DNA change (c.HGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NM_005035.4:c.598G>A}\">NM_005035.4:c.598G>A</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48005-3}\">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title=\"Codes:{http://varnomen.hgvs.org NP_005026.3:p.(Gly200Arg)}\">NP_005026.3:p.(Gly200Arg)</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81258-6}\">Sample variant allelic frequency [NFr]</span></p><p><b>value</b>: 75.6 %<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code% = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "5442" ] ; fhir:display [ fhir:v "POLRMT" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "molecular-consequence" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0001583" ] ; fhir:display [ fhir:v "missense_variant" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:51958-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51958-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.ncbi.nlm.nih.gov/refseq"^^xsd:anyURI ] ; fhir:code [ fhir:v "NM_004656" ] ; fhir:display [ fhir:v "NM_005035" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48004-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48004-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NM_005035.4:c.598G>A" ] ; fhir:display [ fhir:v "NM_005035.4:c.598G>A" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48005-3 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48005-3" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://varnomen.hgvs.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "NP_005026.3:p.(Gly200Arg)" ] ; fhir:display [ fhir:v "NP_005026.3:p.(Gly200Arg)" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:81258-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "81258-6" ] ] ) ] ; fhir:value [ a fhir:Quantity ; fhir:value [ fhir:v "75.6"^^xsd:decimal ] ; fhir:unit [ fhir:v "%" ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "%" ] ] ] [ fhir:code [ ( fhir:coding [ a loinc:62374-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "62374-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA14029-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA14029-5" ] ; fhir:display [ fhir:v "GRCh37" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-bap1> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-diagnostic-implication-bap1"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-diagnostic-implication-bap1\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-diagnostic-implication-bap1</b></p><a name=\"gx-genomic-diagnostic-implication-bap1\"> </a><a name=\"hcgx-genomic-diagnostic-implication-bap1\"> </a><a name=\"gx-genomic-diagnostic-implication-bap1-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href=\"Observation-gx-genomic-variant-somatic-bap1-indel.html\">Observation Genetic variant assessment</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs functional-effect}\">Functional Effect</span></td><td><span title=\"Codes:{http://www.sequenceontology.org/ SO:0002054}\">loss of function variant</span></td></tr></table></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "diagnostic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-bap1-indel" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "functional-effect" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0002054" ] ; fhir:display [ fhir:v "loss of function variant" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-pof1b> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-diagnostic-implication-pof1b"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-diagnostic-implication-pof1b\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-diagnostic-implication-pof1b</b></p><a name=\"gx-genomic-diagnostic-implication-pof1b\"> </a><a name=\"hcgx-genomic-diagnostic-implication-pof1b\"> </a><a name=\"gx-genomic-diagnostic-implication-pof1b-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href=\"Observation-gx-genomic-variant-somatic-pof1b.html\">Observation Genetic variant assessment</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 53037-8}\">Genetic variation clinical significance [Imp]</span></td><td><span title=\"Codes:{http://loinc.org LA26333-7}\">Uncertain significance</span></td></tr></table></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "diagnostic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-pof1b" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:53037-8 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "53037-8" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA26333-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26333-7" ] ; fhir:display [ fhir:v "Uncertain significance" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-diagnostic-implication-polrmt> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-diagnostic-implication-polrmt"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-diagnostic-implication-polrmt\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-diagnostic-implication-polrmt</b></p><a name=\"gx-genomic-diagnostic-implication-polrmt\"> </a><a name=\"hcgx-genomic-diagnostic-implication-polrmt\"> </a><a name=\"gx-genomic-diagnostic-implication-polrmt-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href=\"Observation-gx-genomic-variant-somatic-polrmt.html\">Observation Genetic variant assessment</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 53037-8}\">Genetic variation clinical significance [Imp]</span></td><td><span title=\"Codes:{http://loinc.org LA26333-7}\">Uncertain significance</span></td></tr></table></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "diagnostic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-somatic-polrmt" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:53037-8 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "53037-8" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA26333-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26333-7" ] ; fhir:display [ fhir:v "Uncertain significance" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-fusion-met-alk> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-fusion-met-alk"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-fusion-met-alk\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-variant-fusion-met-alk</b></p><a name=\"gx-genomic-variant-fusion-met-alk\"> </a><a name=\"hcgx-genomic-variant-fusion-met-alk\"> </a><a name=\"gx-genomic-variant-fusion-met-alk-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:7029}, {https://www.ncbi.nlm.nih.gov/gene 4233}\">MET</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:427}, {https://www.ncbi.nlm.nih.gov/gene 238}\">ALK</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48019-4}\">DNA change type</span></p><p><b>value</b>: <span title=\"Codes:{http://www.sequenceontology.org/ SO:0002062}\">complex chromosomal rearrangement</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9633-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9633-4" ] ; fhir:display [ fhir:v "Present" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:7029" ] ; fhir:display [ fhir:v "MET" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "4233" ] ; fhir:display [ fhir:v "MET" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:427" ] ; fhir:display [ fhir:v "ALK" ] ] [ fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/gene"^^xsd:anyURI ] ; fhir:code [ fhir:v "238" ] ; fhir:display [ fhir:v "ALK" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48019-4 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48019-4" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.sequenceontology.org/"^^xsd:anyURI ] ; fhir:code [ fhir:v "SO:0002062" ] ; fhir:display [ fhir:v "complex chromosomal rearrangement" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48002-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48002-0" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA6684-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA6684-0" ] ; fhir:display [ fhir:v "Somatic" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-variant-pertinent-negative-nras-kit-braf> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-variant-pertinent-negative-nras-kit-braf"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-genomic-variant> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-variant-pertinent-negative-nras-kit-braf\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-variant-pertinent-negative-nras-kit-braf</b></p><a name=\"gx-genomic-variant-pertinent-negative-nras-kit-braf\"> </a><a name=\"hcgx-genomic-variant-pertinent-negative-nras-kit-braf\"> </a><a name=\"gx-genomic-variant-pertinent-negative-nras-kit-braf-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9634-2}\">Absent</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:6342}\">NRAS</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:7989}\">KIT</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:1097}\">BRAF</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:69548-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "69548-6" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9634-2 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9634-2" ] ; fhir:display [ fhir:v "Absent" ] ] ) ] ; # fhir:method [ ( fhir:coding [ a loinc:LA26398-0 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA26398-0" ] ; fhir:display [ fhir:v "Sequencing" ] ] ) ] ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:6342" ] ; fhir:display [ fhir:v "NRAS" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:7989" ] ; fhir:display [ fhir:v "KIT" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ a loinc:48018-6 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "48018-6" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.genenames.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "HGNC:1097" ] ; fhir:display [ fhir:v "BRAF" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-tmb> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-tmb"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/tmb"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/tmb> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-tmb\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-tmb</b></p><a name=\"gx-genomic-tmb\"> </a><a name=\"hcgx-genomic-tmb\"> </a><a name=\"gx-genomic-tmb-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 94076-7}\">Mutations/Megabase [# Ratio] in Tumor</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>value</b>: 57.1 1/1000000{Base}<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code1/1000000{Base} = '1/1000000{Base}')</span></p></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a loinc:94076-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "94076-7" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:value [ a fhir:Quantity ; fhir:value [ fhir:v "57.1"^^xsd:decimal ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "1/1000000{Base}" ] ] . # <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-alectinib> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-therapeutic-implication-alectinib"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-therapeutic-implication-alectinib\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-therapeutic-implication-alectinib</b></p><a name=\"gx-genomic-therapeutic-implication-alectinib\"> </a><a name=\"hcgx-genomic-therapeutic-implication-alectinib\"> </a><a name=\"gx-genomic-therapeutic-implication-alectinib-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href=\"Observation-gx-genomic-variant-fusion-met-alk.html\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 1727455}\">alectinib</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs predicted-therapeutic-implication}\">Predicted Therapeutic Implication</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9661-5}\">Presumed responsive</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-fusion-met-alk" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "1727455" ] ; fhir:display [ fhir:v "alectinib" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "predicted-therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9661-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9661-5" ] ; fhir:display [ fhir:v "Presumed responsive" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-brigatinib> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-therapeutic-implication-brigatinib"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-therapeutic-implication-brigatinib\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-therapeutic-implication-brigatinib</b></p><a name=\"gx-genomic-therapeutic-implication-brigatinib\"> </a><a name=\"hcgx-genomic-therapeutic-implication-brigatinib\"> </a><a name=\"gx-genomic-therapeutic-implication-brigatinib-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href=\"Observation-gx-genomic-variant-fusion-met-alk.html\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 1921217}\">brigatinib</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs predicted-therapeutic-implication}\">Predicted Therapeutic Implication</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9661-5}\">Presumed responsive</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-fusion-met-alk" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "1921217" ] ; fhir:display [ fhir:v "brigatinib" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "predicted-therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9661-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9661-5" ] ; fhir:display [ fhir:v "Presumed responsive" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-ceritinib> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-therapeutic-implication-ceritinib"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-therapeutic-implication-ceritinib\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-therapeutic-implication-ceritinib</b></p><a name=\"gx-genomic-therapeutic-implication-ceritinib\"> </a><a name=\"hcgx-genomic-therapeutic-implication-ceritinib\"> </a><a name=\"gx-genomic-therapeutic-implication-ceritinib-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href=\"Observation-gx-genomic-variant-fusion-met-alk.html\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 1535457}\">ceritinib</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs predicted-therapeutic-implication}\">Predicted Therapeutic Implication</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9661-5}\">Presumed responsive</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-fusion-met-alk" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "1535457" ] ; fhir:display [ fhir:v "ceritinib" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "predicted-therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9661-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9661-5" ] ; fhir:display [ fhir:v "Presumed responsive" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-crizotinib> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-therapeutic-implication-crizotinib"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-therapeutic-implication-crizotinib\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-therapeutic-implication-crizotinib</b></p><a name=\"gx-genomic-therapeutic-implication-crizotinib\"> </a><a name=\"hcgx-genomic-therapeutic-implication-crizotinib\"> </a><a name=\"gx-genomic-therapeutic-implication-crizotinib-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href=\"Observation-gx-genomic-variant-fusion-met-alk.html\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 1148495}\">crizotinib</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs predicted-therapeutic-implication}\">Predicted Therapeutic Implication</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9661-5}\">Presumed responsive</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-fusion-met-alk" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "1148495" ] ; fhir:display [ fhir:v "crizotinib" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "predicted-therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9661-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9661-5" ] ; fhir:display [ fhir:v "Presumed responsive" ] ] ) ] ] ) . # <http://example.org/fhir/Observation/gx-genomic-therapeutic-implication-lorlatinib> a fhir:Observation ; fhir:id [ fhir:v "gx-genomic-therapeutic-implication-lorlatinib"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-therapeutic-implication-lorlatinib\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-therapeutic-implication-lorlatinib</b></p><a name=\"gx-genomic-therapeutic-implication-lorlatinib\"> </a><a name=\"hcgx-genomic-therapeutic-implication-lorlatinib\"> </a><a name=\"gx-genomic-therapeutic-implication-lorlatinib-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Patient-gx-cancer-patient-adam-anyperson.html\">Adam Anyperson Male, DoB: 1990-01-01 ( Medical Record Number: 123456789)</a></p><p><b>effective</b>: 2019-04-01</p><p><b>performer</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner Owen Oncologist </a></p><p><b>derivedFrom</b>: <a href=\"Observation-gx-genomic-variant-fusion-met-alk.html\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.nlm.nih.gov/research/umls/rxnorm 2103164}\">lorlatinib</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs predicted-therapeutic-implication}\">Predicted Therapeutic Implication</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9661-5}\">Presumed responsive</span></p></blockquote></div>" ] ; # fhir:status [ fhir:v "final"] ; # fhir:category ( [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ] ; fhir:code [ fhir:v "laboratory" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "therapeutic-implication" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/gx-cancer-patient-adam-anyperson" ] ] ; # fhir:effective [ fhir:v "2019-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ) ; # fhir:derivedFrom ( [ fhir:reference [ fhir:v "Observation/gx-genomic-variant-fusion-met-alk" ] ] ) ; # fhir:component ( [ fhir:code [ ( fhir:coding [ a loinc:51963-7 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "51963-7" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "2103164" ] ; fhir:display [ fhir:v "lorlatinib" ] ] ) ] ] [ fhir:code [ ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ] ; fhir:code [ fhir:v "predicted-therapeutic-implication" ] ] ) ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ a loinc:LA9661-5 ; fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "LA9661-5" ] ; fhir:display [ fhir:v "Presumed responsive" ] ] ) ] ] ) . #
IG © 2019+ HL7 International / Clinical Interoperability Council. Package hl7.fhir.us.mcode#4.0.0 based on FHIR 4.0.1. Generated 2024-12-03
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