Global Core Electronic Medicinal Product Information (ePI)
1.1.0 - trial-use World

Global Core Electronic Medicinal Product Information (ePI), published by HL7 International / Biomedical Research and Regulation. This guide is not an authorized publication; it is the continuous build for version 1.1.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/emedicinal-product-info/ and changes regularly. See the Directory of published versions

: Bundle - ePI Type 3 Diflucan Example

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/Bundle/bundle-epi-type3-example-diflucan> a fhir:Bundle ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "bundle-epi-type3-example-diflucan"] ; # 
  fhir:meta [
     fhir:versionId [ fhir:v "1.0" ] ;
     fhir:lastUpdated [ fhir:v "2026-06-17T10:00:00Z"^^xsd:dateTime ] ;
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/bundle-epi-type3"^^xsd:anyURI ;
       fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/bundle-epi-type3>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:identifier [
     fhir:system [ fhir:v "http://ema.europa.eu/identifier"^^xsd:anyURI ] ;
     fhir:value [ fhir:v "DIFLUCAN-BUNDLE-TYPE3" ]
  ] ; # 
  fhir:type [ fhir:v "document"] ; # 
  fhir:timestamp [ fhir:v "2026-06-17T10:00:00Z"^^xsd:dateTime] ; # 
  fhir:entry ( [
     fhir:fullUrl [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/Composition/composition-diflucan"^^xsd:anyURI ] ;
     fhir:resource ( <http://hl7.org/fhir/uv/emedicinal-product-info/Composition/composition-diflucan> )
  ] [
     fhir:fullUrl [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/Organization/org-diflucan"^^xsd:anyURI ] ;
     fhir:resource ( <http://hl7.org/fhir/uv/emedicinal-product-info/Organization/org-diflucan> )
  ] [
     fhir:fullUrl [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan"^^xsd:anyURI ] ;
     fhir:resource ( <http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan> )
  ] [
     fhir:fullUrl [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/MedicationKnowledge/mk-diflucan"^^xsd:anyURI ] ;
     fhir:resource ( <http://hl7.org/fhir/uv/emedicinal-product-info/MedicationKnowledge/mk-diflucan> )
  ] [
     fhir:fullUrl [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/ClinicalUseDefinition/cud-diflucan-mucosal"^^xsd:anyURI ] ;
     fhir:resource ( <http://hl7.org/fhir/uv/emedicinal-product-info/ClinicalUseDefinition/cud-diflucan-mucosal> )
  ] [
     fhir:fullUrl [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/ClinicalUseDefinition/cud-diflucan-invasive"^^xsd:anyURI ] ;
     fhir:resource ( <http://hl7.org/fhir/uv/emedicinal-product-info/ClinicalUseDefinition/cud-diflucan-invasive> )
  ] [
     fhir:fullUrl [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/ClinicalUseDefinition/cud-diflucan-renal"^^xsd:anyURI ] ;
     fhir:resource ( <http://hl7.org/fhir/uv/emedicinal-product-info/ClinicalUseDefinition/cud-diflucan-renal> )
  ] [
     fhir:fullUrl [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/Group/group-diflucan-adult"^^xsd:anyURI ] ;
     fhir:resource ( <http://hl7.org/fhir/uv/emedicinal-product-info/Group/group-diflucan-adult> )
  ] [
     fhir:fullUrl [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/Group/group-diflucan-renal"^^xsd:anyURI ] ;
     fhir:resource ( <http://hl7.org/fhir/uv/emedicinal-product-info/Group/group-diflucan-renal> )
  ] ) . # 

<http://hl7.org/fhir/uv/emedicinal-product-info/Composition/composition-diflucan> a fhir:Composition ;
  fhir:id [ fhir:v "composition-diflucan"] ; # 
  fhir:meta [
     fhir:versionId [ fhir:v "1" ] ;
     fhir:lastUpdated [ fhir:v "2026-06-17T10:00:00Z"^^xsd:dateTime ] ;
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/composition-epi-type1"^^xsd:anyURI ;
       fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/composition-epi-type1>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xml:lang=\"en\" xmlns=\"http://www.w3.org/1999/xhtml\" lang=\"en\"><a name=\"Composition_composition-diflucan\"> </a><p>Diflucan Summary of Product Characteristics</p></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:identifier ( [
     fhir:system [ fhir:v "http://example.org/identifier"^^xsd:anyURI ] ;
     fhir:value [ fhir:v "composition-diflucan" ]
  ] ) ; # 
  fhir:version [ fhir:v "1.0"] ; # 
  fhir:status [ fhir:v "final"] ; # 
  fhir:type [
     fhir:coding ( [
       fhir:system [ fhir:v "https://spor.ema.europa.eu/rmswi"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "100000155532" ] ;
       fhir:display [ fhir:v "Summary of Product Characteristics" ]
     ] )
  ] ; # 
  fhir:subject ( [
     fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan> ;
     fhir:reference [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan" ]
  ] ) ; # 
  fhir:date [ fhir:v "2026-06-17"^^xsd:date] ; # 
  fhir:author ( [
     fhir:link <http://hl7.org/fhir/Organization/org-diflucan> ;
     fhir:reference [ fhir:v "Organization/org-diflucan" ]
  ] ) ; # 
  fhir:title [ fhir:v "Diflucan 150 mg capsule - Summary of Product Characteristics"] ; # 
  fhir:section ( [
     fhir:id [ fhir:v "diflucan-root" ] ;
     fhir:title [ fhir:v "SUMMARY OF PRODUCT CHARACTERISTICS" ] ;
     fhir:code [
       fhir:coding ( [
         fhir:system [ fhir:v "https://spor.ema.europa.eu/rmswi"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "200000029791" ] ;
         fhir:display [ fhir:v "SUMMARY OF PRODUCT CHARACTERISTICS" ]
       ] )
     ] ;
     fhir:text [
       fhir:status [ fhir:v "generated" ] ;
       fhir:div [ fhir:v "<div xml:lang=\"en\" xmlns=\"http://www.w3.org/1999/xhtml\" lang=\"en\">Summary of Product Characteristics for Diflucan</div>"^^rdf:XMLLiteral ]
     ] ;
     fhir:section ( [
       fhir:id [ fhir:v "diflucan-4-1" ] ;
       fhir:title [ fhir:v "4.1 Therapeutic indications" ] ;
       fhir:code [
         fhir:coding ( [
           fhir:system [ fhir:v "https://spor.ema.europa.eu/rmswi"^^xsd:anyURI ] ;
           fhir:code [ fhir:v "200000029799" ] ;
           fhir:display [ fhir:v "4.1 Therapeutic indications" ]
         ] )
       ] ;
       fhir:text [
         fhir:status [ fhir:v "generated" ] ;
         fhir:div [ fhir:v "<div xml:lang=\"en\" xmlns=\"http://www.w3.org/1999/xhtml\" lang=\"en\"><p>Treatment of mucosal and invasive candidiasis.</p></div>"^^rdf:XMLLiteral ]
       ] ;
       fhir:entry ( [
         fhir:link <http://hl7.org/fhir/ClinicalUseDefinition/cud-diflucan-mucosal> ;
         fhir:reference [ fhir:v "ClinicalUseDefinition/cud-diflucan-mucosal" ]
       ] [
         fhir:link <http://hl7.org/fhir/ClinicalUseDefinition/cud-diflucan-invasive> ;
         fhir:reference [ fhir:v "ClinicalUseDefinition/cud-diflucan-invasive" ]
       ] )
     ] [
       fhir:id [ fhir:v "diflucan-4-2" ] ;
       fhir:title [ fhir:v "4.2 Posology and method of administration" ] ;
       fhir:code [
         fhir:coding ( [
           fhir:system [ fhir:v "https://spor.ema.europa.eu/rmswi"^^xsd:anyURI ] ;
           fhir:code [ fhir:v "200000029800" ] ;
           fhir:display [ fhir:v "4.2 Posology and method of administration" ]
         ] )
       ] ;
       fhir:text [
         fhir:status [ fhir:v "generated" ] ;
         fhir:div [ fhir:v "<div xml:lang=\"en\" xmlns=\"http://www.w3.org/1999/xhtml\" lang=\"en\"><p>Dose depends on the indication and the patient population (see structured dosing). Renal impairment requires dose adjustment for multiple-dose therapy.</p></div>"^^rdf:XMLLiteral ]
       ] ;
       fhir:entry ( [
         fhir:link <http://hl7.org/fhir/MedicationKnowledge/mk-diflucan> ;
         fhir:reference [ fhir:v "MedicationKnowledge/mk-diflucan" ]
       ] [
         fhir:link <http://hl7.org/fhir/ClinicalUseDefinition/cud-diflucan-renal> ;
         fhir:reference [ fhir:v "ClinicalUseDefinition/cud-diflucan-renal" ]
       ] )
     ] )
  ] ) . # 

<http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan> a fhir:uv, fhir:MedicinalProductDefinition ;
  fhir:id [ fhir:v "mpd-diflucan"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/MedicinalProductDefinition-uv-epi"^^xsd:anyURI ;
       fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/MedicinalProductDefinition-uv-epi>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"MedicinalProductDefinition_mpd-diflucan\"> </a><p class=\"res-header-id\"><b>Generated Narrative: MedicinalProductDefinition mpd-diflucan</b></p><a name=\"mpd-diflucan\"> </a><a name=\"hcmpd-diflucan\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-MedicinalProductDefinition-uv-epi.html\">MedicinalProductDefinition (ePI)</a></p></div><p><b>identifier</b>: <code>http://ema.europa.eu/identifier</code>/DIFLUCAN-150MG</p><p><b>status</b>: <span title=\"Codes:{http://hl7.org/fhir/publication-status active}\">Active</span></p><h3>Names</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>ProductName</b></td></tr><tr><td style=\"display: none\">*</td><td>Diflucan 150 mg capsule</td></tr></table></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:identifier ( [
     fhir:system [ fhir:v "http://ema.europa.eu/identifier"^^xsd:anyURI ] ;
     fhir:value [ fhir:v "DIFLUCAN-150MG" ]
  ] ) ; # 
  fhir:status [
     fhir:coding ( [
       fhir:system [ fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "active" ] ;
       fhir:display [ fhir:v "Active" ]
     ] )
  ] ; # 
  fhir:name ( [
     fhir:productName [ fhir:v "Diflucan 150 mg capsule" ]
  ] ) . # 

<http://hl7.org/fhir/Organization/org-diflucan> a fhir:Organization .

<http://hl7.org/fhir/ClinicalUseDefinition/cud-diflucan-mucosal> a fhir:ClinicalUseDefinition .

<http://hl7.org/fhir/ClinicalUseDefinition/cud-diflucan-invasive> a fhir:ClinicalUseDefinition .

<http://hl7.org/fhir/MedicationKnowledge/mk-diflucan> a fhir:MedicationKnowledge .

<http://hl7.org/fhir/ClinicalUseDefinition/cud-diflucan-renal> a fhir:ClinicalUseDefinition .

<http://hl7.org/fhir/uv/emedicinal-product-info/Organization/org-diflucan> a fhir:Organization ;
  fhir:id [ fhir:v "org-diflucan"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/Organization-uv-epi"^^xsd:anyURI ;
       fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/Organization-uv-epi>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Organization_org-diflucan\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Organization org-diflucan</b></p><a name=\"org-diflucan\"> </a><a name=\"hcorg-diflucan\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Organization-uv-epi.html\">Organization (ePI)</a></p></div><p><b>identifier</b>: <code>https://spor.ema.europa.eu/omswi</code>/LOC-100000999</p><p><b>active</b>: true</p><p><b>name</b>: Example Pharma Ltd.</p></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:identifier ( [
     fhir:system [ fhir:v "https://spor.ema.europa.eu/omswi"^^xsd:anyURI ] ;
     fhir:value [ fhir:v "LOC-100000999" ]
  ] ) ; # 
  fhir:active [ fhir:v true] ; # 
  fhir:name [ fhir:v "Example Pharma Ltd."] . # 

<http://hl7.org/fhir/uv/emedicinal-product-info/MedicationKnowledge/mk-diflucan> a fhir:MedicationKnowledge ;
  fhir:id [ fhir:v "mk-diflucan"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/MedicationKnowledge-uv-epi"^^xsd:anyURI ;
       fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/MedicationKnowledge-uv-epi>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"MedicationKnowledge_mk-diflucan\"> </a><p class=\"res-header-id\"><b>Generated Narrative: MedicationKnowledge mk-diflucan</b></p><a name=\"mk-diflucan\"> </a><a name=\"hcmk-diflucan\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-MedicationKnowledge-uv-epi.html\">MedicationKnowledge (ePI)</a></p></div><p><b>identifier</b>: <code>http://example.org/identifier</code>/mk-diflucan</p><p><b>status</b>: Active</p><blockquote><p><b>indicationGuideline</b></p><h3>Indications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"ClinicalUseDefinition-cud-diflucan-mucosal.html\">ClinicalUseDefinition: identifier = http://example.org/identifier#cud-diflucan-mucosal; type = indication; category = Indication; status = Active</a></td></tr></table><blockquote><p><b>dosingGuideline</b></p><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Loading dose (Day 1)</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 200 to 400 mg on Day 1</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>200-400 mg</td></tr></table></blockquote></blockquote><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Maintenance</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 2</p><p><b>text</b>: 100 to 200 mg once daily for 7 to 21 days</p><p><b>timing</b>: Once per 1 day</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>100-200 mg</td></tr></table></blockquote></blockquote><h3>PatientCharacteristics</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type age}\">Age</span></td><td>18-? years</td></tr></table></blockquote><blockquote><p><b>dosingGuideline</b></p><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Initial dose</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 6 mg/kg on the first day</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>6 mg/kg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg/kg = 'mg/kg')</span></td></tr></table></blockquote></blockquote><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Subsequent dose</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 2</p><p><b>text</b>: 3 mg/kg once daily</p><p><b>timing</b>: Once per 1 day</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>3 mg/kg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg/kg = 'mg/kg')</span></td></tr></table></blockquote></blockquote><h3>PatientCharacteristics</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type age}\">Age</span></td><td>28-11 days</td></tr></table></blockquote><blockquote><p><b>dosingGuideline</b></p><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Neonatal dose</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 3 mg/kg every 72 hours (max 12 mg/kg every 72 hours)</p><p><b>timing</b>: Once per 72 hours</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>3 mg/kg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg/kg = 'mg/kg')</span></td></tr></table><p><b>maxDosePerPeriod</b>: 12 mg/kg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg/kg = 'mg/kg')</span>/72 hours<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codeh = 'h')</span></p></blockquote></blockquote><h3>PatientCharacteristics</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type age}\">Age</span></td><td>0-14 days</td></tr></table></blockquote></blockquote><blockquote><p><b>indicationGuideline</b></p><h3>Indications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Reference</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"ClinicalUseDefinition-cud-diflucan-invasive.html\">ClinicalUseDefinition: identifier = http://example.org/identifier#cud-diflucan-invasive; type = indication; category = Indication; status = Active</a></td></tr></table><blockquote><p><b>dosingGuideline</b></p><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Loading dose (Day 1)</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 1</p><p><b>text</b>: 800 mg on Day 1</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>800 mg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg = 'mg')</span></td></tr></table></blockquote></blockquote><blockquote><p><b>dosage</b></p><p><b>type</b>: <span title=\"Codes:\">Maintenance</span></p><blockquote><p><b>dosage</b></p><p><b>sequence</b>: 2</p><p><b>text</b>: 400 mg once daily</p><p><b>timing</b>: Once per 1 day</p><h3>DoseAndRates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Dose[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>400 mg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  codemg = 'mg')</span></td></tr></table></blockquote></blockquote></blockquote></blockquote></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:identifier ( [
     fhir:system [ fhir:v "http://example.org/identifier"^^xsd:anyURI ] ;
     fhir:value [ fhir:v "mk-diflucan" ]
  ] ) ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:indicationGuideline ( [
     fhir:indication ( [
       fhir:reference [
         fhir:link <http://hl7.org/fhir/ClinicalUseDefinition/cud-diflucan-mucosal> ;
         fhir:reference [ fhir:v "ClinicalUseDefinition/cud-diflucan-mucosal" ]
       ]
     ] ) ;
     fhir:dosingGuideline ( [
       fhir:dosage ( [
         fhir:type [
           fhir:text [ fhir:v "Loading dose (Day 1)" ]
         ] ;
         fhir:dosage ( [
           fhir:sequence [ fhir:v 1 ] ;
           fhir:text [ fhir:v "200 to 400 mg on Day 1" ] ;
           fhir:doseAndRate ( [
             fhir:dose [
               a fhir:Range ;
               fhir:low [
                 fhir:value [ fhir:v "200"^^xsd:decimal ] ;
                 fhir:unit [ fhir:v "mg" ] ;
                 fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
                 fhir:code [ fhir:v "mg" ]
               ] ;
               fhir:high [
                 fhir:value [ fhir:v "400"^^xsd:decimal ] ;
                 fhir:unit [ fhir:v "mg" ] ;
                 fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
                 fhir:code [ fhir:v "mg" ]
               ]
             ]
           ] )
         ] )
       ] [
         fhir:type [
           fhir:text [ fhir:v "Maintenance" ]
         ] ;
         fhir:dosage ( [
           fhir:sequence [ fhir:v 2 ] ;
           fhir:text [ fhir:v "100 to 200 mg once daily for 7 to 21 days" ] ;
           fhir:timing [
             fhir:repeat [
               fhir:frequency [ fhir:v "1"^^xsd:positiveInteger ] ;
               fhir:period [ fhir:v "1"^^xsd:decimal ] ;
               fhir:periodUnit [ fhir:v "d" ]
             ]
           ] ;
           fhir:doseAndRate ( [
             fhir:dose [
               a fhir:Range ;
               fhir:low [
                 fhir:value [ fhir:v "100"^^xsd:decimal ] ;
                 fhir:unit [ fhir:v "mg" ] ;
                 fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
                 fhir:code [ fhir:v "mg" ]
               ] ;
               fhir:high [
                 fhir:value [ fhir:v "200"^^xsd:decimal ] ;
                 fhir:unit [ fhir:v "mg" ] ;
                 fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
                 fhir:code [ fhir:v "mg" ]
               ]
             ]
           ] )
         ] )
       ] ) ;
       fhir:patientCharacteristic ( [
         fhir:type [
           fhir:coding ( [
             fhir:system [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type"^^xsd:anyURI ] ;
             fhir:code [ fhir:v "age" ] ;
             fhir:display [ fhir:v "Age" ]
           ] )
         ] ;
         fhir:value [
           a fhir:Range ;
           fhir:low [
             fhir:value [ fhir:v "18"^^xsd:decimal ] ;
             fhir:unit [ fhir:v "years" ] ;
             fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
             fhir:code [ fhir:v "a" ]
           ]
         ]
       ] )
     ] [
       fhir:dosage ( [
         fhir:type [
           fhir:text [ fhir:v "Initial dose" ]
         ] ;
         fhir:dosage ( [
           fhir:sequence [ fhir:v 1 ] ;
           fhir:text [ fhir:v "6 mg/kg on the first day" ] ;
           fhir:doseAndRate ( [
             fhir:dose [
               a fhir:Quantity ;
               fhir:value [ fhir:v "6"^^xsd:decimal ] ;
               fhir:unit [ fhir:v "mg/kg" ] ;
               fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
               fhir:code [ fhir:v "mg/kg" ]
             ]
           ] )
         ] )
       ] [
         fhir:type [
           fhir:text [ fhir:v "Subsequent dose" ]
         ] ;
         fhir:dosage ( [
           fhir:sequence [ fhir:v 2 ] ;
           fhir:text [ fhir:v "3 mg/kg once daily" ] ;
           fhir:timing [
             fhir:repeat [
               fhir:frequency [ fhir:v "1"^^xsd:positiveInteger ] ;
               fhir:period [ fhir:v "1"^^xsd:decimal ] ;
               fhir:periodUnit [ fhir:v "d" ]
             ]
           ] ;
           fhir:doseAndRate ( [
             fhir:dose [
               a fhir:Quantity ;
               fhir:value [ fhir:v "3"^^xsd:decimal ] ;
               fhir:unit [ fhir:v "mg/kg" ] ;
               fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
               fhir:code [ fhir:v "mg/kg" ]
             ]
           ] )
         ] )
       ] ) ;
       fhir:patientCharacteristic ( [
         fhir:type [
           fhir:coding ( [
             fhir:system [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type"^^xsd:anyURI ] ;
             fhir:code [ fhir:v "age" ] ;
             fhir:display [ fhir:v "Age" ]
           ] )
         ] ;
         fhir:value [
           a fhir:Range ;
           fhir:low [
             fhir:value [ fhir:v "28"^^xsd:decimal ] ;
             fhir:unit [ fhir:v "days" ] ;
             fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
             fhir:code [ fhir:v "d" ]
           ] ;
           fhir:high [
             fhir:value [ fhir:v "11"^^xsd:decimal ] ;
             fhir:unit [ fhir:v "years" ] ;
             fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
             fhir:code [ fhir:v "a" ]
           ]
         ]
       ] )
     ] [
       fhir:dosage ( [
         fhir:type [
           fhir:text [ fhir:v "Neonatal dose" ]
         ] ;
         fhir:dosage ( [
           fhir:sequence [ fhir:v 1 ] ;
           fhir:text [ fhir:v "3 mg/kg every 72 hours (max 12 mg/kg every 72 hours)" ] ;
           fhir:timing [
             fhir:repeat [
               fhir:frequency [ fhir:v "1"^^xsd:positiveInteger ] ;
               fhir:period [ fhir:v "72"^^xsd:decimal ] ;
               fhir:periodUnit [ fhir:v "h" ]
             ]
           ] ;
           fhir:doseAndRate ( [
             fhir:dose [
               a fhir:Quantity ;
               fhir:value [ fhir:v "3"^^xsd:decimal ] ;
               fhir:unit [ fhir:v "mg/kg" ] ;
               fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
               fhir:code [ fhir:v "mg/kg" ]
             ]
           ] ) ;
           fhir:maxDosePerPeriod ( [
             fhir:numerator [
               fhir:value [ fhir:v "12"^^xsd:decimal ] ;
               fhir:unit [ fhir:v "mg/kg" ] ;
               fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
               fhir:code [ fhir:v "mg/kg" ]
             ] ;
             fhir:denominator [
               fhir:value [ fhir:v "72"^^xsd:decimal ] ;
               fhir:unit [ fhir:v "hours" ] ;
               fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
               fhir:code [ fhir:v "h" ]
             ]
           ] )
         ] )
       ] ) ;
       fhir:patientCharacteristic ( [
         fhir:type [
           fhir:coding ( [
             fhir:system [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type"^^xsd:anyURI ] ;
             fhir:code [ fhir:v "age" ] ;
             fhir:display [ fhir:v "Age" ]
           ] )
         ] ;
         fhir:value [
           a fhir:Range ;
           fhir:low [
             fhir:value [ fhir:v "0"^^xsd:decimal ] ;
             fhir:unit [ fhir:v "days" ] ;
             fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
             fhir:code [ fhir:v "d" ]
           ] ;
           fhir:high [
             fhir:value [ fhir:v "14"^^xsd:decimal ] ;
             fhir:unit [ fhir:v "days" ] ;
             fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
             fhir:code [ fhir:v "d" ]
           ]
         ]
       ] )
     ] )
  ] [
     fhir:indication ( [
       fhir:reference [
         fhir:link <http://hl7.org/fhir/ClinicalUseDefinition/cud-diflucan-invasive> ;
         fhir:reference [ fhir:v "ClinicalUseDefinition/cud-diflucan-invasive" ]
       ]
     ] ) ;
     fhir:dosingGuideline ( [
       fhir:dosage ( [
         fhir:type [
           fhir:text [ fhir:v "Loading dose (Day 1)" ]
         ] ;
         fhir:dosage ( [
           fhir:sequence [ fhir:v 1 ] ;
           fhir:text [ fhir:v "800 mg on Day 1" ] ;
           fhir:doseAndRate ( [
             fhir:dose [
               a fhir:Quantity ;
               fhir:value [ fhir:v "800"^^xsd:decimal ] ;
               fhir:unit [ fhir:v "mg" ] ;
               fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
               fhir:code [ fhir:v "mg" ]
             ]
           ] )
         ] )
       ] [
         fhir:type [
           fhir:text [ fhir:v "Maintenance" ]
         ] ;
         fhir:dosage ( [
           fhir:sequence [ fhir:v 2 ] ;
           fhir:text [ fhir:v "400 mg once daily" ] ;
           fhir:timing [
             fhir:repeat [
               fhir:frequency [ fhir:v "1"^^xsd:positiveInteger ] ;
               fhir:period [ fhir:v "1"^^xsd:decimal ] ;
               fhir:periodUnit [ fhir:v "d" ]
             ]
           ] ;
           fhir:doseAndRate ( [
             fhir:dose [
               a fhir:Quantity ;
               fhir:value [ fhir:v "400"^^xsd:decimal ] ;
               fhir:unit [ fhir:v "mg" ] ;
               fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
               fhir:code [ fhir:v "mg" ]
             ]
           ] )
         ] )
       ] )
     ] )
  ] ) . # 

<http://hl7.org/fhir/uv/emedicinal-product-info/ClinicalUseDefinition/cud-diflucan-mucosal> a fhir:ClinicalUseDefinition ;
  fhir:id [ fhir:v "cud-diflucan-mucosal"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/ClinicalUseDefinition-indication-uv-epi"^^xsd:anyURI ;
       fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/ClinicalUseDefinition-indication-uv-epi>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ClinicalUseDefinition_cud-diflucan-mucosal\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ClinicalUseDefinition cud-diflucan-mucosal</b></p><a name=\"cud-diflucan-mucosal\"> </a><a name=\"hccud-diflucan-mucosal\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-ClinicalUseDefinition-indication-uv-epi.html\">ClinicalUseDefinition Indication (ePI)</a></p></div><p><b>identifier</b>: <code>http://example.org/identifier</code>/cud-diflucan-mucosal</p><p><b>type</b>: Indication</p><p><b>category</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-ig indication}\">Indication</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-epi-type3-example-diflucan.html#http-//hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan\">MedicinalProductDefinition: identifier = http://ema.europa.eu/identifier#DIFLUCAN-150MG; status = Active</a></p><p><b>status</b>: <span title=\"Codes:{http://hl7.org/fhir/publication-status active}\">Active</span></p><blockquote><p><b>indication</b></p><h3>DiseaseSymptomProcedures</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Concept</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 79740000}\">Candidiasis of mouth</span></td></tr></table></blockquote></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:identifier ( [
     fhir:system [ fhir:v "http://example.org/identifier"^^xsd:anyURI ] ;
     fhir:value [ fhir:v "cud-diflucan-mucosal" ]
  ] ) ; # 
  fhir:type [ fhir:v "indication"] ; # 
  fhir:category ( [
     fhir:coding ( [
       fhir:system [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-ig"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "indication" ] ;
       fhir:display [ fhir:v "Indication" ]
     ] )
  ] ) ; # 
  fhir:subject ( [
     fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan> ;
     fhir:reference [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan" ]
  ] ) ; # 
  fhir:status [
     fhir:coding ( [
       fhir:system [ fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "active" ] ;
       fhir:display [ fhir:v "Active" ]
     ] )
  ] ; # 
  fhir:indication [
     fhir:diseaseSymptomProcedure [
       fhir:concept [
         fhir:coding ( [
           a sct:79740000 ;
           fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ;
           fhir:code [ fhir:v "79740000" ] ;
           fhir:display [ fhir:v "Candidiasis of mouth" ]
         ] )
       ]
     ]
  ] . # 

<http://hl7.org/fhir/uv/emedicinal-product-info/ClinicalUseDefinition/cud-diflucan-invasive> a fhir:ClinicalUseDefinition ;
  fhir:id [ fhir:v "cud-diflucan-invasive"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/ClinicalUseDefinition-indication-uv-epi"^^xsd:anyURI ;
       fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/ClinicalUseDefinition-indication-uv-epi>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ClinicalUseDefinition_cud-diflucan-invasive\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ClinicalUseDefinition cud-diflucan-invasive</b></p><a name=\"cud-diflucan-invasive\"> </a><a name=\"hccud-diflucan-invasive\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-ClinicalUseDefinition-indication-uv-epi.html\">ClinicalUseDefinition Indication (ePI)</a></p></div><p><b>identifier</b>: <code>http://example.org/identifier</code>/cud-diflucan-invasive</p><p><b>type</b>: Indication</p><p><b>category</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-ig indication}\">Indication</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-epi-type3-example-diflucan.html#http-//hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan\">MedicinalProductDefinition: identifier = http://ema.europa.eu/identifier#DIFLUCAN-150MG; status = Active</a></p><p><b>status</b>: <span title=\"Codes:{http://hl7.org/fhir/publication-status active}\">Active</span></p><blockquote><p><b>indication</b></p><h3>DiseaseSymptomProcedures</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Concept</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 70572005}\">Invasive candidiasis</span></td></tr></table></blockquote><p><b>population</b>: <a href=\"Group-group-diflucan-adult.html\">Adults</a></p></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:identifier ( [
     fhir:system [ fhir:v "http://example.org/identifier"^^xsd:anyURI ] ;
     fhir:value [ fhir:v "cud-diflucan-invasive" ]
  ] ) ; # 
  fhir:type [ fhir:v "indication"] ; # 
  fhir:category ( [
     fhir:coding ( [
       fhir:system [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-ig"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "indication" ] ;
       fhir:display [ fhir:v "Indication" ]
     ] )
  ] ) ; # 
  fhir:subject ( [
     fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan> ;
     fhir:reference [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan" ]
  ] ) ; # 
  fhir:status [
     fhir:coding ( [
       fhir:system [ fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "active" ] ;
       fhir:display [ fhir:v "Active" ]
     ] )
  ] ; # 
  fhir:indication [
     fhir:diseaseSymptomProcedure [
       fhir:concept [
         fhir:coding ( [
           a sct:70572005 ;
           fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ;
           fhir:code [ fhir:v "70572005" ] ;
           fhir:display [ fhir:v "Invasive candidiasis" ]
         ] )
       ]
     ]
  ] ; # 
  fhir:population ( [
     fhir:link <http://hl7.org/fhir/Group/group-diflucan-adult> ;
     fhir:reference [ fhir:v "Group/group-diflucan-adult" ] ;
     fhir:display [ fhir:v "Adults" ]
  ] ) . # 

<http://hl7.org/fhir/Group/group-diflucan-adult> a fhir:Group .

<http://hl7.org/fhir/uv/emedicinal-product-info/ClinicalUseDefinition/cud-diflucan-renal> a fhir:ClinicalUseDefinition ;
  fhir:id [ fhir:v "cud-diflucan-renal"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/ClinicalUseDefinition-warning-uv-epi"^^xsd:anyURI ;
       fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/ClinicalUseDefinition-warning-uv-epi>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ClinicalUseDefinition_cud-diflucan-renal\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ClinicalUseDefinition cud-diflucan-renal</b></p><a name=\"cud-diflucan-renal\"> </a><a name=\"hccud-diflucan-renal\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-ClinicalUseDefinition-warning-uv-epi.html\">ClinicalUseDefinition Warning (ePI)</a></p></div><p><b>identifier</b>: <code>http://example.org/identifier</code>/cud-diflucan-renal</p><p><b>type</b>: Warning</p><p><b>category</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-ig warning}\">Warning</span></p><p><b>subject</b>: <a href=\"Bundle-bundle-epi-type3-example-diflucan.html#http-//hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan\">MedicinalProductDefinition: identifier = http://ema.europa.eu/identifier#DIFLUCAN-150MG; status = Active</a></p><p><b>status</b>: <span title=\"Codes:{http://hl7.org/fhir/publication-status active}\">Active</span></p><p><b>population</b>: <a href=\"Group-group-diflucan-renal.html\">Renal impairment (CrCl ≤ 50 mL/min)</a></p><h3>Warnings</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://snomed.info/sct 723188008}\">For multiple-dose therapy, after a normal loading dose, give 50% of the recommended daily dose when CrCl ≤ 50 mL/min (no haemodialysis); give 100% of the recommended dose after each haemodialysis session. Single-dose therapy needs no adjustment. This rule applies to every multiple-dose indication.</span></td></tr></table></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:identifier ( [
     fhir:system [ fhir:v "http://example.org/identifier"^^xsd:anyURI ] ;
     fhir:value [ fhir:v "cud-diflucan-renal" ]
  ] ) ; # 
  fhir:type [ fhir:v "warning"] ; # 
  fhir:category ( [
     fhir:coding ( [
       fhir:system [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-ig"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "warning" ] ;
       fhir:display [ fhir:v "Warning" ]
     ] )
  ] ) ; # 
  fhir:subject ( [
     fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan> ;
     fhir:reference [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/MedicinalProductDefinition/mpd-diflucan" ]
  ] ) ; # 
  fhir:status [
     fhir:coding ( [
       fhir:system [ fhir:v "http://hl7.org/fhir/publication-status"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "active" ] ;
       fhir:display [ fhir:v "Active" ]
     ] )
  ] ; # 
  fhir:population ( [
     fhir:link <http://hl7.org/fhir/Group/group-diflucan-renal> ;
     fhir:reference [ fhir:v "Group/group-diflucan-renal" ] ;
     fhir:display [ fhir:v "Renal impairment (CrCl ≤ 50 mL/min)" ]
  ] ) ; # 
  fhir:warning [
     fhir:code [
       fhir:coding ( [
         a sct:723188008 ;
         fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "723188008" ] ;
         fhir:display [ fhir:v "Renal insufficiency" ]
       ] ) ;
       fhir:text [ fhir:v "For multiple-dose therapy, after a normal loading dose, give 50% of the recommended daily dose when CrCl ≤ 50 mL/min (no haemodialysis); give 100% of the recommended dose after each haemodialysis session. Single-dose therapy needs no adjustment. This rule applies to every multiple-dose indication." ]
     ]
  ] . # 

<http://hl7.org/fhir/Group/group-diflucan-renal> a fhir:Group .

<http://hl7.org/fhir/uv/emedicinal-product-info/Group/group-diflucan-adult> a fhir:Group ;
  fhir:id [ fhir:v "group-diflucan-adult"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/Group-uv-epi"^^xsd:anyURI ;
       fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/Group-uv-epi>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Group_group-diflucan-adult\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Group group-diflucan-adult</b></p><a name=\"group-diflucan-adult\"> </a><a name=\"hcgroup-diflucan-adult\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Group-uv-epi.html\">Group (ePI)</a></p></div><p><b>type</b>: Person</p><p><b>membership</b>: Definitional</p><p><b>name</b>: Adults</p><h3>Characteristics</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td><td><b>Exclude</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type age}\">Age</span></td><td>18-? years</td><td>false</td></tr></table></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:type [ fhir:v "person"] ; # 
  fhir:membership [ fhir:v "definitional"] ; # 
  fhir:name [ fhir:v "Adults"] ; # 
  fhir:characteristic ( [
     fhir:code [
       fhir:coding ( [
         fhir:system [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "age" ] ;
         fhir:display [ fhir:v "Age" ]
       ] )
     ] ;
     fhir:value [
       a fhir:Range ;
       fhir:low [
         fhir:value [ fhir:v "18"^^xsd:decimal ] ;
         fhir:unit [ fhir:v "years" ] ;
         fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "a" ]
       ]
     ] ;
     fhir:exclude [ fhir:v false ]
  ] ) . # 

<http://hl7.org/fhir/uv/emedicinal-product-info/Group/group-diflucan-renal> a fhir:Group ;
  fhir:id [ fhir:v "group-diflucan-renal"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/Group-uv-epi"^^xsd:anyURI ;
       fhir:link <http://hl7.org/fhir/uv/emedicinal-product-info/StructureDefinition/Group-uv-epi>
     ] )
  ] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Group_group-diflucan-renal\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Group group-diflucan-renal</b></p><a name=\"group-diflucan-renal\"> </a><a name=\"hcgroup-diflucan-renal\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-Group-uv-epi.html\">Group (ePI)</a></p></div><p><b>type</b>: Person</p><p><b>membership</b>: Definitional</p><p><b>name</b>: Renal impairment (CrCl ≤ 50 mL/min)</p><h3>Characteristics</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td><td><b>Exclude</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type renal-function}\">Renal function</span></td><td>?-50</td><td>false</td></tr></table></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:type [ fhir:v "person"] ; # 
  fhir:membership [ fhir:v "definitional"] ; # 
  fhir:name [ fhir:v "Renal impairment (CrCl ≤ 50 mL/min)"] ; # 
  fhir:characteristic ( [
     fhir:code [
       fhir:coding ( [
         fhir:system [ fhir:v "http://hl7.org/fhir/uv/emedicinal-product-info/CodeSystem/epi-group-characteristic-type"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "renal-function" ] ;
         fhir:display [ fhir:v "Renal function" ]
       ] )
     ] ;
     fhir:value [
       a fhir:Range ;
       fhir:high [
         fhir:value [ fhir:v "50"^^xsd:decimal ] ;
         fhir:unit [ fhir:v "mL/min" ] ;
         fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "mL/min" ]
       ]
     ] ;
     fhir:exclude [ fhir:v false ]
  ] ) . #