Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

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Extension:

Handling of the variable that is not boolean, continuous, dichotomous, ordinal, or polychotomous.

Context of Use

This extension may be used on the following element(s)

• Element ID: EvidenceVariable
• Element ID: Evidence.statistic.modelCharacteristic.variable

Usage info

Usages:

• Use this Extension: VariableDefinition
• Examples for this Extension: Composition/370503, Composition/370510, Composition/399872, Percentage_of_Participants_Achieving_Treatment_Success_During_Controlled_Insulin_Induced_Hypoglycemia_NCT03421379... Show 27 more, Pharmacodynamics_PD_Change_From_Baseline_in_Maximal_Blood_Glucose_BGmax_of_Glucagon_Nasal_Powder_and_Glucagon_Hydrochloride_Intramuscular_IM_NCT03421379, PD_Time_to_Maximal_Concentration_Tmax_of_Glucagon_Nasal_Powder_and_Glucagon_Hydrochloride_IM_NCT03421379, Pharmacokinetics_PK_Change_From_Baseline_in_Area_Under_the_Concentration_Versus_Time_Curve_From_Zero_to_Time_t_AUC_0_tLast_of_Glucagon_Nasal_Powder_and_Glucagon_Hydrochloride_IM_NCT03421379, PK_Change_From_Baseline_in_Maximal_Concentration_Cmax_of_Glucagon_Nasal_Powder_and_Glucagon_Hydrochloride_IM_NCT03421379, PK_Change_From_Baseline_in_Tmax_of_Glucagon_Nasal_Powder_and_Glucagon_Hydrochloride_IM_NCT03421379, Time_to_integration_of_results_in_a_recommendation, Change_in_Mean_Systolic_Blood_Pressure_NCT03640312, Mean_Systolic_Blood_Pressure_NCT03640312, Change_in_Mean_Diastolic_Blood_Pressure_NCT03640312, Mean_Diastolic_Blood_Pressure_NCT03640312, Proportion_of_Patients_With_Hypertension_Control_NCT03640312, Number_of_Patients_Requiring_Step_up_Treatment_NCT03640312, Proportion_of_Patients_With_Adverse_Event_Free_Hypertension_Control_NCT03640312, Medication_Adherence_NCT03640312, Health_related_Quality_of_Life_NCT03640312, Change_in_Mean_Systolic_Blood_Pressure_NCT03640312, Percentage_of_Participants_With_Serious_Adverse_Events_SAEs_NCT03640312, Percentage_of_Participants_With_Potentially_Related_Adverse_Events_NCT03640312, Rate_of_Adverse_Events_of_Special_Interest_NCT03640312, Mean_Change_in_Serum_Potassium_NCT03640312, Mean_Change_in_Serum_Sodium_NCT03640312, Mean_Change_in_Blood_Urea_Nitrogen_NCT03640312, Mean_Change_in_Serum_Creatinine_NCT03640312, Proportion_of_Patients_With_Hypertension_Control_at_6_and_12_weeks_6_weeks_at_NCT03640312, Proportion_of_Patients_With_Hypertension_Control_at_6_and_12_weeks_12_weeks_at_NCT03640312, Health_related_Quality_of_Life_at_12_weeks_Change_in_Physical_Health_T_score_PROMIS_at_NCT03640312 and Health_related_Quality_of_Life_at_12_weeks_Change_in_Mental_Health_T_score_PROMIS_at_NCT03640312

You can also check for usages in the FHIR IG Statistics

Formal Views of Extension Content

Description Differentials, Snapshots, and other representations.

• Differential Table
• Snapshot Table
• Statistics/References
• All

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Extension		0..*	Extension	How the variable is handled
extension		0..0		Extension
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/evidence-variable-handling-detail"
value[x]		0..1	CodeableConcept	Value of extension Binding: EvidenceVariable Handling Extension Value Set (preferred)
Documentation for this format

Terminology Bindings (Differential)

Path	Status	Usage	ValueSet	Version	Source
Extension.value[x]	Base	preferred	EvidenceVariable Handling Extension Value Set	📦1.0.0-ballot3	This IG

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Extension		0..*	Extension	How the variable is handled
id		0..1	id	Unique id for inter-element referencing
extension		0..0		Extension Slice: Unordered, Open by value:url
url	Σ	1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/evidence-variable-handling-detail"
value[x]	Σ	0..1	CodeableConcept	Value of extension Binding: EvidenceVariable Handling Extension Value Set (preferred)
Documentation for this format

Terminology Bindings

Path	Status	Usage	ValueSet	Version	Source
Extension.value[x]	Base	preferred	EvidenceVariable Handling Extension Value Set	📦1.0.0-ballot3	This IG

Constraints

Id	Grade	Path(s)	Description	Expression
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both	extension.exists() != value.exists()

Summary

Simple Extension with the type CodeableConcept: Handling of the variable that is not boolean, continuous, dichotomous, ordinal, or polychotomous.

Maturity: 1

Differential ViewDifferential View

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Extension		0..*	Extension	How the variable is handled
extension		0..0		Extension
url		1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/evidence-variable-handling-detail"
value[x]		0..1	CodeableConcept	Value of extension Binding: EvidenceVariable Handling Extension Value Set (preferred)
Documentation for this format

Terminology Bindings (Differential)

Path	Status	Usage	ValueSet	Version	Source
Extension.value[x]	Base	preferred	EvidenceVariable Handling Extension Value Set	📦1.0.0-ballot3	This IG

Snapshot View

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Extension		0..*	Extension	How the variable is handled
id		0..1	id	Unique id for inter-element referencing
extension		0..0		Extension Slice: Unordered, Open by value:url
url	Σ	1..1	uri	"http://hl7.org/fhir/uv/ebm/StructureDefinition/evidence-variable-handling-detail"
value[x]	Σ	0..1	CodeableConcept	Value of extension Binding: EvidenceVariable Handling Extension Value Set (preferred)
Documentation for this format

Terminology Bindings

Path	Status	Usage	ValueSet	Version	Source
Extension.value[x]	Base	preferred	EvidenceVariable Handling Extension Value Set	📦1.0.0-ballot3	This IG

Constraints

Id	Grade	Path(s)	Description	Expression
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())
ext-1	error	**ALL** extensions	Must have either extensions or value[x], not both	extension.exists() != value.exists()

Summary

Simple Extension with the type CodeableConcept: Handling of the variable that is not boolean, continuous, dichotomous, ordinal, or polychotomous.

Maturity: 1

Other representations of profile: CSV, Excel, Schematron