Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

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Resource Profile: ComparatorOnlyEvidence

Usages:

• Refer to this Profile: SummaryOfFindings and SummaryOfNetEffect
• Examples for this Profile: AllCauseMortalityControlGroup2022metaAnalysis, ComparatorOnlyEvidence_Additional_GI_surgical_procedure_without_bariatric_surgery_Control_Group_in_JAMA_2018_Norwegian_cohort_study, ComparatorOnlyEvidence_Treatment_with_opioids_without_bariatric_surgery_Control_Group_in_JAMA_2018_Norwegian_cohort_study, ComparatorOnlyEvidence_New_onset_depression_without_bariatric_surgery_Control_Group_in_JAMA_2018_Norwegian_cohort_study... Show 24 more, ComparatorOnlyEvidence_Remission_of_diabetes_without_bariatric_surgery_Control_Group_in_JAMA_2018_Norwegian_cohort_study, ComparatorOnlyEvidence_Myocardial_infarction_or_stroke_without_bariatric_surgery_Control_Group_in_Swedish_Obese_Subjects_SOS_study, All_cause_mortality_Comparator_Evidence_from_MAGICapp_313876, Cardiovascular_mortality_Comparator_Evidence_from_MAGICapp_313877, Nonfatal_myocardial_infarction_Comparator_Evidence_from_MAGICapp_313878, Nonfatal_stroke_Comparator_Evidence_from_MAGICapp_313879, End_stage_kidney_disease_Comparator_Evidence_from_MAGICapp_313880, Heart_failure_Comparator_Evidence_from_MAGICapp_313881, Serious_hyperglycaemia_Comparator_Evidence_from_MAGICapp_313882, Severe_gastrointestinal_events_Comparator_Evidence_from_MAGICapp_313883, Health_related_quality_of_life_Comparator_Evidence_from_MAGICapp_109569, Body_weight_Comparator_Evidence_from_MAGICapp_109570, All_cause_mortality_Comparator_Evidence_from_MAGICapp_313956, Cardiovascular_mortality_Comparator_Evidence_from_MAGICapp_313957, Nonfatal_myocardial_infarction_Comparator_Evidence_from_MAGICapp_313958, Nonfatal_stroke_Comparator_Evidence_from_MAGICapp_313959, End_stage_kidney_disease_Comparator_Evidence_from_MAGICapp_313960, Heart_failure_Comparator_Evidence_from_MAGICapp_313961, Diabetic_ketoacidosis_Comparator_Evidence_from_MAGICapp_313962, Serious_hyperglycaemia_Comparator_Evidence_from_MAGICapp_313963, Genital_infection_Comparator_Evidence_from_MAGICapp_313964, Severe_gastrointestinal_events_Comparator_Evidence_from_MAGICapp_313965, Health_related_quality_of_life_Comparator_Evidence_from_MAGICapp_109587 and Body_weight_Comparator_Evidence_from_MAGICapp_109588

You can also check for usages in the FHIR IG Statistics

Formal Views of Profile Content

Description Differentials, Snapshots, and other representations.

• Key Elements Table
• Differential Table
• Snapshot Table
• Statistics/References
• All

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Evidence	C	0..*	NonComparativeEvidence	Single evidence bit Interfaces Implemented: MetadataResource Constraints: cnl-0
Evidence.implicitRules	?! This element is a modifier element. Σ This element is included in summaries.	0..1	uri	A set of rules under which this content was created
Evidence.contained		0..*	Resource	Contained, inline Resources
Evidence.Slices for extension				Content/Rules for all slices
Evidence.Slices for extension.extension:publicationStatus		0..1	CodeableConcept	Publication status URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status Binding: Cited Artifact Status Type (preferred)
Evidence.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored Slice: Unordered, Open by value:url
Evidence.status	?! This element is a modifier element. Σ This element is included in summaries.	0..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
Evidence.Slices for variableDefinition		2..*	BackboneElement	Description, classification, and definition of a single variable Slice: Unordered, Open by value:variableRole
Evidence.Slices for variableDefinition.variableDefinition:All Slices				Content/Rules for all slices
Evidence.Slices for variableDefinition.variableDefinition:All Slices.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:All Slices.variableRole	Σ This element is included in summaries.	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays.
Evidence.Slices for variableDefinition.variableDefinition:population	S This element must be supported.	1..*	BackboneElement	Description, classification, and definition of a single variable
Evidence.Slices for variableDefinition.variableDefinition:population.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:population.variableRole	Σ This element is included in summaries.	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: population (extensions allowed)
Evidence.Slices for variableDefinition.variableDefinition:population.observed	Σ This element is included in summaries.	0..1	Reference(ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
Evidence.Slices for variableDefinition.variableDefinition:outcome	S This element must be supported.	1..*	BackboneElement	Description, classification, and definition of a single variable
Evidence.Slices for variableDefinition.variableDefinition:outcome.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:outcome.variableRole	Σ This element is included in summaries.	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: outcome (extensions allowed)
Documentation for this format

Terminology Bindings

Path	Status	Usage	ValueSet	Version	Source
Evidence.status	Base	required	PublicationStatus	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition.​variableRole	Base	required	Evidence Variable Role	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition:population.​variableRole	Base	required	Evidence Variable Role	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition:outcome.​variableRole	Base	required	Evidence Variable Role	📍6.0.0-snapshot1	FHIR Std.

Constraints

Id	Grade	Path(s)	Description	Expression
cnl-0	warning	Evidence	Name should be usable as an identifier for the module by machine processing applications such as code generation	name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())

This structure is derived from NonComparativeEvidence

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Evidence		0..*	NonComparativeEvidence	Single evidence bit Interfaces Implemented: MetadataResource
Evidence.variableDefinition		2..*	BackboneElement	Description, classification, and definition of a single variable
Evidence.Slices for variableDefinition				Content/Rules for all slices
Evidence.Slices for variableDefinition.variableDefinition:population		1..*	BackboneElement	Description, classification, and definition of a single variable
Evidence.Slices for variableDefinition.variableDefinition:population.observed		0..1	Reference(ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
Documentation for this format

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Evidence	C	0..*	NonComparativeEvidence	Single evidence bit Interfaces Implemented: MetadataResource Constraints: cnl-0
Evidence.id	Σ This element is included in summaries.	0..1	id	Logical id of this artifact
Evidence.meta	Σ This element is included in summaries.	0..1	Meta	Metadata about the resource
Evidence.implicitRules	?! This element is a modifier element. Σ This element is included in summaries.	0..1	uri	A set of rules under which this content was created
Evidence.language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter
Evidence.text		0..1	Narrative	Text summary of the resource, for human interpretation This profile does not constrain the narrative in regard to content, language, or traceability to data elements
Evidence.contained		0..*	Resource	Contained, inline Resources
Evidence.Slices for extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.Slices for extension.extension:publicationStatus		0..1	CodeableConcept	Publication status URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status Binding: Cited Artifact Status Type (preferred)
Evidence.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored Slice: Unordered, Open by value:url
Evidence.url	Σ This element is included in summaries. C	0..1	uri	Canonical identifier for this evidence, represented as a globally unique URI Constraints: cnl-1
Evidence.identifier	Σ This element is included in summaries.	0..*	Identifier	Additional identifier for the summary
Evidence.version	Σ This element is included in summaries.	0..1	string	Business version of this summary
Evidence.versionAlgorithm[x]	Σ This element is included in summaries.	0..1		How to compare versions Binding: VersionAlgorithm (extensible)
Evidence.versionAlgorithm[x].versionAlgorithmString			string
Evidence.versionAlgorithm[x].versionAlgorithmCoding			Coding
Evidence.name	C	0..1	string	Name for this summary (machine friendly)
Evidence.title	Σ This element is included in summaries.	0..1	string	Name for this summary (human friendly)
Evidence.citeAs		0..1	markdown	Display of how to cite this Evidence
Evidence.status	?! This element is a modifier element. Σ This element is included in summaries.	0..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
Evidence.experimental		0..1	boolean	For testing only - never for real usage
Evidence.date	Σ This element is included in summaries.	0..1	dateTime	Date last changed
Evidence.approvalDate		0..1	date	When the summary was approved by publisher
Evidence.lastReviewDate		0..1	date	When the summary was last reviewed by the publisher
Evidence.author	Σ This element is included in summaries.	0..*	ContactDetail	Who authored the content
Evidence.publisher	Σ This element is included in summaries.	0..1	string	Name of the publisher/steward (organization or individual)
Evidence.contact	Σ This element is included in summaries.	0..*	ContactDetail	Contact details for the publisher
Evidence.recorder		0..*	ContactDetail	Who entered the data for the evidence
Evidence.editor		0..*	ContactDetail	Who edited the content
Evidence.reviewer		0..*	ContactDetail	Who reviewed the content
Evidence.endorser		0..*	ContactDetail	Who endorsed the content
Evidence.useContext	Σ This element is included in summaries.	0..*	UsageContext	The context that the content is intended to support
Evidence.purpose		0..1	markdown	Why this Evidence is defined
Evidence.copyright		0..1	markdown	Intellectual property ownership, may include restrictions on use
Evidence.copyrightLabel		0..1	string	Copyright holder and year(s)
Evidence.relatesTo		0..*	BackboneElement	Relationships to other Resources
Evidence.relatesTo.id		0..1	string	Unique id for inter-element referencing
Evidence.relatesTo.Slices for extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.relatesTo.Slices for extension.extension:quotation		0..1	markdown	Quoted portion from related artifact URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/relates-to-with-quotation
Evidence.relatesTo.Slices for extension.extension:classifier		0..1	CodeableConcept	A classifier of the target artifact in a relatesTo element URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/relatesto-classifier
Evidence.relatesTo.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.relatesTo.type		1..1	CodeableConcept	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as | reprint | reprint-of | summarizes Binding: Artifact Relationship Type (extensible): The type of relationship to the related artifact.
Evidence.relatesTo.target[x]		1..1		The artifact that is related to this Evidence
Evidence.relatesTo.target[x].targetUri			uri
Evidence.relatesTo.target[x].targetAttachment			Attachment
Evidence.relatesTo.target[x].targetCanonical			canonical(Resource)
Evidence.relatesTo.target[x].targetReference			Reference(Resource)
Evidence.relatesTo.target[x].targetMarkdown			markdown
Evidence.description	Σ This element is included in summaries.	0..1	markdown	Description of the particular summary
Evidence.assertion		0..1	markdown	Declarative description of the Evidence
Evidence.note		0..*	Annotation	Footnotes and/or explanatory notes
Evidence.classification	Σ This element is included in summaries.	0..*	BackboneElement	The assignment to an organizing scheme
Evidence.classification.id		0..1	string	Unique id for inter-element referencing
Evidence.classification.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.classification.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.classification.type		0..1	CodeableConcept	The kind of classifier (e.g. population, intervention) Binding: EvidenceClassifierTypeExample (example)
Evidence.classification.classifier		0..*	CodeableReference(Resource)	The specific classification value Binding: ConditionProblemDiagnosisCodes (example)
Evidence.Slices for variableDefinition		2..*	BackboneElement	Description, classification, and definition of a single variable Slice: Unordered, Open by value:variableRole
Evidence.Slices for variableDefinition.variableDefinition:All Slices				Content/Rules for all slices
Evidence.Slices for variableDefinition.variableDefinition:All Slices.id		0..1	string	Unique id for inter-element referencing
Evidence.Slices for variableDefinition.variableDefinition:All Slices.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:All Slices.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:All Slices.description		0..1	markdown	A text description or summary of the variable
Evidence.Slices for variableDefinition.variableDefinition:All Slices.note		0..*	Annotation	Footnotes and/or explanatory notes
Evidence.Slices for variableDefinition.variableDefinition:All Slices.variableRole	Σ This element is included in summaries.	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays.
Evidence.Slices for variableDefinition.variableDefinition:All Slices.roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (example): The sub-role that the variable plays.
Evidence.Slices for variableDefinition.variableDefinition:All Slices.comparatorCategory		0..1	string	The reference value used for comparison
Evidence.Slices for variableDefinition.variableDefinition:All Slices.observed	Σ This element is included in summaries.	0..1	Reference(Group | EvidenceVariable)	Definition of the actual variable related to the statistic(s)
Evidence.Slices for variableDefinition.variableDefinition:All Slices.intended		0..1	Reference(Group | EvidenceVariable)	Definition of the intended variable related to the Evidence
Evidence.Slices for variableDefinition.variableDefinition:All Slices.directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (example): The quality of how direct the match is.
Evidence.Slices for variableDefinition.variableDefinition:population	S This element must be supported.	1..*	BackboneElement	Description, classification, and definition of a single variable
Evidence.Slices for variableDefinition.variableDefinition:population.id		0..1	string	Unique id for inter-element referencing
Evidence.Slices for variableDefinition.variableDefinition:population.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:population.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:population.description		0..1	markdown	A text description or summary of the variable
Evidence.Slices for variableDefinition.variableDefinition:population.note		0..*	Annotation	Footnotes and/or explanatory notes
Evidence.Slices for variableDefinition.variableDefinition:population.variableRole	Σ This element is included in summaries.	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: population (extensions allowed)
Evidence.Slices for variableDefinition.variableDefinition:population.roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (example): The sub-role that the variable plays.
Evidence.Slices for variableDefinition.variableDefinition:population.comparatorCategory		0..1	string	The reference value used for comparison
Evidence.Slices for variableDefinition.variableDefinition:population.observed	Σ This element is included in summaries.	0..1	Reference(ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
Evidence.Slices for variableDefinition.variableDefinition:population.intended		0..1	Reference(Group)	Definition of the intended variable related to the Evidence
Evidence.Slices for variableDefinition.variableDefinition:population.directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (example): The quality of how direct the match is.
Evidence.Slices for variableDefinition.variableDefinition:outcome	S This element must be supported.	1..*	BackboneElement	Description, classification, and definition of a single variable
Evidence.Slices for variableDefinition.variableDefinition:outcome.id		0..1	string	Unique id for inter-element referencing
Evidence.Slices for variableDefinition.variableDefinition:outcome.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:outcome.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:outcome.description		0..1	markdown	A text description or summary of the variable
Evidence.Slices for variableDefinition.variableDefinition:outcome.note		0..*	Annotation	Footnotes and/or explanatory notes
Evidence.Slices for variableDefinition.variableDefinition:outcome.variableRole	Σ This element is included in summaries.	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: outcome (extensions allowed)
Evidence.Slices for variableDefinition.variableDefinition:outcome.roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (example): The sub-role that the variable plays.
Evidence.Slices for variableDefinition.variableDefinition:outcome.comparatorCategory		0..1	string	The reference value used for comparison
Evidence.Slices for variableDefinition.variableDefinition:outcome.observed	Σ This element is included in summaries.	0..1	Reference(VariableDefinition)	Definition of the actual variable related to the statistic(s)
Evidence.Slices for variableDefinition.variableDefinition:outcome.intended		0..1	Reference(EvidenceVariable)	Definition of the intended variable related to the Evidence
Evidence.Slices for variableDefinition.variableDefinition:outcome.directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (example): The quality of how direct the match is.
Evidence.synthesisType		0..*	CodeableConcept	The design of the synthesis (combination of studies) that produced this evidence Binding: StatisticSynthesisType (example): Types of combining results from a body of evidence (e.g. summary data meta-analysis).
Evidence.studyDesign		0..*	CodeableConcept	The design of the study that produced this evidence Binding: Study Design (extensible): This is a set of terms for study design characteristics.
Evidence.statistic		0..*	BackboneElement	Values and parameters for a single statistic
Evidence.statistic.id		0..1	string	Unique id for inter-element referencing
Evidence.statistic.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.statistic.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.statistic.description		0..1	markdown	A natural language summary of the statistic
Evidence.statistic.note		0..*	Annotation	Footnotes and/or explanatory notes
Evidence.statistic.statisticType	Σ This element is included in summaries.	0..1	CodeableConcept	Type of statistic, e.g., relative risk Binding: Statistic Type (extensible)
Evidence.statistic.category		0..1	CodeableConcept	Associated category for categorical variable
Evidence.statistic.quantity	Σ This element is included in summaries.	0..1	Quantity	Statistic value
Evidence.statistic.numberOfEvents		0..1	unsignedInt	The number of events associated with the statistic
Evidence.statistic.numberAffected		0..1	unsignedInt	The number of participants affected
Evidence.statistic.sampleSize		0..1	BackboneElement	Count of participants in the study sample
Evidence.statistic.sampleSize.id		0..1	string	Unique id for inter-element referencing
Evidence.statistic.sampleSize.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.statistic.sampleSize.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.statistic.sampleSize.description		0..1	markdown	Textual description of sample size for statistic
Evidence.statistic.sampleSize.note		0..*	Annotation	Footnote or explanatory note about the sample size
Evidence.statistic.sampleSize.numberOfStudies		0..1	unsignedInt	Number of contributing studies
Evidence.statistic.sampleSize.numberOfParticipants		0..1	unsignedInt	Total number of participants
Evidence.statistic.sampleSize.knownDataCount		0..1	unsignedInt	Number of participants with known results for measured variables
Evidence.statistic.sampleSize.numberAnalyzed		0..1	unsignedInt	Total number of participants who were analayzed
Evidence.statistic.attributeEstimate		0..*	BackboneElement	An attribute of the Statistic
Evidence.statistic.attributeEstimate.id		0..1	string	Unique id for inter-element referencing
Evidence.statistic.attributeEstimate.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.statistic.attributeEstimate.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.statistic.attributeEstimate.description		0..1	markdown	Textual description of the attribute estimate
Evidence.statistic.attributeEstimate.note		0..*	Annotation	Footnote or explanatory note about the estimate
Evidence.statistic.attributeEstimate.type		0..1	CodeableConcept	The type of attribute estimate, e.g., confidence interval or p value Binding: StatisticAttributeEstimateType (extensible)
Evidence.statistic.attributeEstimate.quantity		0..1	Quantity	The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
Evidence.statistic.attributeEstimate.level		0..1	decimal	Level of confidence interval, e.g., 0.95 for 95% confidence interval
Evidence.statistic.attributeEstimate.range		0..1	Range	Lower and upper bound values of the attribute estimate
Evidence.statistic.attributeEstimate.attributeEstimate		0..*	See attributeEstimate (Evidence)	A nested attribute estimate; which is the attribute estimate of an attribute estimate
Evidence.statistic.modelCharacteristic		0..*	BackboneElement	An aspect of the statistical model
Evidence.statistic.modelCharacteristic.id		0..1	string	Unique id for inter-element referencing
Evidence.statistic.modelCharacteristic.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.statistic.modelCharacteristic.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.statistic.modelCharacteristic.code		1..1	CodeableConcept	Model specification Binding: Statistic Model Code (example)
Evidence.statistic.modelCharacteristic.value[x]		0..1		The specific value (when paired with code)
Evidence.statistic.modelCharacteristic.value[x].valueQuantity			Quantity(SimpleQuantity)
Evidence.statistic.modelCharacteristic.value[x].valueRange			Range
Evidence.statistic.modelCharacteristic.value[x].valueCodeableConcept			CodeableConcept
Evidence.statistic.modelCharacteristic.intended		0..1	boolean	The plan for analysis
Evidence.statistic.modelCharacteristic.applied		0..1	boolean	This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan
Evidence.statistic.modelCharacteristic.variable		0..*	BackboneElement	A variable adjusted for in the adjusted analysis
Evidence.statistic.modelCharacteristic.variable.id		0..1	string	Unique id for inter-element referencing
Evidence.statistic.modelCharacteristic.variable.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.statistic.modelCharacteristic.variable.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.statistic.modelCharacteristic.variable.variableDefinition		1..1	Reference(Group | EvidenceVariable)	Description and definition of the variable
Evidence.statistic.modelCharacteristic.variable.handling		0..1	CodeableConcept	boolean | continuous | dichotomous | ordinal | polychotomous | time-to-event | not-specified Binding: Evidence Variable Handling (extensible)
Evidence.statistic.modelCharacteristic.variable.valueCategory		0..*	CodeableConcept	Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
Evidence.statistic.modelCharacteristic.variable.valueQuantity		0..*	Quantity	Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
Evidence.statistic.modelCharacteristic.variable.valueRange		0..*	Range	Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable
Evidence.statistic.modelCharacteristic.attribute		0..*	See attributeEstimate (Evidence)	An attribute of the model characteristic
Evidence.certainty		0..*	BackboneElement	Certainty or quality of the evidence
Evidence.certainty.id		0..1	string	Unique id for inter-element referencing
Evidence.certainty.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.certainty.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.certainty.description		0..1	markdown	Textual description of certainty
Evidence.certainty.note		0..*	Annotation	Footnotes and/or explanatory notes
Evidence.certainty.type		0..1	CodeableConcept	Aspect of certainty being rated Binding: Evidence Certainty Type (example): The aspect of quality, confidence, or certainty.
Evidence.certainty.rating		0..1	CodeableConcept	Assessment or judgement of the aspect Binding: StatisticCertaintyRating (example): The assessment of quality, confidence, or certainty.
Evidence.certainty.rater		0..*	string	Individual or group who did the rating
Evidence.certainty.subcomponent		0..*	See certainty (Evidence)	A domain or subdomain of certainty
Documentation for this format

Terminology Bindings

Path	Status	Usage	ValueSet	Version	Source
Evidence.language	Base	required	All Languages	📍6.0.0-snapshot1	FHIR Std.
Evidence.versionAlgorithm[x]	Base	extensible	Version Algorithm	📍6.0.0-snapshot1	FHIR Std.
Evidence.status	Base	required	PublicationStatus	📍6.0.0-snapshot1	FHIR Std.
Evidence.relatesTo.type	Base	extensible	Artifact Relationship Type	📦1.0.0	THO v7.5
Evidence.classification.​type	Base	example	Evidence Classifier Type Example	📍6.0.0-snapshot1	FHIR Std.
Evidence.classification.​classifier	Base	example	Condition/Problem/Diagnosis Codes	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition.​variableRole	Base	required	Evidence Variable Role	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition.​roleSubtype	Base	example	EvidenceVariableRoleSubtype	📦1.0.1	THO v7.5
Evidence.variableDefinition.​directnessMatch	Base	example	EvidenceDirectness	📦2.0.0	THO v7.5
Evidence.variableDefinition:population.​variableRole	Base	required	Evidence Variable Role	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition:population.​roleSubtype	Base	example	EvidenceVariableRoleSubtype	📦1.0.1	THO v7.5
Evidence.variableDefinition:population.​directnessMatch	Base	example	EvidenceDirectness	📦2.0.0	THO v7.5
Evidence.variableDefinition:outcome.​variableRole	Base	required	Evidence Variable Role	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition:outcome.​roleSubtype	Base	example	EvidenceVariableRoleSubtype	📦1.0.1	THO v7.5
Evidence.variableDefinition:outcome.​directnessMatch	Base	example	EvidenceDirectness	📦2.0.0	THO v7.5
Evidence.synthesisType	Base	example	StatisticSynthesisType	📦2.0.0	THO v7.5
Evidence.studyDesign	Base	extensible	Study Design	📦1.0.0	THO v7.5
Evidence.statistic.statisticType	Base	extensible	Statistic Type	📦2.0.0	THO v7.5
Evidence.statistic.attributeEstimate.​type	Base	extensible	StatisticAttributeEstimateType	📦2.0.0	THO v7.5
Evidence.statistic.modelCharacteristic.​code	Base	example	Statistic Model Code	📦1.0.0	THO v7.5
Evidence.statistic.modelCharacteristic.​variable.handling	Base	extensible	Evidence Variable Handling	📦2.0.0	THO v7.5
Evidence.certainty.type	Base	example	Evidence Certainty Type	📦1.0.0	THO v7.5
Evidence.certainty.rating	Base	example	StatisticCertaintyRating	📦2.0.0	THO v7.5

Constraints

Id	Grade	Path(s)	Description	Expression
cnl-0	warning	Evidence	Name should be usable as an identifier for the module by machine processing applications such as code generation	name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')
cnl-1	warning	Evidence.url	URL should not contain | or # - these characters make processing canonical references problematic	exists() implies matches('^[^|# ]+$')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())

This structure is derived from NonComparativeEvidence

Summary

Structures

This structure refers to these other structures:

• ExposureGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/exposure-group)
• ComparatorGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/comparator-group)
• MetaanalysisStudyGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/metaanalysis-study-group)

Maturity: 1

Key Elements View

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Evidence	C	0..*	NonComparativeEvidence	Single evidence bit Interfaces Implemented: MetadataResource Constraints: cnl-0
Evidence.implicitRules	?! This element is a modifier element. Σ This element is included in summaries.	0..1	uri	A set of rules under which this content was created
Evidence.contained		0..*	Resource	Contained, inline Resources
Evidence.Slices for extension				Content/Rules for all slices
Evidence.Slices for extension.extension:publicationStatus		0..1	CodeableConcept	Publication status URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status Binding: Cited Artifact Status Type (preferred)
Evidence.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored Slice: Unordered, Open by value:url
Evidence.status	?! This element is a modifier element. Σ This element is included in summaries.	0..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
Evidence.Slices for variableDefinition		2..*	BackboneElement	Description, classification, and definition of a single variable Slice: Unordered, Open by value:variableRole
Evidence.Slices for variableDefinition.variableDefinition:All Slices				Content/Rules for all slices
Evidence.Slices for variableDefinition.variableDefinition:All Slices.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:All Slices.variableRole	Σ This element is included in summaries.	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays.
Evidence.Slices for variableDefinition.variableDefinition:population	S This element must be supported.	1..*	BackboneElement	Description, classification, and definition of a single variable
Evidence.Slices for variableDefinition.variableDefinition:population.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:population.variableRole	Σ This element is included in summaries.	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: population (extensions allowed)
Evidence.Slices for variableDefinition.variableDefinition:population.observed	Σ This element is included in summaries.	0..1	Reference(ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
Evidence.Slices for variableDefinition.variableDefinition:outcome	S This element must be supported.	1..*	BackboneElement	Description, classification, and definition of a single variable
Evidence.Slices for variableDefinition.variableDefinition:outcome.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:outcome.variableRole	Σ This element is included in summaries.	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: outcome (extensions allowed)
Documentation for this format

Terminology Bindings

Path	Status	Usage	ValueSet	Version	Source
Evidence.status	Base	required	PublicationStatus	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition.​variableRole	Base	required	Evidence Variable Role	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition:population.​variableRole	Base	required	Evidence Variable Role	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition:outcome.​variableRole	Base	required	Evidence Variable Role	📍6.0.0-snapshot1	FHIR Std.

Constraints

Id	Grade	Path(s)	Description	Expression
cnl-0	warning	Evidence	Name should be usable as an identifier for the module by machine processing applications such as code generation	name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())

Differential View

This structure is derived from NonComparativeEvidence

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Evidence		0..*	NonComparativeEvidence	Single evidence bit Interfaces Implemented: MetadataResource
Evidence.variableDefinition		2..*	BackboneElement	Description, classification, and definition of a single variable
Evidence.Slices for variableDefinition				Content/Rules for all slices
Evidence.Slices for variableDefinition.variableDefinition:population		1..*	BackboneElement	Description, classification, and definition of a single variable
Evidence.Slices for variableDefinition.variableDefinition:population.observed		0..1	Reference(ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
Documentation for this format

Snapshot ViewView

Name	Flags	Card.	Type	Description & Constraints    Filter: Bindings Constraints Obligations
Evidence	C	0..*	NonComparativeEvidence	Single evidence bit Interfaces Implemented: MetadataResource Constraints: cnl-0
Evidence.id	Σ This element is included in summaries.	0..1	id	Logical id of this artifact
Evidence.meta	Σ This element is included in summaries.	0..1	Meta	Metadata about the resource
Evidence.implicitRules	?! This element is a modifier element. Σ This element is included in summaries.	0..1	uri	A set of rules under which this content was created
Evidence.language		0..1	code	Language of the resource content Binding: AllLanguages (required): IETF language tag for a human language Additional Bindings Purpose CommonLanguages Starter
Evidence.text		0..1	Narrative	Text summary of the resource, for human interpretation This profile does not constrain the narrative in regard to content, language, or traceability to data elements
Evidence.contained		0..*	Resource	Contained, inline Resources
Evidence.Slices for extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.Slices for extension.extension:publicationStatus		0..1	CodeableConcept	Publication status URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status Binding: Cited Artifact Status Type (preferred)
Evidence.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored Slice: Unordered, Open by value:url
Evidence.url	Σ This element is included in summaries. C	0..1	uri	Canonical identifier for this evidence, represented as a globally unique URI Constraints: cnl-1
Evidence.identifier	Σ This element is included in summaries.	0..*	Identifier	Additional identifier for the summary
Evidence.version	Σ This element is included in summaries.	0..1	string	Business version of this summary
Evidence.versionAlgorithm[x]	Σ This element is included in summaries.	0..1		How to compare versions Binding: VersionAlgorithm (extensible)
Evidence.versionAlgorithm[x].versionAlgorithmString			string
Evidence.versionAlgorithm[x].versionAlgorithmCoding			Coding
Evidence.name	C	0..1	string	Name for this summary (machine friendly)
Evidence.title	Σ This element is included in summaries.	0..1	string	Name for this summary (human friendly)
Evidence.citeAs		0..1	markdown	Display of how to cite this Evidence
Evidence.status	?! This element is a modifier element. Σ This element is included in summaries.	0..1	code	draft | active | retired | unknown Binding: PublicationStatus (required): The lifecycle status of an artifact.
Evidence.experimental		0..1	boolean	For testing only - never for real usage
Evidence.date	Σ This element is included in summaries.	0..1	dateTime	Date last changed
Evidence.approvalDate		0..1	date	When the summary was approved by publisher
Evidence.lastReviewDate		0..1	date	When the summary was last reviewed by the publisher
Evidence.author	Σ This element is included in summaries.	0..*	ContactDetail	Who authored the content
Evidence.publisher	Σ This element is included in summaries.	0..1	string	Name of the publisher/steward (organization or individual)
Evidence.contact	Σ This element is included in summaries.	0..*	ContactDetail	Contact details for the publisher
Evidence.recorder		0..*	ContactDetail	Who entered the data for the evidence
Evidence.editor		0..*	ContactDetail	Who edited the content
Evidence.reviewer		0..*	ContactDetail	Who reviewed the content
Evidence.endorser		0..*	ContactDetail	Who endorsed the content
Evidence.useContext	Σ This element is included in summaries.	0..*	UsageContext	The context that the content is intended to support
Evidence.purpose		0..1	markdown	Why this Evidence is defined
Evidence.copyright		0..1	markdown	Intellectual property ownership, may include restrictions on use
Evidence.copyrightLabel		0..1	string	Copyright holder and year(s)
Evidence.relatesTo		0..*	BackboneElement	Relationships to other Resources
Evidence.relatesTo.id		0..1	string	Unique id for inter-element referencing
Evidence.relatesTo.Slices for extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.relatesTo.Slices for extension.extension:quotation		0..1	markdown	Quoted portion from related artifact URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/relates-to-with-quotation
Evidence.relatesTo.Slices for extension.extension:classifier		0..1	CodeableConcept	A classifier of the target artifact in a relatesTo element URL: http://hl7.org/fhir/uv/ebm/StructureDefinition/relatesto-classifier
Evidence.relatesTo.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.relatesTo.type		1..1	CodeableConcept	documentation | justification | citation | predecessor | successor | derived-from | depends-on | composed-of | part-of | amends | amended-with | appends | appended-with | cites | cited-by | comments-on | comment-in | contains | contained-in | corrects | correction-in | replaces | replaced-with | retracts | retracted-by | signs | similar-to | supports | supported-with | transforms | transformed-into | transformed-with | documents | specification-of | created-with | cite-as | reprint | reprint-of | summarizes Binding: Artifact Relationship Type (extensible): The type of relationship to the related artifact.
Evidence.relatesTo.target[x]		1..1		The artifact that is related to this Evidence
Evidence.relatesTo.target[x].targetUri			uri
Evidence.relatesTo.target[x].targetAttachment			Attachment
Evidence.relatesTo.target[x].targetCanonical			canonical(Resource)
Evidence.relatesTo.target[x].targetReference			Reference(Resource)
Evidence.relatesTo.target[x].targetMarkdown			markdown
Evidence.description	Σ This element is included in summaries.	0..1	markdown	Description of the particular summary
Evidence.assertion		0..1	markdown	Declarative description of the Evidence
Evidence.note		0..*	Annotation	Footnotes and/or explanatory notes
Evidence.classification	Σ This element is included in summaries.	0..*	BackboneElement	The assignment to an organizing scheme
Evidence.classification.id		0..1	string	Unique id for inter-element referencing
Evidence.classification.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.classification.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.classification.type		0..1	CodeableConcept	The kind of classifier (e.g. population, intervention) Binding: EvidenceClassifierTypeExample (example)
Evidence.classification.classifier		0..*	CodeableReference(Resource)	The specific classification value Binding: ConditionProblemDiagnosisCodes (example)
Evidence.Slices for variableDefinition		2..*	BackboneElement	Description, classification, and definition of a single variable Slice: Unordered, Open by value:variableRole
Evidence.Slices for variableDefinition.variableDefinition:All Slices				Content/Rules for all slices
Evidence.Slices for variableDefinition.variableDefinition:All Slices.id		0..1	string	Unique id for inter-element referencing
Evidence.Slices for variableDefinition.variableDefinition:All Slices.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:All Slices.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:All Slices.description		0..1	markdown	A text description or summary of the variable
Evidence.Slices for variableDefinition.variableDefinition:All Slices.note		0..*	Annotation	Footnotes and/or explanatory notes
Evidence.Slices for variableDefinition.variableDefinition:All Slices.variableRole	Σ This element is included in summaries.	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays.
Evidence.Slices for variableDefinition.variableDefinition:All Slices.roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (example): The sub-role that the variable plays.
Evidence.Slices for variableDefinition.variableDefinition:All Slices.comparatorCategory		0..1	string	The reference value used for comparison
Evidence.Slices for variableDefinition.variableDefinition:All Slices.observed	Σ This element is included in summaries.	0..1	Reference(Group | EvidenceVariable)	Definition of the actual variable related to the statistic(s)
Evidence.Slices for variableDefinition.variableDefinition:All Slices.intended		0..1	Reference(Group | EvidenceVariable)	Definition of the intended variable related to the Evidence
Evidence.Slices for variableDefinition.variableDefinition:All Slices.directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (example): The quality of how direct the match is.
Evidence.Slices for variableDefinition.variableDefinition:population	S This element must be supported.	1..*	BackboneElement	Description, classification, and definition of a single variable
Evidence.Slices for variableDefinition.variableDefinition:population.id		0..1	string	Unique id for inter-element referencing
Evidence.Slices for variableDefinition.variableDefinition:population.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:population.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:population.description		0..1	markdown	A text description or summary of the variable
Evidence.Slices for variableDefinition.variableDefinition:population.note		0..*	Annotation	Footnotes and/or explanatory notes
Evidence.Slices for variableDefinition.variableDefinition:population.variableRole	Σ This element is included in summaries.	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: population (extensions allowed)
Evidence.Slices for variableDefinition.variableDefinition:population.roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (example): The sub-role that the variable plays.
Evidence.Slices for variableDefinition.variableDefinition:population.comparatorCategory		0..1	string	The reference value used for comparison
Evidence.Slices for variableDefinition.variableDefinition:population.observed	Σ This element is included in summaries.	0..1	Reference(ExposureGroup | ComparatorGroup | MetaanalysisStudyGroup)	Definition of the actual variable related to the statistic(s)
Evidence.Slices for variableDefinition.variableDefinition:population.intended		0..1	Reference(Group)	Definition of the intended variable related to the Evidence
Evidence.Slices for variableDefinition.variableDefinition:population.directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (example): The quality of how direct the match is.
Evidence.Slices for variableDefinition.variableDefinition:outcome	S This element must be supported.	1..*	BackboneElement	Description, classification, and definition of a single variable
Evidence.Slices for variableDefinition.variableDefinition:outcome.id		0..1	string	Unique id for inter-element referencing
Evidence.Slices for variableDefinition.variableDefinition:outcome.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:outcome.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.Slices for variableDefinition.variableDefinition:outcome.description		0..1	markdown	A text description or summary of the variable
Evidence.Slices for variableDefinition.variableDefinition:outcome.note		0..*	Annotation	Footnotes and/or explanatory notes
Evidence.Slices for variableDefinition.variableDefinition:outcome.variableRole	Σ This element is included in summaries.	1..1	code	population | exposure | outcome | covariate Binding: EvidenceVariableRole (required): The role that the variable plays. Required Pattern: outcome (extensions allowed)
Evidence.Slices for variableDefinition.variableDefinition:outcome.roleSubtype		0..1	CodeableConcept	Sub-classification of the role of the variable Binding: EvidenceVariableRoleSubtype (example): The sub-role that the variable plays.
Evidence.Slices for variableDefinition.variableDefinition:outcome.comparatorCategory		0..1	string	The reference value used for comparison
Evidence.Slices for variableDefinition.variableDefinition:outcome.observed	Σ This element is included in summaries.	0..1	Reference(VariableDefinition)	Definition of the actual variable related to the statistic(s)
Evidence.Slices for variableDefinition.variableDefinition:outcome.intended		0..1	Reference(EvidenceVariable)	Definition of the intended variable related to the Evidence
Evidence.Slices for variableDefinition.variableDefinition:outcome.directnessMatch		0..1	CodeableConcept	low | moderate | high | exact Binding: EvidenceDirectness (example): The quality of how direct the match is.
Evidence.synthesisType		0..*	CodeableConcept	The design of the synthesis (combination of studies) that produced this evidence Binding: StatisticSynthesisType (example): Types of combining results from a body of evidence (e.g. summary data meta-analysis).
Evidence.studyDesign		0..*	CodeableConcept	The design of the study that produced this evidence Binding: Study Design (extensible): This is a set of terms for study design characteristics.
Evidence.statistic		0..*	BackboneElement	Values and parameters for a single statistic
Evidence.statistic.id		0..1	string	Unique id for inter-element referencing
Evidence.statistic.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.statistic.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.statistic.description		0..1	markdown	A natural language summary of the statistic
Evidence.statistic.note		0..*	Annotation	Footnotes and/or explanatory notes
Evidence.statistic.statisticType	Σ This element is included in summaries.	0..1	CodeableConcept	Type of statistic, e.g., relative risk Binding: Statistic Type (extensible)
Evidence.statistic.category		0..1	CodeableConcept	Associated category for categorical variable
Evidence.statistic.quantity	Σ This element is included in summaries.	0..1	Quantity	Statistic value
Evidence.statistic.numberOfEvents		0..1	unsignedInt	The number of events associated with the statistic
Evidence.statistic.numberAffected		0..1	unsignedInt	The number of participants affected
Evidence.statistic.sampleSize		0..1	BackboneElement	Count of participants in the study sample
Evidence.statistic.sampleSize.id		0..1	string	Unique id for inter-element referencing
Evidence.statistic.sampleSize.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.statistic.sampleSize.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.statistic.sampleSize.description		0..1	markdown	Textual description of sample size for statistic
Evidence.statistic.sampleSize.note		0..*	Annotation	Footnote or explanatory note about the sample size
Evidence.statistic.sampleSize.numberOfStudies		0..1	unsignedInt	Number of contributing studies
Evidence.statistic.sampleSize.numberOfParticipants		0..1	unsignedInt	Total number of participants
Evidence.statistic.sampleSize.knownDataCount		0..1	unsignedInt	Number of participants with known results for measured variables
Evidence.statistic.sampleSize.numberAnalyzed		0..1	unsignedInt	Total number of participants who were analayzed
Evidence.statistic.attributeEstimate		0..*	BackboneElement	An attribute of the Statistic
Evidence.statistic.attributeEstimate.id		0..1	string	Unique id for inter-element referencing
Evidence.statistic.attributeEstimate.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.statistic.attributeEstimate.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.statistic.attributeEstimate.description		0..1	markdown	Textual description of the attribute estimate
Evidence.statistic.attributeEstimate.note		0..*	Annotation	Footnote or explanatory note about the estimate
Evidence.statistic.attributeEstimate.type		0..1	CodeableConcept	The type of attribute estimate, e.g., confidence interval or p value Binding: StatisticAttributeEstimateType (extensible)
Evidence.statistic.attributeEstimate.quantity		0..1	Quantity	The singular quantity of the attribute estimate, for attribute estimates represented as single values, which may include a unit of measure
Evidence.statistic.attributeEstimate.level		0..1	decimal	Level of confidence interval, e.g., 0.95 for 95% confidence interval
Evidence.statistic.attributeEstimate.range		0..1	Range	Lower and upper bound values of the attribute estimate
Evidence.statistic.attributeEstimate.attributeEstimate		0..*	See attributeEstimate (Evidence)	A nested attribute estimate; which is the attribute estimate of an attribute estimate
Evidence.statistic.modelCharacteristic		0..*	BackboneElement	An aspect of the statistical model
Evidence.statistic.modelCharacteristic.id		0..1	string	Unique id for inter-element referencing
Evidence.statistic.modelCharacteristic.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.statistic.modelCharacteristic.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.statistic.modelCharacteristic.code		1..1	CodeableConcept	Model specification Binding: Statistic Model Code (example)
Evidence.statistic.modelCharacteristic.value[x]		0..1		The specific value (when paired with code)
Evidence.statistic.modelCharacteristic.value[x].valueQuantity			Quantity(SimpleQuantity)
Evidence.statistic.modelCharacteristic.value[x].valueRange			Range
Evidence.statistic.modelCharacteristic.value[x].valueCodeableConcept			CodeableConcept
Evidence.statistic.modelCharacteristic.intended		0..1	boolean	The plan for analysis
Evidence.statistic.modelCharacteristic.applied		0..1	boolean	This model characteristic is part of the analysis that was applied, whether or not the analysis followed the plan
Evidence.statistic.modelCharacteristic.variable		0..*	BackboneElement	A variable adjusted for in the adjusted analysis
Evidence.statistic.modelCharacteristic.variable.id		0..1	string	Unique id for inter-element referencing
Evidence.statistic.modelCharacteristic.variable.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.statistic.modelCharacteristic.variable.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.statistic.modelCharacteristic.variable.variableDefinition		1..1	Reference(Group | EvidenceVariable)	Description and definition of the variable
Evidence.statistic.modelCharacteristic.variable.handling		0..1	CodeableConcept	boolean | continuous | dichotomous | ordinal | polychotomous | time-to-event | not-specified Binding: Evidence Variable Handling (extensible)
Evidence.statistic.modelCharacteristic.variable.valueCategory		0..*	CodeableConcept	Qualitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
Evidence.statistic.modelCharacteristic.variable.valueQuantity		0..*	Quantity	Quantitative label used for grouping values of a dichotomous, ordinal, or polychotomous variable
Evidence.statistic.modelCharacteristic.variable.valueRange		0..*	Range	Range of quantitative labels used for grouping values of a dichotomous, ordinal, or polychotomous variable
Evidence.statistic.modelCharacteristic.attribute		0..*	See attributeEstimate (Evidence)	An attribute of the model characteristic
Evidence.certainty		0..*	BackboneElement	Certainty or quality of the evidence
Evidence.certainty.id		0..1	string	Unique id for inter-element referencing
Evidence.certainty.extension		0..*	Extension	Additional content defined by implementations Slice: Unordered, Open by value:url
Evidence.certainty.modifierExtension	?! This element is a modifier element. Σ This element is included in summaries.	0..*	Extension	Extensions that cannot be ignored even if unrecognized Slice: Unordered, Open by value:url
Evidence.certainty.description		0..1	markdown	Textual description of certainty
Evidence.certainty.note		0..*	Annotation	Footnotes and/or explanatory notes
Evidence.certainty.type		0..1	CodeableConcept	Aspect of certainty being rated Binding: Evidence Certainty Type (example): The aspect of quality, confidence, or certainty.
Evidence.certainty.rating		0..1	CodeableConcept	Assessment or judgement of the aspect Binding: StatisticCertaintyRating (example): The assessment of quality, confidence, or certainty.
Evidence.certainty.rater		0..*	string	Individual or group who did the rating
Evidence.certainty.subcomponent		0..*	See certainty (Evidence)	A domain or subdomain of certainty
Documentation for this format

Terminology Bindings

Path	Status	Usage	ValueSet	Version	Source
Evidence.language	Base	required	All Languages	📍6.0.0-snapshot1	FHIR Std.
Evidence.versionAlgorithm[x]	Base	extensible	Version Algorithm	📍6.0.0-snapshot1	FHIR Std.
Evidence.status	Base	required	PublicationStatus	📍6.0.0-snapshot1	FHIR Std.
Evidence.relatesTo.type	Base	extensible	Artifact Relationship Type	📦1.0.0	THO v7.5
Evidence.classification.​type	Base	example	Evidence Classifier Type Example	📍6.0.0-snapshot1	FHIR Std.
Evidence.classification.​classifier	Base	example	Condition/Problem/Diagnosis Codes	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition.​variableRole	Base	required	Evidence Variable Role	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition.​roleSubtype	Base	example	EvidenceVariableRoleSubtype	📦1.0.1	THO v7.5
Evidence.variableDefinition.​directnessMatch	Base	example	EvidenceDirectness	📦2.0.0	THO v7.5
Evidence.variableDefinition:population.​variableRole	Base	required	Evidence Variable Role	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition:population.​roleSubtype	Base	example	EvidenceVariableRoleSubtype	📦1.0.1	THO v7.5
Evidence.variableDefinition:population.​directnessMatch	Base	example	EvidenceDirectness	📦2.0.0	THO v7.5
Evidence.variableDefinition:outcome.​variableRole	Base	required	Evidence Variable Role	📍6.0.0-snapshot1	FHIR Std.
Evidence.variableDefinition:outcome.​roleSubtype	Base	example	EvidenceVariableRoleSubtype	📦1.0.1	THO v7.5
Evidence.variableDefinition:outcome.​directnessMatch	Base	example	EvidenceDirectness	📦2.0.0	THO v7.5
Evidence.synthesisType	Base	example	StatisticSynthesisType	📦2.0.0	THO v7.5
Evidence.studyDesign	Base	extensible	Study Design	📦1.0.0	THO v7.5
Evidence.statistic.statisticType	Base	extensible	Statistic Type	📦2.0.0	THO v7.5
Evidence.statistic.attributeEstimate.​type	Base	extensible	StatisticAttributeEstimateType	📦2.0.0	THO v7.5
Evidence.statistic.modelCharacteristic.​code	Base	example	Statistic Model Code	📦1.0.0	THO v7.5
Evidence.statistic.modelCharacteristic.​variable.handling	Base	extensible	Evidence Variable Handling	📦2.0.0	THO v7.5
Evidence.certainty.type	Base	example	Evidence Certainty Type	📦1.0.0	THO v7.5
Evidence.certainty.rating	Base	example	StatisticCertaintyRating	📦2.0.0	THO v7.5

Constraints

Id	Grade	Path(s)	Description	Expression
cnl-0	warning	Evidence	Name should be usable as an identifier for the module by machine processing applications such as code generation	name.exists() implies name.matches('^[A-Z]([A-Za-z0-9_]){1,254}$')
cnl-1	warning	Evidence.url	URL should not contain | or # - these characters make processing canonical references problematic	exists() implies matches('^[^|# ]+$')
ele-1	error	**ALL** elements	All FHIR elements must have a @value or children	hasValue() or (children().count() > id.count())

This structure is derived from NonComparativeEvidence

Summary

Structures

This structure refers to these other structures:

• ExposureGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/exposure-group)
• ComparatorGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/comparator-group)
• MetaanalysisStudyGroup (http://hl7.org/fhir/uv/ebm/StructureDefinition/metaanalysis-study-group)

Maturity: 1

Other representations of profile: CSV, Excel, Schematron