Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot3 - STU 1 Ballot 3 World

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

Evidence: MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk

Official URL: https://fevir.net/resources/Evidence/557022 Version: 1.0.0-ballot3
Standards status: Informative Computable Name: Cardiovascular_mortality_from_MAGICapp_313877
Other Identifiers: FEvIR Object Identifier: FEvIR Object Identifier#557022, outcomeId: 313877, picoId: 85789, sectionId: 73212, OID:2.16.840.1.113883.4.642.40.44.22.151

Usage: Evidence Communication: ComparativeEvidence

Copyright/Legal: Copyright the Authors else Computable Publishing LLC. Noncommercial use permitted with CC BY-NC-SA 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/). Commercial use permitted as agreed in Terms of Use (https://fevir.net/termsofuse).

This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide.

version: 3; Last updated: 2026-08-29 20:43:48+0000

Profile: ComparativeEvidence

ArtifactPublicationStatus: Active

url: Evidence MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk

identifier: FEvIR Object Identifier/557022, outcomeId/313877, picoId/85789, sectionId/73212, Uniform Resource Identifier (URI)/urn:oid:2.16.840.1.113883.4.642.40.44.22.151

version: 1.0.0-ballot3

name: Cardiovascular_mortality_from_MAGICapp_313877

title: MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk

citeAs:

MAGIC-derived Evidence: Cardiovascular mortality with GLP-1 RA vs. Standard care in Adults with type 2 diabetes with moderate CV risk [Database Entry: FHIR Evidence Resource]. Contributors: Computable Publishing®: MAGIC-to-FEvIR Converter [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 557022. Revised 2026-08-29. Available at: https://fevir.net/resources/Evidence/557022. Computable resource at: https://fevir.net/resources/Evidence/557022#json.

status: Active

date: 2026-11-05 14:34:28+0000

author: Computable Publishing®: MAGIC-to-FEvIR Converter:

publisher: HL7 International / Clinical Decision Support

contact: HL7 International / Clinical Decision Support: http://www.hl7.org/Special/committees/dss

UseContexts

-CodeValue[x]
*Evidence Based Medicine on FHIR Implementation Guide Code System: evidence-communication (Evidence Communication)ComparativeEvidence

copyright:

Copyright the Authors else Computable Publishing LLC. Noncommercial use permitted with CC BY-NC-SA 4.0 (https://creativecommons.org/licenses/by-nc-sa/4.0/). Commercial use permitted as agreed in Terms of Use (https://fevir.net/termsofuse).

RelatesTos

-TypeTarget[x]
*Part OfMAGICapp Conversion Report: SGLT2 inhibitors and GLP-1 RA for type 2 diabetes (Identifier: FEvIR Linking Identifier/MAGIC-5288-j1Wqrn-conversion-report)

description:

This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide.

assertion:

GLP-1 receptor agonists probably reduce the risk of cardiovascular death compared with standard care.

variableDefinition

description:

Adults with type 2 diabetes with moderate CV risk

variableRole: Population

observed: Adults with type 2 diabetes and established CVD (but no CKD)

variableDefinition

description:

GroupAssignment: GLP-1 RA vs. Standard care

variableRole: Exposure

comparatorCategory: Standard care

observed: GroupAssignment: GLP-1 RA vs. Standard care

variableDefinition

description:

Cardiovascular mortality

variableRole: Outcome

observed: Cardiovascular mortality

synthesisType: SYSTEMATIC_REVIEW

studyDesign: randomized assignment

statistic

description:

Risk Difference -0.9% (CI95 -1.5% to -0.3%)

statisticType: risk difference

quantity: -0.009

SampleSizes

-NumberOfStudiesNumberOfParticipants
*2063455

AttributeEstimates

-TypeRange
*CI95-0.015--0.003

statistic

description:

OR 0.88 (CI95 0.8 to 0.96)

statisticType: odds ratio

quantity: 0.88

SampleSizes

-NumberOfStudiesNumberOfParticipants
*2063455

AttributeEstimates

-TypeRange
*CI950.8-0.96

certainty

description:

Due to serious imprecision

type: Overall certainty

rating: Moderate certainty

Subcomponents

-TypeRating
*Risk of BiasNOTSET
*InconsistencyNOTSET
*IndirectnessNOTSET
*ImprecisionNOTSET
*Publication BiasNOTSET