Evidence Based Medicine on FHIR Implementation Guide
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Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot3 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

Evidence: PK: Change From Baseline in Maximal Concentration (Cmax) of Glucagon Nasal Powder and Glucagon Hydrochloride IM at Pre-dose, 5, 10, 15, 20, 25, 30, 40, 50, 60, 90, 120, 240 minutes after each glucagon administration for Glucagon Hydrochloride Solution in NCT03421379

Computable Name:

version: 9; Last updated: 2025-12-11 20:35:21+0000; Language: en

Profile: NonComparativeEvidence

url: https://fevir.net/resources/Evidence/267241

identifier: FEvIR Object Identifier/267241, FEvIR Linking Identifier/NCT03421379-secondaryOutcomeMeasure-3--OG001

name: NCT03421379_secondaryOutcomeMeasure_3_OG001

title: PK: Change From Baseline in Maximal Concentration (Cmax) of Glucagon Nasal Powder and Glucagon Hydrochloride IM at Pre-dose, 5, 10, 15, 20, 25, 30, 40, 50, 60, 90, 120, 240 minutes after each glucagon administration for Glucagon Hydrochloride Solution in NCT03421379

citeAs:

PK: Change From Baseline in Maximal Concentration (Cmax) of Glucagon Nasal Powder and Glucagon Hydrochloride IM at Pre-dose, 5, 10, 15, 20, 25, 30, 40, 50, 60, 90, 120, 240 minutes after each glucagon administration for Glucagon Hydrochloride Solution in NCT03421379 [Database Entry: FHIR Evidence Resource]. Contributors: Computable Publishing®: ClinicalTrials.gov-to-FEvIR Converter [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 267241. Revised 2025-12-11. Available at: https://fevir.net/resources/Evidence/267241. Computable resource at: https://fevir.net/resources/Evidence/267241#json.

status: Active

author: Computable Publishing®: ClinicalTrials.gov-to-FEvIR Converter:

publisher: Computable Publishing LLC

contact: support@computablepublishing.com

copyright:

https://creativecommons.org/licenses/by-nc-sa/4.0/

description:

This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide.

variableDefinition

description:

Glucagon Hydrochloride Solution

note: ,

Outcome Measure Population Description: All randomized participants who received at least one dose of study drug and had evaluable PK data.

Outcome Measure Denominator Units: Participants

variableRole: Population

observed: A single dose of 1 mg glucagon hydrochloride solution was administered IM (Identifier: ClinicalTrials.gov Outcome Measurement Group Id/OG001)

variableDefinition

variableRole: Outcome

observed: PK: Change From Baseline in Maximal Concentration (Cmax) of Glucagon Nasal Powder and Glucagon Hydrochloride IM at Pre-dose, 5, 10, 15, 20, 25, 30, 40, 50, 60, 90, 120, 240 minutes after each glucagon administration - (NCT03421379)

statistic

statisticType: geometric mean

quantity: 3290 picogram/milliliter (pg/mL)

SampleSizes

-KnownDataCount
*68

AttributeEstimates

-TypeQuantity
*Geometric Coefficient of Variation37 picogram/milliliter (pg/mL)