Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot
Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot
Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
| Page standards status: Informative |
version: 13; Last updated: 2025-09-13 16:01:00+0000
ArtifactPublicationStatus: Active
url: Citation Efficacy of Corticosteroids in COVID-19 Patients: A Systematic Review and Meta-Analysis
identifier: FEvIR Object Identifier/112, Uniform Resource Identifier (URI)/urn:oid:2.16.840.1.113883.4.642.40.44.15.61
version: 1.0.0-ballot2
title: Efficacy of Corticosteroids in COVID-19 Patients: A Systematic Review and Meta-Analysis
status: Active
date: 2021-09-24 12:06:23+0000
author: Brian S. Alper:
publisher: HL7 International / Clinical Decision Support
contact: HL7 International / Clinical Decision Support: http://www.hl7.org/Special/committees/dss
description:
A systematic review included in the Steroids SMR Project
| Code | Value[x] |
| UsageContextType program: Program | Steroids SMR Project |
| Citation Classification Type fevir-platform-use: FEvIR Platform Use | Project Specific |
jurisdiction: World
copyright:
https://creativecommons.org/licenses/by-nc-sa/4.0/
| Style | Text |
| Computable Publishing | Efficacy of Corticosteroids in COVID-19 Patients: A Systematic Review and Meta-Analysis [Preprint], version 1. Contributors: Haytham Tlayjeh, Olaa H. Mhish, Mushira A. Enani, Alya Alruwaili, Rana Tleyjeh, Lukman Thalib, Leslie Hassett, Yaseen M. Arabi, Tarek Kashour, Imad M. Tleyjeh. In: Medrxiv the Preprint Server for the Health Sciences, DOI 10.1101/2020.08.13.20174201. Published August 14, 2020. Accessed March 06, 2021. Available at: https://www.medrxiv.org/content/10.1101/2020.08.13.20174201v1. |
| Type | Classifier |
| FEvIR Platform Use | Project Specific |
note:
Now published in Journal of Infection and Public Health doi: 10.1016/j.jiph.2020.09.008
citedArtifact
identifier:
https://doi.org/10.1101/2020.08.13.20174201,https://www.medrxiv.org/content/10.1101/2020.08.13.20174201v1dateAccessed: 2021-03-06
Titles
Type Text Primary title Efficacy of Corticosteroids in COVID-19 Patients: A Systematic Review and Meta-Analysis
Abstracts
Type Text Primary human use Background: To systematically review the literature about the effect of systemic corticosteroid\ntherapy (CST) on outcomes of COVID-19 patients.\nMethods: We searched Medline, Embase, EBM Reviews, Scopus, Web of Science, and preprints\nup to July 20, 2020. We included observational studies and randomized controlled trials (RCT)\nthat assessed COVID-19 patients treated with CST. We pooled adjusted effect estimates of\nmortality and other outcomes using a random effect model, among studies at low or moderate\nrisk for bias. We assessed the certainty of evidence for each outcome using the GRADE\napproach.\nResults: Out of 1067 citations screened for eligibility, one RCT and 19 cohort studies were\nincluded (16,977 hospitalized patients). Ten studies (1 RCT and 9 cohorts) with 10,278 patients\nexamined the effect of CST on short term mortality. The pooled adjusted RR was 0.92 (95% CI\n0.69-1.22, I2\n=81.94 %). This effect was observed across all stages of disease severity. Four\ncohort studies examined the effect of CST on composite outcome of death, ICU admission and\nmechanical ventilation need. The pooled adjusted RR was 0.41(0.23-0.73, I2\n=78.69%). Six\ncohort studies examined the effect of CST on delayed viral clearance. The pooled adjusted RR\nwas 1.47(95% CI 1.11-1.93, I2\n=43.38%).\nConclusion: Heterogeneous and low certainty cumulative evidence suggests that CST lacks\nefficacy in reducing short-term mortality while possibly delaying viral clearance in patients\nhospitalized with COVID-19. Because of the discordant results between the single RCT and\nobservational studies, more research should continue to identify the clinical and biochemical\ncharacteristics of patients’ population that could benefit from CST.
RelatesTos
Type Classifier Replaced With Journal Article publicationForm
PublishedIns
Type Title Database Medrxiv the Preprint Server for the Health Sciences citedMedium: [object Object]
articleDate: 2020-08-14
pageCount: 31 pages
copyright:
The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed
webLocation
classifier: Abstract
url: https://www.medrxiv.org/content/10.1101/2020.08.13.20174201v1
webLocation
classifier: PDF, Full-Text
url: https://www.medrxiv.org/content/10.1101/2020.08.13.20174201v1.full.pdf
classification
type: Steroids SMR project use
classifier: Excluded supporting information
classification
type: Knowledge Artifact Type
classifier: Preprint
classification
type: Funding
classifier: No funding
contributorship
complete: false
Entries
Contributor ForenameInitials Affiliation Role CorrespondingContact Imad M. Tleyjeh Tleyjeh.Imad@mayo.edu IM College of Medicine, Al Faisal University, Riyadh, Saudi Arabia Author/Creator true Summaries
Type Source Value Author string Copied from article Haytham Tlayjeh, Olaa H. Mhish, Mushira A. Enani, Alya Alruwaili, Rana Tleyjeh, Lukman Thalib, Leslie Hassett, Yaseen M. Arabi, Tarek Kashour, Imad M. Tleyjeh
IG © 2024+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#1.0.0-ballot2 based on FHIR 6.0.0-ballot3. Generated 2025-09-13
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