Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot International flag

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: Quadpill once daily - XML Representation

Page standards status: Informative

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<ActivityDefinition xmlns="http://hl7.org/fhir">
  <id value="375159"/>
  <meta>
    <versionId value="16"/>
    <lastUpdated value="2025-09-08T19:29:01.105Z"/>
  </meta>
  <text>
    <status value="additional"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p><b>Title: </b>Quadpill once daily</p>
<p><b>Description: </b>This is describing an intervention used in the QUARTET USA Trial.</p>
<p><b>Product: </b>Quadpill (candesartan 2 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg)</p>
<p><b>Dosage: </b>One pill by mouth once daily</p></div>
  </text>
  <contained>
    <Medication>
      <id value="Quadpill"/>
      <ingredient>
        <item>
          <concept>
            <coding>
              <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
              <code value="1156611"/>
              <display value="candesartan Oral Product"/>
            </coding>
          </concept>
        </item>
        <strengthQuantity>
          <value value="2"/>
          <unit value="milligram (mg)"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="mg"/>
        </strengthQuantity>
      </ingredient>
      <ingredient>
        <item>
          <concept>
            <coding>
              <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
              <code value="19484"/>
              <display value="bisoprolol"/>
            </coding>
          </concept>
        </item>
        <strengthQuantity>
          <value value="2.5"/>
          <unit value="milligram (mg)"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="mg"/>
        </strengthQuantity>
      </ingredient>
      <ingredient>
        <item>
          <concept>
            <coding>
              <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
              <code value="17767"/>
              <display value="amlodipine"/>
            </coding>
          </concept>
        </item>
        <strengthQuantity>
          <value value="1.25"/>
          <unit value="milligram (mg)"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="mg"/>
        </strengthQuantity>
      </ingredient>
      <ingredient>
        <item>
          <concept>
            <coding>
              <system value="http://www.nlm.nih.gov/research/umls/rxnorm"/>
              <code value="5764"/>
              <display value="indapamide"/>
            </coding>
          </concept>
        </item>
        <strengthQuantity>
          <value value="0.625"/>
          <unit value="milligram (mg)"/>
          <system value="http://unitsofmeasure.org"/>
          <code value="mg"/>
        </strengthQuantity>
      </ingredient>
    </Medication>
  </contained>
  <extension url="http://hl7.org/fhir/uv/ebm/StructureDefinition/cite-as">
    <valueMarkdown
                   value="Quadpill once daily [Database Entry: FHIR ActivityDefinition Resource]. Contributors: Joanne Dehnbostel [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 375159. Revised 2025-06-03. Available at: https://fevir.net/resources/ActivityDefinition/375159. Computable resource at: https://fevir.net/resources/ActivityDefinition/375159#json."/>
  </extension>
  <extension
             url="http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status">
    <valueCodeableConcept>
      <coding>
        <system
                value="http://terminology.hl7.org/CodeSystem/cited-artifact-status-type"/>
        <code value="active"/>
        <display value="Active"/>
      </coding>
    </valueCodeableConcept>
  </extension>
  <url value="https://fevir.net/resources/ActivityDefinition/375159"/>
  <identifier>
    <type>
      <coding>
        <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
        <code value="ACSN"/>
        <display value="Accession ID"/>
      </coding>
      <text value="FEvIR Object Identifier"/>
    </type>
    <system value="https://fevir.net/FOI"/>
    <value value="375159"/>
    <assigner>
      <display value="Computable Publishing LLC"/>
    </assigner>
  </identifier>
  <identifier>
    <system value="urn:ietf:rfc:3986"/>
    <value value="urn:oid:2.16.840.1.113883.4.642.40.44.11.3"/>
  </identifier>
  <version value="1.0.0-ballot2"/>
  <title value="Quadpill once daily"/>
  <status value="active"/>
  <date value="2025-09-13T19:21:37+00:00"/>
  <publisher value="HL7 International / Clinical Decision Support"/>
  <contact>
    <name value="HL7 International / Clinical Decision Support"/>
    <telecom>
      <system value="url"/>
      <value value="http://www.hl7.org/Special/committees/dss"/>
    </telecom>
  </contact>
  <description
               value="This is describing an intervention used in the QUARTET USA Trial."/>
  <jurisdiction>
    <coding>
      <system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/>
      <code value="001"/>
      <display value="World"/>
    </coding>
  </jurisdiction>
  <copyright value="https://creativecommons.org/licenses/by-nc-sa/4.0/"/>
  <author>
    <name value="Joanne Dehnbostel"/>
  </author>
  <relatedArtifact>
    <type value="cite-as"/>
    <citation
              value="Quadpill once daily [Database Entry: FHIR ActivityDefinition Resource]. Contributors: Joanne Dehnbostel [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 375159. Revised 2025-09-08. Available at: https://fevir.net/resources/ActivityDefinition/375159. Computable resource at: https://fevir.net/resources/ActivityDefinition/375159#json."/>
  </relatedArtifact>
  <productReference>
    <reference value="#Quadpill"/>
    <type value="Medication"/>
    <display
             value="Quadpill (candesartan 2 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg)"/>
  </productReference>
  <dosage>
    <text value="One pill by mouth once daily"/>
    <timing>
      <code>
        <coding>
          <system
                  value="https://terminology.hl7.org/4.0.0/CodeSystem-v3-GTSAbbreviation.html"/>
          <code value="QD"/>
          <display value="QD"/>
        </coding>
      </code>
    </timing>
    <route>
      <coding>
        <system value="http://snomed.info/sct"/>
        <code value="26643006"/>
        <display value="Oral route"/>
      </coding>
    </route>
    <doseAndRate>
      <doseQuantity>
        <value value="1"/>
        <unit value="pill"/>
      </doseQuantity>
    </doseAndRate>
  </dosage>
</ActivityDefinition>