Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot International flag

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: Quadpill once daily - JSON Representation

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{
  "resourceType" : "ActivityDefinition",
  "id" : "375159",
  "meta" : {
    "versionId" : "16",
    "lastUpdated" : "2025-09-08T19:29:01.105Z"
  },
  "text" : {
    "status" : "additional",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p><b>Title: </b>Quadpill once daily</p>\n<p><b>Description: </b>This is describing an intervention used in the QUARTET USA Trial.</p>\n<p><b>Product: </b>Quadpill (candesartan 2 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg)</p>\n<p><b>Dosage: </b>One pill by mouth once daily</p></div>"
  },
  "contained" : [
    {
      "resourceType" : "Medication",
      "id" : "Quadpill",
      "ingredient" : [
        {
          "item" : {
            "concept" : {
              "coding" : [
                {
                  "system" : "http://www.nlm.nih.gov/research/umls/rxnorm",
                  "code" : "1156611",
                  "display" : "candesartan Oral Product"
                }
              ]
            }
          },
          "strengthQuantity" : {
            "value" : 2,
            "unit" : "milligram (mg)",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg"
          }
        },
        {
          "item" : {
            "concept" : {
              "coding" : [
                {
                  "system" : "http://www.nlm.nih.gov/research/umls/rxnorm",
                  "code" : "19484",
                  "display" : "bisoprolol"
                }
              ]
            }
          },
          "strengthQuantity" : {
            "value" : 2.5,
            "unit" : "milligram (mg)",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg"
          }
        },
        {
          "item" : {
            "concept" : {
              "coding" : [
                {
                  "system" : "http://www.nlm.nih.gov/research/umls/rxnorm",
                  "code" : "17767",
                  "display" : "amlodipine"
                }
              ]
            }
          },
          "strengthQuantity" : {
            "value" : 1.25,
            "unit" : "milligram (mg)",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg"
          }
        },
        {
          "item" : {
            "concept" : {
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                {
                  "system" : "http://www.nlm.nih.gov/research/umls/rxnorm",
                  "code" : "5764",
                  "display" : "indapamide"
                }
              ]
            }
          },
          "strengthQuantity" : {
            "value" : 0.625,
            "unit" : "milligram (mg)",
            "system" : "http://unitsofmeasure.org",
            "code" : "mg"
          }
        }
      ]
    }
  ],
  "extension" : [
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      "url" : "http://hl7.org/fhir/uv/ebm/StructureDefinition/cite-as",
      "valueMarkdown" : "Quadpill once daily [Database Entry: FHIR ActivityDefinition Resource]. Contributors: Joanne Dehnbostel [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 375159. Revised 2025-06-03. Available at: https://fevir.net/resources/ActivityDefinition/375159. Computable resource at: https://fevir.net/resources/ActivityDefinition/375159#json."
    },
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            "display" : "Active"
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      }
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  ],
  "url" : "https://fevir.net/resources/ActivityDefinition/375159",
  "identifier" : [
    {
      "type" : {
        "coding" : [
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            "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
            "code" : "ACSN",
            "display" : "Accession ID"
          }
        ],
        "text" : "FEvIR Object Identifier"
      },
      "system" : "https://fevir.net/FOI",
      "value" : "375159",
      "assigner" : {
        "display" : "Computable Publishing LLC"
      }
    },
    {
      "system" : "urn:ietf:rfc:3986",
      "value" : "urn:oid:2.16.840.1.113883.4.642.40.44.11.3"
    }
  ],
  "version" : "1.0.0-ballot2",
  "title" : "Quadpill once daily",
  "status" : "active",
  "date" : "2025-09-14T19:26:03+00:00",
  "publisher" : "HL7 International / Clinical Decision Support",
  "contact" : [
    {
      "name" : "HL7 International / Clinical Decision Support",
      "telecom" : [
        {
          "system" : "url",
          "value" : "http://www.hl7.org/Special/committees/dss"
        }
      ]
    }
  ],
  "description" : "This is describing an intervention used in the QUARTET USA Trial.",
  "jurisdiction" : [
    {
      "coding" : [
        {
          "system" : "http://unstats.un.org/unsd/methods/m49/m49.htm",
          "code" : "001",
          "display" : "World"
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  "copyright" : "https://creativecommons.org/licenses/by-nc-sa/4.0/",
  "author" : [
    {
      "name" : "Joanne Dehnbostel"
    }
  ],
  "relatedArtifact" : [
    {
      "type" : "cite-as",
      "citation" : "Quadpill once daily [Database Entry: FHIR ActivityDefinition Resource]. Contributors: Joanne Dehnbostel [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 375159. Revised 2025-09-08. Available at: https://fevir.net/resources/ActivityDefinition/375159. Computable resource at: https://fevir.net/resources/ActivityDefinition/375159#json."
    }
  ],
  "productReference" : {
    "reference" : "#Quadpill",
    "type" : "Medication",
    "display" : "Quadpill (candesartan 2\u2009mg, amlodipine 1.25\u2009mg, indapamide 0.625\u2009mg, and bisoprolol 2.5\u2009mg)"
  },
  "dosage" : [
    {
      "text" : "One pill by mouth once daily",
      "timing" : {
        "code" : {
          "coding" : [
            {
              "system" : "https://terminology.hl7.org/4.0.0/CodeSystem-v3-GTSAbbreviation.html",
              "code" : "QD",
              "display" : "QD"
            }
          ]
        }
      },
      "route" : {
        "coding" : [
          {
            "system" : "http://snomed.info/sct",
            "code" : "26643006",
            "display" : "Oral route"
          }
        ]
      },
      "doseAndRate" : [
        {
          "doseQuantity" : {
            "value" : 1,
            "unit" : "pill"
          }
        }
      ]
    }
  ]
}