Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

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: Evidence for Results for Systolic blood pressure at 12 weeks in GroupAssignment: Quadpill vs. Candesartan - XML Representation

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<Evidence xmlns="http://hl7.org/fhir">
  <id value="375907"/>
  <meta>
    <versionId value="11"/>
    <lastUpdated value="2025-08-15T10:17:51.868Z"/>
    <profile
             value="http://hl7.org/fhir/uv/ebm/StructureDefinition/comparative-evidence"/>
  </meta>
  <text>
    <status value="empty"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p>[No data.]</p></div>
  </text>
  <extension
             url="http://hl7.org/fhir/uv/ebm/StructureDefinition/artifact-publication-status">
    <valueCodeableConcept>
      <coding>
        <system
                value="http://terminology.hl7.org/CodeSystem/cited-artifact-status-type"/>
        <code value="active"/>
        <display value="Active"/>
      </coding>
    </valueCodeableConcept>
  </extension>
  <url value="https://fevir.net/resources/Evidence/375907"/>
  <identifier>
    <type>
      <coding>
        <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
        <code value="ACSN"/>
        <display value="Accession ID"/>
      </coding>
      <text value="FEvIR Object Identifier"/>
    </type>
    <system value="https://fevir.net/FOI"/>
    <value value="375907"/>
    <assigner>
      <display value="Computable Publishing LLC"/>
    </assigner>
  </identifier>
  <name
        value="Evidence_for_Results_for_Systolic_blood_pressure_at_12_weeks_in_GroupAssignment_Quadpill_vs_Candesartan"/>
  <title
         value="Evidence for Results for Systolic blood pressure at 12 weeks in GroupAssignment: Quadpill vs. Candesartan"/>
  <citeAs
          value="Evidence for Results for Systolic blood pressure at 12 weeks in GroupAssignment: Quadpill vs. Candesartan [Database Entry: FHIR Evidence Resource]. Contributors: Joanne Dehnbostel [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 375907. Revised 2025-08-15. Available at: https://fevir.net/resources/Evidence/375907. Computable resource at: https://fevir.net/resources/Evidence/375907#json."/>
  <status value="active"/>
  <author>
    <name value="Joanne Dehnbostel"/>
  </author>
  <publisher value="Computable Publishing LLC"/>
  <contact>
    <telecom>
      <system value="email"/>
      <value value="support@computablepublishing.com"/>
    </telecom>
  </contact>
  <copyright value="https://creativecommons.org/licenses/by-nc-sa/4.0/"/>
  <relatesTo>
    <type value="part-of"/>
    <targetReference>🔗 
      <reference value="Composition/375280"/>
      <type value="Composition"/>
      <display value="Outcome Measure Report for QUARTET USA Trial"/>
    </targetReference>
  </relatesTo>
  <description
               value="This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide."/>
  <variableDefinition>
    <variableRole value="exposure"/>
    <comparatorCategory value="Candesartan 8 mg once daily"/>
    <observed>🔗 
      <reference value="EvidenceVariable/375183"/>
      <type value="EvidenceVariable"/>
      <display value="GroupAssignment: Quadpill vs. Candesartan"/>
    </observed>
  </variableDefinition>
  <variableDefinition>
    <variableRole value="outcome"/>
    <observed>🔗 
      <reference value="EvidenceVariable/375185"/>
      <type value="EvidenceVariable"/>
      <display value="Systolic blood pressure at 12 weeks"/>
    </observed>
  </variableDefinition>
  <variableDefinition>
    <variableRole value="population"/>
    <observed>🔗 
      <reference value="Group/372797"/>
      <type value="Group"/>
      <display value="Enrolled Group for QUARTET USA Trial (372797)"/>
    </observed>
  </variableDefinition>
  <statistic>
    <statisticType>
      <coding>
        <system value="https://fevir.net/sevco"/>
        <code value="STATO:0000457"/>
        <display value="difference in means"/>
      </coding>
    </statisticType>
    <quantity>
      <value value="-4.5"/>
      <unit value="mm Hg"/>
    </quantity>
    <sampleSize>
      <extension
                 url="http://hl7.org/fhir/uv/ebm/StructureDefinition/number-analyzed">
        <valueUnsignedInt value="60"/>
      </extension>
      <numberOfParticipants value="62"/>
      <knownDataCount value="53"/>
    </sampleSize>
    <attributeEstimate>
      <type>
        <coding>
          <system value="https://fevir.net/sevco"/>
          <code value="STATO:0000196"/>
          <display value="confidence interval"/>
        </coding>
      </type>
      <level value="0.95"/>
      <range>
        <low>
          <value value="-10.82"/>
          <unit value="mm Hg"/>
        </low>
        <high>
          <value value="1.32"/>
          <unit value="mm Hg"/>
        </high>
      </range>
    </attributeEstimate>
    <attributeEstimate>
      <type>
        <coding>
          <system value="https://fevir.net/sevco"/>
          <code value="STATO:0000700"/>
          <display value="p-value"/>
        </coding>
      </type>
      <quantity>
        <value value="0.123"/>
      </quantity>
    </attributeEstimate>
  </statistic>
</Evidence>