Evidence Based Medicine on FHIR Implementation Guide
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Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: NetEffectContribution: Remission of diabetes for Example for GIN 2022 - TTL Representation

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:Evidence ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "179588"] ; # 
  fhir:meta [
fhir:versionId [ fhir:v "6" ] ;
fhir:lastUpdated [ fhir:v "2023-12-08T13:32:26.958Z"^^xsd:dateTime ] ;
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/net-effect-contribution"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/uv/ebm/StructureDefinition/net-effect-contribution>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "extensions" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Evidence 179588</b></p><a name=\"179588\"> </a><a name=\"hc179588\"> </a><a name=\"179588-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 6; Last updated: 2023-12-08 13:32:26+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-net-effect-contribution.html\">NetEffectContribution</a></p></div><p><b>url</b>: <a href=\"https://fevir.net/resources/Evidence/179588\">https://fevir.net/resources/Evidence/179588</a></p><p><b>identifier</b>: FEvIR Object Identifier/179588</p><p><b>name</b>: NetEffectContribution_Remission_of_diabetes_for_Example_for_GIN_2022</p><p><b>title</b>: NetEffectContribution: Remission of diabetes for Example for GIN 2022</p><p><b>status</b>: Active</p><p><b>publisher</b>: Computable Publishing LLC</p><p><b>contact</b>: <a href=\"mailto:support@computablepublishing.com\">support@computablepublishing.com</a></p><p><b>author</b>: Brian S. Alper: </p><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"CodeSystem-179423.html#179423-evidence-communication\">Evidence Based Medicine on FHIR Implementation Guide Code System evidence-communication</a>: Evidence Communication</td><td><span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 ComparativeEvidence}\">ComparativeEvidence</span></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"CodeSystem-179423.html#179423-evidence-communication\">Evidence Based Medicine on FHIR Implementation Guide Code System evidence-communication</a>: Evidence Communication</td><td><span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 NetEffectContribution}\">NetEffectContribution</span></td></tr></table><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Citation</b></td><td><b>ResourceReference</b></td></tr><tr><td style=\"display: none\">*</td><td>Cite As</td><td><div><p>NetEffectContribution: Remission of diabetes for Example for GIN 2022 [Evidence]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 179588. Revised 2023-12-06. Available at: https://fevir.net/resources/Evidence/179588. Computable resource at: https://fevir.net/resources/Evidence/179588.</p>\n</div></td><td> </td></tr><tr><td style=\"display: none\">*</td><td>Amended With</td><td> </td><td><a href=\"ArtifactAssessment-104193.html\">Outcome Importance Rating (default value 5) of Remission of diabetes</a></td></tr></table><p><b>description</b>: </p><div><p>2.15 (1.33 to 3.26) - example showing statistic.extension:modelExpression</p>\n</div><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>Cohort study with baseline data of exposures from November 2005 through July 2010 and follow-up data from 2006 until death or through December 2015 at a tertiary care outpatient center, Vestfold Hospital Trust, Norway. Consecutive treatment-seeking adult patients (n = 2109) with severe obesity assessed (221 patients excluded and 1888 patients included).</p>\n</div><p><b>variableRole</b>: Population</p><p><b>observed</b>: <a href=\"Group-178427.html\">StudyGroup: Severely Obese Adults 2018 Norwegian Cohort</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>comparison groups of bariatric surgery vs. no bariatric surgery</p>\n</div><p><b>variableRole</b>: Exposure</p><p><b>comparatorCategory</b>: no bariatric surgery</p><p><b>observed</b>: <a href=\"EvidenceVariable-172427.html\">GroupAssignment: Bariatric Surgery vs. no bariatric surgery</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>Remission of diabetes</p>\n</div><p><b>variableRole</b>: Outcome</p><p><b>observed</b>: <a href=\"EvidenceVariable-104117.html\">OutcomeVariable: Remission of diabetes</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>Relative Importance Multiplier</p>\n</div><p><b>variableRole</b>: Covariate</p><p><b>roleSubtype</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 importance-multiplier}\">Relative importance multiplier</span></p><p><b>observed</b>: Relative Importance Multiplier</p></blockquote><blockquote><p><b>statistic</b></p><p><b>StatisticModelExpression</b>: <code>Evidence[id='104121'].statistic[statisticType='Relative Risk'] * Evidence[id='104396'].statistic[statisticType='Proportion'] * $this.relatedArtifact[type=#amended-with].resourceReference(processOutcomeImportance)</code>(<b>Net effect contribution analysis</b>&quot;risk difference (relative risk x control event rate) multiplied by relative importance multiplier (defined in OutcomeImportance Profile) -- expression is pseudocode to demonstrate the concept&quot;)</p><p><b>description</b>: </p><div><p>risk difference 2.15 (95% CI 1.33 to 3.26)</p>\n</div><p><b>statisticType</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/181513 STATO:0000424}\">Risk Difference</span></p><p><b>quantity</b>: 2.15</p><h3>AttributeEstimates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Description</b></td><td><b>Type</b></td><td><b>Level</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td><div><p>95% CI 1.33 to 3.26</p>\n</div></td><td><span title=\"Codes:{https://fevir.net/resources/CodeSystem/181513 STATO:0000196}\">confidence interval</span></td><td>0.95</td><td>1.33-3.26</td></tr></table><h3>ModelCharacteristics</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{https://fevir.net/resources/CodeSystem/181513 TBD:net-effect-contribution-analysis}\">Net effect contribution analysis</span></td></tr></table></blockquote></div>"
  ] ; # 
  fhir:url [ fhir:v "https://fevir.net/resources/Evidence/179588"^^xsd:anyURI] ; # 
  fhir:identifier ( [
fhir:type [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ACSN" ] ;
fhir:display [ fhir:v "Accession ID" ]       ] ) ;
fhir:text [ fhir:v "FEvIR Object Identifier" ]     ] ;
fhir:system [ fhir:v "https://fevir.net"^^xsd:anyURI ] ;
fhir:value [ fhir:v "179588" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]     ]
  ] ) ; # 
  fhir:name [ fhir:v "NetEffectContribution_Remission_of_diabetes_for_Example_for_GIN_2022"] ; # 
  fhir:title [ fhir:v "NetEffectContribution: Remission of diabetes for Example for GIN 2022"] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:publisher [ fhir:v "Computable Publishing LLC"] ; # 
  fhir:contact ( [
    ( fhir:telecom [
fhir:system [ fhir:v "email" ] ;
fhir:value [ fhir:v "support@computablepublishing.com" ]     ] )
  ] ) ; # 
  fhir:author ( [
fhir:name [ fhir:v "Brian S. Alper" ]
  ] ) ; # 
  fhir:useContext ( [
fhir:code [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "evidence-communication" ] ;
fhir:display [ fhir:v "Evidence Communication" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
      ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ComparativeEvidence" ] ;
fhir:display [ fhir:v "ComparativeEvidence" ]       ] )     ]
  ] [
fhir:code [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "evidence-communication" ] ;
fhir:display [ fhir:v "Evidence Communication" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
      ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "NetEffectContribution" ] ;
fhir:display [ fhir:v "NetEffectContribution" ]       ] )     ]
  ] ) ; # 
  fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # 
  fhir:relatedArtifact ( [
fhir:type [ fhir:v "cite-as" ] ;
fhir:citation [ fhir:v "NetEffectContribution: Remission of diabetes for Example for GIN 2022 [Evidence]. Contributors: Brian S. Alper [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 179588. Revised 2023-12-06. Available at: https://fevir.net/resources/Evidence/179588. Computable resource at: https://fevir.net/resources/Evidence/179588." ]
  ] [
fhir:type [ fhir:v "amended-with" ] ;
fhir:resourceReference [
fhir:reference [ fhir:v "ArtifactAssessment/104193" ] ;
fhir:type [ fhir:v "ArtifactAssessment"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Outcome Importance Rating (default value 5) of Remission of diabetes" ]     ]
  ] ) ; # 
  fhir:description [ fhir:v "2.15 (1.33 to 3.26) - example showing statistic.extension:modelExpression"] ; # 
  fhir:variableDefinition ( [
fhir:description [ fhir:v "Cohort study with baseline data of exposures from November 2005 through July 2010 and follow-up data from 2006 until death or through December 2015 at a tertiary care outpatient center, Vestfold Hospital Trust, Norway. Consecutive treatment-seeking adult patients (n = 2109) with severe obesity assessed (221 patients excluded and 1888 patients included)." ] ;
fhir:variableRole [ fhir:v "population" ] ;
fhir:observed [
fhir:reference [ fhir:v "Group/178427" ] ;
fhir:type [ fhir:v "Group"^^xsd:anyURI ] ;
fhir:display [ fhir:v "StudyGroup: Severely Obese Adults 2018 Norwegian Cohort" ]     ]
  ] [
fhir:description [ fhir:v "comparison groups of bariatric surgery vs. no bariatric surgery" ] ;
fhir:variableRole [ fhir:v "exposure" ] ;
fhir:comparatorCategory [ fhir:v "no bariatric surgery" ] ;
fhir:observed [
fhir:reference [ fhir:v "EvidenceVariable/172427" ] ;
fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
fhir:display [ fhir:v "GroupAssignment: Bariatric Surgery vs. no bariatric surgery" ]     ]
  ] [
fhir:description [ fhir:v "Remission of diabetes" ] ;
fhir:variableRole [ fhir:v "outcome" ] ;
fhir:observed [
fhir:reference [ fhir:v "EvidenceVariable/104117" ] ;
fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
fhir:display [ fhir:v "OutcomeVariable: Remission of diabetes" ]     ]
  ] [
fhir:description [ fhir:v "Relative Importance Multiplier" ] ;
fhir:variableRole [ fhir:v "covariate" ] ;
fhir:roleSubtype [
      ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "importance-multiplier" ] ;
fhir:display [ fhir:v "Relative importance multiplier" ]       ] )     ] ;
fhir:observed [
fhir:display [ fhir:v "Relative Importance Multiplier" ]     ]
  ] ) ; # 
  fhir:statistic ( [
    ( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/statistic-model-expression"^^xsd:anyURI ] ;
fhir:value [
a fhir:Expression ;
fhir:description [ fhir:v "risk difference (relative risk x control event rate) multiplied by relative importance multiplier (defined in OutcomeImportance Profile) -- expression is pseudocode to demonstrate the concept" ] ;
fhir:name [ fhir:v "Net effect contribution analysis" ] ;
fhir:expression [ fhir:v "Evidence[id='104121'].statistic[statisticType='Relative Risk'] * Evidence[id='104396'].statistic[statisticType='Proportion'] * $this.relatedArtifact[type=#amended-with].resourceReference(processOutcomeImportance)" ]       ]     ] ) ;
fhir:description [ fhir:v "risk difference 2.15 (95% CI 1.33 to 3.26)" ] ;
fhir:statisticType [
      ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/181513"^^xsd:anyURI ] ;
fhir:code [ fhir:v "STATO:0000424" ] ;
fhir:display [ fhir:v "Risk Difference" ]       ] )     ] ;
fhir:quantity [
fhir:value [ fhir:v "2.15"^^xsd:decimal ]     ] ;
    ( fhir:attributeEstimate [
fhir:description [ fhir:v "95% CI 1.33 to 3.26" ] ;
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/181513"^^xsd:anyURI ] ;
fhir:code [ fhir:v "STATO:0000196" ] ;
fhir:display [ fhir:v "confidence interval" ]         ] )       ] ;
fhir:level [ fhir:v "0.95"^^xsd:decimal ] ;
fhir:range [
fhir:low [
fhir:value [ fhir:v "1.33"^^xsd:decimal ]         ] ;
fhir:high [
fhir:value [ fhir:v "3.26"^^xsd:decimal ]         ]       ]     ] ) ;
    ( fhir:modelCharacteristic [
fhir:code [
        ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/181513"^^xsd:anyURI ] ;
fhir:code [ fhir:v "TBD:net-effect-contribution-analysis" ] ;
fhir:display [ fhir:v "Net effect contribution analysis" ]         ] )       ]     ] )
  ] ) . #