Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide
2.0.0-ballot - ballot
Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
| Active as of 2022-01-10 |
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<div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: Citation 7638</b></p><a name="7638"> </a><a name="hc7638"> </a><a name="7638-en-US"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">version: 32; Last updated: 2023-12-02 12:42:05+0000</p></div><p><b>url</b>: <a href="Citation-7638.html">Citation Citation for FEvIR Evidence 7637: Critically appraised summary of primary outcome of multi-platform RCT of anticoagulation for non-critically ill COVID-19</a></p><p><b>identifier</b>: FEvIR Object Identifier/7638, <a href="http://terminology.hl7.org/6.1.0/NamingSystem-uri.html" title="As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt
This oid is used as an identifier II.root to indicate the the extension is an absolute URI (technically, an IRI). Typically, this is used for OIDs and GUIDs. Note that when this OID is used with OIDs and GUIDs, the II.extension should start with urn:oid or urn:uuid:
Note that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.
This OID may also be used in CD.codeSystem.">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.15.19</p><p><b>version</b>: 2.0.0-ballot</p><p><b>title</b>: Citation for FEvIR Evidence 7637: Critically appraised summary of primary outcome of multi-platform RCT of anticoagulation for non-critically ill COVID-19</p><p><b>status</b>: Active</p><p><b>date</b>: 2022-01-10 13:30:43+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href="http://www.hl7.org/Special/committees/dss">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: </p><div><p>A Evidence Resource to demonstrate complex evidence reporting</p>
</div><h3>UseContexts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><a href="http://terminology.hl7.org/6.1.0/CodeSystem-usage-context-type.html#usage-context-type-program">UsageContextType program</a>: Program</td><td><span title="Codes:">EBMonFHIR/COKA Demonstration</span></td></tr><tr><td style="display: none">*</td><td><a href="http://hl7.org/fhir/R5/codesystem-citation-classification-type.html#citation-classification-type-fevir-platform-use">Citation Classification Type fevir-platform-use</a>: FEvIR Platform Use</td><td><span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier fhir-resource}">Evidence</span></td></tr></table><p><b>jurisdiction</b>: <span title="Codes:{http://unstats.un.org/unsd/methods/m49/m49.htm 001}">World</span></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>
</div><p><b>author</b>: Brian S. Alper: </p><h3>Summaries</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Style</b></td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/citation-summary-style comppub}">Computable Publishing</span></td><td><div><p>Critically appraised summary of primary outcome of multi-platform RCT of anticoagulation for non-critically ill patients with COVID-19 [FHIR Resource]. Contributors: Brian S Alper, Harold Lehmann, Ahmad Sofi-Mahmudi, Joanne Dehnbostel, Ilkka Kunnamo [Authors]; Janice Tufte, Vignesh Subbian, Bhagvan Kommadi, Alfonso Iorio, Muhammad Afzal, Kenneth J Wilkins, Surbhi Shah, Amy Price [Reviewers]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 7637. Published August 05, 2021. Created August 05, 2021. Revised August 25, 2021. Available at: https://fevir.net/resources/Evidence/7637. Computable resource at: https://fevir.net/resources/Evidence/7637.</p>
</div></td></tr></table><h3>Classifications</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/citation-classification-type fevir-platform-use}">FEvIR Platform Use</span></td><td><span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier project-specific}">Project Specific</span></td></tr></table><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: FEvIR Object Identifier/7637</p><p><b>relatedIdentifier</b>: <code>https://doi.org</code>/10.1056/NEJMoa2105911</p><h3>StatusDates</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Activity</b></td><td><b>Actual</b></td><td><b>Period</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/cited-artifact-status-type created}">Created</span></td><td>true</td><td>2021-08-05 --> (ongoing)</td></tr></table><blockquote><p><b>title</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/title-type primary}">Primary title</span>, <span title="Codes:{http://hl7.org/fhir/title-type human-use}">Human use</span></p><p><b>language</b>: <span title="Codes:{urn:ietf:bcp:47 en}">English</span></p><p><b>text</b>: </p><div><p>Critically appraised summary of primary outcome of multi-platform RCT of anticoagulation for non-critically ill patients with COVID-19</p>
</div></blockquote><blockquote><p><b>title</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/title-type earlier-title}">Different text in an earlier version</span></p><p><b>language</b>: <span title="Codes:{urn:ietf:bcp:47 en}">English</span></p><p><b>text</b>: </p><div><p>Critically appraised summary of primary outcome of multi-platform RCT of anticoagulation for non-critically ill COVID-19</p>
</div></blockquote><blockquote><p><b>abstract</b></p><p><b>type</b>: <span title="Codes:{https://fevir.net/resources/CodeSystem/179423 description}">Description</span></p><p><b>language</b>: <span title="Codes:{urn:ietf:bcp:47 en}">English</span></p><p><b>text</b>: </p><div><p>Patients who were hospitalized for COVID-19 and who were not critically ill were randomized in a response-adaptive manner to therapeutic-dose anticoagulation with heparin vs. usual-care pharmacologic thromboprophylaxis. The outcome reported here is the effect on organ support-free days (i.e. days without oxygen delivered by high-flow nasal cannula, noninvasive or invasive mechanical ventilation, or the use of vasopressors or inotropes). The statistical result was a median adjusted odds ratio 1.27 (95% credible interval 1.03 to 1.58), based on 1,740 events among 2,219 participants with known outcome out of 2,244 enrolled participants. The probability of superiority of therapeutic-dose anticoagulation with heparin was 98.6%. The risk of bias in this effect estimate is of extremely serious concern based on a serious concern for confounding covariate bias (confounding difference in calendar time), a very serious concern for performance bias (inadequate blinding of intervention deliverers who may determine the outcome based in part on exposure status), and very serious concern for analysis bias (bias related to selection of the analysis, and early trial termination).</p>
</div></blockquote><blockquote><p><b>abstract</b></p><p><b>type</b>: <span title="Codes:{https://fevir.net/resources/CodeSystem/179423 assertion}">Assertion</span></p><p><b>language</b>: <span title="Codes:{urn:ietf:bcp:47 en}">English</span></p><p><b>text</b>: </p><div><p>It is uncertain whether therapeutic-dose anticoagulation with heparin affects the rate of organ support-free days in hospitalized patients with COVID-19 who are not critically ill.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19 [Journal Article]. Contributors: The ATTACC, ACTIV-4a, and REMAP-CAP Investigators. In: The New England Journal of Medicine, DOI 10.1056/NEJMoa2105911. Published August 04, 2021. Available at: https://doi.org/10.1056/NEJMoa2105911.</p>
</div><h3>Documents</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td><a href="Citation-7636.html">Citation Anticoagulation for COVID-19 Combined RCTs in NEJM</a></td></tr></table><p><b>resourceReference</b>: Identifier: FEvIR Object Identifier/7636</p></blockquote><blockquote><p><b>publicationForm</b></p><h3>PublishedIns</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Title</b></td><td><b>Publisher</b></td><td><b>PublisherLocation</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/published-in-type D019991}">Database</span></td><td>Fast Evidence Interoperability Resources (FEvIR) Platform</td><td>Computable Publishing LLC</td><td>Ipswich, MA, USA</td></tr></table><p><b>articleDate</b>: 2021-08-05</p><p><b>lastRevisionDate</b>: 2021-08-25</p><p><b>language</b>: <span title="Codes:{urn:ietf:bcp:47 en}">English</span></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>
</div></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/artifact-url-classifier computable-resource}">Computable resource</span>, <span title="Codes:{http://hl7.org/fhir/artifact-url-classifier json}">JSON</span></p><p><b>url</b>: <a href="https://fevir.net/resources/Evidence/7637">https://fevir.net/resources/Evidence/7637</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type knowledge-artifact-type}">Knowledge Artifact Type</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier fhir-resource}">FHIR Resource</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier fhir-resource}">fhir-resource</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/fhir-types Evidence}">Evidence</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc7638/contributor0">Practitioner Brian S Alper </a></p><p><b>forenameInitials</b>: BS</p><p><b>affiliation</b>: </p><ul><li>Computable Publishing LLC</li><li>Scientific Knowledge Accelerator Foundation</li><li>COVID-19 Knowledge Accelerator</li></ul><p><b>contributionType</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type conceptualization}">Conceptualization</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type data-curation}">Data curation</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type investigation}">Investigation</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type methodology}">Methodology</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type software}">Software</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type writing-original-draft}">Writing - original draft</span></p><p><b>role</b>: <span title="Codes:{http://hl7.org/fhir/contributor-role author}">Author/Creator</span></p><h3>ContributionInstances</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Time</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{https://fevir.net/resources/CodeSystem/179423 defined-in-text}">Risk of bias assessment</span></td><td>2021-08-05</td></tr></table><p><b>correspondingContact</b>: true</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc7638/contributor1">Practitioner Janice Tufte </a></p><p><b>affiliation</b>: Hassanah Consulting</p><p><b>contributionType</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type writing-review-editing}">Writing - review & editing</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type formal-analysis}">Formal analysis</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type investigation}">Investigation</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type validation}">Validation</span></p><p><b>role</b>: <span title="Codes:{http://hl7.org/fhir/contributor-role reviewer}">Reviewer</span></p><blockquote><p><b>contributionInstance</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-instance-type reviewed}">Reviewed</span></p><p><b>time</b>: 2021-08-05</p></blockquote><blockquote><p><b>contributionInstance</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-instance-type reviewed}">Reviewed</span></p><p><b>time</b>: 2021-08-06</p></blockquote></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc7638/contributor2">Practitioner Harold Lehmann </a></p><p><b>affiliation</b>: Johns Hopkins University</p><p><b>contributionType</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type investigation}">Investigation</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type methodology}">Methodology</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type writing-original-draft}">Writing - original draft</span></p><p><b>role</b>: <span title="Codes:{http://hl7.org/fhir/contributor-role author}">Author/Creator</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc7638/contributor3">Practitioner Ahmad Sofi-Mahmudi </a></p><p><b>affiliation</b>: Cochrane Iran Associate Centre</p><p><b>contributionType</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type investigation}">Investigation</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type methodology}">Methodology</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type validation}">Validation</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type writing-review-editing}">Writing - review & editing</span></p><p><b>role</b>: <span title="Codes:{http://hl7.org/fhir/contributor-role author}">Author/Creator</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc7638/contributor4">Practitioner Joanne Dehnbostel </a></p><p><b>affiliation</b>: Computable Publishing LLC</p><p><b>contributionType</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type project-administration}">Project administration</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type investigation}">Investigation</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type writing-review-editing}">Writing - review & editing</span></p><p><b>role</b>: <span title="Codes:{http://hl7.org/fhir/contributor-role author}">Author/Creator</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc7638/contributor5">Practitioner Vignesh Subbian </a></p><p><b>affiliation</b>: University of Arizona</p><p><b>contributionType</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type formal-analysis}">Formal analysis</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type investigation}">Investigation</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type writing-review-editing}">Writing - review & editing</span></p><p><b>role</b>: <span title="Codes:{http://hl7.org/fhir/contributor-role reviewer}">Reviewer</span></p><h3>ContributionInstances</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Time</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/artifact-contribution-instance-type reviewed}">Reviewed</span></td><td>2021-08-07</td></tr></table></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc7638/contributor6">Practitioner Ilkka Kunnamo </a></p><p><b>affiliation</b>: </p><ul><li>Duodecim Medical Publications Ltd., Finland</li><li>Scientific Knowledge Accelerator Foundation</li></ul><p><b>contributionType</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type writing-review-editing}">Writing - review & editing</span></p><p><b>role</b>: <span title="Codes:{http://hl7.org/fhir/contributor-role author}">Author/Creator</span></p><h3>ContributionInstances</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Time</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/artifact-contribution-instance-type reviewed}">Reviewed</span></td><td>2021-08-09</td></tr></table></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc7638/contributor7">Practitioner Bhagvan Kommadi </a></p><p><b>affiliation</b>: Value Momentum</p><p><b>contributionType</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type methodology}">Methodology</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type validation}">Validation</span></p><p><b>role</b>: <span title="Codes:{http://hl7.org/fhir/contributor-role reviewer}">Reviewer</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc7638/contributor8">Practitioner Alfonso Iorio </a></p><p><b>affiliation</b>: McMaster University</p><p><b>contributionType</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type formal-analysis}">Formal analysis</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type writing-review-editing}">Writing - review & editing</span></p><p><b>role</b>: <span title="Codes:{http://hl7.org/fhir/contributor-role reviewer}">Reviewer</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc7638/contributor9">Practitioner Muhammad Afzal </a></p><p><b>affiliation</b>: Sejong University, Seoul, South Korea</p><p><b>contributionType</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type formal-analysis}">Formal analysis</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type writing-review-editing}">Writing - review & editing</span></p><p><b>role</b>: <span title="Codes:{http://hl7.org/fhir/contributor-role reviewer}">Reviewer</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc7638/contributor10">Practitioner Kenneth J Wilkins </a></p><p><b>affiliation</b>: National Institute of Diabetes & Digestive & Kidney Diseases</p><p><b>contributionType</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type formal-analysis}">Formal analysis</span>, <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type writing-review-editing}">Writing - review & editing</span></p><p><b>role</b>: <span title="Codes:{http://hl7.org/fhir/contributor-role reviewer}">Reviewer</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc7638/contributor11">Practitioner Surbhi Shah </a></p><p><b>affiliation</b>: Mayo Clinic Arizona</p><p><b>contributionType</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type writing-review-editing}">Writing - review & editing</span>, <span title="Codes:{https://fevir.net/resources/CodeSystem/179423 defined-in-text}">Clinical commentary</span></p><p><b>role</b>: <span title="Codes:{http://hl7.org/fhir/contributor-role reviewer}">Reviewer</span></p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc7638/contributor12">Practitioner Amy Price </a></p><p><b>contributionType</b>: <span title="Codes:{http://hl7.org/fhir/artifact-contribution-type writing-review-editing}">Writing - review & editing</span></p><p><b>role</b>: <span title="Codes:{http://hl7.org/fhir/contributor-role reviewer}">Reviewer</span></p></blockquote></blockquote></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor0</b></p><a name="7638/contributor0"> </a><a name="hc7638/contributor0"> </a><a name="7638/contributor0-en-US"> </a><p><b>identifier</b>: <code>https://orcid.org/</code>/0000-0003-4300-4928</p><p><b>name</b>: Brian S Alper </p><p><b>telecom</b>: <a href="mailto:balper@computablepublishing.com">balper@computablepublishing.com</a></p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor1</b></p><a name="7638/contributor1"> </a><a name="hc7638/contributor1"> </a><a name="7638/contributor1-en-US"> </a><p><b>identifier</b>: <code>https://orcid.org/</code>/0000-0002-4346-3238</p><p><b>name</b>: Janice Tufte </p><p><b>telecom</b>: <a href="mailto:hassanahseattle@gmail.com">hassanahseattle@gmail.com</a></p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: 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IG © 2024+ HL7 International / Clinical Decision Support. Package hl7.fhir.uv.ebm#2.0.0-ballot based on FHIR 6.0.0-ballot2. Generated 2024-11-21
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