Evidence Based Medicine on FHIR Implementation Guide
1.0.0-ballot2 - STU 1 ballot International flag

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: 22056152 Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial. - XML Representation

Page standards status: Informative

Raw xml | Download


<Citation xmlns="http://hl7.org/fhir">
  <id value="179626"/>
  <meta>
    <versionId value="10"/>
    <lastUpdated value="2025-03-27T12:27:04.784Z"/>
    <profile
             value="http://hl7.org/fhir/uv/ebm/StructureDefinition/journal-article-citation"/>
  </meta>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: Citation 179626</b></p><a name="179626"> </a><a name="hc179626"> </a><a name="179626-en-US"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">version: 10; Last updated: 2025-03-27 12:27:04+0000</p><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-journal-article-citation.html">JournalArticleCitation</a></p></div><p><b>url</b>: <a href="Citation-179626.html">Citation 22056152 Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial.</a></p><p><b>identifier</b>: FEvIR Object Identifier/https://fevir.net/FOI/179626, <code>https://pubmed.ncbi.nlm.nih.gov</code>/22056152, <a href="http://terminology.hl7.org/6.2.0/NamingSystem-uri.html" title="As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt 

This oid is used as an identifier II.root to indicate the the extension is an absolute URI (technically, an IRI). Typically, this is used for OIDs and GUIDs. Note that when this OID is used with OIDs and GUIDs, the II.extension should start with urn:oid or urn:uuid: 

Note that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.

This OID may also be used in CD.codeSystem.">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.15.21</p><p><b>version</b>: 1.0.0-ballot2</p><p><b>title</b>: 22056152 Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial.</p><p><b>status</b>: Active</p><p><b>date</b>: 2025-04-30 18:55:10+0000</p><p><b>author</b>: Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href="http://www.hl7.org/Special/committees/dss">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: </p><div><p>This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>
</div><h3>UseContexts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><a href="http://hl7.org/fhir/R5/codesystem-citation-classification-type.html#citation-classification-type-fevir-platform-use">Citation Classification Type fevir-platform-use</a>: FEvIR Platform Use</td><td><span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier medline-base}">Medline Base</span></td></tr></table><p><b>jurisdiction</b>: <span title="Codes:{http://unstats.un.org/unsd/methods/m49/m49.htm 001}">World</span></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>
</div><p><b>approvalDate</b>: 2012-01-03</p><p><b>lastReviewDate</b>: 2022-03-21</p><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/citation-classification-type citation-source}">Citation Source</span></p><p><b>classifier</b>: <span title="Codes:">MEDLINE</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/citation-classification-type medline-owner}">MEDLINE Citation Owner</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value NLM}">National Library of Medicine, Index Section</span></p></blockquote><p><b>currentState</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type medline-medline}">Medline Citation Status of Medline</span>, <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-publication-status-ppublish}">PubMed PublicationStatus of ppublish</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-entrez}">PubMed Pubstatus of Entrez</span></p><p><b>period</b>: ?? --&gt; 2011-11-08 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pubmed}">PubMed Pubstatus of Pubmed</span></p><p><b>period</b>: ?? --&gt; 2011-11-08 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-medline}">PubMed Pubstatus of Medline</span></p><p><b>period</b>: ?? --&gt; 2012-01-04 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title="Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pmc-release}">PubMed Pubstatus of PMC release</span></p><p><b>period</b>: ?? --&gt; 2011-12-17</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/22056152, <code>https://www.ncbi.nlm.nih.gov/pmc/</code>/PMC3243932, <code>https://doi.org</code>/10.1016/S0140-6736(11)61095-7, pii/S0140-6736(11)61095-7</p><p><b>relatedIdentifier</b>: ISRCTN24991896, <code>https://clinicaltrials.gov</code>/NCT00002633</p><h3>Titles</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Text</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/title-type primary}">Primary title</span></td><td><div><p>Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial.</p>
</div></td></tr></table><h3>Abstracts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Text</b></td><td><b>Copyright</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/cited-artifact-abstract-type primary-human-use}">Primary human use</span></td><td><div><p><strong>BACKGROUND:</strong> Whether the addition of radiation therapy (RT) improves overall survival in men with locally advanced prostate cancer managed with androgen deprivation therapy (ADT) is unclear. Our aim was to compare outcomes in such patients with locally advanced prostate cancer.
<strong>METHODS:</strong> Patients with: locally advanced (T3 or T4) prostate cancer (n=1057); or organ-confined disease (T2) with either a prostate-specific antigen (PSA) concentration more than 40 ng/mL (n=119) or PSA concentration more than 20 ng/mL and a Gleason score of 8 or higher (n=25), were randomly assigned (done centrally with stratification and dynamic minimisation, not masked) to receive lifelong ADT and RT (65-69 Gy to the prostate and seminal vesicles, 45 Gy to the pelvic nodes). The primary endpoint was overall survival. The results presented here are of an interim analysis planned for when two-thirds of the events for the final analysis were recorded. All efficacy analyses were done by intention to treat and were based on data from all patients. This trial is registered at controlledtrials.com as ISRCTN24991896 and Clinicaltrials.gov as NCT00002633.
<strong>RESULTS:</strong> Between 1995 and 2005, 1205 patients were randomly assigned (602 in the ADT only group and 603 in the ADT and RT group); median follow-up was 6·0 years (IQR 4·4-8·0). At the time of analysis, a total of 320 patients had died, 175 in the ADT only group and 145 in the ADT and RT group. The addition of RT to ADT improved overall survival at 7 years (74%, 95% CI 70-78 vs 66%, 60-70; hazard ratio [HR] 0·77, 95% CI 0·61-0·98, p=0·033). Both toxicity and health-related quality-of-life results showed a small effect of RT on late gastrointestinal toxicity (rectal bleeding grade &gt;3, three patients (0·5%) in the ADT only group, two (0·3%) in the ADT and RT group; diarrhoea grade &gt;3, four patients (0·7%) vs eight (1·3%); urinary toxicity grade &gt;3, 14 patients (2·3%) in both groups).
<strong>INTERPRETATION:</strong> The benefits of combined modality treatment--ADT and RT--should be discussed with all patients with locally advanced prostate cancer.
<strong>FUNDING:</strong> Canadian Cancer Society Research Institute, US National Cancer Institute, and UK Medical Research Council.</p>
</div></td><td><div><p>Copyright © 2011 Elsevier Ltd. All rights reserved.</p>
</div></td></tr></table><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2008;127:2893–2917.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277–300.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Cooperberg MR, Moul JW, Carroll PR. The changing face of prostate cancer. J Clin Oncol. 2005;23:8146–8151.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Eastham JA, Evans CP, Zietman A. What is the optimal management of high risk, clinically localized prostate cancer? Urol Oncol. 2010;28:557–567.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Fellows GJ, Clark PB, Beynon LL. Treatment of advanced localised prostatic cancer by orchiectomy, radiotherapy, or combined treatment. A Medical Research Council Study. Urological Cancer Working Party—Subgroup on Prostatic Cancer. Br J Urol. 1992;70:304–309.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Pocock SJ, Simon R. Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial. Biometrics. 1975;31:103–115.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Aaronson NK, Ahmedzai S, Bergman B. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365–376.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Esper P, Mo F, Chodak G, Sinner M, Cella D, Pienta KJ. Measuring quality of life in men with prostate cancer using the functional assessment of cancer therapy-prostate instrument. Urology. 1997;50:920–928.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Monti AF, Ostinelli A, Frigerio M. An ICRU 50 radiotherapy treatment chart. Radiother Oncol. 1995;35:145–150.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Bolla M, van Tienhoven G, Warde P. External irradiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study. Lancet Oncol. 2010;11:1066–1073.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Bolla M, Gonzalez D, Warde P. Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin. N Engl J Med. 1997;337:295–300.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>citation</b>: </p><div><p>Gray R. A class of K-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat. 1988;16:1141–1154.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>citation</b>: </p><div><p>Lan G, DeMets D. Discrete sequential boundaries for clinical trials. Biometrika. 1983;70:659–663.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Widmark A, Klepp O, Solberg A. Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial. Lancet. 2009;373:301–308.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Cella D, Nichol MB, Eton D, Nelson JB, Mulani P. Estimating clinically meaningful changes for the Functional Assessment of Cancer Therapy—prostate: results from a clinical trial of patients with metastatic hormone-refractory prostate cancer. Value Health. 2009;12:124–129.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Osoba D, Bezjak A, Brundage M, Zee B, Tu D, Pater J. Analysis and interpretation of health-related quality-of-life data from clinical trials: basic approach of The National Cancer Institute of Canada Clinical Trials Group. Eur J Cancer. 2005;41:280–287.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Bolla M, de Reijke TM, van Tienhoven G. Duration of androgen suppression in the treatment of prostate cancer. N Engl J Med. 2009;360:2516–2527.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Horwitz EM, Bae K, Hanks GE. Ten-year follow-up of radiation therapy oncology group protocol 92-02: a phase III trial of the duration of elective androgen deprivation in locally advanced prostate cancer. J Clin Oncol. 2008;26:2497–2504.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Alibhai SM, Duong-Hua M, Cheung AM. Fracture types and risk factors in men with prostate cancer on androgen deprivation therapy: a matched cohort study of 19,079 men. J Urol. 2010;184:918–923.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Alibhai SM, Mohamedali HZ. Cardiac and cognitive effects of androgen deprivation therapy: are they real? Curr Oncol. 2010;17(suppl 2):S55–S64.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Keating NL, O'Malley AJ, Smith MR. Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. J Clin Oncol. 2006;24:4448–4456.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Shahinian VB, Kuo YF, Freeman JL, Goodwin JS. Risk of fracture after androgen deprivation for prostate cancer. N Engl J Med. 2005;352:154–164.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>McMullen KP, Lee WR. A structured literature review to determine the use of the American Society for Therapeutic Radiology and Oncology consensus definition of biochemical failure. Urology. 2003;61:391–396.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Kuban DA, Tucker SL, Dong L. Long-term results of the M D Anderson randomized dose-escalation trial for prostate cancer. Int J Radiat Oncol Biol Phys. 2008;70:67–74.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Zietman AL, DeSilvio ML, Slater JD. Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial. JAMA. 2005;294:1233–1239.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Rosenthal SA, Sandler HM. Treatment strategies for high-risk locally advanced prostate cancer. Nat Rev Urol. 2010;7:31–38.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Cites</p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>citation</b>: </p><div><p>Cooperberg MR, Broering JM, Carroll PR. Time trends and local variation in primary treatment of localized prostate cancer. J Clin Oncol. 2010;28:1117–1123.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Has Comment In</p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D016420}">Comment</span></p><p><b>citation</b>: </p><div><p>Lancet. 2011 Dec 17;378(9809):2056-7. doi: 10.1016/S0140-6736(11)61254-3.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Has Comment In</p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D016420}">Comment</span></p><p><b>citation</b>: </p><div><p>Ann Intern Med. 2012 Apr 17;156(8):JC4-05, JC4-04. doi: 10.7326/0003-4819-156-8-201204170-02005.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Has Comment In</p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D016420}">Comment</span></p><p><b>citation</b>: </p><div><p>J Urol. 2012 Sep;188(3):810. doi: 10.1016/j.juro.2012.05.065.</p>
</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: Has Comment In</p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D016420}">Comment</span></p><p><b>citation</b>: </p><div><p>Eur Urol. 2012 Nov;62(5):932-3. doi: 10.1016/j.eururo.2012.08.041.</p>
</div></blockquote><blockquote><p><b>publicationForm</b></p><blockquote><p><b>publishedIn</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/published-in-type D020492}">Periodical</span></p><p><b>identifier</b>: Electronic ISSN Type/1474-547X, ISOAbbreviation/Lancet, ISSN Linking/0140-6736, Medline Title Abbreviation/Lancet, NLM Unique ID/2985213R</p><p><b>title</b>: Lancet (London, England)</p><p><b>publisherLocation</b>: England</p></blockquote><p><b>citedMedium</b>: <span title="Codes:{http://hl7.org/fhir/cited-medium internet}">Internet</span></p><p><b>volume</b>: 378</p><p><b>issue</b>: 9809</p><p><b>articleDate</b>: 2011-12-17</p><p><b>publicationDateText</b>: 2011-Dec-17</p><p><b>pageString</b>: 2104-11</p></blockquote><blockquote><p><b>publicationForm</b></p><p><b>citedMedium</b>: <span title="Codes:{http://hl7.org/fhir/cited-medium internet-without-issue}">Internet without issue</span></p><p><b>articleDate</b>: 2011-11-02</p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/artifact-url-classifier abstract}">Abstract</span></p><p><b>url</b>: <a href="https://pubmed.ncbi.nlm.nih.gov/22056152/">https://pubmed.ncbi.nlm.nih.gov/22056152/</a></p></blockquote><blockquote><p><b>webLocation</b></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/artifact-url-classifier doi-based}">DOI Based</span></p><p><b>url</b>: <a href="https://doi.org/10.1016/S0140-6736(11)61095-7">https://doi.org/10.1016/S0140-6736(11)61095-7</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type publishing-model}">Publishing Model</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier Print-Electronic}">Print Electronic</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type chemical}">Chemical</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D000726}">Androgen Antagonists</span>, <span title="Codes:{https://www.cas.org/support/documentation/chemical-substances 33515-09-2}, {https://www.nlm.nih.gov/mesh D007987}">Gonadotropin-Releasing Hormone</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">MeSH heading</span></p><p><b>artifactAssessment</b>: <a href="#hc179626/meshHeading0">ArtifactAssessment: artifact[x] = this resource</a></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type publication-type}">Publication type</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D017428}">Clinical Trial, Phase III</span>, <span title="Codes:{https://www.nlm.nih.gov/mesh D016428}">Journal Article</span>, <span title="Codes:{https://www.nlm.nih.gov/mesh D016448}">Multicenter Study</span>, <span title="Codes:{https://www.nlm.nih.gov/mesh D016449}">Randomized Controlled Trial</span>, <span title="Codes:{https://www.nlm.nih.gov/mesh D052061}">Research Support, N.I.H., Extramural</span>, <span title="Codes:{https://www.nlm.nih.gov/mesh D013485}">Research Support, Non-U.S. Gov't</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type knowledge-artifact-type}">Knowledge Artifact Type</span></p><p><b>classifier</b>: <span title="Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}">Journal Article</span></p><p><b>artifactAssessment</b>: Classifier added by Computable Publishing LLC</p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type citation-subset}">Citation subset</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset IM}">IM</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor0">Warde P</a></p><p><b>forenameInitials</b>: P</p><p><b>affiliation</b>: Princess Margaret Hospital, Toronto, Canada. padraig.warde@rmp.uhn.on.ca</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor1">Mason M</a></p><p><b>forenameInitials</b>: M</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor2">Ding K</a></p><p><b>forenameInitials</b>: K</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor3">Kirkbride P</a></p><p><b>forenameInitials</b>: P</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor4">Brundage M</a></p><p><b>forenameInitials</b>: M</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor5">Cowan R</a></p><p><b>forenameInitials</b>: R</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor6">Gospodarowicz M</a></p><p><b>forenameInitials</b>: M</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor7">Sanders K</a></p><p><b>forenameInitials</b>: K</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor8">Kostashuk E</a></p><p><b>forenameInitials</b>: E</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor9">Swanson G</a></p><p><b>forenameInitials</b>: G</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor10">Barber J</a></p><p><b>forenameInitials</b>: J</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor11">Hiltz A</a></p><p><b>forenameInitials</b>: A</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor12">Parmar MK</a></p><p><b>forenameInitials</b>: MK</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor13">Sathya J</a></p><p><b>forenameInitials</b>: J</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor14">Anderson J</a></p><p><b>forenameInitials</b>: J</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor15">Hayter C</a></p><p><b>forenameInitials</b>: C</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor16">Hetherington J</a></p><p><b>forenameInitials</b>: J</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor17">Sydes MR</a></p><p><b>forenameInitials</b>: MR</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor18">Parulekar W</a></p><p><b>forenameInitials</b>: W</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href="#hc179626/contributor19">NCIC CTG PR.3/MRC UK PR07 investigators</a></p></blockquote></blockquote></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor0</b></p><a name="179626/contributor0"> </a><a name="hc179626/contributor0"> </a><a name="179626/contributor0-en-US"> </a><p><b>name</b>: Padraig Warde </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor1</b></p><a name="179626/contributor1"> </a><a name="hc179626/contributor1"> </a><a name="179626/contributor1-en-US"> </a><p><b>name</b>: Malcolm Mason </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor2</b></p><a name="179626/contributor2"> </a><a name="hc179626/contributor2"> </a><a name="179626/contributor2-en-US"> </a><p><b>name</b>: Keyue Ding </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor3</b></p><a name="179626/contributor3"> </a><a name="hc179626/contributor3"> </a><a name="179626/contributor3-en-US"> </a><p><b>name</b>: Peter Kirkbride </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor4</b></p><a name="179626/contributor4"> </a><a name="hc179626/contributor4"> </a><a name="179626/contributor4-en-US"> </a><p><b>name</b>: Michael Brundage </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor5</b></p><a name="179626/contributor5"> </a><a name="hc179626/contributor5"> </a><a name="179626/contributor5-en-US"> </a><p><b>name</b>: Richard Cowan </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor6</b></p><a name="179626/contributor6"> </a><a name="hc179626/contributor6"> </a><a name="179626/contributor6-en-US"> </a><p><b>name</b>: Mary Gospodarowicz </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor7</b></p><a name="179626/contributor7"> </a><a name="hc179626/contributor7"> </a><a name="179626/contributor7-en-US"> </a><p><b>name</b>: Karen Sanders </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor8</b></p><a name="179626/contributor8"> </a><a name="hc179626/contributor8"> </a><a name="179626/contributor8-en-US"> </a><p><b>name</b>: Edmund Kostashuk </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor9</b></p><a name="179626/contributor9"> </a><a name="hc179626/contributor9"> </a><a name="179626/contributor9-en-US"> </a><p><b>name</b>: Greg Swanson </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor10</b></p><a name="179626/contributor10"> </a><a name="hc179626/contributor10"> </a><a name="179626/contributor10-en-US"> </a><p><b>name</b>: Jim Barber </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor11</b></p><a name="179626/contributor11"> </a><a name="hc179626/contributor11"> </a><a name="179626/contributor11-en-US"> </a><p><b>name</b>: Andrea Hiltz </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor12</b></p><a name="179626/contributor12"> </a><a name="hc179626/contributor12"> </a><a name="179626/contributor12-en-US"> </a><p><b>name</b>: Mahesh K B Parmar </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor13</b></p><a name="179626/contributor13"> </a><a name="hc179626/contributor13"> </a><a name="179626/contributor13-en-US"> </a><p><b>name</b>: Jinka Sathya </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor14</b></p><a name="179626/contributor14"> </a><a name="hc179626/contributor14"> </a><a name="179626/contributor14-en-US"> </a><p><b>name</b>: John Anderson </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor15</b></p><a name="179626/contributor15"> </a><a name="hc179626/contributor15"> </a><a name="179626/contributor15-en-US"> </a><p><b>name</b>: Charles Hayter </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor16</b></p><a name="179626/contributor16"> </a><a name="hc179626/contributor16"> </a><a name="179626/contributor16-en-US"> </a><p><b>name</b>: John Hetherington </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor17</b></p><a name="179626/contributor17"> </a><a name="hc179626/contributor17"> </a><a name="179626/contributor17-en-US"> </a><p><b>name</b>: Matthew R Sydes </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Practitioner #contributor18</b></p><a name="179626/contributor18"> </a><a name="hc179626/contributor18"> </a><a name="179626/contributor18-en-US"> </a><p><b>name</b>: Wendy Parulekar </p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: Organization #contributor19</b></p><a name="179626/contributor19"> </a><a name="hc179626/contributor19"> </a><a name="179626/contributor19-en-US"> </a><p><b>name</b>: NCIC CTG PR.3/MRC UK PR07 investigators</p></blockquote><hr/><blockquote><p class="res-header-id"><b>Generated Narrative: ArtifactAssessment #meshHeading0</b></p><a name="179626/meshHeading0"> </a><a name="hc179626/meshHeading0"> </a><a name="179626/meshHeading0-en-US"> </a><p><b>artifact</b>: <a href="#hc179626">Citation 22056152 Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial.</a></p><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D000230}">Adenocarcinoma</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh Q000401}">mortality</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh Q000532}">radiotherapy</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh Q000628}">therapy</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D000369}">Aged, 80 and over</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D000726}">Androgen Antagonists</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh Q000009}">adverse effects</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh Q000627}">therapeutic use</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D003131}">Combined Modality Therapy</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D007987}">Gonadotropin-Releasing Hormone</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh Q000819}">agonists</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D006801}">Humans</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D008297}">Male</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D009919}">Orchiectomy</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D011471}">Prostatic Neoplasms</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh Q000401}">mortality</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh Q000532}">radiotherapy</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh Q000628}">therapy</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49488}">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D011788}">Quality of Life</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D011878}">Radiotherapy</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title="Codes:">qualifier</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh Q000009}">adverse effects</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">is Major topic</span></td><td><span title="Codes:{http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl C49487}">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title="Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title="Codes:{https://www.nlm.nih.gov/mesh D015996}">Survival Rate</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:">qualifier</span></td><td><span title="Codes:">is not a major topic</span></td></tr></table></blockquote></blockquote></div>
  </text>
  <contained>
    <Practitioner>
      <id value="contributor0"/>
      <name>
        <family value="Warde"/>
        <given value="Padraig"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor1"/>
      <name>
        <family value="Mason"/>
        <given value="Malcolm"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor2"/>
      <name>
        <family value="Ding"/>
        <given value="Keyue"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor3"/>
      <name>
        <family value="Kirkbride"/>
        <given value="Peter"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor4"/>
      <name>
        <family value="Brundage"/>
        <given value="Michael"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor5"/>
      <name>
        <family value="Cowan"/>
        <given value="Richard"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor6"/>
      <name>
        <family value="Gospodarowicz"/>
        <given value="Mary"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor7"/>
      <name>
        <family value="Sanders"/>
        <given value="Karen"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor8"/>
      <name>
        <family value="Kostashuk"/>
        <given value="Edmund"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor9"/>
      <name>
        <family value="Swanson"/>
        <given value="Greg"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor10"/>
      <name>
        <family value="Barber"/>
        <given value="Jim"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor11"/>
      <name>
        <family value="Hiltz"/>
        <given value="Andrea"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor12"/>
      <name>
        <family value="Parmar"/>
        <given value="Mahesh K B"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor13"/>
      <name>
        <family value="Sathya"/>
        <given value="Jinka"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor14"/>
      <name>
        <family value="Anderson"/>
        <given value="John"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor15"/>
      <name>
        <family value="Hayter"/>
        <given value="Charles"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor16"/>
      <name>
        <family value="Hetherington"/>
        <given value="John"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor17"/>
      <name>
        <family value="Sydes"/>
        <given value="Matthew R"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Practitioner>
      <id value="contributor18"/>
      <name>
        <family value="Parulekar"/>
        <given value="Wendy"/>
      </name>
    </Practitioner>
  </contained>
  <contained>
    <Organization>
      <id value="contributor19"/>
      <name value="NCIC CTG PR.3/MRC UK PR07 investigators"/>
    </Organization>
  </contained>
  <contained>
    <ArtifactAssessment>
      <id value="meshHeading0"/>
      <artifactReference>
        <reference value="#"/>
        <type value="Citation"/>
      </artifactReference>
      <content>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/cited-artifact-classification-type"/>
            <code value="mesh-heading"/>
            <display value="MeSH heading"/>
          </coding>
          <text value="components (if present) include qualifier codings"/>
        </type>
        <classifier>
          <coding>
            <system value="https://www.nlm.nih.gov/mesh"/>
            <code value="D000230"/>
            <display value="Adenocarcinoma"/>
            <userSelected value="false"/>
          </coding>
        </classifier>
        <freeToShare value="true"/>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <text value="is not a major topic"/>
          </classifier>
        </component>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <coding>
              <system value="https://www.nlm.nih.gov/mesh"/>
              <code value="Q000401"/>
              <display value="mortality"/>
            </coding>
          </classifier>
          <component>
            <type>
              <text value="is Major topic"/>
            </type>
            <classifier>
              <coding>
                <system
                        value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                <code value="C49487"/>
                <display value="No"/>
              </coding>
            </classifier>
          </component>
        </component>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <coding>
              <system value="https://www.nlm.nih.gov/mesh"/>
              <code value="Q000532"/>
              <display value="radiotherapy"/>
            </coding>
          </classifier>
          <component>
            <type>
              <text value="is Major topic"/>
            </type>
            <classifier>
              <coding>
                <system
                        value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                <code value="C49487"/>
                <display value="No"/>
              </coding>
            </classifier>
          </component>
        </component>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <coding>
              <system value="https://www.nlm.nih.gov/mesh"/>
              <code value="Q000628"/>
              <display value="therapy"/>
            </coding>
          </classifier>
          <component>
            <type>
              <text value="is Major topic"/>
            </type>
            <classifier>
              <coding>
                <system
                        value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                <code value="C49488"/>
                <display value="Yes"/>
              </coding>
            </classifier>
          </component>
        </component>
      </content>
      <content>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/cited-artifact-classification-type"/>
            <code value="mesh-heading"/>
            <display value="MeSH heading"/>
          </coding>
          <text value="components (if present) include qualifier codings"/>
        </type>
        <classifier>
          <coding>
            <system value="https://www.nlm.nih.gov/mesh"/>
            <code value="D000369"/>
            <display value="Aged, 80 and over"/>
            <userSelected value="false"/>
          </coding>
        </classifier>
        <freeToShare value="true"/>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <text value="is not a major topic"/>
          </classifier>
        </component>
      </content>
      <content>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/cited-artifact-classification-type"/>
            <code value="mesh-heading"/>
            <display value="MeSH heading"/>
          </coding>
          <text value="components (if present) include qualifier codings"/>
        </type>
        <classifier>
          <coding>
            <system value="https://www.nlm.nih.gov/mesh"/>
            <code value="D000726"/>
            <display value="Androgen Antagonists"/>
            <userSelected value="false"/>
          </coding>
        </classifier>
        <freeToShare value="true"/>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <text value="is not a major topic"/>
          </classifier>
        </component>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <coding>
              <system value="https://www.nlm.nih.gov/mesh"/>
              <code value="Q000009"/>
              <display value="adverse effects"/>
            </coding>
          </classifier>
          <component>
            <type>
              <text value="is Major topic"/>
            </type>
            <classifier>
              <coding>
                <system
                        value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                <code value="C49487"/>
                <display value="No"/>
              </coding>
            </classifier>
          </component>
        </component>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <coding>
              <system value="https://www.nlm.nih.gov/mesh"/>
              <code value="Q000627"/>
              <display value="therapeutic use"/>
            </coding>
          </classifier>
          <component>
            <type>
              <text value="is Major topic"/>
            </type>
            <classifier>
              <coding>
                <system
                        value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                <code value="C49488"/>
                <display value="Yes"/>
              </coding>
            </classifier>
          </component>
        </component>
      </content>
      <content>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/cited-artifact-classification-type"/>
            <code value="mesh-heading"/>
            <display value="MeSH heading"/>
          </coding>
          <text value="components (if present) include qualifier codings"/>
        </type>
        <classifier>
          <coding>
            <system value="https://www.nlm.nih.gov/mesh"/>
            <code value="D003131"/>
            <display value="Combined Modality Therapy"/>
            <userSelected value="false"/>
          </coding>
        </classifier>
        <freeToShare value="true"/>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <text value="is not a major topic"/>
          </classifier>
        </component>
      </content>
      <content>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/cited-artifact-classification-type"/>
            <code value="mesh-heading"/>
            <display value="MeSH heading"/>
          </coding>
          <text value="components (if present) include qualifier codings"/>
        </type>
        <classifier>
          <coding>
            <system value="https://www.nlm.nih.gov/mesh"/>
            <code value="D007987"/>
            <display value="Gonadotropin-Releasing Hormone"/>
            <userSelected value="false"/>
          </coding>
        </classifier>
        <freeToShare value="true"/>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <text value="is not a major topic"/>
          </classifier>
        </component>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <coding>
              <system value="https://www.nlm.nih.gov/mesh"/>
              <code value="Q000819"/>
              <display value="agonists"/>
            </coding>
          </classifier>
          <component>
            <type>
              <text value="is Major topic"/>
            </type>
            <classifier>
              <coding>
                <system
                        value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                <code value="C49488"/>
                <display value="Yes"/>
              </coding>
            </classifier>
          </component>
        </component>
      </content>
      <content>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/cited-artifact-classification-type"/>
            <code value="mesh-heading"/>
            <display value="MeSH heading"/>
          </coding>
          <text value="components (if present) include qualifier codings"/>
        </type>
        <classifier>
          <coding>
            <system value="https://www.nlm.nih.gov/mesh"/>
            <code value="D006801"/>
            <display value="Humans"/>
            <userSelected value="false"/>
          </coding>
        </classifier>
        <freeToShare value="true"/>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <text value="is not a major topic"/>
          </classifier>
        </component>
      </content>
      <content>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/cited-artifact-classification-type"/>
            <code value="mesh-heading"/>
            <display value="MeSH heading"/>
          </coding>
          <text value="components (if present) include qualifier codings"/>
        </type>
        <classifier>
          <coding>
            <system value="https://www.nlm.nih.gov/mesh"/>
            <code value="D008297"/>
            <display value="Male"/>
            <userSelected value="false"/>
          </coding>
        </classifier>
        <freeToShare value="true"/>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <text value="is not a major topic"/>
          </classifier>
        </component>
      </content>
      <content>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/cited-artifact-classification-type"/>
            <code value="mesh-heading"/>
            <display value="MeSH heading"/>
          </coding>
          <text value="components (if present) include qualifier codings"/>
        </type>
        <classifier>
          <coding>
            <system value="https://www.nlm.nih.gov/mesh"/>
            <code value="D009919"/>
            <display value="Orchiectomy"/>
            <userSelected value="false"/>
          </coding>
        </classifier>
        <freeToShare value="true"/>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <text value="is not a major topic"/>
          </classifier>
        </component>
      </content>
      <content>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/cited-artifact-classification-type"/>
            <code value="mesh-heading"/>
            <display value="MeSH heading"/>
          </coding>
          <text value="components (if present) include qualifier codings"/>
        </type>
        <classifier>
          <coding>
            <system value="https://www.nlm.nih.gov/mesh"/>
            <code value="D011471"/>
            <display value="Prostatic Neoplasms"/>
            <userSelected value="false"/>
          </coding>
        </classifier>
        <freeToShare value="true"/>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <text value="is not a major topic"/>
          </classifier>
        </component>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <coding>
              <system value="https://www.nlm.nih.gov/mesh"/>
              <code value="Q000401"/>
              <display value="mortality"/>
            </coding>
          </classifier>
          <component>
            <type>
              <text value="is Major topic"/>
            </type>
            <classifier>
              <coding>
                <system
                        value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                <code value="C49487"/>
                <display value="No"/>
              </coding>
            </classifier>
          </component>
        </component>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <coding>
              <system value="https://www.nlm.nih.gov/mesh"/>
              <code value="Q000532"/>
              <display value="radiotherapy"/>
            </coding>
          </classifier>
          <component>
            <type>
              <text value="is Major topic"/>
            </type>
            <classifier>
              <coding>
                <system
                        value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                <code value="C49487"/>
                <display value="No"/>
              </coding>
            </classifier>
          </component>
        </component>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <coding>
              <system value="https://www.nlm.nih.gov/mesh"/>
              <code value="Q000628"/>
              <display value="therapy"/>
            </coding>
          </classifier>
          <component>
            <type>
              <text value="is Major topic"/>
            </type>
            <classifier>
              <coding>
                <system
                        value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                <code value="C49488"/>
                <display value="Yes"/>
              </coding>
            </classifier>
          </component>
        </component>
      </content>
      <content>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/cited-artifact-classification-type"/>
            <code value="mesh-heading"/>
            <display value="MeSH heading"/>
          </coding>
          <text value="components (if present) include qualifier codings"/>
        </type>
        <classifier>
          <coding>
            <system value="https://www.nlm.nih.gov/mesh"/>
            <code value="D011788"/>
            <display value="Quality of Life"/>
            <userSelected value="false"/>
          </coding>
        </classifier>
        <freeToShare value="true"/>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <text value="is not a major topic"/>
          </classifier>
        </component>
      </content>
      <content>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/cited-artifact-classification-type"/>
            <code value="mesh-heading"/>
            <display value="MeSH heading"/>
          </coding>
          <text value="components (if present) include qualifier codings"/>
        </type>
        <classifier>
          <coding>
            <system value="https://www.nlm.nih.gov/mesh"/>
            <code value="D011878"/>
            <display value="Radiotherapy"/>
            <userSelected value="false"/>
          </coding>
        </classifier>
        <freeToShare value="true"/>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <text value="is not a major topic"/>
          </classifier>
        </component>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <coding>
              <system value="https://www.nlm.nih.gov/mesh"/>
              <code value="Q000009"/>
              <display value="adverse effects"/>
            </coding>
          </classifier>
          <component>
            <type>
              <text value="is Major topic"/>
            </type>
            <classifier>
              <coding>
                <system
                        value="http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"/>
                <code value="C49487"/>
                <display value="No"/>
              </coding>
            </classifier>
          </component>
        </component>
      </content>
      <content>
        <type>
          <coding>
            <system
                    value="http://hl7.org/fhir/cited-artifact-classification-type"/>
            <code value="mesh-heading"/>
            <display value="MeSH heading"/>
          </coding>
          <text value="components (if present) include qualifier codings"/>
        </type>
        <classifier>
          <coding>
            <system value="https://www.nlm.nih.gov/mesh"/>
            <code value="D015996"/>
            <display value="Survival Rate"/>
            <userSelected value="false"/>
          </coding>
        </classifier>
        <freeToShare value="true"/>
        <component>
          <type>
            <text value="qualifier"/>
          </type>
          <classifier>
            <text value="is not a major topic"/>
          </classifier>
        </component>
      </content>
    </ArtifactAssessment>
  </contained>
  <url value="https://fevir.net/resources/Citation/179626"/>
  <identifier>
    <type>
      <coding>
        <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
        <code value="ACSN"/>
        <display value="Accession ID"/>
      </coding>
      <text value="FEvIR Object Identifier"/>
    </type>
    <system value="urn:ietf:rfc:3986"/>
    <value value="https://fevir.net/FOI/179626"/>
    <assigner>
      <display value="Computable Publishing LLC"/>
    </assigner>
  </identifier>
  <identifier>
    <system value="https://pubmed.ncbi.nlm.nih.gov"/>
    <value value="22056152"/>
  </identifier>
  <identifier>
    <system value="urn:ietf:rfc:3986"/>
    <value value="urn:oid:2.16.840.1.113883.4.642.40.44.15.21"/>
  </identifier>
  <version value="1.0.0-ballot2"/>
  <title
         value="22056152 Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial."/>
  <status value="active"/>
  <date value="2025-04-30T18:55:10+00:00"/>
  <author>
    <name value="Computable Publishing®: MEDLINE-to-FEvIR Converter"/>
  </author>
  <publisher value="HL7 International / Clinical Decision Support"/>
  <contact>
    <name value="HL7 International / Clinical Decision Support"/>
    <telecom>
      <system value="url"/>
      <value value="http://www.hl7.org/Special/committees/dss"/>
    </telecom>
  </contact>
  <description
               value="This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide."/>
  <useContext>
    <code>
      <system value="http://hl7.org/fhir/citation-classification-type"/>
      <code value="fevir-platform-use"/>
      <display value="FEvIR Platform Use"/>
    </code>
    <valueCodeableConcept>
      <coding>
        <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
        <code value="medline-base"/>
        <display value="Medline Base"/>
        <userSelected value="false"/>
      </coding>
    </valueCodeableConcept>
  </useContext>
  <jurisdiction>
    <coding>
      <system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/>
      <code value="001"/>
      <display value="World"/>
    </coding>
  </jurisdiction>
  <copyright value="https://creativecommons.org/licenses/by-nc-sa/4.0/"/>
  <approvalDate value="2012-01-03"/>
  <lastReviewDate value="2022-03-21"/>
  <classification>
    <type>
      <coding>
        <system value="http://hl7.org/fhir/citation-classification-type"/>
        <code value="citation-source"/>
        <display value="Citation Source"/>
      </coding>
    </type>
    <classifier>
      <text value="MEDLINE"/>
    </classifier>
  </classification>
  <classification>
    <type>
      <coding>
        <system value="http://hl7.org/fhir/citation-classification-type"/>
        <code value="medline-owner"/>
        <display value="MEDLINE Citation Owner"/>
      </coding>
    </type>
    <classifier>
      <coding>
        <system
                value="https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value"/>
        <code value="NLM"/>
        <display value="National Library of Medicine, Index Section"/>
        <userSelected value="false"/>
      </coding>
    </classifier>
  </classification>
  <currentState>
    <coding>
      <system value="http://hl7.org/fhir/citation-status-type"/>
      <code value="medline-medline"/>
      <display value="Medline Citation Status of Medline"/>
    </coding>
  </currentState>
  <currentState>
    <coding>
      <system value="http://hl7.org/fhir/citation-status-type"/>
      <code value="pubmed-publication-status-ppublish"/>
      <display value="PubMed PublicationStatus of ppublish"/>
    </coding>
  </currentState>
  <statusDate>
    <activity>
      <coding>
        <system value="http://hl7.org/fhir/citation-status-type"/>
        <code value="pubmed-pubstatus-entrez"/>
        <display value="PubMed Pubstatus of Entrez"/>
      </coding>
    </activity>
    <period>
      <end value="2011-11-08T06:00:00.000Z"/>
    </period>
  </statusDate>
  <statusDate>
    <activity>
      <coding>
        <system value="http://hl7.org/fhir/citation-status-type"/>
        <code value="pubmed-pubstatus-pubmed"/>
        <display value="PubMed Pubstatus of Pubmed"/>
      </coding>
    </activity>
    <period>
      <end value="2011-11-08T06:00:00.000Z"/>
    </period>
  </statusDate>
  <statusDate>
    <activity>
      <coding>
        <system value="http://hl7.org/fhir/citation-status-type"/>
        <code value="pubmed-pubstatus-medline"/>
        <display value="PubMed Pubstatus of Medline"/>
      </coding>
    </activity>
    <period>
      <end value="2012-01-04T06:00:00.000Z"/>
    </period>
  </statusDate>
  <statusDate>
    <activity>
      <coding>
        <system value="http://hl7.org/fhir/citation-status-type"/>
        <code value="pubmed-pubstatus-pmc-release"/>
        <display value="PubMed Pubstatus of PMC release"/>
      </coding>
    </activity>
    <period>
      <end value="2011-12-17"/>
    </period>
  </statusDate>
  <citedArtifact>
    <identifier>
      <system value="https://pubmed.ncbi.nlm.nih.gov"/>
      <value value="22056152"/>
    </identifier>
    <identifier>
      <system value="https://www.ncbi.nlm.nih.gov/pmc/"/>
      <value value="PMC3243932"/>
    </identifier>
    <identifier>
      <system value="https://doi.org"/>
      <value value="10.1016/S0140-6736(11)61095-7"/>
    </identifier>
    <identifier>
      <type>
        <coding>
          <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
          <code value="ACSN"/>
          <display value="Accession ID"/>
        </coding>
        <text value="pii"/>
      </type>
      <value value="S0140-6736(11)61095-7"/>
    </identifier>
    <relatedIdentifier>
      <value value="ISRCTN24991896"/>
      <assigner>
        <display value="ISRCTN"/>
      </assigner>
    </relatedIdentifier>
    <relatedIdentifier>
      <system value="https://clinicaltrials.gov"/>
      <value value="NCT00002633"/>
      <assigner>
        <display value="ClinicalTrials.gov"/>
      </assigner>
    </relatedIdentifier>
    <title>
      <type>
        <coding>
          <system value="http://hl7.org/fhir/title-type"/>
          <code value="primary"/>
          <display value="Primary title"/>
        </coding>
      </type>
      <text
            value="Combined androgen deprivation therapy and radiation therapy for locally advanced prostate cancer: a randomised, phase 3 trial."/>
    </title>
    <abstract>
      <type>
        <coding>
          <system value="http://hl7.org/fhir/cited-artifact-abstract-type"/>
          <code value="primary-human-use"/>
          <display value="Primary human use"/>
        </coding>
      </type>
      <text
            value="**BACKGROUND:** Whether the addition of radiation therapy (RT) improves overall survival in men with locally advanced prostate cancer managed with androgen deprivation therapy (ADT) is unclear. Our aim was to compare outcomes in such patients with locally advanced prostate cancer.
**METHODS:** Patients with: locally advanced (T3 or T4) prostate cancer (n=1057); or organ-confined disease (T2) with either a prostate-specific antigen (PSA) concentration more than 40 ng/mL (n=119) or PSA concentration more than 20 ng/mL and a Gleason score of 8 or higher (n=25), were randomly assigned (done centrally with stratification and dynamic minimisation, not masked) to receive lifelong ADT and RT (65-69 Gy to the prostate and seminal vesicles, 45 Gy to the pelvic nodes). The primary endpoint was overall survival. The results presented here are of an interim analysis planned for when two-thirds of the events for the final analysis were recorded. All efficacy analyses were done by intention to treat and were based on data from all patients. This trial is registered at controlledtrials.com as ISRCTN24991896 and Clinicaltrials.gov as NCT00002633.
**RESULTS:** Between 1995 and 2005, 1205 patients were randomly assigned (602 in the ADT only group and 603 in the ADT and RT group); median follow-up was 6·0 years (IQR 4·4-8·0). At the time of analysis, a total of 320 patients had died, 175 in the ADT only group and 145 in the ADT and RT group. The addition of RT to ADT improved overall survival at 7 years (74%, 95% CI 70-78 vs 66%, 60-70; hazard ratio [HR] 0·77, 95% CI 0·61-0·98, p=0·033). Both toxicity and health-related quality-of-life results showed a small effect of RT on late gastrointestinal toxicity (rectal bleeding grade &amp;gt;3, three patients (0·5%) in the ADT only group, two (0·3%) in the ADT and RT group; diarrhoea grade &amp;gt;3, four patients (0·7%) vs eight (1·3%); urinary toxicity grade &amp;gt;3, 14 patients (2·3%) in both groups).
**INTERPRETATION:** The benefits of combined modality treatment--ADT and RT--should be discussed with all patients with locally advanced prostate cancer.
**FUNDING:** Canadian Cancer Society Research Institute, US National Cancer Institute, and UK Medical Research Council."/>
      <copyright value="Copyright © 2011 Elsevier Ltd. All rights reserved."/>
    </abstract>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2008;127:2893–2917."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277–300."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Cooperberg MR, Moul JW, Carroll PR. The changing face of prostate cancer. J Clin Oncol. 2005;23:8146–8151."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Eastham JA, Evans CP, Zietman A. What is the optimal management of high risk, clinically localized prostate cancer? Urol Oncol. 2010;28:557–567."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Fellows GJ, Clark PB, Beynon LL. Treatment of advanced localised prostatic cancer by orchiectomy, radiotherapy, or combined treatment. A Medical Research Council Study. Urological Cancer Working Party—Subgroup on Prostatic Cancer. Br J Urol. 1992;70:304–309."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Pocock SJ, Simon R. Sequential treatment assignment with balancing for prognostic factors in the controlled clinical trial. Biometrics. 1975;31:103–115."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Aaronson NK, Ahmedzai S, Bergman B. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85:365–376."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Esper P, Mo F, Chodak G, Sinner M, Cella D, Pienta KJ. Measuring quality of life in men with prostate cancer using the functional assessment of cancer therapy-prostate instrument. Urology. 1997;50:920–928."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Monti AF, Ostinelli A, Frigerio M. An ICRU 50 radiotherapy treatment chart. Radiother Oncol. 1995;35:145–150."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Bolla M, van Tienhoven G, Warde P. External irradiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study. Lancet Oncol. 2010;11:1066–1073."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Bolla M, Gonzalez D, Warde P. Improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin. N Engl J Med. 1997;337:295–300."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <citation
                value="Gray R. A class of K-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat. 1988;16:1141–1154."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <citation
                value="Lan G, DeMets D. Discrete sequential boundaries for clinical trials. Biometrika. 1983;70:659–663."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Widmark A, Klepp O, Solberg A. Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial. Lancet. 2009;373:301–308."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Cella D, Nichol MB, Eton D, Nelson JB, Mulani P. Estimating clinically meaningful changes for the Functional Assessment of Cancer Therapy—prostate: results from a clinical trial of patients with metastatic hormone-refractory prostate cancer. Value Health. 2009;12:124–129."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Osoba D, Bezjak A, Brundage M, Zee B, Tu D, Pater J. Analysis and interpretation of health-related quality-of-life data from clinical trials: basic approach of The National Cancer Institute of Canada Clinical Trials Group. Eur J Cancer. 2005;41:280–287."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Bolla M, de Reijke TM, van Tienhoven G. Duration of androgen suppression in the treatment of prostate cancer. N Engl J Med. 2009;360:2516–2527."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Horwitz EM, Bae K, Hanks GE. Ten-year follow-up of radiation therapy oncology group protocol 92-02: a phase III trial of the duration of elective androgen deprivation in locally advanced prostate cancer. J Clin Oncol. 2008;26:2497–2504."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Alibhai SM, Duong-Hua M, Cheung AM. Fracture types and risk factors in men with prostate cancer on androgen deprivation therapy: a matched cohort study of 19,079 men. J Urol. 2010;184:918–923."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Alibhai SM, Mohamedali HZ. Cardiac and cognitive effects of androgen deprivation therapy: are they real? Curr Oncol. 2010;17(suppl 2):S55–S64."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Keating NL, O'Malley AJ, Smith MR. Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer. J Clin Oncol. 2006;24:4448–4456."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Shahinian VB, Kuo YF, Freeman JL, Goodwin JS. Risk of fracture after androgen deprivation for prostate cancer. N Engl J Med. 2005;352:154–164."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="McMullen KP, Lee WR. A structured literature review to determine the use of the American Society for Therapeutic Radiology and Oncology consensus definition of biochemical failure. Urology. 2003;61:391–396."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Kuban DA, Tucker SL, Dong L. Long-term results of the M D Anderson randomized dose-escalation trial for prostate cancer. Int J Radiat Oncol Biol Phys. 2008;70:67–74."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Zietman AL, DeSilvio ML, Slater JD. Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial. JAMA. 2005;294:1233–1239."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Rosenthal SA, Sandler HM. Treatment strategies for high-risk locally advanced prostate cancer. Nat Rev Urol. 2010;7:31–38."/>
    </relatesTo>
    <relatesTo>
      <type value="cites"/>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
        </coding>
      </classifier>
      <citation
                value="Cooperberg MR, Broering JM, Carroll PR. Time trends and local variation in primary treatment of localized prostate cancer. J Clin Oncol. 2010;28:1117–1123."/>
    </relatesTo>
    <relatesTo>
      <type value="comment-in"/>
      <classifier>
        <coding>
          <system value="https://www.nlm.nih.gov/mesh"/>
          <code value="D016420"/>
          <display value="Comment"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
      <citation
                value="Lancet. 2011 Dec 17;378(9809):2056-7. doi: 10.1016/S0140-6736(11)61254-3."/>
    </relatesTo>
    <relatesTo>
      <type value="comment-in"/>
      <classifier>
        <coding>
          <system value="https://www.nlm.nih.gov/mesh"/>
          <code value="D016420"/>
          <display value="Comment"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
      <citation
                value="Ann Intern Med. 2012 Apr 17;156(8):JC4-05, JC4-04. doi: 10.7326/0003-4819-156-8-201204170-02005."/>
    </relatesTo>
    <relatesTo>
      <type value="comment-in"/>
      <classifier>
        <coding>
          <system value="https://www.nlm.nih.gov/mesh"/>
          <code value="D016420"/>
          <display value="Comment"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
      <citation
                value="J Urol. 2012 Sep;188(3):810. doi: 10.1016/j.juro.2012.05.065."/>
    </relatesTo>
    <relatesTo>
      <type value="comment-in"/>
      <classifier>
        <coding>
          <system value="https://www.nlm.nih.gov/mesh"/>
          <code value="D016420"/>
          <display value="Comment"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
      <citation
                value="Eur Urol. 2012 Nov;62(5):932-3. doi: 10.1016/j.eururo.2012.08.041."/>
    </relatesTo>
    <publicationForm>
      <publishedIn>
        <type>
          <coding>
            <system value="http://hl7.org/fhir/published-in-type"/>
            <code value="D020492"/>
            <display value="Periodical"/>
          </coding>
        </type>
        <identifier>
          <type>
            <coding>
              <system
                      value="https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#issn"/>
              <code value="Electronic"/>
              <display value="Electronic"/>
            </coding>
            <text value="Electronic ISSN Type"/>
          </type>
          <system value="https://portal.issn.org"/>
          <value value="1474-547X"/>
        </identifier>
        <identifier>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="XX"/>
              <display value="Organization identifier"/>
            </coding>
            <text value="ISOAbbreviation"/>
          </type>
          <system
                  value="https://www.issn.org/services/online-services/access-to-the-ltwa/"/>
          <value value="Lancet"/>
        </identifier>
        <identifier>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="XX"/>
              <display value="Organization identifier"/>
            </coding>
            <text value="ISSN Linking"/>
          </type>
          <system
                  value="https://www.issn.org/understanding-the-issn/assignment-rules/the-issn-l-for-publications-on-multiple-media/"/>
          <value value="0140-6736"/>
        </identifier>
        <identifier>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="XX"/>
              <display value="Organization identifier"/>
            </coding>
            <text value="Medline Title Abbreviation"/>
          </type>
          <system
                  value="https://www.nlm.nih.gov/tsd/cataloging/contructitleabbre.html"/>
          <value value="Lancet"/>
        </identifier>
        <identifier>
          <type>
            <coding>
              <system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
              <code value="XX"/>
              <display value="Organization identifier"/>
            </coding>
            <text value="NLM Unique ID"/>
          </type>
          <system
                  value="https://locatorplus.gov/cgi-bin/Pwebrecon.cgi?DB=local"/>
          <value value="2985213R"/>
        </identifier>
        <title value="Lancet (London, England)"/>
        <publisherLocation value="England"/>
      </publishedIn>
      <citedMedium>
        <coding>
          <system value="http://hl7.org/fhir/cited-medium"/>
          <code value="internet"/>
          <display value="Internet"/>
        </coding>
      </citedMedium>
      <volume value="378"/>
      <issue value="9809"/>
      <articleDate value="2011-12-17"/>
      <publicationDateText value="2011-Dec-17"/>
      <pageString value="2104-11"/>
    </publicationForm>
    <publicationForm>
      <citedMedium>
        <coding>
          <system value="http://hl7.org/fhir/cited-medium"/>
          <code value="internet-without-issue"/>
          <display value="Internet without issue"/>
        </coding>
      </citedMedium>
      <articleDate value="2011-11-02"/>
    </publicationForm>
    <webLocation>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/artifact-url-classifier"/>
          <code value="abstract"/>
          <display value="Abstract"/>
        </coding>
      </classifier>
      <url value="https://pubmed.ncbi.nlm.nih.gov/22056152/"/>
    </webLocation>
    <webLocation>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/artifact-url-classifier"/>
          <code value="doi-based"/>
          <display value="DOI Based"/>
        </coding>
      </classifier>
      <url value="https://doi.org/10.1016/S0140-6736(11)61095-7"/>
    </webLocation>
    <classification>
      <type>
        <coding>
          <system
                  value="http://hl7.org/fhir/cited-artifact-classification-type"/>
          <code value="publishing-model"/>
          <display value="Publishing Model"/>
          <userSelected value="false"/>
        </coding>
      </type>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="Print-Electronic"/>
          <display value="Print Electronic"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
    </classification>
    <classification>
      <type>
        <coding>
          <system
                  value="http://hl7.org/fhir/cited-artifact-classification-type"/>
          <code value="chemical"/>
          <display value="Chemical"/>
          <userSelected value="false"/>
        </coding>
      </type>
      <classifier>
        <coding>
          <system value="https://www.nlm.nih.gov/mesh"/>
          <code value="D000726"/>
          <display value="Androgen Antagonists"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
      <classifier>
        <coding>
          <system
                  value="https://www.cas.org/support/documentation/chemical-substances"/>
          <code value="33515-09-2"/>
          <userSelected value="false"/>
        </coding>
        <coding>
          <system value="https://www.nlm.nih.gov/mesh"/>
          <code value="D007987"/>
          <display value="Gonadotropin-Releasing Hormone"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
    </classification>
    <classification>
      <type>
        <coding>
          <system
                  value="http://hl7.org/fhir/cited-artifact-classification-type"/>
          <code value="mesh-heading"/>
          <display value="MeSH heading"/>
        </coding>
      </type>
      <artifactAssessment>
        <reference value="#meshHeading0"/>
        <type value="ArtifactAssessment"/>
      </artifactAssessment>
    </classification>
    <classification>
      <type>
        <coding>
          <system
                  value="http://hl7.org/fhir/cited-artifact-classification-type"/>
          <code value="publication-type"/>
          <display value="Publication type"/>
        </coding>
      </type>
      <classifier>
        <coding>
          <system value="https://www.nlm.nih.gov/mesh"/>
          <code value="D017428"/>
          <display value="Clinical Trial, Phase III"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
      <classifier>
        <coding>
          <system value="https://www.nlm.nih.gov/mesh"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
      <classifier>
        <coding>
          <system value="https://www.nlm.nih.gov/mesh"/>
          <code value="D016448"/>
          <display value="Multicenter Study"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
      <classifier>
        <coding>
          <system value="https://www.nlm.nih.gov/mesh"/>
          <code value="D016449"/>
          <display value="Randomized Controlled Trial"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
      <classifier>
        <coding>
          <system value="https://www.nlm.nih.gov/mesh"/>
          <code value="D052061"/>
          <display value="Research Support, N.I.H., Extramural"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
      <classifier>
        <coding>
          <system value="https://www.nlm.nih.gov/mesh"/>
          <code value="D013485"/>
          <display value="Research Support, Non-U.S. Gov't"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
    </classification>
    <classification>
      <type>
        <coding>
          <system
                  value="http://hl7.org/fhir/cited-artifact-classification-type"/>
          <code value="knowledge-artifact-type"/>
          <display value="Knowledge Artifact Type"/>
          <userSelected value="false"/>
        </coding>
      </type>
      <classifier>
        <coding>
          <system value="http://hl7.org/fhir/citation-artifact-classifier"/>
          <code value="D016428"/>
          <display value="Journal Article"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
      <artifactAssessment>
        <display value="Classifier added by Computable Publishing LLC"/>
      </artifactAssessment>
    </classification>
    <classification>
      <type>
        <coding>
          <system
                  value="http://hl7.org/fhir/cited-artifact-classification-type"/>
          <code value="citation-subset"/>
          <display value="Citation subset"/>
          <userSelected value="false"/>
        </coding>
      </type>
      <classifier>
        <coding>
          <system
                  value="https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset"/>
          <code value="IM"/>
          <display value="IM"/>
          <userSelected value="false"/>
        </coding>
      </classifier>
    </classification>
    <contributorship>
      <complete value="true"/>
      <entry>
        <contributor>
          <reference value="#contributor0"/>
          <type value="Practitioner"/>
          <display value="Warde P"/>
        </contributor>
        <forenameInitials value="P"/>
        <affiliation>
          <display
                   value="Princess Margaret Hospital, Toronto, Canada. padraig.warde@rmp.uhn.on.ca"/>
        </affiliation>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor1"/>
          <type value="Practitioner"/>
          <display value="Mason M"/>
        </contributor>
        <forenameInitials value="M"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor2"/>
          <type value="Practitioner"/>
          <display value="Ding K"/>
        </contributor>
        <forenameInitials value="K"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor3"/>
          <type value="Practitioner"/>
          <display value="Kirkbride P"/>
        </contributor>
        <forenameInitials value="P"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor4"/>
          <type value="Practitioner"/>
          <display value="Brundage M"/>
        </contributor>
        <forenameInitials value="M"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor5"/>
          <type value="Practitioner"/>
          <display value="Cowan R"/>
        </contributor>
        <forenameInitials value="R"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor6"/>
          <type value="Practitioner"/>
          <display value="Gospodarowicz M"/>
        </contributor>
        <forenameInitials value="M"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor7"/>
          <type value="Practitioner"/>
          <display value="Sanders K"/>
        </contributor>
        <forenameInitials value="K"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor8"/>
          <type value="Practitioner"/>
          <display value="Kostashuk E"/>
        </contributor>
        <forenameInitials value="E"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor9"/>
          <type value="Practitioner"/>
          <display value="Swanson G"/>
        </contributor>
        <forenameInitials value="G"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor10"/>
          <type value="Practitioner"/>
          <display value="Barber J"/>
        </contributor>
        <forenameInitials value="J"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor11"/>
          <type value="Practitioner"/>
          <display value="Hiltz A"/>
        </contributor>
        <forenameInitials value="A"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor12"/>
          <type value="Practitioner"/>
          <display value="Parmar MK"/>
        </contributor>
        <forenameInitials value="MK"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor13"/>
          <type value="Practitioner"/>
          <display value="Sathya J"/>
        </contributor>
        <forenameInitials value="J"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor14"/>
          <type value="Practitioner"/>
          <display value="Anderson J"/>
        </contributor>
        <forenameInitials value="J"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor15"/>
          <type value="Practitioner"/>
          <display value="Hayter C"/>
        </contributor>
        <forenameInitials value="C"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor16"/>
          <type value="Practitioner"/>
          <display value="Hetherington J"/>
        </contributor>
        <forenameInitials value="J"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor17"/>
          <type value="Practitioner"/>
          <display value="Sydes MR"/>
        </contributor>
        <forenameInitials value="MR"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor18"/>
          <type value="Practitioner"/>
          <display value="Parulekar W"/>
        </contributor>
        <forenameInitials value="W"/>
      </entry>
      <entry>
        <contributor>
          <reference value="#contributor19"/>
          <type value="Organization"/>
          <display value="NCIC CTG PR.3/MRC UK PR07 investigators"/>
        </contributor>
      </entry>
    </contributorship>
  </citedArtifact>
</Citation>