27308831 Efficacy and Safety of Combined Androgen Deprivation Therapy (ADT) and Docetaxel Compared with ADT Alone for Metastatic Hormone-Naive Prostate Cancer: A Systematic Review and Meta-Analysis. - TTL Representation - Evidence Based Medicine on FHIR Implementation Guide v2.0.0-ballot

Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions
: 27308831 Efficacy and Safety of Combined Androgen Deprivation Therapy (ADT) and Docetaxel Compared with ADT Alone for Metastatic Hormone-Naive Prostate Cancer: A Systematic Review and Meta-Analysis. - TTL Representation

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@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

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fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Citation 179613</b></p><a name=\"179613\"> </a><a name=\"hc179613\"> </a><a name=\"179613-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 9; Last updated: 2024-11-22 19:27:51+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-journal-article-citation.html\">JournalArticleCitation</a></p></div><p><b>url</b>: <a href=\"Citation-179613.html\">Citation 27308831 Efficacy and Safety of Combined Androgen Deprivation Therapy (ADT) and Docetaxel Compared with ADT Alone for Metastatic Hormone-Naive Prostate Cancer: A Systematic Review and Meta-Analysis.</a></p><p><b>identifier</b>: FEvIR Object Identifier/https://fevir.net/FOI/179613, <code>https://pubmed.ncbi.nlm.nih.gov</code>/27308831, <a href=\"http://terminology.hl7.org/6.1.0/NamingSystem-uri.html\" title=\"As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt \r\n\r\nThis oid is used as an identifier II.root to indicate the the extension is an absolute URI (technically, an IRI). Typically, this is used for OIDs and GUIDs. Note that when this OID is used with OIDs and GUIDs, the II.extension should start with urn:oid or urn:uuid: \r\n\r\nNote that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.\r\n\r\nThis OID may also be used in CD.codeSystem.\">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.15.27</p><p><b>version</b>: 2.0.0-ballot</p><p><b>title</b>: 27308831 Efficacy and Safety of Combined Androgen Deprivation Therapy (ADT) and Docetaxel Compared with ADT Alone for Metastatic Hormone-Naive Prostate Cancer: A Systematic Review and Meta-Analysis.</p><p><b>status</b>: Active</p><p><b>date</b>: 2024-12-19 14:29:51+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>description</b>: </p><div><p>This Citation Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"http://hl7.org/fhir/R5/codesystem-citation-classification-type.html#citation-classification-type-fevir-platform-use\">Citation Classification Type fevir-platform-use</a>: FEvIR Platform Use</td><td><span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier medline-base}\">Medline Base</span></td></tr></table><p><b>jurisdiction</b>: <span title=\"Codes:{http://unstats.un.org/unsd/methods/m49/m49.htm 001}\">World</span></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>approvalDate</b>: 2017-07-26</p><p><b>lastReviewDate</b>: 2024-03-27</p><p><b>author</b>: Computable Publishing®: MEDLINE-to-FEvIR Converter: </p><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-classification-type citation-source}\">Citation Source</span></p><p><b>classifier</b>: <span title=\"Codes:\">MEDLINE</span></p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-classification-type medline-owner}\">MEDLINE Citation Owner</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#owner_value NLM}\">National Library of Medicine, Index Section</span></p></blockquote><p><b>currentState</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type medline-medline}\">Medline Citation Status of Medline</span>, <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-publication-status-epublish}\">PubMed PublicationStatus of epublish</span></p><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-received}\">PubMed Pubstatus of Received</span></p><p><b>period</b>: ?? --&gt; 2016-04-01</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-accepted}\">PubMed Pubstatus of Accepted</span></p><p><b>period</b>: ?? --&gt; 2016-06-02</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-entrez}\">PubMed Pubstatus of Entrez</span></p><p><b>period</b>: ?? --&gt; 2016-06-17 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pubmed}\">PubMed Pubstatus of Pubmed</span></p><p><b>period</b>: ?? --&gt; 2016-06-17 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-medline}\">PubMed Pubstatus of Medline</span></p><p><b>period</b>: ?? --&gt; 2017-07-27 06:00:00+0000</p></blockquote><blockquote><p><b>statusDate</b></p><p><b>activity</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-status-type pubmed-pubstatus-pmc-release}\">PubMed Pubstatus of PMC release</span></p><p><b>period</b>: ?? --&gt; 2016-06-16</p></blockquote><blockquote><p><b>citedArtifact</b></p><p><b>identifier</b>: <code>https://pubmed.ncbi.nlm.nih.gov</code>/27308831, <code>https://www.ncbi.nlm.nih.gov/pmc/</code>/PMC4911003, <code>https://doi.org</code>/10.1371/journal.pone.0157660, pii/PONE-D-16-10077</p><h3>Titles</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Language</b></td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/title-type primary}\">Primary title</span></td><td><span title=\"Codes:{urn:ietf:bcp:47 en}\">English</span></td><td><div><p>Efficacy and Safety of Combined Androgen Deprivation Therapy (ADT) and Docetaxel Compared with ADT Alone for Metastatic Hormone-Naive Prostate Cancer: A Systematic Review and Meta-Analysis.</p>\n</div></td></tr></table><h3>Abstracts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Text</b></td></tr><tr><td style=\"display: none\">*</td><td><div><p><strong>OBJECTIVE:</strong> Prostate cancer is the most common nonskin cancer and second most common cause of cancer mortality in older men in the United States (USA) and Western Europe. Androgen-deprivation therapy alone (ADT) remains the first line of treatment in most cases, for metastatic disease. We performed a systematic review and meta-analysis of all randomized controlled trials (RCT) that compared the efficacy and adverse events profile of a chemohormonal therapy (ADT ± docetaxel) for metastatic hormone-naive prostate cancer (mHNPC).\n<strong>METHODS:</strong> Several databases were searched, including MEDLINE, EMBASE, LILACS, and CENTRAL. The primary endpoint was overall survival. Data extracted from the studies were combined by using the hazard ratio (HR) or risk ratio (RR) with their corresponding 95% confidence intervals (95% CI).\n<strong>RESULTS:</strong> The final analysis included 3 trials comprising 2,264 patients (mHNPC). Patients who received the chemohormonal therapy had a longer clinical progression-free survival interval (HR = 0.64; 95% CI: 0.55 to 0.75; p&lt;0.00001), and no heterogeneity (Chi2 = 0.64; df = 1 [p = 0.42]; I2 = 0%). The biochemical progression-free survival (bPFS) also was higher in patients treated with ADT plus docetaxel (HR = 0.63; 95% CI: 0.57 to 0.69; p&lt;0.00001), also with no heterogeneity noted (Chi2 = 0.48; df = 2 [p = 0.79]; I2 = 0%). Finally, the combination of ADT with docetaxel showed a superior overall survival (OS) compared with ADT alone (HR = 0.73; 95% CI: 0.64 to 0.84; p&lt;0.0001), with moderate heterogeneity (Chi2 = 3.84; df = 2 [p = 0.15]; I2 = 48%). A random-effects model analysis was performed, and the results remained favorable to the use of ADT plus docetaxel (HR = 0.73; 95% CI: 0.60 to 0.89; p = 0.002). In the final combined analysis of the high-volume disease patients, the use of the combination therapy also favored an increased overall survival (HR = 0.67; 95% CI: 0.54 to 0.83; p = 0.0003). Regarding adverse events and severe toxicity (grade ≥3), the group receiving the combined therapy had higher rates of neutropenia, febrile neutropenia and fatigue.\n<strong>CONCLUSION:</strong> The combination of ADT with docetaxel improved the clinical progression-free survival, bPFS and OS of patients with mHNPC. A superior OS was seen especially for patients with metastatic and high-volume disease. This contemporary combination therapy may now be offered as a first-line treatment for selected patients.</p>\n</div></td></tr></table><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>http://clinicaltrials.gov/ct2/show/NCT00514540.</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Beltran H, Beer TM, Carducci MA, de Bono J, Gleave M, Hussain M, et al. New therapies for castration-resistant prostate cancer: efficacy and safety. Eur Urol. 2011;60(2):279–90. Epub 2011/05/20. doi: S0302-2838(11)00477-5 [pii] 10.1016/j.eururo.2011.04.038 .</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/21592649/\">https://pubmed.ncbi.nlm.nih.gov/21592649/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/21592649</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Botrel TE, Clark O, Pompeo AC, Bretas FF, Sadi MV, Ferreira U, et al. Immunotherapy with Sipuleucel-T (APC8015) in patients with metastatic castration-refractory prostate cancer (mCRPC): a systematic review and meta-analysis. International braz j urol: official journal of the Brazilian Society of Urology. 2012;38(6):717–27. Epub 2013/01/11. .</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/23302410/\">https://pubmed.ncbi.nlm.nih.gov/23302410/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/23302410</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Loblaw DA, Virgo KS, Nam R, Somerfield MR, Ben-Josef E, Mendelson DS, et al. Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guideline. J Clin Oncol. 2007;25(12):1596–605. Epub 2007/04/04. doi: JCO.2006.10.1949 [pii] 10.1200/JCO.2006.10.1949 .</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/17404365/\">https://pubmed.ncbi.nlm.nih.gov/17404365/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/17404365</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Heidenreich A, Bastian PJ, Bellmunt J, Bolla M, Joniau S, van der Kwast T, et al. EAU guidelines on prostate cancer. Part II: Treatment of advanced, relapsing, and castration-resistant prostate cancer. European urology. 2014;65(2):467–79. Epub 2013/12/11. 10.1016/j.eururo.2013.11.002 .</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/24321502/\">https://pubmed.ncbi.nlm.nih.gov/24321502/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/24321502</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Parker C, Gillessen S, Heidenreich A, Horwich A. Cancer of the prostate: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26 Suppl 5:v69–77. Epub 2015/07/25. 10.1093/annonc/mdv222 .</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/26205393/\">https://pubmed.ncbi.nlm.nih.gov/26205393/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/26205393</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Noguchi M, Noda S, Yoshida M, Ueda S, Shiraishi T, Itoh K. Chemohormonal therapy as primary treatment for metastatic prostate cancer: a randomized study of estramustine phosphate plus luteinizing hormone-releasing hormone agonist versus flutamide plus luteinizing hormone-releasing hormone agonist. Int J Urol. 2004;11(2):103–9. Epub 2004/01/07. .</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/14706014/\">https://pubmed.ncbi.nlm.nih.gov/14706014/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/14706014</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Petrylak DP, Tangen CM, Hussain MH, Lara PN Jr., Jones JA, Taplin ME, et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. The New England journal of medicine. 2004;351(15):1513–20. Epub 2004/10/08. 10.1056/NEJMoa041318 .</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/15470214/\">https://pubmed.ncbi.nlm.nih.gov/15470214/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/15470214</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Tannock IF, de Wit R, Berry WR, Horti J, Pluzanska A, Chi KN, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. The New England journal of medicine. 2004;351(15):1502–12. Epub 2004/10/08. 10.1056/NEJMoa040720 .</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/15470213/\">https://pubmed.ncbi.nlm.nih.gov/15470213/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/15470213</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Fizazi K, Jenkins C, Tannock IF. Should docetaxel be standard of care for patients with metastatic hormone-sensitive prostate cancer? Pro and contra. Ann Oncol. 2015;26(8):1660–7. Epub 2015/05/24. 10.1093/annonc/mdv245</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/26002607/\">https://pubmed.ncbi.nlm.nih.gov/26002607/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/26002607</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Gravis G, Fizazi K, Joly F, Oudard S, Priou F, Esterni B, et al. Androgen-deprivation therapy alone or with docetaxel in non-castrate metastatic prostate cancer (GETUG-AFU 15): a randomised, open-label, phase 3 trial. The Lancet Oncology. 2013;14(2):149–58. Epub 2013/01/12. 10.1016/s1470-2045(12)70560-0 .</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/23306100/\">https://pubmed.ncbi.nlm.nih.gov/23306100/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/23306100</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>Gravis G, Boher JM, Joly F, et al. Androgen deprivation therapy plus docetaxel versus ADT alone for hormone-naive metastatic prostate cancer: Long-term analysis of the GETUG-AFU 15 phase III trial. 2015 Genitourinary Cancers Symposium Abstract 140 Presented February 26, 2015.</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Gravis G, Boher JM, Joly F, Soulie M, Albiges L, Priou F, et al. Androgen Deprivation Therapy (ADT) Plus Docetaxel Versus ADT Alone in Metastatic Non castrate Prostate Cancer: Impact of Metastatic Burden and Long-term Survival Analysis of the Randomized Phase 3 GETUG-AFU15 Trial. European urology. 2015. Epub 2015/11/28. 10.1016/j.eururo.2015.11.005 .</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/26610858/\">https://pubmed.ncbi.nlm.nih.gov/26610858/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/26610858</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Sweeney CJ, Chen YH, Carducci M, Liu G, Jarrard DF, Eisenberger M, et al. Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer. The New England journal of medicine. 2015;373(8):737–46. Epub 2015/08/06. 10.1056/NEJMoa1503747</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/26244877/\">https://pubmed.ncbi.nlm.nih.gov/26244877/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/26244877</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>Sweeney CJ, Chen YH, Carducci M, Liu G, Jarrard DF, Eisenberger M, et al. Impact on overall survival (OS) with chemohormonal therapy versus hormonal therapy for hormone-sensitive newly metastatic prostate cancer (mPrCa): An ECOG-led phase III randomized trial. J Clin Oncol 32:5s, 2014. 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Epub 2014/10/11. 10.1016/j.eururo.2014.09.032 .</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/25301760/\">https://pubmed.ncbi.nlm.nih.gov/25301760/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/25301760</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>James ND, Sydes MR, Mason M, et al. Docetaxel and/or zoledronic acid for hormone-naïve prostate cancer: First overall survival results from STAMPEDE (NCT00268476). J Clin Oncol 33, 2015. (suppl; abstr 5001).</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>Patrick-Miller LJ, Chen YH, Carducci MA, Cella D, DiPaola RS, Gartrell BA, et al. Quality of life (QOL) analysis from E3805, chemohormonal androgen ablation randomized trial (CHAARTED) in prostate cancer (PrCa). J Clin Oncol 34, 2016. (suppl 2S; abstr 286).</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Morgan SC, Waldron TS, Eapen L, Mayhew LA, Winquist E, Lukka H. Adjuvant radiotherapy following radical prostatectomy for pathologic T3 or margin-positive prostate cancer: a systematic review and meta-analysis. Radiother Oncol. 2008;88(1):1–9. Epub 2008/05/27. doi: S0167-8140(08)00233-8 [pii] 10.1016/j.radonc.2008.04.013 .</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/18501455/\">https://pubmed.ncbi.nlm.nih.gov/18501455/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/18501455</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Gillessen S, Omlin A, Attard G, de Bono JS, Efstathiou E, Fizazi K, et al. Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015. Ann Oncol. 2015;26(8):1589–604. Epub 2015/06/05. 10.1093/annonc/mdv257</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://pubmed.ncbi.nlm.nih.gov/26041764/\">https://pubmed.ncbi.nlm.nih.gov/26041764/</a></td></tr></table><p><b>resourceReference</b>: Identifier: <code>https://pubmed.ncbi.nlm.nih.gov</code>/26041764</p></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>classifier</b>: <span title=\"Codes:{http://hl7.org/fhir/citation-artifact-classifier D016428}\">Journal Article</span></p><p><b>citation</b>: </p><div><p>Kellokumpu-Lehtinen PL, Harmenberg U, Joensuu T, McDermott R, Hervonen P, Ginman C, et al. 2-Weekly versus 3-weekly docetaxel to treat castration-resistant advanced prostate cancer: a randomised, phase 3 trial. The Lancet Oncology. 2013;14(2):117–24. 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Prostate Cancer (Version 1.2016). http://www.nccn.org/professionals/physician_gls/pdf/prostate.pdf.</p>\n</div></blockquote><blockquote><p><b>relatesTo</b></p><p><b>type</b>: cites</p><p><b>citation</b>: </p><div><p>Liaw BC, Oh WK. Is Docetaxel Chemotherapy a New Standard of Care for Metastatic Hormone-Sensitive Prostate Cancer? 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Classifier added by Computable Publishing LLC</p></blockquote><blockquote><p><b>classification</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type citation-subset}\">Citation subset</span></p><p><b>classifier</b>: <span title=\"Codes:{https://www.nlm.nih.gov/bsd/licensee/elements_descriptions.html#citationsubset IM}\">IM</span></p></blockquote><blockquote><p><b>contributorship</b></p><p><b>complete</b>: true</p><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179613/contributor0\">Botrel TE</a></p><p><b>forenameInitials</b>: TE</p><p><b>affiliation</b>: </p><ul><li>Evidencias - A Kantar Health Company, Campinas, São Paulo, Brazil.</li><li>Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil.</li></ul></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179613/contributor1\">Clark O</a></p><p><b>forenameInitials</b>: O</p><p><b>affiliation</b>: </p><ul><li>Evidencias - A Kantar Health Company, Campinas, São Paulo, Brazil.</li><li>Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil.</li></ul></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179613/contributor2\">Lima Pompeo AC</a></p><p><b>forenameInitials</b>: AC</p><p><b>affiliation</b>: Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179613/contributor3\">Horta Bretas FF</a></p><p><b>forenameInitials</b>: FF</p><p><b>affiliation</b>: Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179613/contributor4\">Sadi MV</a></p><p><b>forenameInitials</b>: MV</p><p><b>affiliation</b>: Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179613/contributor5\">Ferreira U</a></p><p><b>forenameInitials</b>: U</p><p><b>affiliation</b>: Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil.</p></blockquote><blockquote><p><b>entry</b></p><p><b>contributor</b>: <a href=\"#hc179613/contributor6\">Borges Dos Reis R</a></p><p><b>forenameInitials</b>: R</p><p><b>affiliation</b>: Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil.</p></blockquote></blockquote></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor0</b></p><a name=\"179613/contributor0\"> </a><a name=\"hc179613/contributor0\"> </a><a name=\"179613/contributor0-en-US\"> </a><p><b>name</b>: Tobias Engel Ayer Botrel </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor1</b></p><a name=\"179613/contributor1\"> </a><a name=\"hc179613/contributor1\"> </a><a name=\"179613/contributor1-en-US\"> </a><p><b>name</b>: Otávio Clark </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor2</b></p><a name=\"179613/contributor2\"> </a><a name=\"hc179613/contributor2\"> </a><a name=\"179613/contributor2-en-US\"> </a><p><b>name</b>: Antônio Carlos Lima Pompeo </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor3</b></p><a name=\"179613/contributor3\"> </a><a name=\"hc179613/contributor3\"> </a><a name=\"179613/contributor3-en-US\"> </a><p><b>name</b>: Francisco Flávio Horta Bretas </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor4</b></p><a name=\"179613/contributor4\"> </a><a name=\"hc179613/contributor4\"> </a><a name=\"179613/contributor4-en-US\"> </a><p><b>name</b>: Marcus Vinicius Sadi </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor5</b></p><a name=\"179613/contributor5\"> </a><a name=\"hc179613/contributor5\"> </a><a name=\"179613/contributor5-en-US\"> </a><p><b>name</b>: Ubirajara Ferreira </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: Practitioner #contributor6</b></p><a name=\"179613/contributor6\"> </a><a name=\"hc179613/contributor6\"> </a><a name=\"179613/contributor6-en-US\"> </a><p><b>name</b>: Rodolfo Borges Dos Reis </p></blockquote><hr/><blockquote><p class=\"res-header-id\"><b>Generated Narrative: ArtifactAssessment #meshHeading0</b></p><a name=\"179613/meshHeading0\"> </a><a name=\"hc179613/meshHeading0\"> </a><a name=\"179613/meshHeading0-en-US\"> </a><p><b>artifact</b>: <a href=\"#hc179613\">Citation 27308831 Efficacy and Safety of Combined Androgen Deprivation Therapy (ADT) and Docetaxel Compared with ADT Alone for Metastatic Hormone-Naive Prostate Cancer: A Systematic Review and Meta-Analysis.</a></p><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000368}\">Aged</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000726}\">Androgen Antagonists</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000970}\">Antineoplastic Agents</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D000971}\">Antineoplastic Combined Chemotherapy Protocols</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser 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topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D008297}\">Male</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D008875}\">Middle Aged</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D061214}\">Patient Safety</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D011471}\">Prostatic Neoplasms</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000188}\">drug therapy</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49488}\">Yes</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000401}\">mortality</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}\">No</span></td></tr></table></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000473}\">pathology</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49487}\">No</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016032}\">Randomized Controlled Trials as Topic</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016019}\">Survival Analysis</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D043823}\">Taxoids</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49488}\">Yes</span></td></tr></table></blockquote></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D016896}\">Treatment Outcome</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">qualifier</span></td><td><span title=\"Codes:\">is not a major topic</span></td></tr></table></blockquote><blockquote><p><b>content</b></p><p><b>type</b>: <span title=\"Codes:{http://hl7.org/fhir/cited-artifact-classification-type mesh-heading}\">components (if present) include qualifier codings</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ D050257}\">Tubulin Modulators</span></p><p><b>freeToShare</b>: true</p><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:\">is not a major topic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>type</b>: <span title=\"Codes:\">qualifier</span></p><p><b>classifier</b>: <span title=\"Codes:{https://meshb.nlm.nih.gov/ Q000627}\">therapeutic use</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Classifier</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">is Major topic</span></td><td><span title=\"Codes:{https://ncithesaurus.nci.nih.gov/ncitbrowser C49488}\">Yes</span></td></tr></table></blockquote></blockquote></blockquote></div>"
  ] ; # 
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a fhir:Practitioner ;
fhir:id [ fhir:v "contributor0" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Botrel" ] ;
      ( fhir:given [ fhir:v "Tobias Engel Ayer" ] )     ] )
  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor1" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Clark" ] ;
      ( fhir:given [ fhir:v "Otávio" ] )     ] )
  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor2" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Lima Pompeo" ] ;
      ( fhir:given [ fhir:v "Antônio Carlos" ] )     ] )
  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor3" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Horta Bretas" ] ;
      ( fhir:given [ fhir:v "Francisco Flávio" ] )     ] )
  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor4" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Sadi" ] ;
      ( fhir:given [ fhir:v "Marcus Vinicius" ] )     ] )
  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor5" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Ferreira" ] ;
      ( fhir:given [ fhir:v "Ubirajara" ] )     ] )
  ] [
a fhir:Practitioner ;
fhir:id [ fhir:v "contributor6" ] ;
    ( fhir:name [
fhir:family [ fhir:v "Borges Dos Reis" ] ;
      ( fhir:given [ fhir:v "Rodolfo" ] )     ] )
  ] [
a fhir:ArtifactAssessment ;
fhir:id [ fhir:v "meshHeading0" ] ;
fhir:artifact [
a fhir:Reference ;
fhir:reference [ fhir:v "#" ] ;
fhir:type [ fhir:v "Citation"^^xsd:anyURI ]     ] ;
    ( fhir:content [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D000368" ] ;
fhir:display [ fhir:v "Aged" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D000726" ] ;
fhir:display [ fhir:v "Androgen Antagonists" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Q000627" ] ;
fhir:display [ fhir:v "therapeutic use" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C49488" ] ;
fhir:display [ fhir:v "Yes" ]             ] )           ] )         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D000970" ] ;
fhir:display [ fhir:v "Antineoplastic Agents" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Q000627" ] ;
fhir:display [ fhir:v "therapeutic use" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C49488" ] ;
fhir:display [ fhir:v "Yes" ]             ] )           ] )         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D000971" ] ;
fhir:display [ fhir:v "Antineoplastic Combined Chemotherapy Protocols" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
          ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Q000627" ] ;
fhir:display [ fhir:v "therapeutic use" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
          ( fhir:classifier [
            ( fhir:coding [
fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C49488" ] ;
fhir:display [ fhir:v "Yes" ]             ] )           ] )         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D000077143" ] ;
fhir:display [ fhir:v "Docetaxel" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D006801" ] ;
fhir:display [ fhir:v "Humans" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D008207" ] ;
fhir:display [ fhir:v "Lymphatic Metastasis" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D008297" ] ;
fhir:display [ fhir:v "Male" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
      ( fhir:classifier [
        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D008875" ] ;
fhir:display [ fhir:v "Middle Aged" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D061214" ] ;
fhir:display [ fhir:v "Patient Safety" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
        ( fhir:classifier [
fhir:text [ fhir:v "is not a major topic" ]         ] )       ] )     ] [
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/cited-artifact-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mesh-heading" ] ;
fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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        ( fhir:coding [
fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D011471" ] ;
fhir:display [ fhir:v "Prostatic Neoplasms" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
      ( fhir:component [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:text [ fhir:v "is not a major topic" ]         ] )       ] [
fhir:type [
fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Q000188" ] ;
fhir:display [ fhir:v "drug therapy" ]           ] )         ] ) ;
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fhir:type [
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fhir:type [
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fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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fhir:display [ fhir:v "Treatment Outcome" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
fhir:freeToShare [ fhir:v "true"^^xsd:boolean ] ;
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fhir:display [ fhir:v "MeSH heading" ]         ] ) ;
fhir:text [ fhir:v "components (if present) include qualifier codings" ]       ] ;
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fhir:display [ fhir:v "Tubulin Modulators" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]         ] )       ] ) ;
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fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:text [ fhir:v "qualifier" ]         ] ;
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fhir:system [ fhir:v "https://meshb.nlm.nih.gov/"^^xsd:anyURI ] ;
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fhir:display [ fhir:v "therapeutic use" ]           ] )         ] ) ;
        ( fhir:component [
fhir:type [
fhir:text [ fhir:v "is Major topic" ]           ] ;
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fhir:system [ fhir:v "https://ncithesaurus.nci.nih.gov/ncitbrowser"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C49488" ] ;
fhir:display [ fhir:v "Yes" ]             ] )           ] )         ] )       ] )     ] )
  ] ) ; # 
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fhir:type [
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fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ACSN" ] ;
fhir:display [ fhir:v "Accession ID" ]       ] ) ;
fhir:text [ fhir:v "FEvIR Object Identifier" ]     ] ;
fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ;
fhir:value [ fhir:v "https://fevir.net/FOI/179613" ] ;
fhir:assigner [
fhir:display [ fhir:v "Computable Publishing LLC" ]     ]
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fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ;
fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.40.44.15.27" ]
  ] ) ; # 
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  fhir:title [ fhir:v "27308831 Efficacy and Safety of Combined Androgen Deprivation Therapy (ADT) and Docetaxel Compared with ADT Alone for Metastatic Hormone-Naive Prostate Cancer: A Systematic Review and Meta-Analysis."] ; # 
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fhir:name [ fhir:v "HL7 International / Clinical Decision Support" ] ;
    ( fhir:telecom [
fhir:system [ fhir:v "url" ] ;
fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ]     ] )
  ] ) ; # 
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fhir:code [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-classification-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "fevir-platform-use" ] ;
fhir:display [ fhir:v "FEvIR Platform Use" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
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fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ;
fhir:code [ fhir:v "medline-base" ] ;
fhir:display [ fhir:v "Medline Base" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]       ] )     ]
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fhir:system [ fhir:v "http://unstats.un.org/unsd/methods/m49/m49.htm"^^xsd:anyURI ] ;
fhir:code [ fhir:v "001" ] ;
fhir:display [ fhir:v "World" ]     ] )
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fhir:name [ fhir:v "Computable Publishing®: MEDLINE-to-FEvIR Converter" ]
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fhir:display [ fhir:v "National Library of Medicine, Index Section" ] ;
fhir:userSelected [ fhir:v "false"^^xsd:boolean ]       ] )     ] )
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    ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "medline-medline" ] ;
fhir:display [ fhir:v "Medline Citation Status of Medline" ]     ] )
  ] [
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fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "pubmed-publication-status-epublish" ] ;
fhir:display [ fhir:v "PubMed PublicationStatus of epublish" ]     ] )
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fhir:activity [
      ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ;
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fhir:display [ fhir:v "PubMed Pubstatus of Accepted" ]       ] )     ] ;
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fhir:system [ fhir:v "http://hl7.org/fhir/citation-status-type"^^xsd:anyURI ] ;
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fhir:display [ fhir:v "PubMed Pubstatus of Entrez" ]       ] )     ] ;
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fhir:display [ fhir:v "PubMed Pubstatus of Pubmed" ]       ] )     ] ;
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fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ;
fhir:value [ fhir:v "27308831" ]     ] [
fhir:system [ fhir:v "https://www.ncbi.nlm.nih.gov/pmc/"^^xsd:anyURI ] ;
fhir:value [ fhir:v "PMC4911003" ]     ] [
fhir:system [ fhir:v "https://doi.org"^^xsd:anyURI ] ;
fhir:value [ fhir:v "10.1371/journal.pone.0157660" ]     ] [
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        ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ACSN" ] ;
fhir:display [ fhir:v "Accession ID" ]         ] ) ;
fhir:text [ fhir:v "pii" ]       ] ;
fhir:value [ fhir:v "PONE-D-16-10077" ]     ] ) ;
    ( fhir:title [
      ( fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/title-type"^^xsd:anyURI ] ;
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fhir:language [
        ( fhir:coding [
fhir:system [ fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ] ;
fhir:code [ fhir:v "en" ] ;
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fhir:text [ fhir:v "Efficacy and Safety of Combined Androgen Deprivation Therapy (ADT) and Docetaxel Compared with ADT Alone for Metastatic Hormone-Naive Prostate Cancer: A Systematic Review and Meta-Analysis." ]     ] ) ;
    ( fhir:abstract [
fhir:text [ fhir:v "**OBJECTIVE:** Prostate cancer is the most common nonskin cancer and second most common cause of cancer mortality in older men in the United States (USA) and Western Europe. Androgen-deprivation therapy alone (ADT) remains the first line of treatment in most cases, for metastatic disease. We performed a systematic review and meta-analysis of all randomized controlled trials (RCT) that compared the efficacy and adverse events profile of a chemohormonal therapy (ADT ± docetaxel) for metastatic hormone-naive prostate cancer (mHNPC).\n**METHODS:** Several databases were searched, including MEDLINE, EMBASE, LILACS, and CENTRAL. The primary endpoint was overall survival. Data extracted from the studies were combined by using the hazard ratio (HR) or risk ratio (RR) with their corresponding 95% confidence intervals (95% CI).\n**RESULTS:** The final analysis included 3 trials comprising 2,264 patients (mHNPC). Patients who received the chemohormonal therapy had a longer clinical progression-free survival interval (HR = 0.64; 95% CI: 0.55 to 0.75; p&lt;0.00001), and no heterogeneity (Chi2 = 0.64; df = 1 [p = 0.42]; I2 = 0%). The biochemical progression-free survival (bPFS) also was higher in patients treated with ADT plus docetaxel (HR = 0.63; 95% CI: 0.57 to 0.69; p&lt;0.00001), also with no heterogeneity noted (Chi2 = 0.48; df = 2 [p = 0.79]; I2 = 0%). Finally, the combination of ADT with docetaxel showed a superior overall survival (OS) compared with ADT alone (HR = 0.73; 95% CI: 0.64 to 0.84; p&lt;0.0001), with moderate heterogeneity (Chi2 = 3.84; df = 2 [p = 0.15]; I2 = 48%). A random-effects model analysis was performed, and the results remained favorable to the use of ADT plus docetaxel (HR = 0.73; 95% CI: 0.60 to 0.89; p = 0.002). In the final combined analysis of the high-volume disease patients, the use of the combination therapy also favored an increased overall survival (HR = 0.67; 95% CI: 0.54 to 0.83; p = 0.0003). Regarding adverse events and severe toxicity (grade ≥3), the group receiving the combined therapy had higher rates of neutropenia, febrile neutropenia and fatigue.\n**CONCLUSION:** The combination of ADT with docetaxel improved the clinical progression-free survival, bPFS and OS of patients with mHNPC. A superior OS was seen especially for patients with metastatic and high-volume disease. This contemporary combination therapy may now be offered as a first-line treatment for selected patients." ]     ] ) ;
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fhir:type [ fhir:v "cites" ] ;
fhir:citation [ fhir:v "http://clinicaltrials.gov/ct2/show/NCT00514540." ]     ] [
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        ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/citation-artifact-classifier"^^xsd:anyURI ] ;
fhir:code [ fhir:v "D016428" ] ;
fhir:display [ fhir:v "Journal Article" ]         ] )       ] ) ;
fhir:citation [ fhir:v "Beltran H, Beer TM, Carducci MA, de Bono J, Gleave M, Hussain M, et al. New therapies for castration-resistant prostate cancer: efficacy and safety. Eur Urol. 2011;60(2):279–90. Epub 2011/05/20. doi: S0302-2838(11)00477-5 [pii] 10.1016/j.eururo.2011.04.038 ." ] ;
fhir:document [
fhir:url [ fhir:v "https://pubmed.ncbi.nlm.nih.gov/21592649/"^^xsd:anyURI ]       ] ;
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fhir:display [ fhir:v "Journal Article" ]         ] )       ] ) ;
fhir:citation [ fhir:v "Botrel TE, Clark O, Pompeo AC, Bretas FF, Sadi MV, Ferreira U, et al. Immunotherapy with Sipuleucel-T (APC8015) in patients with metastatic castration-refractory prostate cancer (mCRPC): a systematic review and meta-analysis. International braz j urol: official journal of the Brazilian Society of Urology. 2012;38(6):717–27. Epub 2013/01/11. ." ] ;
fhir:document [
fhir:url [ fhir:v "https://pubmed.ncbi.nlm.nih.gov/23302410/"^^xsd:anyURI ]       ] ;
fhir:resourceReference [
fhir:identifier [
fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ;
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fhir:code [ fhir:v "D016428" ] ;
fhir:display [ fhir:v "Journal Article" ]         ] )       ] ) ;
fhir:citation [ fhir:v "Loblaw DA, Virgo KS, Nam R, Somerfield MR, Ben-Josef E, Mendelson DS, et al. Initial hormonal management of androgen-sensitive metastatic, recurrent, or progressive prostate cancer: 2006 update of an American Society of Clinical Oncology practice guideline. J Clin Oncol. 2007;25(12):1596–605. Epub 2007/04/04. doi: JCO.2006.10.1949 [pii] 10.1200/JCO.2006.10.1949 ." ] ;
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fhir:url [ fhir:v "https://pubmed.ncbi.nlm.nih.gov/17404365/"^^xsd:anyURI ]       ] ;
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fhir:system [ fhir:v "https://pubmed.ncbi.nlm.nih.gov"^^xsd:anyURI ] ;
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fhir:display [ fhir:v "Journal Article" ]         ] )       ] ) ;
fhir:citation [ fhir:v "Heidenreich A, Bastian PJ, Bellmunt J, Bolla M, Joniau S, van der Kwast T, et al. EAU guidelines on prostate cancer. Part II: Treatment of advanced, relapsing, and castration-resistant prostate cancer. European urology. 2014;65(2):467–79. Epub 2013/12/11. 10.1016/j.eururo.2013.11.002 ." ] ;
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fhir:display [ fhir:v "Evidencias - A Kantar Health Company, Campinas, São Paulo, Brazil." ]         ] [
fhir:display [ fhir:v "Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil." ]         ] )       ] [
fhir:contributor [
fhir:reference [ fhir:v "#contributor1" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Clark O" ]         ] ;
fhir:forenameInitials [ fhir:v "O" ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Evidencias - A Kantar Health Company, Campinas, São Paulo, Brazil." ]         ] [
fhir:display [ fhir:v "Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil." ]         ] )       ] [
fhir:contributor [
fhir:reference [ fhir:v "#contributor2" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Lima Pompeo AC" ]         ] ;
fhir:forenameInitials [ fhir:v "AC" ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil." ]         ] )       ] [
fhir:contributor [
fhir:reference [ fhir:v "#contributor3" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Horta Bretas FF" ]         ] ;
fhir:forenameInitials [ fhir:v "FF" ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil." ]         ] )       ] [
fhir:contributor [
fhir:reference [ fhir:v "#contributor4" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Sadi MV" ]         ] ;
fhir:forenameInitials [ fhir:v "MV" ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil." ]         ] )       ] [
fhir:contributor [
fhir:reference [ fhir:v "#contributor5" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Ferreira U" ]         ] ;
fhir:forenameInitials [ fhir:v "U" ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil." ]         ] )       ] [
fhir:contributor [
fhir:reference [ fhir:v "#contributor6" ] ;
fhir:type [ fhir:v "Practitioner"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Borges Dos Reis R" ]         ] ;
fhir:forenameInitials [ fhir:v "R" ] ;
        ( fhir:affiliation [
fhir:display [ fhir:v "Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil." ]         ] )       ] )     ]
  ] . #