Generated Narrative: Citation 179613

url: Citation 27308831 Efficacy and Safety of Combined Androgen Deprivation Therapy (ADT) and Docetaxel Compared with ADT Alone for Metastatic Hormone-Naive Prostate Cancer: A Systematic Review and Meta-Analysis.

identifier: FEvIR Object Identifier/https://fevir.net/FOI/179613, https://pubmed.ncbi.nlm.nih.gov/27308831, Uniform Resource Identifier (URI)/urn:oid:2.16.840.1.113883.4.642.40.44.15.27

version: 2.0.0-ballot

title: 27308831 Efficacy and Safety of Combined Androgen Deprivation Therapy (ADT) and Docetaxel Compared with ADT Alone for Metastatic Hormone-Naive Prostate Cancer: A Systematic Review and Meta-Analysis.

status: Active

date: 2024-12-19 14:29:51+0000

publisher: HL7 International / Clinical Decision Support

contact: HL7 International / Clinical Decision Support: http://www.hl7.org/Special/committees/dss

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approvalDate: 2017-07-26

lastReviewDate: 2024-03-27

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type: Citation Source

classifier: MEDLINE

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type: MEDLINE Citation Owner

classifier: National Library of Medicine, Index Section

currentState: Medline Citation Status of Medline, PubMed PublicationStatus of epublish

statusDate

activity: PubMed Pubstatus of Received

period: ?? --> 2016-04-01

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activity: PubMed Pubstatus of Accepted

period: ?? --> 2016-06-02

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activity: PubMed Pubstatus of Entrez

period: ?? --> 2016-06-17 06:00:00+0000

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activity: PubMed Pubstatus of Pubmed

period: ?? --> 2016-06-17 06:00:00+0000

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activity: PubMed Pubstatus of Medline

period: ?? --> 2017-07-27 06:00:00+0000

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activity: PubMed Pubstatus of PMC release

period: ?? --> 2016-06-16

citedArtifact

identifier: https://pubmed.ncbi.nlm.nih.gov/27308831, https://www.ncbi.nlm.nih.gov/pmc//PMC4911003, https://doi.org/10.1371/journal.pone.0157660, pii/PONE-D-16-10077

Titles

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*	Primary title	English	Efficacy and Safety of Combined Androgen Deprivation Therapy (ADT) and Docetaxel Compared with ADT Alone for Metastatic Hormone-Naive Prostate Cancer: A Systematic Review and Meta-Analysis.

Abstracts

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Text

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OBJECTIVE: Prostate cancer is the most common nonskin cancer and second most common cause of cancer mortality in older men in the United States (USA) and Western Europe. Androgen-deprivation therapy alone (ADT) remains the first line of treatment in most cases, for metastatic disease. We performed a systematic review and meta-analysis of all randomized controlled trials (RCT) that compared the efficacy and adverse events profile of a chemohormonal therapy (ADT ± docetaxel) for metastatic hormone-naive prostate cancer (mHNPC). METHODS: Several databases were searched, including MEDLINE, EMBASE, LILACS, and CENTRAL. The primary endpoint was overall survival. Data extracted from the studies were combined by using the hazard ratio (HR) or risk ratio (RR) with their corresponding 95% confidence intervals (95% CI). RESULTS: The final analysis included 3 trials comprising 2,264 patients (mHNPC). Patients who received the chemohormonal therapy had a longer clinical progression-free survival interval (HR = 0.64; 95% CI: 0.55 to 0.75; p<0.00001), and no heterogeneity (Chi2 = 0.64; df = 1 [p = 0.42]; I2 = 0%). The biochemical progression-free survival (bPFS) also was higher in patients treated with ADT plus docetaxel (HR = 0.63; 95% CI: 0.57 to 0.69; p<0.00001), also with no heterogeneity noted (Chi2 = 0.48; df = 2 [p = 0.79]; I2 = 0%). Finally, the combination of ADT with docetaxel showed a superior overall survival (OS) compared with ADT alone (HR = 0.73; 95% CI: 0.64 to 0.84; p<0.0001), with moderate heterogeneity (Chi2 = 3.84; df = 2 [p = 0.15]; I2 = 48%). A random-effects model analysis was performed, and the results remained favorable to the use of ADT plus docetaxel (HR = 0.73; 95% CI: 0.60 to 0.89; p = 0.002). In the final combined analysis of the high-volume disease patients, the use of the combination therapy also favored an increased overall survival (HR = 0.67; 95% CI: 0.54 to 0.83; p = 0.0003). Regarding adverse events and severe toxicity (grade ≥3), the group receiving the combined therapy had higher rates of neutropenia, febrile neutropenia and fatigue. CONCLUSION: The combination of ADT with docetaxel improved the clinical progression-free survival, bPFS and OS of patients with mHNPC. A superior OS was seen especially for patients with metastatic and high-volume disease. This contemporary combination therapy may now be offered as a first-line treatment for selected patients.

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contributor: Botrel TE

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affiliation:

• Evidencias - A Kantar Health Company, Campinas, São Paulo, Brazil.
• Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil.

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contributor: Clark O

forenameInitials: O

affiliation:

• Evidencias - A Kantar Health Company, Campinas, São Paulo, Brazil.
• Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil.

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contributor: Lima Pompeo AC

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affiliation: Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil.

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affiliation: Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil.

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affiliation: Comitê Brasileiro de Estudos em Uro-Oncologia - CoBEU, São Paulo, São Paulo, Brazil.

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name: Tobias Engel Ayer Botrel

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name: Otávio Clark

Generated Narrative: Practitioner #contributor2

name: Antônio Carlos Lima Pompeo

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artifact: Citation 27308831 Efficacy and Safety of Combined Androgen Deprivation Therapy (ADT) and Docetaxel Compared with ADT Alone for Metastatic Hormone-Naive Prostate Cancer: A Systematic Review and Meta-Analysis.

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