Clinical Genomics Resource Incubator, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 0.1.0-ci-build built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/cg-incubator/ and changes regularly. See the Directory of published versions

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: Molecular Definition Topology CodeSystem

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<CodeSystem xmlns="http://hl7.org/fhir">
  <id value="moleculardefinition-topology"/>
  <meta>
    <lastUpdated value="2026-03-23T00:00:00Z"/>
    <profile
             value="http://hl7.org/fhir/StructureDefinition/shareablecodesystem"/>
  </meta>
  <language value="en"/>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: CodeSystem moleculardefinition-topology</b></p><a name="moleculardefinition-topology"> </a><a name="hcmoleculardefinition-topology"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Last updated: 2026-03-23 00:00:00+0000</p><p style="margin-bottom: 0px">Profile: <a href="http://hl7.org/fhir/R5/shareablecodesystem.html">Shareable CodeSystem</a></p></div><p>This case-sensitive code system <code>http://hl7.org/fhir/uv/cg-incubator/CodeSystem/moleculardefinition-topology</code> defines the following codes:</p><table class="codes"><tr><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style="white-space:nowrap">linear<a name="moleculardefinition-topology-linear"> </a></td><td>Linear</td><td>Linear, contiguous sequence (e.g., a chromosome segment, allele, or mRNA).</td></tr><tr><td style="white-space:nowrap">linear-discontiguous<a name="moleculardefinition-topology-linear-discontiguous"> </a></td><td>Linear discontiguous</td><td>Linear sequence with gaps; the molecule consists of multiple non-contiguous segments on a linear axis (e.g., a haplotype spanning multiple exons).</td></tr><tr><td style="white-space:nowrap">circular<a name="moleculardefinition-topology-circular"> </a></td><td>Circular</td><td>Circular, contiguous sequence with no free ends (e.g., a plasmid, mitochondrial genome, or circular RNA).</td></tr><tr><td style="white-space:nowrap">branched<a name="moleculardefinition-topology-branched"> </a></td><td>Branched</td><td>Branched molecular structure (e.g., carbohydrate modifications or branched RNA).</td></tr></table></div>
  </text>
  <extension
             url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
    <valueCode value="cg"/>
  </extension>
  <extension
             url="http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status">
    <valueCode value="informative"/>
  </extension>
  <extension
             url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm">
    <valueInteger value="0"/>
  </extension>
  <url
       value="http://hl7.org/fhir/uv/cg-incubator/CodeSystem/moleculardefinition-topology"/>
  <identifier>
    <system value="urn:ietf:rfc:3986"/>
    <value value="urn:oid:2.16.840.1.113883.4.642.4.3003"/>
  </identifier>
  <version value="0.1.0-ci-build"/>
  <name value="MolecularDefinitionTopology"/>
  <title value="Molecular Definition Topology CodeSystem"/>
  <status value="draft"/>
  <experimental value="true"/>
  <date value="2026-03-23"/>
  <publisher value="HL7 International / Clinical Genomics"/>
  <contact>
    <name value="HL7 International / Clinical Genomics"/>
    <telecom>
      <system value="url"/>
      <value value="http://www.hl7.org/Special/committees/clingenomics"/>
    </telecom>
    <telecom>
      <system value="email"/>
      <value value="clingenomics@lists.hl7.org"/>
    </telecom>
  </contact>
  <description
               value="The structural topology of a molecular entity as defined by the MolecularDefinition resource. Includes linear, circular, linear-discontiguous (gapped), and branched forms."/>
  <jurisdiction>
    <coding>
      <system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/>
      <code value="001"/>
      <display value="World"/>
    </coding>
  </jurisdiction>
  <caseSensitive value="true"/>
  <valueSet
            value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/moleculardefinition-topology"/>
  <content value="complete"/>
  <concept>
    <code value="linear"/>
    <display value="Linear"/>
    <definition
                value="Linear, contiguous sequence (e.g., a chromosome segment, allele, or mRNA)."/>
  </concept>
  <concept>
    <code value="linear-discontiguous"/>
    <display value="Linear discontiguous"/>
    <definition
                value="Linear sequence with gaps; the molecule consists of multiple non-contiguous segments on a linear axis (e.g., a haplotype spanning multiple exons)."/>
  </concept>
  <concept>
    <code value="circular"/>
    <display value="Circular"/>
    <definition
                value="Circular, contiguous sequence with no free ends (e.g., a plasmid, mitochondrial genome, or circular RNA)."/>
  </concept>
  <concept>
    <code value="branched"/>
    <display value="Branched"/>
    <definition
                value="Branched molecular structure (e.g., carbohydrate modifications or branched RNA)."/>
  </concept>
</CodeSystem>