Clinical Genomics Resource Incubator, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 0.1.0-ci-build built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/cg-incubator/ and changes regularly. See the Directory of published versions

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: Molecular Definition Topology CodeSystem

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{
  "resourceType" : "CodeSystem",
  "id" : "moleculardefinition-topology",
  "meta" : {
    "lastUpdated" : "2026-03-23T00:00:00Z",
    "profile" : [
      🔗 "http://hl7.org/fhir/StructureDefinition/shareablecodesystem"
    ]
  },
  "language" : "en",
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: CodeSystem moleculardefinition-topology</b></p><a name=\"moleculardefinition-topology\"> </a><a name=\"hcmoleculardefinition-topology\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Last updated: 2026-03-23 00:00:00+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/R5/shareablecodesystem.html\">Shareable CodeSystem</a></p></div><p>This case-sensitive code system <code>http://hl7.org/fhir/uv/cg-incubator/CodeSystem/moleculardefinition-topology</code> defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">linear<a name=\"moleculardefinition-topology-linear\"> </a></td><td>Linear</td><td>Linear, contiguous sequence (e.g., a chromosome segment, allele, or mRNA).</td></tr><tr><td style=\"white-space:nowrap\">linear-discontiguous<a name=\"moleculardefinition-topology-linear-discontiguous\"> </a></td><td>Linear discontiguous</td><td>Linear sequence with gaps; the molecule consists of multiple non-contiguous segments on a linear axis (e.g., a haplotype spanning multiple exons).</td></tr><tr><td style=\"white-space:nowrap\">circular<a name=\"moleculardefinition-topology-circular\"> </a></td><td>Circular</td><td>Circular, contiguous sequence with no free ends (e.g., a plasmid, mitochondrial genome, or circular RNA).</td></tr><tr><td style=\"white-space:nowrap\">branched<a name=\"moleculardefinition-topology-branched\"> </a></td><td>Branched</td><td>Branched molecular structure (e.g., carbohydrate modifications or branched RNA).</td></tr></table></div>"
  },
  "extension" : [
    {
      "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg",
      "valueCode" : "cg"
    },
    {
      "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status",
      "valueCode" : "informative"
    },
    {
      "url" : "http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm",
      "valueInteger" : 0
    }
  ],
  "url" : "http://hl7.org/fhir/uv/cg-incubator/CodeSystem/moleculardefinition-topology",
  "identifier" : [
    {
      "system" : "urn:ietf:rfc:3986",
      "value" : "urn:oid:2.16.840.1.113883.4.642.4.3003"
    }
  ],
  "version" : "0.1.0-ci-build",
  "name" : "MolecularDefinitionTopology",
  "title" : "Molecular Definition Topology CodeSystem",
  "status" : "draft",
  "experimental" : true,
  "date" : "2026-03-23",
  "publisher" : "HL7 International / Clinical Genomics",
  "contact" : [
    {
      "name" : "HL7 International / Clinical Genomics",
      "telecom" : [
        {
          "system" : "url",
          "value" : "http://www.hl7.org/Special/committees/clingenomics"
        },
        {
          "system" : "email",
          "value" : "clingenomics@lists.hl7.org"
        }
      ]
    }
  ],
  "description" : "The structural topology of a molecular entity as defined by the MolecularDefinition resource. Includes linear, circular, linear-discontiguous (gapped), and branched forms.",
  "jurisdiction" : [
    {
      "coding" : [
        {
          "system" : "http://unstats.un.org/unsd/methods/m49/m49.htm",
          "code" : "001",
          "display" : "World"
        }
      ]
    }
  ],
  "caseSensitive" : true,
  "valueSet" : "http://hl7.org/fhir/uv/cg-incubator/ValueSet/moleculardefinition-topology",
  "content" : "complete",
  "concept" : [
    {
      "code" : "linear",
      "display" : "Linear",
      "definition" : "Linear, contiguous sequence (e.g., a chromosome segment, allele, or mRNA)."
    },
    {
      "code" : "linear-discontiguous",
      "display" : "Linear discontiguous",
      "definition" : "Linear sequence with gaps; the molecule consists of multiple non-contiguous segments on a linear axis (e.g., a haplotype spanning multiple exons)."
    },
    {
      "code" : "circular",
      "display" : "Circular",
      "definition" : "Circular, contiguous sequence with no free ends (e.g., a plasmid, mitochondrial genome, or circular RNA)."
    },
    {
      "code" : "branched",
      "display" : "Branched",
      "definition" : "Branched molecular structure (e.g., carbohydrate modifications or branched RNA)."
    }
  ]
}