Clinical Genomics Resource Incubator, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 0.1.0-ci-build built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/cg-incubator/ and changes regularly. See the Directory of published versions

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: Molecular Definition Strand CodeSystem

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<CodeSystem xmlns="http://hl7.org/fhir">
  <id value="moleculardefinition-strand"/>
  <meta>
    <lastUpdated value="2026-03-23T00:00:00Z"/>
    <profile
             value="http://hl7.org/fhir/StructureDefinition/shareablecodesystem"/>
  </meta>
  <language value="en"/>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: CodeSystem moleculardefinition-strand</b></p><a name="moleculardefinition-strand"> </a><a name="hcmoleculardefinition-strand"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Last updated: 2026-03-23 00:00:00+0000</p><p style="margin-bottom: 0px">Profile: <a href="http://hl7.org/fhir/R5/shareablecodesystem.html">Shareable CodeSystem</a></p></div><p>This case-sensitive code system <code>http://hl7.org/fhir/uv/cg-incubator/CodeSystem/moleculardefinition-strand</code> defines the following codes:</p><table class="codes"><tr><td style="white-space:nowrap"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style="white-space:nowrap">forward<a name="moleculardefinition-strand-forward"> </a></td><td>Forward strand</td><td>5' to 3' for nucleotides or N-to-C for amino acids; also known as the positive/plus/sense/Watson strand. Single stranded sequences are conventionally represented in the forward direction.</td></tr><tr><td style="white-space:nowrap">reverse<a name="moleculardefinition-strand-reverse"> </a></td><td>Reverse strand</td><td>3' to 5' orientation; also known as the negative/minus/antisense/Crick strand. Applicable only to double stranded sequences.</td></tr></table></div>
  </text>
  <extension
             url="http://hl7.org/fhir/StructureDefinition/structuredefinition-wg">
    <valueCode value="cg"/>
  </extension>
  <extension
             url="http://hl7.org/fhir/StructureDefinition/structuredefinition-standards-status">
    <valueCode value="informative"/>
  </extension>
  <extension
             url="http://hl7.org/fhir/StructureDefinition/structuredefinition-fmm">
    <valueInteger value="0"/>
  </extension>
  <url
       value="http://hl7.org/fhir/uv/cg-incubator/CodeSystem/moleculardefinition-strand"/>
  <identifier>
    <system value="urn:ietf:rfc:3986"/>
    <value value="urn:oid:2.16.840.1.113883.4.642.4.3006"/>
  </identifier>
  <version value="0.1.0-ci-build"/>
  <name value="MolecularDefinitionStrand"/>
  <title value="Molecular Definition Strand CodeSystem"/>
  <status value="draft"/>
  <experimental value="true"/>
  <date value="2026-03-23"/>
  <publisher value="HL7 International / Clinical Genomics"/>
  <contact>
    <name value="HL7 International / Clinical Genomics"/>
    <telecom>
      <system value="url"/>
      <value value="http://www.hl7.org/Special/committees/clingenomics"/>
    </telecom>
    <telecom>
      <system value="email"/>
      <value value="clingenomics@lists.hl7.org"/>
    </telecom>
  </contact>
  <description
               value="The strand orientation of a sequenceLocation. Orientation of molecular sequences, indicating directionality for nucleotides (5' to 3' or 3' to 5') or amino acids (N to C terminus)."/>
  <jurisdiction>
    <coding>
      <system value="http://unstats.un.org/unsd/methods/m49/m49.htm"/>
      <code value="001"/>
      <display value="World"/>
    </coding>
  </jurisdiction>
  <caseSensitive value="true"/>
  <valueSet
            value="http://hl7.org/fhir/uv/cg-incubator/ValueSet/moleculardefinition-strand"/>
  <content value="complete"/>
  <concept>
    <code value="forward"/>
    <display value="Forward strand"/>
    <definition
                value="5' to 3' for nucleotides or N-to-C for amino acids; also known as the positive/plus/sense/Watson strand. Single stranded sequences are conventionally represented in the forward direction."/>
  </concept>
  <concept>
    <code value="reverse"/>
    <display value="Reverse strand"/>
    <definition
                value="3' to 5' orientation; also known as the negative/minus/antisense/Crick strand. Applicable only to double stranded sequences."/>
  </concept>
</CodeSystem>