GenomeX Data Exchange FHIR IG
0.2.0 - draft
GenomeX Data Exchange FHIR IG, published by MITRE. This guide is not an authorized publication; it is the continuous build for version 0.2.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/CodeX-HL7-FHIR-Accelerator/GenomeX-DataExchange/ and changes regularly. See the Directory of published versions
<Bundle xmlns="http://hl7.org/fhir">
<id value="ct-xT-bundle"/>
<meta>
<profile
value="http://mitre.org/gdx/StructureDefinition/gdx-genomics-somatic-bundle"/>
</meta>
<type value="transaction"/>
<entry>
<fullUrl value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
<resource>
<Patient>
<id value="ct-xT-Patient"/>
<meta>
<profile
value="http://mitre.org/gdx/StructureDefinition/gdx-patient"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Patient_ct-xT-Patient"> </a><p class="res-header-id"><b>Generated Narrative: Patient ct-xT-Patient</b></p><a name="ct-xT-Patient"> </a><a name="hcct-xT-Patient"> </a><a name="ct-xT-Patient-en-US"> </a><p style="border: 1px #661aff solid; background-color: #e6e6ff; padding: 10px;">Mela Mann Female, DoB: 1926-08-06 ( Medical Record Number: 993456789 (use: official, ))</p><hr/><table class="grid"><tr><td style="background-color: #f3f5da" title="Other Id (see the one above)">Other Id:</td><td colspan="3">Patient external identifier/23ef1d1b-03a5-47d6-81e0-b9b4cbb15ccf (use: official, )</td></tr></table></div>
</text>
<identifier>
<use value="official"/>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="PT"/>
<display value="Patient external identifier"/>
</coding>
</type>
<system value="https://www.tempus.com"/>
<value value="23ef1d1b-03a5-47d6-81e0-b9b4cbb15ccf"/>
</identifier>
<identifier>
<use value="official"/>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="MR"/>
<display value="Medical Record Number"/>
</coding>
</type>
<system value="http://hospital.example.org"/>
<value value="993456789"/>
</identifier>
<name>
<family value="Mann"/>
<given value="Mela"/>
</name>
<gender value="Female"/>
<birthDate value="1926-08-06"/>
</Patient>
</resource>
<request>
<method value="POST"/>
<url value="Patient"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:56eeebfb-9df4-4789-955b-76bcec2d77a4"/>
<resource>
<DiagnosticReport>
<id value="ct-xT-DiagnosticReport"/>
<meta>
<profile
value="http://mitre.org/gdx/StructureDefinition/gdx-genomic-report"/>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="DiagnosticReport_ct-xT-DiagnosticReport"> </a><p class="res-header-id"><b>Generated Narrative: DiagnosticReport ct-xT-DiagnosticReport</b></p><a name="ct-xT-DiagnosticReport"> </a><a name="hcct-xT-DiagnosticReport"> </a><a name="ct-xT-DiagnosticReport-en-US"> </a><h2><span title="Codes:{http://loinc.org 51969-4}">Genetic analysis report</span> (<span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:">DNA</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>) </h2><table class="grid"><tr><td>Subject</td><td>Not done yet</td></tr><tr><td>When For</td><td>2019-02-15 19:28:58+0500</td></tr><tr><td>Performer</td><td> <a href="Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae">Bundle: type = transaction</a></td></tr><tr><td>Identifiers</td><td> Accession ID/TL-22-D3MTCAU4 Pipeline Version/3.9.3 Placer Identifier/d6eeedd1-92d3-45b9-bf33-6401e804425f</td></tr></table><p><b>Report Details</b></p><table class="grid"><tr><td><b>Code</b></td><td><b>Value</b></td></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr></table></div>
</text>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-reference">
<valueReference>
<reference value="urn:uuid:16f2715b-10ea-42ae-a3a2-185b14e6e21f"/>
</valueReference>
</extension>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-reference">
<valueReference>
<reference value="urn:uuid:88f2715b-10ea-42ae-a3a2-185b14e6e666"/>
</valueReference>
</extension>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report-note">
<valueAnnotation>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/annotation-code">
<valueCodeableConcept>
<coding>
<code value="copyright"/>
</coding>
</valueCodeableConcept>
</extension>
<text value="(c) Copyright Tempus 2022. All Rights Reserved."/>
</valueAnnotation>
</extension>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report-note">
<valueAnnotation>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/annotation-code">
<valueCodeableConcept>
<coding>
<code value="schemaVersion"/>
</coding>
</valueCodeableConcept>
</extension>
<text value="1.5.0"/>
</valueAnnotation>
</extension>
<identifier>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="ACSN"/>
<display value="Accession ID"/>
</coding>
</type>
<system value="https://www.tempus.com"/>
<value value="TL-22-D3MTCAU4"/>
</identifier>
<identifier>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="RI"/>
<display value="Pipeline Version"/>
</coding>
</type>
<system value="https://www.tempus.com"/>
<value value="3.9.3"/>
</identifier>
<identifier>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="PLAC"/>
<display value="Placer Identifier"/>
</coding>
</type>
<system value="https://www.tempus.com"/>
<value value="d6eeedd1-92d3-45b9-bf33-6401e804425f"/>
</identifier>
<basedOn>
<reference value="urn:uuid:28395cc2-c6e4-4006-84af-ebf40113656a"/>
</basedOn>
<status value="final"/>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<category>
<text value="DNA"/>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="51969-4"/>
<display value="Genetic analysis report"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<effectiveDateTime value="2019-02-15T19:28:58+05:00"/>
<performer>
<reference value="urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"/>
</performer>
<resultsInterpreter>
<reference value="urn:uuid:9ebd0cb1-4733-4b8e-999c-a66bcbd939dd"/>
</resultsInterpreter>
<specimen>
<reference value="urn:uuid:f5418e88-295b-43f8-af03-76c8c4aa516e"/>
</specimen>
<specimen>
<reference value="urn:uuid:1e6f171a-1dea-41b8-a51d-1f86130a43cc"/>
</specimen>
<result>
<reference value="urn:uuid:ccab39c5-49cf-4aa6-a1e7-2e0c9dd3a7d5"/>
</result>
<result>
<reference value="urn:uuid:fc637e0b-dced-4245-946e-3fa13ec128e3"/>
</result>
<result>
<reference value="urn:uuid:c7a1db28-0c8f-4667-a40a-79401833b26b"/>
</result>
<result>
<reference value="urn:uuid:6e333995-6a74-4dcd-ac7f-d7cf5ad20ac9"/>
</result>
<result>
<reference value="urn:uuid:d7318c30-3975-4f62-9840-3b8d7e7b56cd"/>
</result>
<result>
<reference value="urn:uuid:86ad3e6b-7ed8-4c7d-b99c-574ac5e2b4b9"/>
</result>
<result>
<reference value="urn:uuid:5dfa33cc-9038-44d0-9f71-f319b3cb4c9a"/>
</result>
<result>
<reference value="urn:uuid:52554ca2-dcdd-4105-9cb7-059f0a863483"/>
</result>
<result>
<reference value="urn:uuid:3c30e177-2c41-4f13-b6c0-1adf5af4c71d"/>
</result>
<result>
<reference value="urn:uuid:0c06b231-47e9-4a3b-88bd-2d8937d615a7"/>
</result>
<result>
<reference value="urn:uuid:00e47ced-f260-4baf-9da4-ee88224d3bc5"/>
</result>
<result>
<reference value="urn:uuid:bbe36a66-b7c9-4130-a181-81bb72e3f4cc"/>
</result>
<result>
<reference value="urn:uuid:7bb9b47d-2b77-47a6-ae2a-62f0b1d01d05"/>
</result>
<result>
<reference value="urn:uuid:dddaac5f-e8ba-4c55-a70c-5c6d80903356"/>
</result>
<result>
<reference value="urn:uuid:69b54656-b1eb-4393-ac69-f25f32fde680"/>
</result>
<result>
<reference value="urn:uuid:f845d26f-7308-45ab-9898-ebc86d6ae22c"/>
</result>
<result>
<reference value="urn:uuid:4be89099-d07b-4c94-a1ef-be16233a79d8"/>
</result>
<result>
<reference value="urn:uuid:da3cfb61-7b73-429d-b933-36b41b5e4a66"/>
</result>
<result>
<reference value="urn:uuid:b745fef5-462d-4b6c-bddc-a7c573c614ef"/>
</result>
<result>
<reference value="urn:uuid:29d40ea4-2946-4a90-a259-7a6025b3b090"/>
</result>
<result>
<reference value="urn:uuid:9095423d-db5e-4c28-a876-53a3b19fb6de"/>
</result>
<result>
<reference value="urn:uuid:da9b5431-1b88-461d-ab57-49502fe20117"/>
</result>
<result>
<reference value="urn:uuid:148fddd2-ab27-4abe-b096-8cf905905bc0"/>
</result>
<result>
<reference value="urn:uuid:82a8b9db-a68e-4e06-897e-77ed3ea5aced"/>
</result>
<result>
<reference value="urn:uuid:dc69c7c9-031b-466f-bf63-8be56d658c50"/>
</result>
<result>
<reference value="urn:uuid:kbe36a66-b7c9-4130-a181-81bb72e3f4zz"/>
</result>
</DiagnosticReport>
</resource>
<request>
<method value="POST"/>
<url value="DiagnosticReport"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:28395cc2-c6e4-4006-84af-ebf40113656a"/>
<resource>
<ServiceRequest>
<id value="ct-xT-ServiceRequest"/>
<meta>
<profile
value="http://mitre.org/gdx/StructureDefinition/gdx-service-request"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="ServiceRequest_ct-xT-ServiceRequest"> </a><p class="res-header-id"><b>Generated Narrative: ServiceRequest ct-xT-ServiceRequest</b></p><a name="ct-xT-ServiceRequest"> </a><a name="hcct-xT-ServiceRequest"> </a><a name="ct-xT-ServiceRequest-en-US"> </a><p><b>identifier</b>: Filler Identifier/23gcimeh</p><p><b>requisition</b>: Accession ID/TL-23-5B8EHM49</p><p><b>status</b>: Completed</p><p><b>intent</b>: Order</p><p><b>code</b>: <span title="Codes:{https://www.tempus.com XT.V4}">xT - 648 gene panel</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>requester</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-3b3363be-d153-40ae-952f-09d15df1d9bf">Bundle: type = transaction</a></p><p><b>reasonCode</b>: <span title="Codes:{http://hl7.org/fhir/sid/icd-10-cm C34.9}, {http://terminology.hl7.org/CodeSystem/icd-o-3 C34.9 8140/3}">Malignant neoplasm of unspecified part of bronchus or lung</span></p></div>
</text>
<identifier>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="FILL"/>
<display value="Filler Identifier"/>
</coding>
</type>
<system value="https://www.tempus.com"/>
<value value="23gcimeh"/>
</identifier>
<requisition>
<type>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0203"/>
<code value="ACSN"/>
<display value="Accession ID"/>
</coding>
</type>
<system value="https://www.tempus.com"/>
<value value="TL-23-5B8EHM49"/>
</requisition>
<status value="completed"/>
<intent value="order"/>
<code>
<coding>
<system value="https://www.tempus.com"/>
<code value="XT.V4"/>
<display value="xT - 648 gene panel"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<requester>
<reference value="urn:uuid:3b3363be-d153-40ae-952f-09d15df1d9bf"/>
</requester>
<reasonCode>
<coding>
<system value="http://hl7.org/fhir/sid/icd-10-cm"/>
<code value="C34.9"/>
<display
value="Malignant neoplasm of unspecified part of bronchus or lung"/>
</coding>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/icd-o-3"/>
<code value="C34.9 8140/3"/>
<display value="Lung adenocarcinoma"/>
</coding>
</reasonCode>
</ServiceRequest>
</resource>
<request>
<method value="POST"/>
<url value="ServiceRequest"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:3b3363be-d153-40ae-952f-09d15df1d9bf"/>
<resource>
<Practitioner>
<id value="ct-xT-practitioner"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Practitioner_ct-xT-practitioner"> </a><p class="res-header-id"><b>Generated Narrative: Practitioner ct-xT-practitioner</b></p><a name="ct-xT-practitioner"> </a><a name="hcct-xT-practitioner"> </a><a name="ct-xT-practitioner-en-US"> </a><p><b>identifier</b>: <a href="http://terminology.hl7.org/5.3.0/NamingSystem-npi.html" title="National Provider Identifier">United States National Provider Identifier</a>/9988776345</p><p><b>name</b>: Test Physician </p><p><b>address</b>: 600 Chicago Drive Everywhere TX 16789 US (work)</p><p><b>gender</b>: Female</p><h3>Qualifications</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0360 MD}">Doctor of Medicine</span></td></tr></table></div>
</text>
<identifier>
<system value="http://hl7.org/fhir/sid/us-npi"/>
<value value="9988776345"/>
</identifier>
<name>
<family value="Physician"/>
<given value="Test"/>
<prefix value="Dr."/>
</name>
<address>
<use value="work"/>
<line value="600 Chicago Drive"/>
<city value="Everywhere"/>
<state value="TX"/>
<postalCode value="16789"/>
<country value="US"/>
</address>
<gender value="female"/>
<qualification>
<code>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0360"/>
<version value="2.7"/>
<code value="MD"/>
</coding>
</code>
</qualification>
</Practitioner>
</resource>
<request>
<method value="POST"/>
<url value="Practitioner"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:60863097-6033-41af-9f6a-d7b012e276ae"/>
<resource>
<PractitionerRole>
<id value="ct-xT-physicianRole"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="PractitionerRole_ct-xT-physicianRole"> </a><p class="res-header-id"><b>Generated Narrative: PractitionerRole ct-xT-physicianRole</b></p><a name="ct-xT-physicianRole"> </a><a name="hcct-xT-physicianRole"> </a><a name="ct-xT-physicianRole-en-US"> </a><p><b>practitioner</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-3b3363be-d153-40ae-952f-09d15df1d9bf">Bundle: type = transaction</a></p><p><b>organization</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-f55969f0-aad6-4d9d-8af8-ae73b0ca4e8e">Bundle: type = transaction</a></p></div>
</text>
<practitioner>
<reference value="urn:uuid:3b3363be-d153-40ae-952f-09d15df1d9bf"/>
</practitioner>
<organization>
<reference value="urn:uuid:f55969f0-aad6-4d9d-8af8-ae73b0ca4e8e"/>
</organization>
</PractitionerRole>
</resource>
<request>
<method value="POST"/>
<url value="PractitionerRole"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:f55969f0-aad6-4d9d-8af8-ae73b0ca4e8e"/>
<resource>
<Organization>
<id value="ct-xT-OrderingOrganization"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Organization_ct-xT-OrderingOrganization"> </a><p class="res-header-id"><b>Generated Narrative: Organization ct-xT-OrderingOrganization</b></p><a name="ct-xT-OrderingOrganization"> </a><a name="hcct-xT-OrderingOrganization"> </a><a name="ct-xT-OrderingOrganization-en-US"> </a><p><b>identifier</b>: <a href="http://terminology.hl7.org/5.3.0/NamingSystem-CLIA.html" title=""The Centers for Medicare & Medicaid Services (CMS) regulates all laboratory testing (except research) performed on humans in the U.S. through the Clinical Laboratory Improvement Amendments (CLIA). In total, CLIA covers approximately 330,000 laboratory entities. The Division of Clinical Laboratory Improvement & Quality, within the Quality, Safety & Oversight Group, under the Center for Clinical Standards and Quality (CCSQ) has the responsibility for implementing the CLIA Program.
The objective of the CLIA program is to ensure quality laboratory testing. Although all clinical laboratories must be properly certified to receive Medicare or Medicaid payments, CLIA has no direct Medicare or Medicaid program responsibilities."
CMS CLIA certified laboratories will be assigned a10-digit alphanumeric CLIA identification number, with the "D" in the third position identifying the provider/supplier as a laboratory certified under CLIA."
CLIA is maintained by CMS. It is in the public domain and free to use without restriction.
See http://cms.gov/regulations-and-guidance/legislation/clia.">Clinical Laboratory Improvement Amendments</a>/14D2114007</p><p><b>active</b>: true</p><p><b>name</b>: Ordering Organization</p></div>
</text>
<identifier>
<system value="urn:oid:2.16.840.1.113883.4.7"/>
<value value="14D2114007"/>
</identifier>
<active value="true"/>
<name value="Ordering Organization"/>
</Organization>
</resource>
<request>
<method value="POST"/>
<url value="Organization"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:9ebd0cb1-4733-4b8e-999c-a66bcbd939dd"/>
<resource>
<Practitioner>
<id value="ct-xT-Pathologist"/>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Practitioner_ct-xT-Pathologist"> </a><p class="res-header-id"><b>Generated Narrative: Practitioner ct-xT-Pathologist</b></p><a name="ct-xT-Pathologist"> </a><a name="hcct-xT-Pathologist"> </a><a name="ct-xT-Pathologist-en-US"> </a><p><b>identifier</b>: <code>http://www.acme.com/identifiers/patient</code>/123456</p><p><b>name</b>: Test Pathologist </p></div>
</text>
<identifier>
<system value="http://www.acme.com/identifiers/patient"/>
<value value="123456"/>
</identifier>
<name>
<family value="Pathologist"/>
<given value="Test"/>
</name>
</Practitioner>
</resource>
<request>
<method value="POST"/>
<url value="Practitioner"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"/>
<resource>
<Organization>
<id value="ct-xT-Tempus-Organization"/>
<meta>
<profile
value="http://mitre.org/gdx/StructureDefinition/gdx-lab-organization"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Organization_ct-xT-Tempus-Organization"> </a><p class="res-header-id"><b>Generated Narrative: Organization ct-xT-Tempus-Organization</b></p><a name="ct-xT-Tempus-Organization"> </a><a name="hcct-xT-Tempus-Organization"> </a><a name="ct-xT-Tempus-Organization-en-US"> </a><p><b>identifier</b>: <a href="http://terminology.hl7.org/5.3.0/NamingSystem-CLIA.html" title=""The Centers for Medicare & Medicaid Services (CMS) regulates all laboratory testing (except research) performed on humans in the U.S. through the Clinical Laboratory Improvement Amendments (CLIA). In total, CLIA covers approximately 330,000 laboratory entities. The Division of Clinical Laboratory Improvement & Quality, within the Quality, Safety & Oversight Group, under the Center for Clinical Standards and Quality (CCSQ) has the responsibility for implementing the CLIA Program.
The objective of the CLIA program is to ensure quality laboratory testing. Although all clinical laboratories must be properly certified to receive Medicare or Medicaid payments, CLIA has no direct Medicare or Medicaid program responsibilities."
CMS CLIA certified laboratories will be assigned a10-digit alphanumeric CLIA identification number, with the "D" in the third position identifying the provider/supplier as a laboratory certified under CLIA."
CLIA is maintained by CMS. It is in the public domain and free to use without restriction.
See http://cms.gov/regulations-and-guidance/legislation/clia.">Clinical Laboratory Improvement Amendments</a>/14D2114007</p><p><b>active</b>: true</p><p><b>name</b>: Tempus Labs, Inc</p><p><b>telecom</b>: <a href="mailto:support@tempus.com">support@tempus.com</a></p><p><b>address</b>: 600 W Chicago Avenue, Ste 510 Chicago IL 60654 USA </p><h3>Contacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Name</b></td></tr><tr><td style="display: none">*</td><td>Nike Beaubier, M,FCAP,MGAP</td></tr></table></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="Specimen_ct-xT-specimen-normal"> </a><p class="res-header-id"><b>Generated Narrative: Specimen ct-xT-specimen-normal</b></p><a name="ct-xT-specimen-normal"> </a><a name="hcct-xT-specimen-normal"> </a><a name="ct-xT-specimen-normal-en-US"> </a><p><b>status</b>: Available</p><p><b>type</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0487 BLD}">Whole Blood</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>receivedTime</b>: 2021-02-09 21:30:50+0500</p><h3>Collections</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Collected[x]</b></td></tr><tr><td style="display: none">*</td><td>2021-02-06 17:15:00+0500</td></tr></table></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-Observation1"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-Observation1</b></p><a name="ct-xT-Observation1"> </a><a name="hcct-xT-Observation1"> </a><a name="ct-xT-Observation1-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9633-4}">Present</span></p><p><b>method</b>: <span title="Codes:{http://loinc.org LA26398-0}">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:950}, {https://www.ncbi.nlm.nih.gov/gene 3815}">BAP1</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 51958-7}">Transcript reference sequence [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_004656}">NM_004656.4</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48004-6}">DNA change (c.HGVS)</span></p><p><b>value</b>: <span title="Codes:">c.1768C>T</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48005-3}">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title="Codes:">p.Q590*</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48002-0}">Genomic source class [Type]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA6684-0}">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 81258-6}">Sample variant allelic frequency [NFr]</span></p><p><b>value</b>: 57.4 %<span style="background: LightGoldenRodYellow"> (Details: UCUM code% = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 62374-4}">Human reference sequence assembly version</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA14029-5}">GRCh37</span></p></blockquote></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-Observation5"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-Observation5</b></p><a name="ct-xT-Observation5"> </a><a name="hcct-xT-Observation5"> </a><a name="ct-xT-Observation5-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9633-4}">Present</span></p><p><b>method</b>: <span title="Codes:{http://loinc.org LA26398-0}">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:583}, {https://www.ncbi.nlm.nih.gov/gene 324}">APC encodes a multi-domain protein that interacts with factors involved in cellular proliferation, differentiation, maintenance, and structure including the microtubules and beta-catenin within the Wnt pathway. The APC p.I1307K variant has been associated with increased risk of developing colorectal cancer in the Ashkenazi Jewish population. For heterozygous patients, the increased risk if estimated as follows: odds ratio (OR) of 2.17 (95% confidence interval: 1.64-2.86) (PMID: 23576677) or adjusted OR of 1.75 (95% confidence interval: 1.26-2.45) (PMID: 23896379). The risk may be further increased in homozygous patients. The risk associated with the APC p.I1307K variant in other populations is still under study. Clinical correlation, including confirmation of this variant through a validated germline assay, and genetic counseling are recommended for this patient and any potentially at-risk family members.</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48002-0}">Genomic source class</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA6683-2}">Germline</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 51958-7}">Transcript reference sequence [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_000038}">NM_000038.6</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48004-6}">DNA change (c.HGVS)</span></p><p><b>value</b>: <span title="Codes:">c.3920T>A</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48005-3}">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title="Codes:">p.I1307K</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48000-4}">Chromosome [Identifier] in Blood or Tissue by Molecular genetics method</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA21258-1}">Chromosome 5</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 81254-5}">Variant exact start-end</span></p><p><b>value</b>: 112175211-?</p></blockquote></div>
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<code value="LA9633-4"/>
<display value="Present"/>
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<coding>
<system value="http://loinc.org"/>
<code value="LA26398-0"/>
<display value="Sequencing"/>
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<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:13711"/>
<display value="POF1B"/>
</coding>
<coding>
<system value="https://www.ncbi.nlm.nih.gov/gene"/>
<code value="79983"/>
<display value="POF1B"/>
</coding>
</valueCodeableConcept>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48002-0"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA6684-0"/>
<display value="Somatic"/>
</coding>
</valueCodeableConcept>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="51958-7"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.ncbi.nlm.nih.gov/refseq"/>
<code value="NM_004656"/>
<display value="NM_004656"/>
</coding>
</valueCodeableConcept>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48004-6"/>
</coding>
</code>
<valueCodeableConcept>
<text value="c.430C>T"/>
</valueCodeableConcept>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48005-3"/>
</coding>
</code>
<valueCodeableConcept>
<text value="p.P144S"/>
</valueCodeableConcept>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="81258-6"/>
</coding>
</code>
<valueQuantity>
<value value="78.6"/>
<unit value="%"/>
<system value="http://unitsofmeasure.org"/>
<code value="%"/>
</valueQuantity>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="62374-4"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA14029-5"/>
<display value="GRCh37"/>
</coding>
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</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:82a8b9db-a68e-4e06-897e-77ed3ea5aced"/>
<resource>
<Observation>
<id value="ct-xT-variant-fusion-met-alk"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant"/>
<profile
value="https://hl7.org/fhir/uv/genomics-reporting/2024Jan/StructureDefinition-variant.html"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-variant-fusion-met-alk"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-variant-fusion-met-alk</b></p><a name="ct-xT-variant-fusion-met-alk"> </a><a name="hcct-xT-variant-fusion-met-alk"> </a><a name="ct-xT-variant-fusion-met-alk-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 69548-6}">Genetic variant assessment</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>value</b>: <span title="Codes:{http://loinc.org LA9633-4}">Present</span></p><p><b>method</b>: <span title="Codes:{http://loinc.org LA26398-0}">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:7029}, {https://www.ncbi.nlm.nih.gov/gene 4233}">MET</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></p><p><b>value</b>: <span title="Codes:{http://www.genenames.org HGNC:427}, {https://www.ncbi.nlm.nih.gov/gene 238}">ALK</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48019-4}">DNA change type</span></p><p><b>value</b>: <span title="Codes:{http://sequenceontology.org SO:0002062}">complex_chromosomal_rearrangement</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 48002-0}">Genomic source class [Type]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA6684-0}">Somatic</span></p></blockquote></div>
</text>
<status value="final"/>
<category>
<coding>
<system
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<code value="laboratory"/>
</coding>
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<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
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<category>
<coding>
<system
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<code value="laboratory"/>
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<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
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<code>
<coding>
<system value="http://loinc.org"/>
<code value="69548-6"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
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<effectiveDateTime value="2019-04-01"/>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA9633-4"/>
<display value="Present"/>
</coding>
</valueCodeableConcept>
<method>
<coding>
<system value="http://loinc.org"/>
<code value="LA26398-0"/>
<display value="Sequencing"/>
</coding>
</method>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:7029"/>
<display value="MET"/>
</coding>
<coding>
<system value="https://www.ncbi.nlm.nih.gov/gene"/>
<code value="4233"/>
<display value="MET"/>
</coding>
</valueCodeableConcept>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:427"/>
<display value="ALK"/>
</coding>
<coding>
<system value="https://www.ncbi.nlm.nih.gov/gene"/>
<code value="238"/>
<display value="ALK"/>
</coding>
</valueCodeableConcept>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48019-4"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://sequenceontology.org"/>
<code value="SO:0002062"/>
<display value="complex_chromosomal_rearrangement"/>
</coding>
</valueCodeableConcept>
</component>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48002-0"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://loinc.org"/>
<code value="LA6684-0"/>
<display value="Somatic"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:5dfa33cc-9038-44d0-9f71-f319b3cb4c9a"/>
<resource>
<Observation>
<id value="ct-xT-molecular-consequence-observation-1"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-molecular-consequence-observation-1"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-molecular-consequence-observation-1</b></p><a name="ct-xT-molecular-consequence-observation-1"> </a><a name="hcct-xT-molecular-consequence-observation-1"> </a><a name="ct-xT-molecular-consequence-observation-1-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-08-23</p><p><b>performer</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-ccab39c5-49cf-4aa6-a1e7-2e0c9dd3a7d5">Bundle: type = transaction</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs feature-consequence}">Feature Consequence</span></p><p><b>value</b>: <span title="Codes:">Stop gain</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs functional-effect}">Functional Effect</span></p><p><b>value</b>: <span title="Codes:">loss of function</span></p></blockquote></div>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="molecular-consequence"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<effectiveDateTime value="2019-08-23"/>
<performer>
<reference value="urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"/>
</performer>
<derivedFrom>
<reference value="urn:uuid:ccab39c5-49cf-4aa6-a1e7-2e0c9dd3a7d5"/>
</derivedFrom>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="feature-consequence"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Stop gain"/>
</valueCodeableConcept>
</component>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="functional-effect"/>
</coding>
</code>
<valueCodeableConcept>
<text value="loss of function"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:3c30e177-2c41-4f13-b6c0-1adf5af4c71d"/>
<resource>
<Observation>
<id value="ct-xT-molecular-consequence-observation-4"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-molecular-consequence-observation-4"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-molecular-consequence-observation-4</b></p><a name="ct-xT-molecular-consequence-observation-4"> </a><a name="hcct-xT-molecular-consequence-observation-4"> </a><a name="ct-xT-molecular-consequence-observation-4-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-08-23</p><p><b>performer</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-6e333995-6a74-4dcd-ac7f-d7cf5ad20ac9">Bundle: type = transaction</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs feature-consequence}">Feature Consequence</span></td><td><span title="Codes:">Stop gain</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="molecular-consequence"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<effectiveDateTime value="2019-08-23"/>
<performer>
<reference value="urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"/>
</performer>
<derivedFrom>
<reference value="urn:uuid:6e333995-6a74-4dcd-ac7f-d7cf5ad20ac9"/>
</derivedFrom>
<component>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="feature-consequence"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Stop gain"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:0c06b231-47e9-4a3b-88bd-2d8937d615a7"/>
<resource>
<Observation>
<id value="ct-xT-molecular-consequence-observation-5"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-molecular-consequence-observation-5"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-molecular-consequence-observation-5</b></p><a name="ct-xT-molecular-consequence-observation-5"> </a><a name="hcct-xT-molecular-consequence-observation-5"> </a><a name="ct-xT-molecular-consequence-observation-5-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-08-23</p><p><b>performer</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-d7318c30-3975-4f62-9840-3b8d7e7b56cd">Bundle: type = transaction</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs feature-consequence}">Feature Consequence</span></td><td><span title="Codes:">Missense variant</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="molecular-consequence"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<effectiveDateTime value="2019-08-23"/>
<performer>
<reference value="urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"/>
</performer>
<derivedFrom>
<reference value="urn:uuid:d7318c30-3975-4f62-9840-3b8d7e7b56cd"/>
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<component>
<code>
<coding>
<system
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<code value="feature-consequence"/>
</coding>
</code>
<valueCodeableConcept>
<text value="Missense variant"/>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:00e47ced-f260-4baf-9da4-ee88224d3bc5"/>
<resource>
<Observation>
<id value="ct-xT-molecular-consequence-observation-6"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-molecular-consequence-observation-6"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-molecular-consequence-observation-6</b></p><a name="ct-xT-molecular-consequence-observation-6"> </a><a name="hcct-xT-molecular-consequence-observation-6"> </a><a name="ct-xT-molecular-consequence-observation-6-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-08-23</p><p><b>performer</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-86ad3e6b-7ed8-4c7d-b99c-574ac5e2b4b9">Bundle: type = transaction</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs feature-consequence}">Feature Consequence</span></td><td><span title="Codes:">Missense variant</span></td></tr></table></div>
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<code value="GE"/>
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<code>
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<code value="molecular-consequence"/>
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<subject>
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<component>
<code>
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<method value="POST"/>
<url value="Observation"/>
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<entry>
<fullUrl value="urn:uuid:dc69c7c9-031b-466f-bf63-8be56d658c50"/>
<resource>
<Observation>
<id value="ct-xT-molecular-consequence-observation-fusion"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-molecular-consequence-observation-fusion"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-molecular-consequence-observation-fusion</b></p><a name="ct-xT-molecular-consequence-observation-fusion"> </a><a name="hcct-xT-molecular-consequence-observation-fusion"> </a><a name="ct-xT-molecular-consequence-observation-fusion-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}">Molecular Consequence</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-08-23</p><p><b>performer</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href="Bundle-ct-xG-bundle.html#urn-uuid-82a8b9db-a68e-4e06-897e-77ed3ea5aced">Bundle: type = transaction</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs feature-consequence}">Feature Consequence</span></td><td><span title="Codes:{http://sequenceontology.org SO:0001565}">gene_fusion</span></td></tr></table></div>
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<code value="GE"/>
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<code value="laboratory"/>
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<category>
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<code value="GE"/>
</coding>
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<code>
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<system
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<code value="molecular-consequence"/>
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<subject>
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<derivedFrom>
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<component>
<code>
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<system
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<code value="feature-consequence"/>
</coding>
</code>
<valueCodeableConcept>
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<system value="http://sequenceontology.org"/>
<code value="SO:0001565"/>
<display value="gene_fusion"/>
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<method value="POST"/>
<url value="Observation"/>
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</entry>
<entry>
<fullUrl value="urn:uuid:kbe36a66-b7c9-4130-a181-81bb72e3f4zz"/>
<resource>
<Observation>
<id value="ct-xT-diagnostic-implication-fusion"/>
<meta>
<profile
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</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-diagnostic-implication-fusion"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-fusion</b></p><a name="ct-xT-diagnostic-implication-fusion"> </a><a name="hcct-xT-diagnostic-implication-fusion"> </a><a name="ct-xT-diagnostic-implication-fusion-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}">Diagnostic Implication</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href="Bundle-ct-xG-bundle.html#urn-uuid-82a8b9db-a68e-4e06-897e-77ed3ea5aced">Bundle: type = transaction</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 53037-8}">Genetic variation clinical significance [Imp]</span></td><td><span title="Codes:{http://loinc.org LA6668-3}">Pathogenic</span></td></tr></table></div>
</text>
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<category>
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<code value="laboratory"/>
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<category>
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<code value="GE"/>
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<category>
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<system
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<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="diagnostic-implication"/>
<display value="Diagnostic Implication"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<effectiveDateTime value="2019-04-01"/>
<derivedFrom>
<reference value="urn:uuid:82a8b9db-a68e-4e06-897e-77ed3ea5aced"/>
</derivedFrom>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="53037-8"/>
<display value="Genetic variation clinical significance [Imp]"/>
</coding>
</code>
<valueCodeableConcept>
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<system value="http://loinc.org"/>
<code value="LA6668-3"/>
<display value="Pathogenic"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
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</entry>
<entry>
<fullUrl value="urn:uuid:bbe36a66-b7c9-4130-a181-81bb72e3f4cc"/>
<resource>
<Observation>
<id value="ct-xT-diagnostic-implication-1"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-diagnostic-implication-1"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-1</b></p><a name="ct-xT-diagnostic-implication-1"> </a><a name="hcct-xT-diagnostic-implication-1"> </a><a name="ct-xT-diagnostic-implication-1-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}">Diagnostic Implication</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-ccab39c5-49cf-4aa6-a1e7-2e0c9dd3a7d5">Bundle: type = transaction</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 53037-8}">Genetic variation clinical significance [Imp]</span></td><td><span title="Codes:{http://loinc.org LA6668-3}">Pathogenic</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
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<code value="laboratory"/>
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</category>
<category>
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<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<category>
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<system
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<code value="laboratory"/>
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<category>
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<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system
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<code value="diagnostic-implication"/>
<display value="Diagnostic Implication"/>
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</code>
<subject>
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</subject>
<effectiveDateTime value="2019-04-01"/>
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<code value="53037-8"/>
<display value="Genetic variation clinical significance [Imp]"/>
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<valueCodeableConcept>
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<system value="http://loinc.org"/>
<code value="LA6668-3"/>
<display value="Pathogenic"/>
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<url value="Observation"/>
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<entry>
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<resource>
<Observation>
<id value="ct-xT-diagnostic-implication-2"/>
<meta>
<profile
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</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-diagnostic-implication-2"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-2</b></p><a name="ct-xT-diagnostic-implication-2"> </a><a name="hcct-xT-diagnostic-implication-2"> </a><a name="ct-xT-diagnostic-implication-2-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}">Diagnostic Implication</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-fc637e0b-dced-4245-946e-3fa13ec128e3">Bundle: type = transaction</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 53037-8}">Genetic variation clinical significance [Imp]</span></td><td><span title="Codes:{http://loinc.org LA6668-3}">Pathogenic</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
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<code value="laboratory"/>
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</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<category>
<coding>
<system
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<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system
value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
<code value="diagnostic-implication"/>
<display value="Diagnostic Implication"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<effectiveDateTime value="2019-04-01"/>
<derivedFrom>
<reference value="urn:uuid:fc637e0b-dced-4245-946e-3fa13ec128e3"/>
</derivedFrom>
<component>
<code>
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<code value="53037-8"/>
<display value="Genetic variation clinical significance [Imp]"/>
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<system value="http://loinc.org"/>
<code value="LA6668-3"/>
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<entry>
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<resource>
<Observation>
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<meta>
<profile
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</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-diagnostic-implication-3"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-3</b></p><a name="ct-xT-diagnostic-implication-3"> </a><a name="hcct-xT-diagnostic-implication-3"> </a><a name="ct-xT-diagnostic-implication-3-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}">Diagnostic Implication</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-c7a1db28-0c8f-4667-a40a-79401833b26b">Bundle: type = transaction</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 53037-8}">Genetic variation clinical significance [Imp]</span></td><td><span title="Codes:{http://loinc.org LA6668-3}">Pathogenic</span></td></tr></table></div>
</text>
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<category>
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<code value="laboratory"/>
</coding>
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<category>
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<code value="GE"/>
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<category>
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<system
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<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system
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<code value="diagnostic-implication"/>
<display value="Diagnostic Implication"/>
</coding>
</code>
<subject>
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<code>
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<code value="53037-8"/>
<display value="Genetic variation clinical significance [Imp]"/>
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<system value="http://loinc.org"/>
<code value="LA6668-3"/>
<display value="Pathogenic"/>
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</Observation>
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<request>
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<entry>
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<resource>
<Observation>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-diagnostic-implication-4"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-4</b></p><a name="ct-xT-diagnostic-implication-4"> </a><a name="hcct-xT-diagnostic-implication-4"> </a><a name="ct-xT-diagnostic-implication-4-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}">Diagnostic Implication</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-6e333995-6a74-4dcd-ac7f-d7cf5ad20ac9">Bundle: type = transaction</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 53037-8}">Genetic variation clinical significance [Imp]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA6668-3}">Pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 81259-4}">Associated phenotype</span></p><p><b>value</b>: <span title="Codes:">NTHL1 tumor syndrome, NTHL1-associated polyposis</span></p></blockquote></div>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-diagnostic-implication-5"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-5</b></p><a name="ct-xT-diagnostic-implication-5"> </a><a name="hcct-xT-diagnostic-implication-5"> </a><a name="ct-xT-diagnostic-implication-5-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}">Diagnostic Implication</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-d7318c30-3975-4f62-9840-3b8d7e7b56cd">Bundle: type = transaction</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 53037-8}">Genetic variation clinical significance [Imp]</span></p><p><b>value</b>: <span title="Codes:{http://loinc.org LA26332-9}">Likely Pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 81259-4}">Associated phenotype</span></p><p><b>value</b>: <span title="Codes:">APC-associated conditions</span></p></blockquote></div>
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<entry>
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<Observation>
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<meta>
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<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-diagnostic-implication-6"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-6</b></p><a name="ct-xT-diagnostic-implication-6"> </a><a name="hcct-xT-diagnostic-implication-6"> </a><a name="ct-xT-diagnostic-implication-6-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}">Diagnostic Implication</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-86ad3e6b-7ed8-4c7d-b99c-574ac5e2b4b9">Bundle: type = transaction</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 53037-8}">Genetic variation clinical significance [Imp]</span></td><td><span title="Codes:{http://loinc.org LA26333-7}">Uncertain Significance</span></td></tr></table></div>
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<resource>
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<meta>
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<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Procedure_ct-xT-procedure1"> </a><p class="res-header-id"><b>Generated Narrative: Procedure ct-xT-procedure1</b></p><a name="ct-xT-procedure1"> </a><a name="hcct-xT-procedure1"> </a><a name="ct-xT-procedure1-en-US"> </a><blockquote><p><b>Genomic Study Analysis Regions</b></p><ul><li>description: Pertinent Negative</li><li>studied: <span title="Codes:{http://www.genenames.org HGNC:7989}, {https://www.ncbi.nlm.nih.gov/gene 4893}">NRAS</span></li><li>studied: <span title="Codes:{http://www.genenames.org HGNC:6342}, {https://www.ncbi.nlm.nih.gov/gene 3815}">KIT</span></li><li>studied: <span title="Codes:{http://www.genenames.org HGNC:1097}, {https://www.ncbi.nlm.nih.gov/gene 673}">BRAF</span></li></ul></blockquote><p><b>status</b>: Completed</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>performed</b>: 2023-08-09 01:01:10-0600</p></div>
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<request>
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<entry>
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<resource>
<Procedure>
<id value="ct-xT-genomicStudy"/>
<meta>
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<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Procedure_ct-xT-genomicStudy"> </a><p class="res-header-id"><b>Generated Narrative: Procedure ct-xT-genomicStudy</b></p><a name="ct-xT-genomicStudy"> </a><a name="hcct-xT-genomicStudy"> </a><a name="ct-xT-genomicStudy-en-US"> </a><p><b>Genomic Study Analysis Extension</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-5fe0e4c4-fd4b-4e9d-af1e-b3b40c28a21a">Bundle: type = transaction</a></p><p><b>basedOn</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-28395cc2-c6e4-4006-84af-ebf40113656a">Bundle: type = transaction</a></p><p><b>status</b>: Completed</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:">xT panel</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>performed</b>: 2023-08-09</p></div>
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<performedDateTime value="2023-08-09"/>
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<entry>
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<meta>
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<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_gx-genomic-tmb"> </a><p class="res-header-id"><b>Generated Narrative: Observation gx-genomic-tmb</b></p><a name="gx-genomic-tmb"> </a><a name="hcgx-genomic-tmb"> </a><a name="gx-genomic-tmb-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}">A characterization of a given biomarker observation.</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 94076-7}">Mutations/Megabase [# Ratio] in Tumor</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>value</b>: 5.2 1/1000000{Base}<span style="background: LightGoldenRodYellow"> (Details: UCUM code1/1000000{Base} = '1/1000000{Base}')</span></p></div>
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<entry>
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<resource>
<ResearchStudy>
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<text>
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<div xmlns="http://www.w3.org/1999/xhtml"><a name="ResearchStudy_gx-genomic-research-study-implication-clinical-trial-NCT02693535"> </a><p class="res-header-id"><b>Generated Narrative: ResearchStudy gx-genomic-research-study-implication-clinical-trial-NCT02693535</b></p><a name="gx-genomic-research-study-implication-clinical-trial-NCT02693535"> </a><a name="hcgx-genomic-research-study-implication-clinical-trial-NCT02693535"> </a><a name="gx-genomic-research-study-implication-clinical-trial-NCT02693535-en-US"> </a><p><b>identifier</b>: <a href="http://terminology.hl7.org/6.1.0/NamingSystem-ClinicalTrialsGov.html" title="The U.S. National Institutes of Health, Department of Health and Human Services, through its National Library of Medicine, has developed [ClinicalTrials.gov](http://clinicaltrials.gov) to provide patients, family members, and members of the public current information about clinical research studies. [ClinicalTrials.gov](http://clinicaltrials.gov) contains summary information about clinical studies being conducted throughout the United States and in many countries throughout the world. These data are provided to the National Library of Medicine by organizations and institutions that sponsor and implement the studies.
[ClinicalTrials.gov](http://clinicaltrials.gov) is updated daily. You should check [ClinicalTrials.gov](http://clinicaltrials.gov) frequently for updated information.
More information about ClinicalTrials.gov can be found [here](https://clinicaltrials.gov/about-site/about-ctg).">ClinicalTrials.gov</a>/NCT02693535</p><p><b>title</b>: TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer</p><p><b>status</b>: Active</p><p><b>phase</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/research-study-phase phase-2}">Phase 2</span></p><h3>RelatedArtifacts</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Type</b></td><td><b>Url</b></td></tr><tr><td style="display: none">*</td><td>Citation</td><td><a href="https://clinicaltrials.gov/ct2/show/NCT02693535">https://clinicaltrials.gov/ct2/show/NCT02693535</a></td></tr></table><p><b>site</b>: Zion, Illinois (Identifier: <code>https://www.usps.com/</code>/IL)</p></div>
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<display value="Zion, Illinois"/>
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<entry>
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<Observation>
<id value="ct-xT-clinicalTrial"/>
<meta>
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value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"/>
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<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-clinicalTrial"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-clinicalTrial</b></p><a name="ct-xT-clinicalTrial"> </a><a name="hcct-xT-clinicalTrial"> </a><a name="ct-xT-clinicalTrial-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}">Therapeutic Implication</span></p><p><b>derivedFrom</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-fc637e0b-dced-4245-946e-3fa13ec128e3">Bundle: type = transaction</a></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Extension</b></td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td/><td><span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs associated-therapy}">Associated Therapy</span></td><td><span title="Codes:{http://clinicaltrials.gov NCT02693535}">NCT02693535</span></td></tr></table></div>
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<status value="final"/>
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<code value="laboratory"/>
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<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
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<code>
<coding>
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<code value="therapeutic-implication"/>
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<derivedFrom>
<reference value="urn:uuid:fc637e0b-dced-4245-946e-3fa13ec128e3"/>
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<component>
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<code value="associated-therapy"/>
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<entry>
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<resource>
<Observation>
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<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"/>
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<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-HLA-A-haplotype1"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-HLA-A-haplotype1</b></p><a name="ct-xT-HLA-A-haplotype1"> </a><a name="hcct-xT-HLA-A-haplotype1"> </a><a name="ct-xT-HLA-A-haplotype1-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 84414-2}">Haplotype Name</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-02-01</p><p><b>issued</b>: 2019-02-01 00:00:00-0500</p><p><b>performer</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae">Bundle: type = transaction</a></p><p><b>value</b>: <span title="Codes:{http://www.ebi.ac.uk/ipd/imgt/hla A*03:01}">HLA-A*03:01</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></td><td><span title="Codes:{http://www.genenames.org HGNC:4931}">HLA-A</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
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<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84414-2"/>
<display value="Haplotype Name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<effectiveDateTime value="2019-02-01"/>
<issued value="2019-02-01T00:00:00-05:00"/>
<performer>
<reference value="urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"/>
</performer>
<valueCodeableConcept>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<code value="A*03:01"/>
<display value="HLA-A*03:01"/>
</coding>
</valueCodeableConcept>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4931"/>
<display value="HLA-A"/>
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</Observation>
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<request>
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<url value="Observation"/>
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</entry>
<entry>
<fullUrl value="urn:uuid:b745fef5-462d-4b6c-bddc-a7c573c614ef"/>
<resource>
<Observation>
<id value="ct-xT-HLA-A-haplotype2"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-HLA-A-haplotype2"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-HLA-A-haplotype2</b></p><a name="ct-xT-HLA-A-haplotype2"> </a><a name="hcct-xT-HLA-A-haplotype2"> </a><a name="ct-xT-HLA-A-haplotype2-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 84414-2}">Haplotype Name</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-02-01</p><p><b>issued</b>: 2019-02-01 00:00:00-0500</p><p><b>performer</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae">Bundle: type = transaction</a></p><p><b>value</b>: <span title="Codes:{http://www.ebi.ac.uk/ipd/imgt/hla A*31:01}">HLA-A*31:01</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></td><td><span title="Codes:{http://www.genenames.org HGNC:4931}">HLA-A</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84414-2"/>
<display value="Haplotype Name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<effectiveDateTime value="2019-02-01"/>
<issued value="2019-02-01T00:00:00-05:00"/>
<performer>
<reference value="urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"/>
</performer>
<valueCodeableConcept>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<code value="A*31:01"/>
<display value="HLA-A*31:01"/>
</coding>
</valueCodeableConcept>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4931"/>
<display value="HLA-A"/>
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</Observation>
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<request>
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</entry>
<entry>
<fullUrl value="urn:uuid:29d40ea4-2946-4a90-a259-7a6025b3b090"/>
<resource>
<Observation>
<id value="ct-xT-HLA-B-haplotype1"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-HLA-B-haplotype1"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-HLA-B-haplotype1</b></p><a name="ct-xT-HLA-B-haplotype1"> </a><a name="hcct-xT-HLA-B-haplotype1"> </a><a name="ct-xT-HLA-B-haplotype1-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 84414-2}">Haplotype Name</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-02-01</p><p><b>issued</b>: 2019-02-01 00:00:00-0500</p><p><b>performer</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae">Bundle: type = transaction</a></p><p><b>value</b>: <span title="Codes:{http://www.ebi.ac.uk/ipd/imgt/hla B*07:02}">HLA-B*07:02</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></td><td><span title="Codes:{http://www.genenames.org HGNC:4932}">HLA-B</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84414-2"/>
<display value="Haplotype Name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<effectiveDateTime value="2019-02-01"/>
<issued value="2019-02-01T00:00:00-05:00"/>
<performer>
<reference value="urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"/>
</performer>
<valueCodeableConcept>
<coding>
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<code value="B*07:02"/>
<display value="HLA-B*07:02"/>
</coding>
</valueCodeableConcept>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4932"/>
<display value="HLA-B"/>
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</Observation>
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<method value="POST"/>
<url value="Observation"/>
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</entry>
<entry>
<fullUrl value="urn:uuid:9095423d-db5e-4c28-a876-53a3b19fb6de"/>
<resource>
<Observation>
<id value="ct-xT-HLA-B-haplotype2"/>
<meta>
<profile
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</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-HLA-B-haplotype2"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-HLA-B-haplotype2</b></p><a name="ct-xT-HLA-B-haplotype2"> </a><a name="hcct-xT-HLA-B-haplotype2"> </a><a name="ct-xT-HLA-B-haplotype2-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 84414-2}">Haplotype Name</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-02-01</p><p><b>issued</b>: 2019-02-01 00:00:00-0500</p><p><b>performer</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae">Bundle: type = transaction</a></p><p><b>value</b>: <span title="Codes:{http://www.ebi.ac.uk/ipd/imgt/hla B*35:01}">HLA-B*35:01</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></td><td><span title="Codes:{http://www.genenames.org HGNC:4932}">HLA-B</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
<system
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<code value="laboratory"/>
</coding>
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<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84414-2"/>
<display value="Haplotype Name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<effectiveDateTime value="2019-02-01"/>
<issued value="2019-02-01T00:00:00-05:00"/>
<performer>
<reference value="urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"/>
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<valueCodeableConcept>
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<code value="B*35:01"/>
<display value="HLA-B*35:01"/>
</coding>
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<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4932"/>
<display value="HLA-B"/>
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</Observation>
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<request>
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<url value="Observation"/>
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</entry>
<entry>
<fullUrl value="urn:uuid:da9b5431-1b88-461d-ab57-49502fe20117"/>
<resource>
<Observation>
<id value="ct-xT-HLA-C-haplotype1"/>
<meta>
<profile
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</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-HLA-C-haplotype1"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-HLA-C-haplotype1</b></p><a name="ct-xT-HLA-C-haplotype1"> </a><a name="hcct-xT-HLA-C-haplotype1"> </a><a name="ct-xT-HLA-C-haplotype1-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 84414-2}">Haplotype Name</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-02-01</p><p><b>issued</b>: 2019-02-01 00:00:00-0500</p><p><b>performer</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae">Bundle: type = transaction</a></p><p><b>value</b>: <span title="Codes:{http://www.ebi.ac.uk/ipd/imgt/hla C*04:01}">HLA-C*04:01</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></td><td><span title="Codes:{http://www.genenames.org HGNC:4933}">HLA-C</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
<system
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<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84414-2"/>
<display value="Haplotype Name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<effectiveDateTime value="2019-02-01"/>
<issued value="2019-02-01T00:00:00-05:00"/>
<performer>
<reference value="urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"/>
</performer>
<valueCodeableConcept>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<code value="C*04:01"/>
<display value="HLA-C*04:01"/>
</coding>
</valueCodeableConcept>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4933"/>
<display value="HLA-C"/>
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</Observation>
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<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:148fddd2-ab27-4abe-b096-8cf905905bc0"/>
<resource>
<Observation>
<id value="ct-xT-HLA-C-haplotype2"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Observation_ct-xT-HLA-C-haplotype2"> </a><p class="res-header-id"><b>Generated Narrative: Observation ct-xT-HLA-C-haplotype2</b></p><a name="ct-xT-HLA-C-haplotype2"> </a><a name="hcct-xT-HLA-C-haplotype2"> </a><a name="ct-xT-HLA-C-haplotype2-en-US"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span>, <span title="Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}">Genetics</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 84414-2}">Haplotype Name</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-02-01</p><p><b>issued</b>: 2019-02-01 00:00:00-0500</p><p><b>performer</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae">Bundle: type = transaction</a></p><p><b>value</b>: <span title="Codes:{http://www.ebi.ac.uk/ipd/imgt/hla C*07:02}">HLA-C*07:02</span></p><h3>Components</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style="display: none">*</td><td><span title="Codes:{http://loinc.org 48018-6}">Gene studied [ID]</span></td><td><span title="Codes:{http://www.genenames.org HGNC:4933}">HLA-C</span></td></tr></table></div>
</text>
<status value="final"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<category>
<coding>
<system value="http://terminology.hl7.org/CodeSystem/v2-0074"/>
<code value="GE"/>
</coding>
</category>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="84414-2"/>
<display value="Haplotype Name"/>
</coding>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<effectiveDateTime value="2019-02-01"/>
<issued value="2019-02-01T00:00:00-05:00"/>
<performer>
<reference value="urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"/>
</performer>
<valueCodeableConcept>
<coding>
<system value="http://www.ebi.ac.uk/ipd/imgt/hla"/>
<code value="C*07:02"/>
<display value="HLA-C*07:02"/>
</coding>
</valueCodeableConcept>
<component>
<code>
<coding>
<system value="http://loinc.org"/>
<code value="48018-6"/>
</coding>
</code>
<valueCodeableConcept>
<coding>
<system value="http://www.genenames.org"/>
<code value="HGNC:4933"/>
<display value="HLA-C"/>
</coding>
</valueCodeableConcept>
</component>
</Observation>
</resource>
<request>
<method value="POST"/>
<url value="Observation"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:b3s0f176-e402-4eaf-989c-959e80d91n5f"/>
<resource>
<DocumentReference>
<id value="ct-xT-GeneList"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-data-file"/>
</meta>
<text>
<status value="generated"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="DocumentReference_ct-xT-GeneList"> </a><p class="res-header-id"><b>Generated Narrative: DocumentReference ct-xT-GeneList</b></p><a name="ct-xT-GeneList"> </a><a name="hcct-xT-GeneList"> </a><a name="ct-xT-GeneList-en-US"> </a><p><b>identifier</b>: <code>https://www.tempus.com</code>/11120</p><p><b>status</b>: Current</p><p><b>docStatus</b>: Preliminary</p><p><b>description</b>: Gene List</p><blockquote><p><b>content</b></p><h3>Attachments</h3><table class="grid"><tr><td style="display: none">-</td><td><b>Url</b></td><td><b>Title</b></td><td><b>Creation</b></td></tr><tr><td style="display: none">*</td><td><a href="https://edge-api-demo.stagingtempus.com/fhir/R4/static/Gene_List_1.json">https://edge-api-demo.stagingtempus.com/fhir/R4/static/Gene_List_1.json</a></td><td>GeneList</td><td>2019-03-01 01:02:01+0100</td></tr></table></blockquote></div>
</text>
<identifier>
<system value="https://www.tempus.com"/>
<value value="11120"/>
</identifier>
<status value="current"/>
<docStatus value="preliminary"/>
<description value="Gene List"/>
<content>
<attachment>
<url
value="https://edge-api-demo.stagingtempus.com/fhir/R4/static/Gene_List_1.json"/>
<title value="GeneList"/>
<creation value="2019-03-01T01:02:01+01:00"/>
</attachment>
</content>
</DocumentReference>
</resource>
<request>
<method value="POST"/>
<url value="DocumentReference"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:11163097-6033-41af-9f6a-d7b012e27aaa"/>
<resource>
<Procedure>
<id value="ct-xT-genomicStudyAnalysis"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Procedure_ct-xT-genomicStudyAnalysis"> </a><p class="res-header-id"><b>Generated Narrative: Procedure ct-xT-genomicStudyAnalysis</b></p><a name="ct-xT-genomicStudyAnalysis"> </a><a name="hcct-xT-genomicStudyAnalysis"> </a><a name="ct-xT-genomicStudyAnalysis-en-US"> </a><blockquote><p><b>Genomic Study Analysis Regions</b></p><ul><li>studied: <a href="Bundle-ct-xT-bundle.html#urn-uuid-b3s0f176-e402-4eaf-989c-959e80d91n5f">Bundle: type = transaction</a></li></ul></blockquote><p><b>Genomic Study Analysis Specimen</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-f5418e88-295b-43f8-af03-76c8c4aa516e">Bundle: type = transaction</a></p><p><b>Genomic Study Analysis Focus</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>status</b>: Completed</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>performed</b>: 2023-02-02 01:01:10-0600</p></div>
</text>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-regions">
<extension url="studied">
<valueReference>
<reference
value="urn:uuid:b3s0f176-e402-4eaf-989c-959e80d91n5f"/>
</valueReference>
</extension>
</extension>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-specimen">
<valueReference>
<reference value="urn:uuid:f5418e88-295b-43f8-af03-76c8c4aa516e"/>
</valueReference>
</extension>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-focus">
<valueReference>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</valueReference>
</extension>
<status value="completed"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<performedDateTime value="2023-02-02T01:01:10-06:00"/>
</Procedure>
</resource>
<request>
<method value="POST"/>
<url value="Procedure"/>
</request>
</entry>
<entry>
<fullUrl value="urn:uuid:88f2715b-10ea-42ae-a3a2-185b14e6e666"/>
<resource>
<Procedure>
<id value="ct-xT-genomicStudy-2"/>
<meta>
<profile
value="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study"/>
</meta>
<text>
<status value="extensions"/>
<div xmlns="http://www.w3.org/1999/xhtml"><a name="Procedure_ct-xT-genomicStudy-2"> </a><p class="res-header-id"><b>Generated Narrative: Procedure ct-xT-genomicStudy-2</b></p><a name="ct-xT-genomicStudy-2"> </a><a name="hcct-xT-genomicStudy-2"> </a><a name="ct-xT-genomicStudy-2-en-US"> </a><p><b>Genomic Study Analysis Extension</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-11163097-6033-41af-9f6a-d7b012e27aaa">Bundle: type = transaction</a></p><p><b>basedOn</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-28395cc2-c6e4-4006-84af-ebf40113656a">Bundle: type = transaction</a></p><p><b>status</b>: Completed</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Laboratory</span></p><p><b>code</b>: <span title="Codes:">xT panel</span></p><p><b>subject</b>: <a href="Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4">Bundle: type = transaction</a></p><p><b>performed</b>: 2023-08-09</p></div>
</text>
<extension
url="http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-ext">
<valueReference>
<reference value="urn:uuid:11163097-6033-41af-9f6a-d7b012e27aaa"/>
</valueReference>
</extension>
<basedOn>
<reference value="urn:uuid:28395cc2-c6e4-4006-84af-ebf40113656a"/>
</basedOn>
<status value="completed"/>
<category>
<coding>
<system
value="http://terminology.hl7.org/CodeSystem/observation-category"/>
<code value="laboratory"/>
</coding>
</category>
<code>
<text value="xT panel"/>
</code>
<subject>
<reference value="urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"/>
</subject>
<performedDateTime value="2023-08-09"/>
</Procedure>
</resource>
<request>
<method value="POST"/>
<url value="Procedure"/>
</request>
</entry>
</Bundle>