GenomeX Data Exchange FHIR IG
0.2.0 - draft

GenomeX Data Exchange FHIR IG, published by MITRE. This guide is not an authorized publication; it is the continuous build for version 0.2.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/CodeX-HL7-FHIR-Accelerator/GenomeX-DataExchange/ and changes regularly. See the Directory of published versions

: ct-xT-bundle - JSON Representation

Raw json | Download

{
  "resourceType" : "Bundle",
  "id" : "ct-xT-bundle",
  "meta" : {
    "profile" : [
      🔗 "http://mitre.org/gdx/StructureDefinition/gdx-genomics-somatic-bundle"
    ]
  },
  "type" : "transaction",
  "entry" : [
    {
      "fullUrl" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4",
      "resource" : {
        "resourceType" : "Patient",
        "id" : "ct-xT-Patient",
        "meta" : {
          "profile" : [
            🔗 "http://mitre.org/gdx/StructureDefinition/gdx-patient"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Patient_ct-xT-Patient\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Patient ct-xT-Patient</b></p><a name=\"ct-xT-Patient\"> </a><a name=\"hcct-xT-Patient\"> </a><a name=\"ct-xT-Patient-en-US\"> </a><p style=\"border: 1px #661aff solid; background-color: #e6e6ff; padding: 10px;\">Mela Mann  Female, DoB: 1926-08-06 ( Medical Record Number: 993456789\u00a0(use:\u00a0official,\u00a0))</p><hr/><table class=\"grid\"><tr><td style=\"background-color: #f3f5da\" title=\"Other Id (see the one above)\">Other Id:</td><td colspan=\"3\">Patient external identifier/23ef1d1b-03a5-47d6-81e0-b9b4cbb15ccf\u00a0(use:\u00a0official,\u00a0)</td></tr></table></div>"
        },
        "identifier" : [
          {
            "use" : "official",
            "type" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                  "code" : "PT",
                  "display" : "Patient external identifier"
                }
              ]
            },
            "system" : "https://www.tempus.com",
            "value" : "23ef1d1b-03a5-47d6-81e0-b9b4cbb15ccf"
          },
          {
            "use" : "official",
            "type" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                  "code" : "MR",
                  "display" : "Medical Record Number"
                }
              ]
            },
            "system" : "http://hospital.example.org",
            "value" : "993456789"
          }
        ],
        "name" : [
          {
            "family" : "Mann",
            "given" : [
              "Mela"
            ]
          }
        ],
        "gender" : "Female",
        "birthDate" : "1926-08-06"
      },
      "request" : {
        "method" : "POST",
        "url" : "Patient"
      }
    },
    {
      "fullUrl" : "urn:uuid:56eeebfb-9df4-4789-955b-76bcec2d77a4",
      "resource" : {
        "resourceType" : "DiagnosticReport",
        "id" : "ct-xT-DiagnosticReport",
        "meta" : {
          "profile" : [
            🔗 "http://mitre.org/gdx/StructureDefinition/gdx-genomic-report"🔗 ,
            "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DiagnosticReport_ct-xT-DiagnosticReport\"> </a><p class=\"res-header-id\"><b>Generated Narrative: DiagnosticReport ct-xT-DiagnosticReport</b></p><a name=\"ct-xT-DiagnosticReport\"> </a><a name=\"hcct-xT-DiagnosticReport\"> </a><a name=\"ct-xT-DiagnosticReport-en-US\"> </a><h2><span title=\"Codes:{http://loinc.org 51969-4}\">Genetic analysis report</span> (<span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:\">DNA</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>) </h2><table class=\"grid\"><tr><td>Subject</td><td>Not done yet</td></tr><tr><td>When For</td><td>2019-02-15 19:28:58+0500</td></tr><tr><td>Performer</td><td> <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae\">Bundle: type = transaction</a></td></tr><tr><td>Identifiers</td><td> Accession ID/TL-22-D3MTCAU4 Pipeline Version/3.9.3 Placer Identifier/d6eeedd1-92d3-45b9-bf33-6401e804425f</td></tr></table><p><b>Report Details</b></p><table class=\"grid\"><tr><td><b>Code</b></td><td><b>Value</b></td></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr><tr><td/><td/></tr></table></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-reference",
            "valueReference" : {
              "reference" : "urn:uuid:16f2715b-10ea-42ae-a3a2-185b14e6e21f"
            }
          },
          {
            "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-reference",
            "valueReference" : {
              "reference" : "urn:uuid:88f2715b-10ea-42ae-a3a2-185b14e6e666"
            }
          },
          {
            "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report-note",
            "valueAnnotation" : {
              "extension" : [
                {
                  "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/annotation-code",
                  "valueCodeableConcept" : {
                    "coding" : [
                      {
                        "code" : "copyright"
                      }
                    ]
                  }
                }
              ],
              "text" : "(c) Copyright Tempus 2022. All Rights Reserved."
            }
          },
          {
            "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report-note",
            "valueAnnotation" : {
              "extension" : [
                {
                  "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/annotation-code",
                  "valueCodeableConcept" : {
                    "coding" : [
                      {
                        "code" : "schemaVersion"
                      }
                    ]
                  }
                }
              ],
              "text" : "1.5.0"
            }
          }
        ],
        "identifier" : [
          {
            "type" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                  "code" : "ACSN",
                  "display" : "Accession ID"
                }
              ]
            },
            "system" : "https://www.tempus.com",
            "value" : "TL-22-D3MTCAU4"
          },
          {
            "type" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                  "code" : "RI",
                  "display" : "Pipeline Version"
                }
              ]
            },
            "system" : "https://www.tempus.com",
            "value" : "3.9.3"
          },
          {
            "type" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                  "code" : "PLAC",
                  "display" : "Placer Identifier"
                }
              ]
            },
            "system" : "https://www.tempus.com",
            "value" : "d6eeedd1-92d3-45b9-bf33-6401e804425f"
          }
        ],
        "basedOn" : [
          {
            "reference" : "urn:uuid:28395cc2-c6e4-4006-84af-ebf40113656a"
          }
        ],
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "text" : "DNA"
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "51969-4",
              "display" : "Genetic analysis report"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-02-15T19:28:58+05:00",
        "performer" : [
          {
            "reference" : "urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"
          }
        ],
        "resultsInterpreter" : [
          {
            "reference" : "urn:uuid:9ebd0cb1-4733-4b8e-999c-a66bcbd939dd"
          }
        ],
        "specimen" : [
          {
            "reference" : "urn:uuid:f5418e88-295b-43f8-af03-76c8c4aa516e"
          },
          {
            "reference" : "urn:uuid:1e6f171a-1dea-41b8-a51d-1f86130a43cc"
          }
        ],
        "result" : [
          {
            "reference" : "urn:uuid:ccab39c5-49cf-4aa6-a1e7-2e0c9dd3a7d5"
          },
          {
            "reference" : "urn:uuid:fc637e0b-dced-4245-946e-3fa13ec128e3"
          },
          {
            "reference" : "urn:uuid:c7a1db28-0c8f-4667-a40a-79401833b26b"
          },
          {
            "reference" : "urn:uuid:6e333995-6a74-4dcd-ac7f-d7cf5ad20ac9"
          },
          {
            "reference" : "urn:uuid:d7318c30-3975-4f62-9840-3b8d7e7b56cd"
          },
          {
            "reference" : "urn:uuid:86ad3e6b-7ed8-4c7d-b99c-574ac5e2b4b9"
          },
          {
            "reference" : "urn:uuid:5dfa33cc-9038-44d0-9f71-f319b3cb4c9a"
          },
          {
            "reference" : "urn:uuid:52554ca2-dcdd-4105-9cb7-059f0a863483"
          },
          {
            "reference" : "urn:uuid:3c30e177-2c41-4f13-b6c0-1adf5af4c71d"
          },
          {
            "reference" : "urn:uuid:0c06b231-47e9-4a3b-88bd-2d8937d615a7"
          },
          {
            "reference" : "urn:uuid:00e47ced-f260-4baf-9da4-ee88224d3bc5"
          },
          {
            "reference" : "urn:uuid:bbe36a66-b7c9-4130-a181-81bb72e3f4cc"
          },
          {
            "reference" : "urn:uuid:7bb9b47d-2b77-47a6-ae2a-62f0b1d01d05"
          },
          {
            "reference" : "urn:uuid:dddaac5f-e8ba-4c55-a70c-5c6d80903356"
          },
          {
            "reference" : "urn:uuid:69b54656-b1eb-4393-ac69-f25f32fde680"
          },
          {
            "reference" : "urn:uuid:f845d26f-7308-45ab-9898-ebc86d6ae22c"
          },
          {
            "reference" : "urn:uuid:4be89099-d07b-4c94-a1ef-be16233a79d8"
          },
          {
            "reference" : "urn:uuid:da3cfb61-7b73-429d-b933-36b41b5e4a66"
          },
          {
            "reference" : "urn:uuid:b745fef5-462d-4b6c-bddc-a7c573c614ef"
          },
          {
            "reference" : "urn:uuid:29d40ea4-2946-4a90-a259-7a6025b3b090"
          },
          {
            "reference" : "urn:uuid:9095423d-db5e-4c28-a876-53a3b19fb6de"
          },
          {
            "reference" : "urn:uuid:da9b5431-1b88-461d-ab57-49502fe20117"
          },
          {
            "reference" : "urn:uuid:148fddd2-ab27-4abe-b096-8cf905905bc0"
          },
          {
            "reference" : "urn:uuid:82a8b9db-a68e-4e06-897e-77ed3ea5aced"
          },
          {
            "reference" : "urn:uuid:dc69c7c9-031b-466f-bf63-8be56d658c50"
          },
          {
            "reference" : "urn:uuid:kbe36a66-b7c9-4130-a181-81bb72e3f4zz"
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "DiagnosticReport"
      }
    },
    {
      "fullUrl" : "urn:uuid:28395cc2-c6e4-4006-84af-ebf40113656a",
      "resource" : {
        "resourceType" : "ServiceRequest",
        "id" : "ct-xT-ServiceRequest",
        "meta" : {
          "profile" : [
            🔗 "http://mitre.org/gdx/StructureDefinition/gdx-service-request"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ServiceRequest_ct-xT-ServiceRequest\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ServiceRequest ct-xT-ServiceRequest</b></p><a name=\"ct-xT-ServiceRequest\"> </a><a name=\"hcct-xT-ServiceRequest\"> </a><a name=\"ct-xT-ServiceRequest-en-US\"> </a><p><b>identifier</b>: Filler Identifier/23gcimeh</p><p><b>requisition</b>: Accession ID/TL-23-5B8EHM49</p><p><b>status</b>: Completed</p><p><b>intent</b>: Order</p><p><b>code</b>: <span title=\"Codes:{https://www.tempus.com XT.V4}\">xT - 648 gene panel</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>requester</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3b3363be-d153-40ae-952f-09d15df1d9bf\">Bundle: type = transaction</a></p><p><b>reasonCode</b>: <span title=\"Codes:{http://hl7.org/fhir/sid/icd-10-cm C34.9}, {http://terminology.hl7.org/CodeSystem/icd-o-3 C34.9 8140/3}\">Malignant neoplasm of unspecified part of bronchus or lung</span></p></div>"
        },
        "identifier" : [
          {
            "type" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                  "code" : "FILL",
                  "display" : "Filler Identifier"
                }
              ]
            },
            "system" : "https://www.tempus.com",
            "value" : "23gcimeh"
          }
        ],
        "requisition" : {
          "type" : {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                "code" : "ACSN",
                "display" : "Accession ID"
              }
            ]
          },
          "system" : "https://www.tempus.com",
          "value" : "TL-23-5B8EHM49"
        },
        "status" : "completed",
        "intent" : "order",
        "code" : {
          "coding" : [
            {
              "system" : "https://www.tempus.com",
              "code" : "XT.V4",
              "display" : "xT - 648 gene panel"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "requester" : {
          "reference" : "urn:uuid:3b3363be-d153-40ae-952f-09d15df1d9bf"
        },
        "reasonCode" : [
          {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/sid/icd-10-cm",
                "code" : "C34.9",
                "display" : "Malignant neoplasm of unspecified part of bronchus or lung"
              },
              {
                "system" : "http://terminology.hl7.org/CodeSystem/icd-o-3",
                "code" : "C34.9 8140/3",
                "display" : "Lung adenocarcinoma"
              }
            ]
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "ServiceRequest"
      }
    },
    {
      "fullUrl" : "urn:uuid:3b3363be-d153-40ae-952f-09d15df1d9bf",
      "resource" : {
        "resourceType" : "Practitioner",
        "id" : "ct-xT-practitioner",
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Practitioner_ct-xT-practitioner\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Practitioner ct-xT-practitioner</b></p><a name=\"ct-xT-practitioner\"> </a><a name=\"hcct-xT-practitioner\"> </a><a name=\"ct-xT-practitioner-en-US\"> </a><p><b>identifier</b>: <a href=\"http://terminology.hl7.org/5.3.0/NamingSystem-npi.html\" title=\"National Provider Identifier\">United States National Provider Identifier</a>/9988776345</p><p><b>name</b>: Test Physician </p><p><b>address</b>: 600 Chicago Drive Everywhere TX 16789 US (work)</p><p><b>gender</b>: Female</p><h3>Qualifications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0360 MD}\">Doctor of Medicine</span></td></tr></table></div>"
        },
        "identifier" : [
          {
            "system" : "http://hl7.org/fhir/sid/us-npi",
            "value" : "9988776345"
          }
        ],
        "name" : [
          {
            "family" : "Physician",
            "given" : [
              "Test"
            ],
            "prefix" : [
              "Dr."
            ]
          }
        ],
        "address" : [
          {
            "use" : "work",
            "line" : [
              "600 Chicago Drive"
            ],
            "city" : "Everywhere",
            "state" : "TX",
            "postalCode" : "16789",
            "country" : "US"
          }
        ],
        "gender" : "female",
        "qualification" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://terminology.hl7.org/CodeSystem/v2-0360",
                  "version" : "2.7",
                  "code" : "MD"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Practitioner"
      }
    },
    {
      "fullUrl" : "urn:uuid:60863097-6033-41af-9f6a-d7b012e276ae",
      "resource" : {
        "resourceType" : "PractitionerRole",
        "id" : "ct-xT-physicianRole",
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"PractitionerRole_ct-xT-physicianRole\"> </a><p class=\"res-header-id\"><b>Generated Narrative: PractitionerRole ct-xT-physicianRole</b></p><a name=\"ct-xT-physicianRole\"> </a><a name=\"hcct-xT-physicianRole\"> </a><a name=\"ct-xT-physicianRole-en-US\"> </a><p><b>practitioner</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3b3363be-d153-40ae-952f-09d15df1d9bf\">Bundle: type = transaction</a></p><p><b>organization</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-f55969f0-aad6-4d9d-8af8-ae73b0ca4e8e\">Bundle: type = transaction</a></p></div>"
        },
        "practitioner" : {
          "reference" : "urn:uuid:3b3363be-d153-40ae-952f-09d15df1d9bf"
        },
        "organization" : {
          "reference" : "urn:uuid:f55969f0-aad6-4d9d-8af8-ae73b0ca4e8e"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "PractitionerRole"
      }
    },
    {
      "fullUrl" : "urn:uuid:f55969f0-aad6-4d9d-8af8-ae73b0ca4e8e",
      "resource" : {
        "resourceType" : "Organization",
        "id" : "ct-xT-OrderingOrganization",
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Organization_ct-xT-OrderingOrganization\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Organization ct-xT-OrderingOrganization</b></p><a name=\"ct-xT-OrderingOrganization\"> </a><a name=\"hcct-xT-OrderingOrganization\"> </a><a name=\"ct-xT-OrderingOrganization-en-US\"> </a><p><b>identifier</b>: <a href=\"http://terminology.hl7.org/5.3.0/NamingSystem-CLIA.html\" title=\"&quot;The Centers for Medicare &amp; Medicaid Services (CMS) regulates all laboratory testing (except research) performed on humans in the U.S. through the Clinical Laboratory Improvement Amendments (CLIA). In total, CLIA covers approximately 330,000 laboratory entities. The Division of Clinical Laboratory Improvement &amp; Quality, within the Quality, Safety &amp; Oversight Group, under the Center for Clinical Standards and Quality (CCSQ) has the responsibility for implementing the CLIA Program.\r\n\r\nThe objective of the CLIA program is to ensure quality laboratory testing. Although all clinical laboratories must be properly certified to receive Medicare or Medicaid payments, CLIA has no direct Medicare or Medicaid program responsibilities.&quot;\r\n\r\nCMS CLIA certified laboratories will be assigned a10-digit alphanumeric CLIA identification number, with the &quot;D&quot; in the third position identifying the provider/supplier as a laboratory certified under CLIA.&quot;\r\n\r\nCLIA is maintained by CMS. It is in the public domain and free to use without restriction.\r\n\r\nSee http://cms.gov/regulations-and-guidance/legislation/clia.\">Clinical Laboratory Improvement Amendments</a>/14D2114007</p><p><b>active</b>: true</p><p><b>name</b>: Ordering Organization</p></div>"
        },
        "identifier" : [
          {
            "system" : "urn:oid:2.16.840.1.113883.4.7",
            "value" : "14D2114007"
          }
        ],
        "active" : true,
        "name" : "Ordering Organization"
      },
      "request" : {
        "method" : "POST",
        "url" : "Organization"
      }
    },
    {
      "fullUrl" : "urn:uuid:9ebd0cb1-4733-4b8e-999c-a66bcbd939dd",
      "resource" : {
        "resourceType" : "Practitioner",
        "id" : "ct-xT-Pathologist",
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Practitioner_ct-xT-Pathologist\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Practitioner ct-xT-Pathologist</b></p><a name=\"ct-xT-Pathologist\"> </a><a name=\"hcct-xT-Pathologist\"> </a><a name=\"ct-xT-Pathologist-en-US\"> </a><p><b>identifier</b>: <code>http://www.acme.com/identifiers/patient</code>/123456</p><p><b>name</b>: Test Pathologist </p></div>"
        },
        "identifier" : [
          {
            "system" : "http://www.acme.com/identifiers/patient",
            "value" : "123456"
          }
        ],
        "name" : [
          {
            "family" : "Pathologist",
            "given" : [
              "Test"
            ]
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Practitioner"
      }
    },
    {
      "fullUrl" : "urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae",
      "resource" : {
        "resourceType" : "Organization",
        "id" : "ct-xT-Tempus-Organization",
        "meta" : {
          "profile" : [
            🔗 "http://mitre.org/gdx/StructureDefinition/gdx-lab-organization"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Organization_ct-xT-Tempus-Organization\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Organization ct-xT-Tempus-Organization</b></p><a name=\"ct-xT-Tempus-Organization\"> </a><a name=\"hcct-xT-Tempus-Organization\"> </a><a name=\"ct-xT-Tempus-Organization-en-US\"> </a><p><b>identifier</b>: <a href=\"http://terminology.hl7.org/5.3.0/NamingSystem-CLIA.html\" title=\"&quot;The Centers for Medicare &amp; Medicaid Services (CMS) regulates all laboratory testing (except research) performed on humans in the U.S. through the Clinical Laboratory Improvement Amendments (CLIA). In total, CLIA covers approximately 330,000 laboratory entities. The Division of Clinical Laboratory Improvement &amp; Quality, within the Quality, Safety &amp; Oversight Group, under the Center for Clinical Standards and Quality (CCSQ) has the responsibility for implementing the CLIA Program.\r\n\r\nThe objective of the CLIA program is to ensure quality laboratory testing. Although all clinical laboratories must be properly certified to receive Medicare or Medicaid payments, CLIA has no direct Medicare or Medicaid program responsibilities.&quot;\r\n\r\nCMS CLIA certified laboratories will be assigned a10-digit alphanumeric CLIA identification number, with the &quot;D&quot; in the third position identifying the provider/supplier as a laboratory certified under CLIA.&quot;\r\n\r\nCLIA is maintained by CMS. It is in the public domain and free to use without restriction.\r\n\r\nSee http://cms.gov/regulations-and-guidance/legislation/clia.\">Clinical Laboratory Improvement Amendments</a>/14D2114007</p><p><b>active</b>: true</p><p><b>name</b>: Tempus Labs, Inc</p><p><b>telecom</b>: <a href=\"mailto:support@tempus.com\">support@tempus.com</a></p><p><b>address</b>: 600 W Chicago Avenue, Ste 510 Chicago IL 60654 USA </p><h3>Contacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Name</b></td></tr><tr><td style=\"display: none\">*</td><td>Nike Beaubier, M,FCAP,MGAP</td></tr></table></div>"
        },
        "identifier" : [
          {
            "system" : "urn:oid:2.16.840.1.113883.4.7",
            "value" : "14D2114007"
          }
        ],
        "active" : true,
        "name" : "Tempus Labs, Inc",
        "telecom" : [
          {
            "system" : "email",
            "value" : "support@tempus.com"
          }
        ],
        "address" : [
          {
            "line" : [
              "600 W Chicago Avenue, Ste 510"
            ],
            "city" : "Chicago",
            "state" : "IL",
            "postalCode" : "60654",
            "country" : "USA"
          }
        ],
        "contact" : [
          {
            "name" : {
              "text" : "Nike Beaubier, M,FCAP,MGAP"
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Organization"
      }
    },
    {
      "fullUrl" : "urn:uuid:f5418e88-295b-43f8-af03-76c8c4aa516e",
      "resource" : {
        "resourceType" : "Specimen",
        "id" : "ct-xT-specimen-tumor",
        "meta" : {
          "profile" : [
            "http://hl7.org/fhir/us/core/StructureDefinition/us-core-Specimen"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Specimen_ct-xT-specimen-tumor\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Specimen ct-xT-specimen-tumor</b></p><a name=\"ct-xT-specimen-tumor\"> </a><a name=\"hcct-xT-specimen-tumor\"> </a><a name=\"ct-xT-specimen-tumor-en-US\"> </a><p><b>status</b>: Available</p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0487 TUMOR}\">Tumor</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>receivedTime</b>: 2021-02-09 21:30:50+0500</p><blockquote><p><b>collection</b></p><blockquote><p><b>id</b></p>TestInstitutionPathologyLaboratoryS22123456</blockquote><p><b>collected</b>: 2021-02-06 17:15:00+0500</p><p><b>bodySite</b>: <span title=\"Codes:{http://snomed.info/sct 44029006}\">Left lung structure (body structure)</span></p></blockquote><h3>Containers</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Identifier</b></td></tr><tr><td style=\"display: none\">*</td><td>Specimen ID/A2</td></tr></table></div>"
        },
        "status" : "available",
        "type" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/v2-0487",
              "code" : "TUMOR",
              "display" : "Tumor"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "receivedTime" : "2021-02-09T21:30:50+05:00",
        "collection" : {
          "id" : "TestInstitutionPathologyLaboratoryS22123456",
          "collectedDateTime" : "2021-02-06T17:15:00+05:00",
          "bodySite" : {
            "coding" : [
              {
                "system" : "http://snomed.info/sct",
                "version" : "http://snomed.info/sct/900000000000207008",
                "code" : "44029006",
                "display" : "Left lung structure (body structure)"
              }
            ]
          }
        },
        "container" : [
          {
            "identifier" : [
              {
                "type" : {
                  "coding" : [
                    {
                      "system" : "http://terminology.hl7.org/CodeSystem/v2-0203",
                      "code" : "SID",
                      "display" : "Specimen ID"
                    }
                  ]
                },
                "system" : "https://www.tempus.com",
                "value" : "A2"
              }
            ]
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Specimen"
      }
    },
    {
      "fullUrl" : "urn:uuid:1e6f171a-1dea-41b8-a51d-1f86130a43cc",
      "resource" : {
        "resourceType" : "Specimen",
        "id" : "ct-xT-specimen-normal",
        "meta" : {
          "profile" : [
            "http://hl7.org/fhir/us/core/StructureDefinition/us-core-Specimen"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Specimen_ct-xT-specimen-normal\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Specimen ct-xT-specimen-normal</b></p><a name=\"ct-xT-specimen-normal\"> </a><a name=\"hcct-xT-specimen-normal\"> </a><a name=\"ct-xT-specimen-normal-en-US\"> </a><p><b>status</b>: Available</p><p><b>type</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0487 BLD}\">Whole Blood</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>receivedTime</b>: 2021-02-09 21:30:50+0500</p><h3>Collections</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Collected[x]</b></td></tr><tr><td style=\"display: none\">*</td><td>2021-02-06 17:15:00+0500</td></tr></table></div>"
        },
        "status" : "available",
        "type" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/v2-0487",
              "code" : "BLD",
              "display" : "Whole Blood"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "receivedTime" : "2021-02-09T21:30:50+05:00",
        "collection" : {
          "collectedDateTime" : "2021-02-06T17:15:00+05:00"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "Specimen"
      }
    },
    {
      "fullUrl" : "urn:uuid:ccab39c5-49cf-4aa6-a1e7-2e0c9dd3a7d5",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-Observation1",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant",
            "https://hl7.org/fhir/uv/genomics-reporting/2024Jan/StructureDefinition-variant.html"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-Observation1\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-Observation1</b></p><a name=\"ct-xT-Observation1\"> </a><a name=\"hcct-xT-Observation1\"> </a><a name=\"ct-xT-Observation1-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:950}, {https://www.ncbi.nlm.nih.gov/gene 3815}\">BAP1</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51958-7}\">Transcript reference sequence [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_004656}\">NM_004656.4</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48004-6}\">DNA change (c.HGVS)</span></p><p><b>value</b>: <span title=\"Codes:\">c.1768C&gt;T</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48005-3}\">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title=\"Codes:\">p.Q590*</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81258-6}\">Sample variant allelic frequency [NFr]</span></p><p><b>value</b>: 57.4 %<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code% = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "69548-6"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA9633-4",
              "display" : "Present"
            }
          ]
        },
        "method" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA26398-0",
              "display" : "Sequencing"
            }
          ]
        },
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:950",
                  "display" : "BAP1"
                },
                {
                  "system" : "https://www.ncbi.nlm.nih.gov/gene",
                  "code" : "3815",
                  "display" : "BAP1"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "51958-7"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.ncbi.nlm.nih.gov/refseq",
                  "code" : "NM_004656",
                  "display" : "NM_004656.4"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48004-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "c.1768C>T"
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48005-3"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "p.Q590*"
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48002-0"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA6684-0",
                  "display" : "Somatic"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "81258-6"
                }
              ]
            },
            "valueQuantity" : {
              "value" : 57.4,
              "unit" : "%",
              "system" : "http://unitsofmeasure.org",
              "code" : "%"
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "62374-4"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA14029-5",
                  "display" : "GRCh37"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:fc637e0b-dced-4245-946e-3fa13ec128e3",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-Observation2",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant",
            "https://hl7.org/fhir/uv/genomics-reporting/2024Jan/StructureDefinition-variant.html"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-Observation2\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-Observation2</b></p><a name=\"ct-xT-Observation2\"> </a><a name=\"hcct-xT-Observation2\"> </a><a name=\"ct-xT-Observation2-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:1787}, {https://www.ncbi.nlm.nih.gov/gene 1029}\">CDKN2A</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48019-4}\">DNA change type</span></p><p><b>value</b>: <span title=\"Codes:\">copy number loss</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "69548-6"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-04-01",
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA9633-4",
              "display" : "Present"
            }
          ]
        },
        "method" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA26398-0",
              "display" : "Sequencing"
            }
          ]
        },
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:1787",
                  "display" : "CDKN2A"
                },
                {
                  "system" : "https://www.ncbi.nlm.nih.gov/gene",
                  "code" : "1029",
                  "display" : "CDKN2A"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48019-4"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "copy number loss"
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48002-0"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA6684-0",
                  "display" : "Somatic"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "62374-4"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA14029-5",
                  "display" : "GRCh37"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:c7a1db28-0c8f-4667-a40a-79401833b26b",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-Observation3",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant",
            "https://hl7.org/fhir/uv/genomics-reporting/2024Jan/StructureDefinition-variant.html"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-Observation3\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-Observation3</b></p><a name=\"ct-xT-Observation3\"> </a><a name=\"hcct-xT-Observation3\"> </a><a name=\"ct-xT-Observation3-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:7413}, {https://www.ncbi.nlm.nih.gov/gene 4507}\">MTAP</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48019-4}\">DNA change type</span></p><p><b>value</b>: <span title=\"Codes:\">copy number loss</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "69548-6"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-04-01",
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA9633-4",
              "display" : "Present"
            }
          ]
        },
        "method" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA26398-0",
              "display" : "Sequencing"
            }
          ]
        },
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:7413",
                  "display" : "MTAP"
                },
                {
                  "system" : "https://www.ncbi.nlm.nih.gov/gene",
                  "code" : "4507",
                  "display" : "MTAP"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48002-0"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA6684-0",
                  "display" : "Somatic"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48019-4"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "copy number loss"
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "62374-4"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA14029-5",
                  "display" : "GRCh37"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:6e333995-6a74-4dcd-ac7f-d7cf5ad20ac9",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-Observation4",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant",
            "https://hl7.org/fhir/uv/genomics-reporting/2024Jan/StructureDefinition-variant.html"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-Observation4\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-Observation4</b></p><a name=\"ct-xT-Observation4\"> </a><a name=\"hcct-xT-Observation4\"> </a><a name=\"ct-xT-Observation4-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:8028}, {https://www.ncbi.nlm.nih.gov/gene 4913}\">NTHL1 encodes an endonuclease III-like protein important in the base excision pathway usually through repair of oxidative pyrimidine lesions. Germline pathogenic variants in NTHL1 have been associated with autosomal recessive NTHL1-associated polyposis; heterozygotes are considered carriers, while homozygotes or compound heterozygotes are likely to be affected (PMID: 30753826). This is an adult onset hereditary cancer predisposition syndrome associated with development of colonic adenomas which can progress to colorectal cancer. Clinical correlation, including confirmation of this variant through a validated germline assay, and genetic counseling are recommended for this patient and any potentially at-risk family members.</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6683-2}\">Germline</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51958-7}\">Transcript reference sequence [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_002528}\">NM_002528.7</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48004-6}\">DNA change (c.HGVS)</span></p><p><b>value</b>: <span title=\"Codes:\">c.268C&gt;T</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48005-3}\">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title=\"Codes:\">p.Q90*</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48000-4}\">Chromosome [Identifier] in Blood or Tissue by Molecular genetics method</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA21269-8}\">Chromosome 16</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81254-5}\">Variant exact start-end</span></p><p><b>value</b>: 2096239-?</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "69548-6"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-04-01",
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA9633-4",
              "display" : "Present"
            }
          ]
        },
        "method" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA26398-0",
              "display" : "Sequencing"
            }
          ]
        },
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6",
                  "display" : "Gene studied [ID]"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:8028",
                  "display" : "NTHL1"
                },
                {
                  "system" : "https://www.ncbi.nlm.nih.gov/gene",
                  "code" : "4913",
                  "display" : "NTHL1"
                }
              ],
              "text" : "NTHL1 encodes an endonuclease III-like protein important in the base excision pathway usually through repair of oxidative pyrimidine lesions. Germline pathogenic variants in NTHL1 have been associated with autosomal recessive NTHL1-associated polyposis; heterozygotes are considered carriers, while homozygotes or compound heterozygotes are likely to be affected (PMID: 30753826). This is an adult onset hereditary cancer predisposition syndrome associated with development of colonic adenomas which can progress to colorectal cancer. Clinical correlation, including confirmation of this variant through a validated germline assay, and genetic counseling are recommended for this patient and any potentially at-risk family members."
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48002-0"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA6683-2",
                  "display" : "Germline"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "51958-7",
                  "display" : "Transcript reference sequence [ID]"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.ncbi.nlm.nih.gov/refseq",
                  "code" : "NM_002528",
                  "display" : "NM_002528.7"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48004-6",
                  "display" : "DNA change (c.HGVS)"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "c.268C>T"
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48005-3",
                  "display" : "Amino acid change (pHGVS)"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "p.Q90*"
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48000-4"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA21269-8",
                  "display" : "Chromosome 16"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "81254-5",
                  "display" : "Variant exact start-end"
                }
              ]
            },
            "valueRange" : {
              "low" : {
                "value" : 2096239
              }
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "62374-4",
                  "display" : "Human reference sequence assembly version"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA14029-5",
                  "display" : "GRCh37"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:d7318c30-3975-4f62-9840-3b8d7e7b56cd",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-Observation5",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant",
            "https://hl7.org/fhir/uv/genomics-reporting/2024Jan/StructureDefinition-variant.html"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-Observation5\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-Observation5</b></p><a name=\"ct-xT-Observation5\"> </a><a name=\"hcct-xT-Observation5\"> </a><a name=\"ct-xT-Observation5-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:583}, {https://www.ncbi.nlm.nih.gov/gene 324}\">APC encodes a multi-domain protein that interacts with factors involved in cellular proliferation, differentiation, maintenance, and structure including the microtubules and beta-catenin within the Wnt pathway. The APC p.I1307K variant has been associated with increased risk of developing colorectal cancer in the Ashkenazi Jewish population. For heterozygous patients, the increased risk if estimated as follows: odds ratio (OR) of 2.17 (95% confidence interval: 1.64-2.86) (PMID: 23576677) or adjusted OR of 1.75 (95% confidence interval: 1.26-2.45) (PMID: 23896379). The risk may be further increased in homozygous patients. The risk associated with the APC p.I1307K variant in other populations is still under study. Clinical correlation, including confirmation of this variant through a validated germline assay, and genetic counseling are recommended for this patient and any potentially at-risk family members.</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6683-2}\">Germline</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51958-7}\">Transcript reference sequence [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_000038}\">NM_000038.6</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48004-6}\">DNA change (c.HGVS)</span></p><p><b>value</b>: <span title=\"Codes:\">c.3920T&gt;A</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48005-3}\">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title=\"Codes:\">p.I1307K</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48000-4}\">Chromosome [Identifier] in Blood or Tissue by Molecular genetics method</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA21258-1}\">Chromosome 5</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81254-5}\">Variant exact start-end</span></p><p><b>value</b>: 112175211-?</p></blockquote></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "69548-6"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-04-01",
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA9633-4",
              "display" : "Present"
            }
          ]
        },
        "method" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA26398-0",
              "display" : "Sequencing"
            }
          ]
        },
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6",
                  "display" : "Gene studied [ID]"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:583",
                  "display" : "APC"
                },
                {
                  "system" : "https://www.ncbi.nlm.nih.gov/gene",
                  "code" : "324",
                  "display" : "APC"
                }
              ],
              "text" : "APC encodes a multi-domain protein that interacts with factors involved in cellular proliferation, differentiation, maintenance, and structure including the microtubules and beta-catenin within the Wnt pathway. The APC p.I1307K variant has been associated with increased risk of developing colorectal cancer in the Ashkenazi Jewish population. For heterozygous patients, the increased risk if estimated as follows: odds ratio (OR) of 2.17 (95% confidence interval: 1.64-2.86) (PMID: 23576677) or adjusted OR of 1.75 (95% confidence interval: 1.26-2.45) (PMID: 23896379). The risk may be further increased in homozygous patients. The risk associated with the APC p.I1307K variant in other populations is still under study. Clinical correlation, including confirmation of this variant through a validated germline assay, and genetic counseling are recommended for this patient and any potentially at-risk family members."
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48002-0",
                  "display" : "Genomic source class"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA6683-2",
                  "display" : "Germline"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "51958-7",
                  "display" : "Transcript reference sequence [ID]"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.ncbi.nlm.nih.gov/refseq",
                  "code" : "NM_000038",
                  "display" : "NM_000038.6"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48004-6",
                  "display" : "DNA change (c.HGVS)"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "c.3920T>A"
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48005-3",
                  "display" : "Amino acid change (pHGVS)"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "p.I1307K"
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48000-4"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA21258-1",
                  "display" : "Chromosome 5"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "81254-5",
                  "display" : "Variant exact start-end"
                }
              ]
            },
            "valueRange" : {
              "low" : {
                "value" : 112175211
              }
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:86ad3e6b-7ed8-4c7d-b99c-574ac5e2b4b9",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-Observation6",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant",
            "https://hl7.org/fhir/uv/genomics-reporting/2024Jan/StructureDefinition-variant.html"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-Observation6\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-Observation6</b></p><a name=\"ct-xT-Observation6\"> </a><a name=\"hcct-xT-Observation6\"> </a><a name=\"ct-xT-Observation6-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:13711}, {https://www.ncbi.nlm.nih.gov/gene 79983}\">POF1B</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51958-7}\">Transcript reference sequence [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.ncbi.nlm.nih.gov/refseq NM_004656}\">NM_004656</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48004-6}\">DNA change (c.HGVS)</span></p><p><b>value</b>: <span title=\"Codes:\">c.430C&gt;T</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48005-3}\">Amino acid change (pHGVS)</span></p><p><b>value</b>: <span title=\"Codes:\">p.P144S</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81258-6}\">Sample variant allelic frequency [NFr]</span></p><p><b>value</b>: 78.6 %<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code% = '%')</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62374-4}\">Human reference sequence assembly version</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA14029-5}\">GRCh37</span></p></blockquote></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "69548-6"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-04-01",
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA9633-4",
              "display" : "Present"
            }
          ]
        },
        "method" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA26398-0",
              "display" : "Sequencing"
            }
          ]
        },
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:13711",
                  "display" : "POF1B"
                },
                {
                  "system" : "https://www.ncbi.nlm.nih.gov/gene",
                  "code" : "79983",
                  "display" : "POF1B"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48002-0"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA6684-0",
                  "display" : "Somatic"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "51958-7"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.ncbi.nlm.nih.gov/refseq",
                  "code" : "NM_004656",
                  "display" : "NM_004656"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48004-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "c.430C>T"
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48005-3"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "p.P144S"
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "81258-6"
                }
              ]
            },
            "valueQuantity" : {
              "value" : 78.6,
              "unit" : "%",
              "system" : "http://unitsofmeasure.org",
              "code" : "%"
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "62374-4"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA14029-5",
                  "display" : "GRCh37"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:82a8b9db-a68e-4e06-897e-77ed3ea5aced",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-variant-fusion-met-alk",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/variant",
            "https://hl7.org/fhir/uv/genomics-reporting/2024Jan/StructureDefinition-variant.html"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-variant-fusion-met-alk\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-variant-fusion-met-alk</b></p><a name=\"ct-xT-variant-fusion-met-alk\"> </a><a name=\"hcct-xT-variant-fusion-met-alk\"> </a><a name=\"ct-xT-variant-fusion-met-alk-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></p><p><b>method</b>: <span title=\"Codes:{http://loinc.org LA26398-0}\">Sequencing</span></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:7029}, {https://www.ncbi.nlm.nih.gov/gene 4233}\">MET</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://www.genenames.org HGNC:427}, {https://www.ncbi.nlm.nih.gov/gene 238}\">ALK</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48019-4}\">DNA change type</span></p><p><b>value</b>: <span title=\"Codes:{http://sequenceontology.org SO:0002062}\">complex_chromosomal_rearrangement</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 48002-0}\">Genomic source class [Type]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6684-0}\">Somatic</span></p></blockquote></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "69548-6"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-04-01",
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA9633-4",
              "display" : "Present"
            }
          ]
        },
        "method" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "LA26398-0",
              "display" : "Sequencing"
            }
          ]
        },
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:7029",
                  "display" : "MET"
                },
                {
                  "system" : "https://www.ncbi.nlm.nih.gov/gene",
                  "code" : "4233",
                  "display" : "MET"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:427",
                  "display" : "ALK"
                },
                {
                  "system" : "https://www.ncbi.nlm.nih.gov/gene",
                  "code" : "238",
                  "display" : "ALK"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48019-4"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://sequenceontology.org",
                  "code" : "SO:0002062",
                  "display" : "complex_chromosomal_rearrangement"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48002-0"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA6684-0",
                  "display" : "Somatic"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:5dfa33cc-9038-44d0-9f71-f319b3cb4c9a",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-molecular-consequence-observation-1",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-molecular-consequence-observation-1\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-molecular-consequence-observation-1</b></p><a name=\"ct-xT-molecular-consequence-observation-1\"> </a><a name=\"hcct-xT-molecular-consequence-observation-1\"> </a><a name=\"ct-xT-molecular-consequence-observation-1-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-08-23</p><p><b>performer</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae\">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-ccab39c5-49cf-4aa6-a1e7-2e0c9dd3a7d5\">Bundle: type = transaction</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs feature-consequence}\">Feature Consequence</span></p><p><b>value</b>: <span title=\"Codes:\">Stop gain</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs functional-effect}\">Functional Effect</span></p><p><b>value</b>: <span title=\"Codes:\">loss of function</span></p></blockquote></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
              "code" : "molecular-consequence"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-08-23",
        "performer" : [
          {
            "reference" : "urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"
          }
        ],
        "derivedFrom" : [
          {
            "reference" : "urn:uuid:ccab39c5-49cf-4aa6-a1e7-2e0c9dd3a7d5"
          }
        ],
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
                  "code" : "feature-consequence"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "Stop gain"
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
                  "code" : "functional-effect"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "loss of function"
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:3c30e177-2c41-4f13-b6c0-1adf5af4c71d",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-molecular-consequence-observation-4",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-molecular-consequence-observation-4\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-molecular-consequence-observation-4</b></p><a name=\"ct-xT-molecular-consequence-observation-4\"> </a><a name=\"hcct-xT-molecular-consequence-observation-4\"> </a><a name=\"ct-xT-molecular-consequence-observation-4-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-08-23</p><p><b>performer</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae\">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-6e333995-6a74-4dcd-ac7f-d7cf5ad20ac9\">Bundle: type = transaction</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs feature-consequence}\">Feature Consequence</span></td><td><span title=\"Codes:\">Stop gain</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
              "code" : "molecular-consequence"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-08-23",
        "performer" : [
          {
            "reference" : "urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"
          }
        ],
        "derivedFrom" : [
          {
            "reference" : "urn:uuid:6e333995-6a74-4dcd-ac7f-d7cf5ad20ac9"
          }
        ],
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
                  "code" : "feature-consequence"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "Stop gain"
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:0c06b231-47e9-4a3b-88bd-2d8937d615a7",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-molecular-consequence-observation-5",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-molecular-consequence-observation-5\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-molecular-consequence-observation-5</b></p><a name=\"ct-xT-molecular-consequence-observation-5\"> </a><a name=\"hcct-xT-molecular-consequence-observation-5\"> </a><a name=\"ct-xT-molecular-consequence-observation-5-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-08-23</p><p><b>performer</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae\">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-d7318c30-3975-4f62-9840-3b8d7e7b56cd\">Bundle: type = transaction</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs feature-consequence}\">Feature Consequence</span></td><td><span title=\"Codes:\">Missense variant</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
              "code" : "molecular-consequence"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-08-23",
        "performer" : [
          {
            "reference" : "urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"
          }
        ],
        "derivedFrom" : [
          {
            "reference" : "urn:uuid:d7318c30-3975-4f62-9840-3b8d7e7b56cd"
          }
        ],
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
                  "code" : "feature-consequence"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "Missense variant"
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:00e47ced-f260-4baf-9da4-ee88224d3bc5",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-molecular-consequence-observation-6",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-molecular-consequence-observation-6\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-molecular-consequence-observation-6</b></p><a name=\"ct-xT-molecular-consequence-observation-6\"> </a><a name=\"hcct-xT-molecular-consequence-observation-6\"> </a><a name=\"ct-xT-molecular-consequence-observation-6-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-08-23</p><p><b>performer</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae\">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-86ad3e6b-7ed8-4c7d-b99c-574ac5e2b4b9\">Bundle: type = transaction</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs feature-consequence}\">Feature Consequence</span></td><td><span title=\"Codes:\">Missense variant</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
              "code" : "molecular-consequence"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-08-23",
        "performer" : [
          {
            "reference" : "urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"
          }
        ],
        "derivedFrom" : [
          {
            "reference" : "urn:uuid:86ad3e6b-7ed8-4c7d-b99c-574ac5e2b4b9"
          }
        ],
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
                  "code" : "feature-consequence"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "Missense variant"
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:dc69c7c9-031b-466f-bf63-8be56d658c50",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-molecular-consequence-observation-fusion",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-consequence"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-molecular-consequence-observation-fusion\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-molecular-consequence-observation-fusion</b></p><a name=\"ct-xT-molecular-consequence-observation-fusion\"> </a><a name=\"hcct-xT-molecular-consequence-observation-fusion\"> </a><a name=\"ct-xT-molecular-consequence-observation-fusion-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-08-23</p><p><b>performer</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae\">Bundle: type = transaction</a></p><p><b>derivedFrom</b>: <a href=\"Bundle-ct-xG-bundle.html#urn-uuid-82a8b9db-a68e-4e06-897e-77ed3ea5aced\">Bundle: type = transaction</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs feature-consequence}\">Feature Consequence</span></td><td><span title=\"Codes:{http://sequenceontology.org SO:0001565}\">gene_fusion</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
              "code" : "molecular-consequence"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-08-23",
        "performer" : [
          {
            "reference" : "urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"
          }
        ],
        "derivedFrom" : [
          {
            "reference" : "urn:uuid:82a8b9db-a68e-4e06-897e-77ed3ea5aced"
          }
        ],
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
                  "code" : "feature-consequence"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://sequenceontology.org",
                  "code" : "SO:0001565",
                  "display" : "gene_fusion"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:kbe36a66-b7c9-4130-a181-81bb72e3f4zz",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-diagnostic-implication-fusion",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-diagnostic-implication-fusion\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-fusion</b></p><a name=\"ct-xT-diagnostic-implication-fusion\"> </a><a name=\"hcct-xT-diagnostic-implication-fusion\"> </a><a name=\"ct-xT-diagnostic-implication-fusion-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href=\"Bundle-ct-xG-bundle.html#urn-uuid-82a8b9db-a68e-4e06-897e-77ed3ea5aced\">Bundle: type = transaction</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 53037-8}\">Genetic variation clinical significance [Imp]</span></td><td><span title=\"Codes:{http://loinc.org LA6668-3}\">Pathogenic</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
              "code" : "diagnostic-implication",
              "display" : "Diagnostic Implication"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-04-01",
        "derivedFrom" : [
          {
            "reference" : "urn:uuid:82a8b9db-a68e-4e06-897e-77ed3ea5aced"
          }
        ],
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "53037-8",
                  "display" : "Genetic variation clinical significance [Imp]"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA6668-3",
                  "display" : "Pathogenic"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:bbe36a66-b7c9-4130-a181-81bb72e3f4cc",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-diagnostic-implication-1",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-diagnostic-implication-1\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-1</b></p><a name=\"ct-xT-diagnostic-implication-1\"> </a><a name=\"hcct-xT-diagnostic-implication-1\"> </a><a name=\"ct-xT-diagnostic-implication-1-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-ccab39c5-49cf-4aa6-a1e7-2e0c9dd3a7d5\">Bundle: type = transaction</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 53037-8}\">Genetic variation clinical significance [Imp]</span></td><td><span title=\"Codes:{http://loinc.org LA6668-3}\">Pathogenic</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
              "code" : "diagnostic-implication",
              "display" : "Diagnostic Implication"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-04-01",
        "derivedFrom" : [
          {
            "reference" : "urn:uuid:ccab39c5-49cf-4aa6-a1e7-2e0c9dd3a7d5"
          }
        ],
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "53037-8",
                  "display" : "Genetic variation clinical significance [Imp]"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA6668-3",
                  "display" : "Pathogenic"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:7bb9b47d-2b77-47a6-ae2a-62f0b1d01d05",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-diagnostic-implication-2",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-diagnostic-implication-2\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-2</b></p><a name=\"ct-xT-diagnostic-implication-2\"> </a><a name=\"hcct-xT-diagnostic-implication-2\"> </a><a name=\"ct-xT-diagnostic-implication-2-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-fc637e0b-dced-4245-946e-3fa13ec128e3\">Bundle: type = transaction</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 53037-8}\">Genetic variation clinical significance [Imp]</span></td><td><span title=\"Codes:{http://loinc.org LA6668-3}\">Pathogenic</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
              "code" : "diagnostic-implication",
              "display" : "Diagnostic Implication"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-04-01",
        "derivedFrom" : [
          {
            "reference" : "urn:uuid:fc637e0b-dced-4245-946e-3fa13ec128e3"
          }
        ],
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "53037-8",
                  "display" : "Genetic variation clinical significance [Imp]"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA6668-3",
                  "display" : "Pathogenic"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:52554ca2-dcdd-4105-9cb7-059f0a863483",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-diagnostic-implication-3",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-diagnostic-implication-3\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-3</b></p><a name=\"ct-xT-diagnostic-implication-3\"> </a><a name=\"hcct-xT-diagnostic-implication-3\"> </a><a name=\"ct-xT-diagnostic-implication-3-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-c7a1db28-0c8f-4667-a40a-79401833b26b\">Bundle: type = transaction</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 53037-8}\">Genetic variation clinical significance [Imp]</span></td><td><span title=\"Codes:{http://loinc.org LA6668-3}\">Pathogenic</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
              "code" : "diagnostic-implication",
              "display" : "Diagnostic Implication"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-04-01",
        "derivedFrom" : [
          {
            "reference" : "urn:uuid:c7a1db28-0c8f-4667-a40a-79401833b26b"
          }
        ],
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "53037-8",
                  "display" : "Genetic variation clinical significance [Imp]"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA6668-3",
                  "display" : "Pathogenic"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:dddaac5f-e8ba-4c55-a70c-5c6d80903356",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-diagnostic-implication-4",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-diagnostic-implication-4\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-4</b></p><a name=\"ct-xT-diagnostic-implication-4\"> </a><a name=\"hcct-xT-diagnostic-implication-4\"> </a><a name=\"ct-xT-diagnostic-implication-4-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-6e333995-6a74-4dcd-ac7f-d7cf5ad20ac9\">Bundle: type = transaction</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 53037-8}\">Genetic variation clinical significance [Imp]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA6668-3}\">Pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81259-4}\">Associated phenotype</span></p><p><b>value</b>: <span title=\"Codes:\">NTHL1 tumor syndrome, NTHL1-associated polyposis</span></p></blockquote></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
              "code" : "diagnostic-implication",
              "display" : "Diagnostic Implication"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-04-01",
        "derivedFrom" : [
          {
            "reference" : "urn:uuid:6e333995-6a74-4dcd-ac7f-d7cf5ad20ac9"
          }
        ],
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "53037-8",
                  "display" : "Genetic variation clinical significance [Imp]"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA6668-3",
                  "display" : "Pathogenic"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "81259-4",
                  "display" : "Associated phenotype"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "NTHL1 tumor syndrome, NTHL1-associated polyposis"
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:69b54656-b1eb-4393-ac69-f25f32fde680",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-diagnostic-implication-5",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-diagnostic-implication-5\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-5</b></p><a name=\"ct-xT-diagnostic-implication-5\"> </a><a name=\"hcct-xT-diagnostic-implication-5\"> </a><a name=\"ct-xT-diagnostic-implication-5-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-d7318c30-3975-4f62-9840-3b8d7e7b56cd\">Bundle: type = transaction</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 53037-8}\">Genetic variation clinical significance [Imp]</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA26332-9}\">Likely Pathogenic</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81259-4}\">Associated phenotype</span></p><p><b>value</b>: <span title=\"Codes:\">APC-associated conditions</span></p></blockquote></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
              "code" : "diagnostic-implication",
              "display" : "Diagnostic Implication"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-04-01",
        "derivedFrom" : [
          {
            "reference" : "urn:uuid:d7318c30-3975-4f62-9840-3b8d7e7b56cd"
          }
        ],
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "53037-8",
                  "display" : "Genetic variation clinical significance [Imp]"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA26332-9",
                  "display" : "Likely Pathogenic"
                }
              ]
            }
          },
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "81259-4",
                  "display" : "Associated phenotype"
                }
              ]
            },
            "valueCodeableConcept" : {
              "text" : "APC-associated conditions"
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:f845d26f-7308-45ab-9898-ebc86d6ae22c",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-diagnostic-implication-6",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/diagnostic-implication"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-diagnostic-implication-6\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-diagnostic-implication-6</b></p><a name=\"ct-xT-diagnostic-implication-6\"> </a><a name=\"hcct-xT-diagnostic-implication-6\"> </a><a name=\"ct-xT-diagnostic-implication-6-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-04-01</p><p><b>derivedFrom</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-86ad3e6b-7ed8-4c7d-b99c-574ac5e2b4b9\">Bundle: type = transaction</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 53037-8}\">Genetic variation clinical significance [Imp]</span></td><td><span title=\"Codes:{http://loinc.org LA26333-7}\">Uncertain Significance</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
              "code" : "diagnostic-implication",
              "display" : "Diagnostic Implication"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-04-01",
        "derivedFrom" : [
          {
            "reference" : "urn:uuid:86ad3e6b-7ed8-4c7d-b99c-574ac5e2b4b9"
          }
        ],
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "53037-8",
                  "display" : "Genetic variation clinical significance [Imp]"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "LA26333-7",
                  "display" : "Uncertain Significance"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:5fe0e4c4-fd4b-4e9d-af1e-b3b40c28a21a",
      "resource" : {
        "resourceType" : "Procedure",
        "id" : "ct-xT-procedure1",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Procedure_ct-xT-procedure1\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Procedure ct-xT-procedure1</b></p><a name=\"ct-xT-procedure1\"> </a><a name=\"hcct-xT-procedure1\"> </a><a name=\"ct-xT-procedure1-en-US\"> </a><blockquote><p><b>Genomic Study Analysis Regions</b></p><ul><li>description: Pertinent Negative</li><li>studied: <span title=\"Codes:{http://www.genenames.org HGNC:7989}, {https://www.ncbi.nlm.nih.gov/gene 4893}\">NRAS</span></li><li>studied: <span title=\"Codes:{http://www.genenames.org HGNC:6342}, {https://www.ncbi.nlm.nih.gov/gene 3815}\">KIT</span></li><li>studied: <span title=\"Codes:{http://www.genenames.org HGNC:1097}, {https://www.ncbi.nlm.nih.gov/gene 673}\">BRAF</span></li></ul></blockquote><p><b>status</b>: Completed</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>performed</b>: 2023-08-09 01:01:10-0600</p></div>"
        },
        "extension" : [
          {
            "extension" : [
              {
                "url" : "description",
                "valueString" : "Pertinent Negative"
              },
              {
                "url" : "studied",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://www.genenames.org",
                      "code" : "HGNC:7989",
                      "display" : "NRAS"
                    },
                    {
                      "system" : "https://www.ncbi.nlm.nih.gov/gene",
                      "code" : "4893",
                      "display" : "NRAS"
                    }
                  ]
                }
              },
              {
                "url" : "studied",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://www.genenames.org",
                      "code" : "HGNC:6342",
                      "display" : "KIT"
                    },
                    {
                      "system" : "https://www.ncbi.nlm.nih.gov/gene",
                      "code" : "3815",
                      "display" : "KIT"
                    }
                  ]
                }
              },
              {
                "url" : "studied",
                "valueCodeableConcept" : {
                  "coding" : [
                    {
                      "system" : "http://www.genenames.org",
                      "code" : "HGNC:1097",
                      "display" : "BRAF"
                    },
                    {
                      "system" : "https://www.ncbi.nlm.nih.gov/gene",
                      "code" : "673",
                      "display" : "BRAF"
                    }
                  ]
                }
              }
            ],
            "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-regions"
          }
        ],
        "status" : "completed",
        "category" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
              "code" : "laboratory"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "performedDateTime" : "2023-08-09T01:01:10-06:00"
      },
      "request" : {
        "method" : "POST",
        "url" : "Procedure"
      }
    },
    {
      "fullUrl" : "urn:uuid:16f2715b-10ea-42ae-a3a2-185b14e6e21f",
      "resource" : {
        "resourceType" : "Procedure",
        "id" : "ct-xT-genomicStudy",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Procedure_ct-xT-genomicStudy\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Procedure ct-xT-genomicStudy</b></p><a name=\"ct-xT-genomicStudy\"> </a><a name=\"hcct-xT-genomicStudy\"> </a><a name=\"ct-xT-genomicStudy-en-US\"> </a><p><b>Genomic Study Analysis Extension</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-5fe0e4c4-fd4b-4e9d-af1e-b3b40c28a21a\">Bundle: type = transaction</a></p><p><b>basedOn</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-28395cc2-c6e4-4006-84af-ebf40113656a\">Bundle: type = transaction</a></p><p><b>status</b>: Completed</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:\">xT panel</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>performed</b>: 2023-08-09</p></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-ext",
            "valueReference" : {
              "reference" : "urn:uuid:5fe0e4c4-fd4b-4e9d-af1e-b3b40c28a21a"
            }
          }
        ],
        "basedOn" : [
          {
            "reference" : "urn:uuid:28395cc2-c6e4-4006-84af-ebf40113656a"
          }
        ],
        "status" : "completed",
        "category" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
              "code" : "laboratory"
            }
          ]
        },
        "code" : {
          "text" : "xT panel"
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "performedDateTime" : "2023-08-09"
      },
      "request" : {
        "method" : "POST",
        "url" : "Procedure"
      }
    },
    {
      "fullUrl" : "urn:uuid:4be89099-d07b-4c94-a1ef-be16233a79d8",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "gx-genomic-tmb",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/molecular-biomarker"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_gx-genomic-tmb\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation gx-genomic-tmb</b></p><a name=\"gx-genomic-tmb\"> </a><a name=\"hcgx-genomic-tmb\"> </a><a name=\"gx-genomic-tmb-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}\">A characterization of a given biomarker observation.</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 94076-7}\">Mutations/Megabase [# Ratio] in Tumor</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>value</b>: 5.2 1/1000000{Base}<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code1/1000000{Base} = '1/1000000{Base}')</span></p></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
                "code" : "biomarker-category"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "94076-7",
              "display" : "Mutations/Megabase [# Ratio] in Tumor"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "valueQuantity" : {
          "value" : 5.2,
          "system" : "http://unitsofmeasure.org",
          "code" : "1/1000000{Base}"
        }
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:68b6b4ac-47df-4b0b-857a-d9427d5e2538",
      "resource" : {
        "resourceType" : "ResearchStudy",
        "id" : "gx-genomic-research-study-implication-clinical-trial-NCT02693535",
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ResearchStudy_gx-genomic-research-study-implication-clinical-trial-NCT02693535\"> </a><p class=\"res-header-id\"><b>Generated Narrative: ResearchStudy gx-genomic-research-study-implication-clinical-trial-NCT02693535</b></p><a name=\"gx-genomic-research-study-implication-clinical-trial-NCT02693535\"> </a><a name=\"hcgx-genomic-research-study-implication-clinical-trial-NCT02693535\"> </a><a name=\"gx-genomic-research-study-implication-clinical-trial-NCT02693535-en-US\"> </a><p><b>identifier</b>: <a href=\"http://terminology.hl7.org/6.1.0/NamingSystem-ClinicalTrialsGov.html\" title=\"The U.S. National Institutes of Health, Department of Health and Human Services, through its National Library of Medicine, has developed [ClinicalTrials.gov](http://clinicaltrials.gov) to provide patients, family members, and members of the public current information about clinical research studies. [ClinicalTrials.gov](http://clinicaltrials.gov) contains summary information about clinical studies being conducted throughout the United States and in many countries throughout the world. These data are provided to the National Library of Medicine by organizations and institutions that sponsor and implement the studies.\r\n\r\n[ClinicalTrials.gov](http://clinicaltrials.gov) is updated daily. You should check [ClinicalTrials.gov](http://clinicaltrials.gov) frequently for updated information.\r\n\r\nMore information about ClinicalTrials.gov can be found [here](https://clinicaltrials.gov/about-site/about-ctg).\">ClinicalTrials.gov</a>/NCT02693535</p><p><b>title</b>: TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer</p><p><b>status</b>: Active</p><p><b>phase</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/research-study-phase phase-2}\">Phase 2</span></p><h3>RelatedArtifacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td>Citation</td><td><a href=\"https://clinicaltrials.gov/ct2/show/NCT02693535\">https://clinicaltrials.gov/ct2/show/NCT02693535</a></td></tr></table><p><b>site</b>: Zion, Illinois (Identifier: <code>https://www.usps.com/</code>/IL)</p></div>"
        },
        "identifier" : [
          {
            "system" : "http://clinicaltrials.gov",
            "value" : "NCT02693535"
          }
        ],
        "title" : "TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer",
        "status" : "active",
        "phase" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/research-study-phase",
              "code" : "phase-2",
              "display" : "Phase 2"
            }
          ]
        },
        "relatedArtifact" : [
          {
            "type" : "citation",
            "url" : "https://clinicaltrials.gov/ct2/show/NCT02693535"
          }
        ],
        "site" : [
          {
            "identifier" : {
              "system" : "https://www.usps.com/",
              "value" : "IL"
            },
            "display" : "Zion, Illinois"
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "ResearchStudy"
      }
    },
    {
      "fullUrl" : "urn:uuid:cd1ba6c7-553d-4b04-b5d6-07571129c52d",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-clinicalTrial",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-clinicalTrial\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-clinicalTrial</b></p><a name=\"ct-xT-clinicalTrial\"> </a><a name=\"hcct-xT-clinicalTrial\"> </a><a name=\"ct-xT-clinicalTrial-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>derivedFrom</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-fc637e0b-dced-4245-946e-3fa13ec128e3\">Bundle: type = transaction</a></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Extension</b></td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td/><td><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs associated-therapy}\">Associated Therapy</span></td><td><span title=\"Codes:{http://clinicaltrials.gov NCT02693535}\">NCT02693535</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
              "code" : "therapeutic-implication"
            }
          ]
        },
        "derivedFrom" : [
          {
            "reference" : "urn:uuid:fc637e0b-dced-4245-946e-3fa13ec128e3"
          }
        ],
        "component" : [
          {
            "extension" : [
              {
                "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapy-assessed-reference",
                "valueReference" : {
                  "reference" : "urn:uuid:68b6b4ac-47df-4b0b-857a-d9427d5e2538"
                }
              }
            ],
            "code" : {
              "coding" : [
                {
                  "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
                  "code" : "associated-therapy"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://clinicaltrials.gov",
                  "code" : "NCT02693535"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:da3cfb61-7b73-429d-b933-36b41b5e4a66",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-HLA-A-haplotype1",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-HLA-A-haplotype1\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-HLA-A-haplotype1</b></p><a name=\"ct-xT-HLA-A-haplotype1\"> </a><a name=\"hcct-xT-HLA-A-haplotype1\"> </a><a name=\"ct-xT-HLA-A-haplotype1-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 84414-2}\">Haplotype Name</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-02-01</p><p><b>issued</b>: 2019-02-01 00:00:00-0500</p><p><b>performer</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae\">Bundle: type = transaction</a></p><p><b>value</b>: <span title=\"Codes:{http://www.ebi.ac.uk/ipd/imgt/hla A*03:01}\">HLA-A*03:01</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></td><td><span title=\"Codes:{http://www.genenames.org HGNC:4931}\">HLA-A</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "84414-2",
              "display" : "Haplotype Name"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-02-01",
        "issued" : "2019-02-01T00:00:00-05:00",
        "performer" : [
          {
            "reference" : "urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"
          }
        ],
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://www.ebi.ac.uk/ipd/imgt/hla",
              "code" : "A*03:01",
              "display" : "HLA-A*03:01"
            }
          ]
        },
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:4931",
                  "display" : "HLA-A"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:b745fef5-462d-4b6c-bddc-a7c573c614ef",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-HLA-A-haplotype2",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-HLA-A-haplotype2\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-HLA-A-haplotype2</b></p><a name=\"ct-xT-HLA-A-haplotype2\"> </a><a name=\"hcct-xT-HLA-A-haplotype2\"> </a><a name=\"ct-xT-HLA-A-haplotype2-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 84414-2}\">Haplotype Name</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-02-01</p><p><b>issued</b>: 2019-02-01 00:00:00-0500</p><p><b>performer</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae\">Bundle: type = transaction</a></p><p><b>value</b>: <span title=\"Codes:{http://www.ebi.ac.uk/ipd/imgt/hla A*31:01}\">HLA-A*31:01</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></td><td><span title=\"Codes:{http://www.genenames.org HGNC:4931}\">HLA-A</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "84414-2",
              "display" : "Haplotype Name"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-02-01",
        "issued" : "2019-02-01T00:00:00-05:00",
        "performer" : [
          {
            "reference" : "urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"
          }
        ],
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://www.ebi.ac.uk/ipd/imgt/hla",
              "code" : "A*31:01",
              "display" : "HLA-A*31:01"
            }
          ]
        },
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:4931",
                  "display" : "HLA-A"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:29d40ea4-2946-4a90-a259-7a6025b3b090",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-HLA-B-haplotype1",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-HLA-B-haplotype1\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-HLA-B-haplotype1</b></p><a name=\"ct-xT-HLA-B-haplotype1\"> </a><a name=\"hcct-xT-HLA-B-haplotype1\"> </a><a name=\"ct-xT-HLA-B-haplotype1-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 84414-2}\">Haplotype Name</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-02-01</p><p><b>issued</b>: 2019-02-01 00:00:00-0500</p><p><b>performer</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae\">Bundle: type = transaction</a></p><p><b>value</b>: <span title=\"Codes:{http://www.ebi.ac.uk/ipd/imgt/hla B*07:02}\">HLA-B*07:02</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></td><td><span title=\"Codes:{http://www.genenames.org HGNC:4932}\">HLA-B</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "84414-2",
              "display" : "Haplotype Name"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-02-01",
        "issued" : "2019-02-01T00:00:00-05:00",
        "performer" : [
          {
            "reference" : "urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"
          }
        ],
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://www.ebi.ac.uk/ipd/imgt/hla",
              "code" : "B*07:02",
              "display" : "HLA-B*07:02"
            }
          ]
        },
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:4932",
                  "display" : "HLA-B"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:9095423d-db5e-4c28-a876-53a3b19fb6de",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-HLA-B-haplotype2",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-HLA-B-haplotype2\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-HLA-B-haplotype2</b></p><a name=\"ct-xT-HLA-B-haplotype2\"> </a><a name=\"hcct-xT-HLA-B-haplotype2\"> </a><a name=\"ct-xT-HLA-B-haplotype2-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 84414-2}\">Haplotype Name</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-02-01</p><p><b>issued</b>: 2019-02-01 00:00:00-0500</p><p><b>performer</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae\">Bundle: type = transaction</a></p><p><b>value</b>: <span title=\"Codes:{http://www.ebi.ac.uk/ipd/imgt/hla B*35:01}\">HLA-B*35:01</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></td><td><span title=\"Codes:{http://www.genenames.org HGNC:4932}\">HLA-B</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "84414-2",
              "display" : "Haplotype Name"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-02-01",
        "issued" : "2019-02-01T00:00:00-05:00",
        "performer" : [
          {
            "reference" : "urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"
          }
        ],
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://www.ebi.ac.uk/ipd/imgt/hla",
              "code" : "B*35:01",
              "display" : "HLA-B*35:01"
            }
          ]
        },
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:4932",
                  "display" : "HLA-B"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:da9b5431-1b88-461d-ab57-49502fe20117",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-HLA-C-haplotype1",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-HLA-C-haplotype1\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-HLA-C-haplotype1</b></p><a name=\"ct-xT-HLA-C-haplotype1\"> </a><a name=\"hcct-xT-HLA-C-haplotype1\"> </a><a name=\"ct-xT-HLA-C-haplotype1-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 84414-2}\">Haplotype Name</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-02-01</p><p><b>issued</b>: 2019-02-01 00:00:00-0500</p><p><b>performer</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae\">Bundle: type = transaction</a></p><p><b>value</b>: <span title=\"Codes:{http://www.ebi.ac.uk/ipd/imgt/hla C*04:01}\">HLA-C*04:01</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></td><td><span title=\"Codes:{http://www.genenames.org HGNC:4933}\">HLA-C</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "84414-2",
              "display" : "Haplotype Name"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-02-01",
        "issued" : "2019-02-01T00:00:00-05:00",
        "performer" : [
          {
            "reference" : "urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"
          }
        ],
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://www.ebi.ac.uk/ipd/imgt/hla",
              "code" : "C*04:01",
              "display" : "HLA-C*04:01"
            }
          ]
        },
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:4933",
                  "display" : "HLA-C"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:148fddd2-ab27-4abe-b096-8cf905905bc0",
      "resource" : {
        "resourceType" : "Observation",
        "id" : "ct-xT-HLA-C-haplotype2",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/haplotype"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Observation_ct-xT-HLA-C-haplotype2\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Observation ct-xT-HLA-C-haplotype2</b></p><a name=\"ct-xT-HLA-C-haplotype2\"> </a><a name=\"hcct-xT-HLA-C-haplotype2\"> </a><a name=\"ct-xT-HLA-C-haplotype2-en-US\"> </a><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 84414-2}\">Haplotype Name</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>effective</b>: 2019-02-01</p><p><b>issued</b>: 2019-02-01 00:00:00-0500</p><p><b>performer</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-3970f176-e402-4eaf-989c-959e80d918ae\">Bundle: type = transaction</a></p><p><b>value</b>: <span title=\"Codes:{http://www.ebi.ac.uk/ipd/imgt/hla C*07:02}\">HLA-C*07:02</span></p><h3>Components</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:{http://loinc.org 48018-6}\">Gene studied [ID]</span></td><td><span title=\"Codes:{http://www.genenames.org HGNC:4933}\">HLA-C</span></td></tr></table></div>"
        },
        "status" : "final",
        "category" : [
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
                "code" : "laboratory"
              }
            ]
          },
          {
            "coding" : [
              {
                "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
                "code" : "GE"
              }
            ]
          }
        ],
        "code" : {
          "coding" : [
            {
              "system" : "http://loinc.org",
              "code" : "84414-2",
              "display" : "Haplotype Name"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "effectiveDateTime" : "2019-02-01",
        "issued" : "2019-02-01T00:00:00-05:00",
        "performer" : [
          {
            "reference" : "urn:uuid:3970f176-e402-4eaf-989c-959e80d918ae"
          }
        ],
        "valueCodeableConcept" : {
          "coding" : [
            {
              "system" : "http://www.ebi.ac.uk/ipd/imgt/hla",
              "code" : "C*07:02",
              "display" : "HLA-C*07:02"
            }
          ]
        },
        "component" : [
          {
            "code" : {
              "coding" : [
                {
                  "system" : "http://loinc.org",
                  "code" : "48018-6"
                }
              ]
            },
            "valueCodeableConcept" : {
              "coding" : [
                {
                  "system" : "http://www.genenames.org",
                  "code" : "HGNC:4933",
                  "display" : "HLA-C"
                }
              ]
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "Observation"
      }
    },
    {
      "fullUrl" : "urn:uuid:b3s0f176-e402-4eaf-989c-959e80d91n5f",
      "resource" : {
        "resourceType" : "DocumentReference",
        "id" : "ct-xT-GeneList",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-data-file"
          ]
        },
        "text" : {
          "status" : "generated",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DocumentReference_ct-xT-GeneList\"> </a><p class=\"res-header-id\"><b>Generated Narrative: DocumentReference ct-xT-GeneList</b></p><a name=\"ct-xT-GeneList\"> </a><a name=\"hcct-xT-GeneList\"> </a><a name=\"ct-xT-GeneList-en-US\"> </a><p><b>identifier</b>: <code>https://www.tempus.com</code>/11120</p><p><b>status</b>: Current</p><p><b>docStatus</b>: Preliminary</p><p><b>description</b>: Gene List</p><blockquote><p><b>content</b></p><h3>Attachments</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td><td><b>Title</b></td><td><b>Creation</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://edge-api-demo.stagingtempus.com/fhir/R4/static/Gene_List_1.json\">https://edge-api-demo.stagingtempus.com/fhir/R4/static/Gene_List_1.json</a></td><td>GeneList</td><td>2019-03-01 01:02:01+0100</td></tr></table></blockquote></div>"
        },
        "identifier" : [
          {
            "system" : "https://www.tempus.com",
            "value" : "11120"
          }
        ],
        "status" : "current",
        "docStatus" : "preliminary",
        "description" : "Gene List",
        "content" : [
          {
            "attachment" : {
              "url" : "https://edge-api-demo.stagingtempus.com/fhir/R4/static/Gene_List_1.json",
              "title" : "GeneList",
              "creation" : "2019-03-01T01:02:01+01:00"
            }
          }
        ]
      },
      "request" : {
        "method" : "POST",
        "url" : "DocumentReference"
      }
    },
    {
      "fullUrl" : "urn:uuid:11163097-6033-41af-9f6a-d7b012e27aaa",
      "resource" : {
        "resourceType" : "Procedure",
        "id" : "ct-xT-genomicStudyAnalysis",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Procedure_ct-xT-genomicStudyAnalysis\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Procedure ct-xT-genomicStudyAnalysis</b></p><a name=\"ct-xT-genomicStudyAnalysis\"> </a><a name=\"hcct-xT-genomicStudyAnalysis\"> </a><a name=\"ct-xT-genomicStudyAnalysis-en-US\"> </a><blockquote><p><b>Genomic Study Analysis Regions</b></p><ul><li>studied: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-b3s0f176-e402-4eaf-989c-959e80d91n5f\">Bundle: type = transaction</a></li></ul></blockquote><p><b>Genomic Study Analysis Specimen</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-f5418e88-295b-43f8-af03-76c8c4aa516e\">Bundle: type = transaction</a></p><p><b>Genomic Study Analysis Focus</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>status</b>: Completed</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>performed</b>: 2023-02-02 01:01:10-0600</p></div>"
        },
        "extension" : [
          {
            "extension" : [
              {
                "url" : "studied",
                "valueReference" : {
                  "reference" : "urn:uuid:b3s0f176-e402-4eaf-989c-959e80d91n5f"
                }
              }
            ],
            "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-regions"
          },
          {
            "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-specimen",
            "valueReference" : {
              "reference" : "urn:uuid:f5418e88-295b-43f8-af03-76c8c4aa516e"
            }
          },
          {
            "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-focus",
            "valueReference" : {
              "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
            }
          }
        ],
        "status" : "completed",
        "category" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
              "code" : "laboratory"
            }
          ]
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "performedDateTime" : "2023-02-02T01:01:10-06:00"
      },
      "request" : {
        "method" : "POST",
        "url" : "Procedure"
      }
    },
    {
      "fullUrl" : "urn:uuid:88f2715b-10ea-42ae-a3a2-185b14e6e666",
      "resource" : {
        "resourceType" : "Procedure",
        "id" : "ct-xT-genomicStudy-2",
        "meta" : {
          "profile" : [
            🔗 "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study"
          ]
        },
        "text" : {
          "status" : "extensions",
          "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Procedure_ct-xT-genomicStudy-2\"> </a><p class=\"res-header-id\"><b>Generated Narrative: Procedure ct-xT-genomicStudy-2</b></p><a name=\"ct-xT-genomicStudy-2\"> </a><a name=\"hcct-xT-genomicStudy-2\"> </a><a name=\"ct-xT-genomicStudy-2-en-US\"> </a><p><b>Genomic Study Analysis Extension</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-11163097-6033-41af-9f6a-d7b012e27aaa\">Bundle: type = transaction</a></p><p><b>basedOn</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-28395cc2-c6e4-4006-84af-ebf40113656a\">Bundle: type = transaction</a></p><p><b>status</b>: Completed</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span></p><p><b>code</b>: <span title=\"Codes:\">xT panel</span></p><p><b>subject</b>: <a href=\"Bundle-ct-xT-bundle.html#urn-uuid-2ddeec04-75de-441c-8767-18c884ece7h4\">Bundle: type = transaction</a></p><p><b>performed</b>: 2023-08-09</p></div>"
        },
        "extension" : [
          {
            "url" : "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-analysis-ext",
            "valueReference" : {
              "reference" : "urn:uuid:11163097-6033-41af-9f6a-d7b012e27aaa"
            }
          }
        ],
        "basedOn" : [
          {
            "reference" : "urn:uuid:28395cc2-c6e4-4006-84af-ebf40113656a"
          }
        ],
        "status" : "completed",
        "category" : {
          "coding" : [
            {
              "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
              "code" : "laboratory"
            }
          ]
        },
        "code" : {
          "text" : "xT panel"
        },
        "subject" : {
          "reference" : "urn:uuid:2ddeec04-75de-441c-8767-18c884ece7h4"
        },
        "performedDateTime" : "2023-08-09"
      },
      "request" : {
        "method" : "POST",
        "url" : "Procedure"
      }
    }
  ]
}