15.9 Resource SubstanceDefinition - Content

Name	Flags	Card.	Type	Description & Constraints
SubstanceDefinition	TU		DomainResource	The detailed description of a substance, typically at a level beyond what is used for prescribing Elements defined in Ancestors: id, meta, implicitRules, language, text, contained, extension, modifierExtension
identifier	Σ	0..*	Identifier	Identifier by which this substance is known
version	Σ	0..1	string	A business level version identifier of the substance
status	Σ	0..1	CodeableConcept	Status of substance within the catalogue e.g. active, retired Binding: PublicationStatus (Preferred)
classification	Σ	0..*	CodeableConcept	A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity
domain	Σ	0..1	CodeableConcept	If the substance applies to human or veterinary use Binding: Medicinal Product Domain (Example)
grade	Σ	0..*	CodeableConcept	The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP) Binding: Substance Grade (Example)
description	Σ	0..1	markdown	Textual description of the substance
informationSource	Σ	0..*	Reference(Citation)	Supporting literature
note	Σ	0..*	Annotation	Textual comment about the substance's catalogue or registry record
manufacturer	Σ	0..*	Reference(Organization)	The entity that creates, makes, produces or fabricates the substance
supplier	Σ	0..*	Reference(Organization)	An entity that is the source for the substance. It may be different from the manufacturer
moiety	Σ	0..*	BackboneElement	Moiety, for structural modifications
role	Σ	0..1	CodeableConcept	Role that the moiety is playing
identifier	Σ	0..1	Identifier	Identifier by which this moiety substance is known
name	Σ	0..1	string	Textual name for this moiety substance
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type Binding: Stereochemistry (Example)
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type Binding: Optical Activity (Example)
molecularFormula	Σ	0..1	string	Molecular formula for this moiety (e.g. with the Hill system)
amount[x]	Σ	0..1		Quantitative value for this moiety
amountQuantity			Quantity
amountString			string
measurementType	Σ	0..1	CodeableConcept	The measurement type of the quantitative value Binding: Substance Amount Type (Example)
characterization	Σ	0..*	BackboneElement	General specifications for this substance
technique	Σ	0..1	CodeableConcept	The method used to find the characterization e.g. HPLC Binding: Structure Technique (Example)
form	Σ	0..1	CodeableConcept	Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form Binding: Substance Form (Example)
description	Σ	0..1	markdown	The description or justification in support of the interpretation of the data file
file	Σ	0..*	Attachment	The data produced by the analytical instrument or a pictorial representation of that data. Examples: a JCAMP, JDX, or ADX file, or a chromatogram or spectrum analysis
property	Σ	0..*	BackboneElement	General specifications for this substance
type	Σ	1..1	CodeableConcept	A code expressing the type of property Binding: Product Characteristic (Example)
value[x]	Σ	0..1		A value for the property
valueCodeableConcept			CodeableConcept
valueQuantity			Quantity
valueDate			date
valueBoolean			boolean
valueAttachment			Attachment
referenceInformation	Σ	0..1	Reference(SubstanceReferenceInformation)	General information detailing this substance
molecularWeight	Σ	0..*	BackboneElement	The average mass of a molecule of a compound
method	Σ	0..1	CodeableConcept	The method by which the weight was determined Binding: Weight Method (Example)
type	Σ	0..1	CodeableConcept	Type of molecular weight e.g. exact, average, weight average Binding: Weight Type (Example)
amount	Σ	1..1	Quantity	Used to capture quantitative values for a variety of elements
structure	Σ	0..1	BackboneElement	Structural information
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type Binding: Stereochemistry (Example)
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type Binding: Optical Activity (Example)
molecularFormula	Σ	0..1	string	An expression which states the number and type of atoms present in a molecule of a substance
molecularFormulaByMoiety	Σ	0..1	string	Specified per moiety according to the Hill system
molecularWeight	Σ	0..1	see molecularWeight	The molecular weight or weight range
technique	Σ	0..*	CodeableConcept	The method used to find the structure e.g. X-ray, NMR Binding: Structure Technique (Example)
sourceDocument	Σ	0..*	Reference(DocumentReference)	Source of information for the structure
representation	Σ	0..*	BackboneElement	A depiction of the structure of the substance
type	Σ	0..1	CodeableConcept	The kind of structural representation (e.g. full, partial) Binding: Substance Representation Type (Example)
representation	Σ	0..1	string	The structural representation as a text string in a standard format
format	Σ	0..1	CodeableConcept	The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format) Binding: Substance Representation Format (Example)
document	Σ	0..1	Reference(DocumentReference)	An attachment with the structural representation e.g. a structure graphic or AnIML file
code	Σ	0..*	BackboneElement	Codes associated with the substance
code	Σ	0..1	CodeableConcept	The specific code
status	Σ	0..1	CodeableConcept	Status of the code assignment, for example 'provisional', 'approved' Binding: PublicationStatus (Preferred)
statusDate	Σ	0..1	dateTime	The date at which the code status was changed
note	Σ	0..*	Annotation	Any comment can be provided in this field
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
name	Σ	0..*	BackboneElement	Names applicable to this substance
name	Σ	1..1	string	The actual name
type	Σ	0..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: Substance Name Type (Example)
status	Σ	0..1	CodeableConcept	The status of the name e.g. 'current', 'proposed' Binding: PublicationStatus (Preferred)
preferred	Σ	0..1	boolean	If this is the preferred name for this substance
language	Σ	0..*	CodeableConcept	Human language that the name is written in Binding: All Languages (Required) Additional Bindings Purpose Common Languages Starter Set
domain	Σ	0..*	CodeableConcept	The use context of this name e.g. as an active ingredient or as a food colour additive Binding: Substance Name Domain (Example)
jurisdiction	Σ	0..*	CodeableConcept	The jurisdiction where this name applies Binding: Jurisdiction ValueSet (Example)
synonym	Σ	0..*	see name	A synonym of this particular name, by which the substance is also known
translation	Σ	0..*	see name	A translation for this name into another human language
official	Σ	0..*	BackboneElement	Details of the official nature of this name
authority	Σ	0..1	CodeableConcept	Which authority uses this official name Binding: Substance Name Authority (Preferred)
status	Σ	0..1	CodeableConcept	The status of the official name, for example 'draft', 'active' Binding: PublicationStatus (Preferred)
date	Σ	0..1	dateTime	Date of official name change
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
relationship	Σ	0..*	BackboneElement	A link between this substance and another
substanceDefinition[x]	Σ	0..1		A pointer to another substance, as a resource or a representational code
substanceDefinitionReference			Reference(SubstanceDefinition)
substanceDefinitionCodeableConcept			CodeableConcept
type	Σ	1..1	CodeableConcept	For example "salt to parent", "active moiety" Binding: Substance Relationship Type (Example)
isDefining	Σ	0..1	boolean	For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
amount[x]	Σ	0..1		A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other
amountQuantity			Quantity
amountRatio			Ratio
amountString			string
ratioHighLimitAmount	Σ	0..1	Ratio	For use when the numeric has an uncertain range
comparator	Σ	0..1	CodeableConcept	An operator for the amount, for example "average", "approximately", "less than" Binding: Substance Amount Type (Example)
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
nucleicAcid	Σ	0..1	Reference(SubstanceNucleicAcid)	Data items specific to nucleic acids
polymer	Σ	0..1	Reference(SubstancePolymer)	Data items specific to polymers
protein	Σ	0..1	Reference(SubstanceProtein)	Data items specific to proteins
sourceMaterial	Σ	0..1	BackboneElement	Material or taxonomic/anatomical source
type	Σ	0..1	CodeableConcept	Classification of the origin of the raw material. e.g. cat hair is an Animal source type Binding: Source Material Type (Example)
genus	Σ	0..1	CodeableConcept	The genus of an organism e.g. the Latin epithet of the plant/animal scientific name Binding: Source Material Genus (Example)
species	Σ	0..1	CodeableConcept	The species of an organism e.g. the Latin epithet of the species of the plant/animal Binding: Source Material Species (Example)
part	Σ	0..1	CodeableConcept	An anatomical origin of the source material within an organism Binding: Source Material Part (Example)
countryOfOrigin	Σ	0..*	CodeableConcept	The country or countries where the material is harvested Binding: Country ValueSet (Required)
Documentation for this format

See the Extensions for this resource

<SubstanceDefinition xmlns="http://hl7.org/fhir"> 
 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <identifier><!-- 0..* Identifier Identifier by which this substance is known --></identifier>
 <version value="[string]"/><!-- 0..1 A business level version identifier of the substance -->
 <status><!-- 0..1 CodeableConcept Status of substance within the catalogue e.g. active, retired --></status>
 <classification><!-- 0..* CodeableConcept A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity --></classification>
 <domain><!-- 0..1 CodeableConcept If the substance applies to human or veterinary use --></domain>
 <grade><!-- 0..* CodeableConcept The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP) --></grade>
 <description value="[markdown]"/><!-- 0..1 Textual description of the substance -->
 <informationSource><!-- 0..* Reference(Citation) Supporting literature --></informationSource>
 <note><!-- 0..* Annotation Textual comment about the substance's catalogue or registry record --></note>
 <manufacturer><!-- 0..* Reference(Organization) The entity that creates, makes, produces or fabricates the substance --></manufacturer>
 <supplier><!-- 0..* Reference(Organization) An entity that is the source for the substance. It may be different from the manufacturer --></supplier>
 <moiety>  <!-- 0..* Moiety, for structural modifications -->
  <role><!-- 0..1 CodeableConcept Role that the moiety is playing --></role>
  <identifier><!-- 0..1 Identifier Identifier by which this moiety substance is known --></identifier>
  <name value="[string]"/><!-- 0..1 Textual name for this moiety substance -->
  <stereochemistry><!-- 0..1 CodeableConcept Stereochemistry type --></stereochemistry>
  <opticalActivity><!-- 0..1 CodeableConcept Optical activity type --></opticalActivity>
  <molecularFormula value="[string]"/><!-- 0..1 Molecular formula for this moiety (e.g. with the Hill system) -->
  <amount[x]><!-- 0..1 Quantity|string Quantitative value for this moiety --></amount[x]>
  <measurementType><!-- 0..1 CodeableConcept The measurement type of the quantitative value --></measurementType>
 </moiety>
 <characterization>  <!-- 0..* General specifications for this substance -->
  <technique><!-- 0..1 CodeableConcept The method used to find the characterization e.g. HPLC --></technique>
  <form><!-- 0..1 CodeableConcept Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form --></form>
  <description value="[markdown]"/><!-- 0..1 The description or justification in support of the interpretation of the data file -->
  <file><!-- 0..* Attachment The data produced by the analytical instrument or a pictorial representation of that data. Examples: a JCAMP, JDX, or ADX file, or a chromatogram or spectrum analysis --></file>
 </characterization>
 <property>  <!-- 0..* General specifications for this substance -->
  <type><!-- 1..1 CodeableConcept A code expressing the type of property --></type>
  <value[x]><!-- 0..1 CodeableConcept|Quantity|date|boolean|Attachment A value for the property --></value[x]>
 </property>
 <referenceInformation><!-- 0..1 Reference(SubstanceReferenceInformation) General information detailing this substance --></referenceInformation>
 <molecularWeight>  <!-- 0..* The average mass of a molecule of a compound -->
  <method><!-- 0..1 CodeableConcept The method by which the weight was determined --></method>
  <type><!-- 0..1 CodeableConcept Type of molecular weight e.g. exact, average, weight average --></type>
  <amount><!-- 1..1 Quantity Used to capture quantitative values for a variety of elements --></amount>
 </molecularWeight>
 <structure>  <!-- 0..1 Structural information -->
  <stereochemistry><!-- 0..1 CodeableConcept Stereochemistry type --></stereochemistry>
  <opticalActivity><!-- 0..1 CodeableConcept Optical activity type --></opticalActivity>
  <molecularFormula value="[string]"/><!-- 0..1 An expression which states the number and type of atoms present in a molecule of a substance -->
  <molecularFormulaByMoiety value="[string]"/><!-- 0..1 Specified per moiety according to the Hill system -->
  <molecularWeight><!-- 0..1 Content as for SubstanceDefinition.molecularWeight The molecular weight or weight range --></molecularWeight>
  <technique><!-- 0..* CodeableConcept The method used to find the structure e.g. X-ray, NMR --></technique>
  <sourceDocument><!-- 0..* Reference(DocumentReference) Source of information for the structure --></sourceDocument>
  <representation>  <!-- 0..* A depiction of the structure of the substance -->
   <type><!-- 0..1 CodeableConcept The kind of structural representation (e.g. full, partial) --></type>
   <representation value="[string]"/><!-- 0..1 The structural representation as a text string in a standard format -->
   <format><!-- 0..1 CodeableConcept The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format) --></format>
   <document><!-- 0..1 Reference(DocumentReference) An attachment with the structural representation e.g. a structure graphic or AnIML file --></document>
  </representation>
 </structure>
 <code>  <!-- 0..* Codes associated with the substance -->
  <code><!-- 0..1 CodeableConcept The specific code --></code>
  <status><!-- 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved' --></status>
  <statusDate value="[dateTime]"/><!-- 0..1 The date at which the code status was changed -->
  <note><!-- 0..* Annotation Any comment can be provided in this field --></note>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </code>
 <name>  <!-- 0..* Names applicable to this substance -->
  <name value="[string]"/><!-- 1..1 The actual name -->
  <type><!-- 0..1 CodeableConcept Name type e.g. 'systematic',  'scientific, 'brand' --></type>
  <status><!-- 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed' --></status>
  <preferred value="[boolean]"/><!-- 0..1 If this is the preferred name for this substance -->
  <language><!-- 0..* CodeableConcept Human language that the name is written in --></language>
  <domain><!-- 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive --></domain>
  <jurisdiction><!-- 0..* CodeableConcept The jurisdiction where this name applies --></jurisdiction>
  <synonym><!-- 0..* Content as for SubstanceDefinition.name A synonym of this particular name, by which the substance is also known --></synonym>
  <translation><!-- 0..* Content as for SubstanceDefinition.name A translation for this name into another human language --></translation>
  <official>  <!-- 0..* Details of the official nature of this name -->
   <authority><!-- 0..1 CodeableConcept Which authority uses this official name --></authority>
   <status><!-- 0..1 CodeableConcept The status of the official name, for example 'draft', 'active' --></status>
   <date value="[dateTime]"/><!-- 0..1 Date of official name change -->
  </official>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </name>
 <relationship>  <!-- 0..* A link between this substance and another -->
  <substanceDefinition[x]><!-- 0..1 Reference(SubstanceDefinition)|
    CodeableConcept A pointer to another substance, as a resource or a representational code --></substanceDefinition[x]>
  <type><!-- 1..1 CodeableConcept For example "salt to parent", "active moiety" --></type>
  <isDefining value="[boolean]"/><!-- 0..1 For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships -->
  <amount[x]><!-- 0..1 Quantity|Ratio|string A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other --></amount[x]>
  <ratioHighLimitAmount><!-- 0..1 Ratio For use when the numeric has an uncertain range --></ratioHighLimitAmount>
  <comparator><!-- 0..1 CodeableConcept An operator for the amount, for example "average", "approximately", "less than" --></comparator>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </relationship>
 <nucleicAcid><!-- 0..1 Reference(SubstanceNucleicAcid) Data items specific to nucleic acids --></nucleicAcid>
 <polymer><!-- 0..1 Reference(SubstancePolymer) Data items specific to polymers --></polymer>
 <protein><!-- 0..1 Reference(SubstanceProtein) Data items specific to proteins --></protein>
 <sourceMaterial>  <!-- 0..1 Material or taxonomic/anatomical source -->
  <type><!-- 0..1 CodeableConcept Classification of the origin of the raw material. e.g. cat hair is an Animal source type --></type>
  <genus><!-- 0..1 CodeableConcept The genus of an organism e.g. the Latin epithet of the plant/animal scientific name --></genus>
  <species><!-- 0..1 CodeableConcept The species of an organism e.g. the Latin epithet of the species of the plant/animal --></species>
  <part><!-- 0..1 CodeableConcept An anatomical origin of the source material within an organism --></part>
  <countryOfOrigin><!-- 0..* CodeableConcept The country or countries where the material is harvested --></countryOfOrigin>
 </sourceMaterial>
</SubstanceDefinition>

{
  "resourceType" : "SubstanceDefinition",
  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "identifier" : [{ Identifier }], // Identifier by which this substance is known
  "version" : "<string>", // A business level version identifier of the substance
  "status" : { CodeableConcept }, // Status of substance within the catalogue e.g. active, retired
  "classification" : [{ CodeableConcept }], // A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity
  "domain" : { CodeableConcept }, // If the substance applies to human or veterinary use
  "grade" : [{ CodeableConcept }], // The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
  "description" : "<markdown>", // Textual description of the substance
  "informationSource" : [{ Reference(Citation) }], // Supporting literature
  "note" : [{ Annotation }], // Textual comment about the substance's catalogue or registry record
  "manufacturer" : [{ Reference(Organization) }], // The entity that creates, makes, produces or fabricates the substance
  "supplier" : [{ Reference(Organization) }], // An entity that is the source for the substance. It may be different from the manufacturer
  "moiety" : [{ // Moiety, for structural modifications
    "role" : { CodeableConcept }, // Role that the moiety is playing
    "identifier" : { Identifier }, // Identifier by which this moiety substance is known
    "name" : "<string>", // Textual name for this moiety substance
    "stereochemistry" : { CodeableConcept }, // Stereochemistry type
    "opticalActivity" : { CodeableConcept }, // Optical activity type
    "molecularFormula" : "<string>", // Molecular formula for this moiety (e.g. with the Hill system)
    // amount[x]: Quantitative value for this moiety. One of these 2:
    "amountQuantity" : { Quantity },
    "amountString" : "<string>",
    "measurementType" : { CodeableConcept } // The measurement type of the quantitative value
  }],
  "characterization" : [{ // General specifications for this substance
    "technique" : { CodeableConcept }, // The method used to find the characterization e.g. HPLC
    "form" : { CodeableConcept }, // Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form
    "description" : "<markdown>", // The description or justification in support of the interpretation of the data file
    "file" : [{ Attachment }] // The data produced by the analytical instrument or a pictorial representation of that data. Examples: a JCAMP, JDX, or ADX file, or a chromatogram or spectrum analysis
  }],
  "property" : [{ // General specifications for this substance
    "type" : { CodeableConcept }, // R!  A code expressing the type of property
    // value[x]: A value for the property. One of these 5:
    "valueCodeableConcept" : { CodeableConcept },
    "valueQuantity" : { Quantity },
    "valueDate" : "<date>",
    "valueBoolean" : <boolean>,
    "valueAttachment" : { Attachment }
  }],
  "referenceInformation" : { Reference(SubstanceReferenceInformation) }, // General information detailing this substance
  "molecularWeight" : [{ // The average mass of a molecule of a compound
    "method" : { CodeableConcept }, // The method by which the weight was determined
    "type" : { CodeableConcept }, // Type of molecular weight e.g. exact, average, weight average
    "amount" : { Quantity } // R!  Used to capture quantitative values for a variety of elements
  }],
  "structure" : { // Structural information
    "stereochemistry" : { CodeableConcept }, // Stereochemistry type
    "opticalActivity" : { CodeableConcept }, // Optical activity type
    "molecularFormula" : "<string>", // An expression which states the number and type of atoms present in a molecule of a substance
    "molecularFormulaByMoiety" : "<string>", // Specified per moiety according to the Hill system
    "molecularWeight" : { Content as for SubstanceDefinition.molecularWeight }, // The molecular weight or weight range
    "technique" : [{ CodeableConcept }], // The method used to find the structure e.g. X-ray, NMR
    "sourceDocument" : [{ Reference(DocumentReference) }], // Source of information for the structure
    "representation" : [{ // A depiction of the structure of the substance
      "type" : { CodeableConcept }, // The kind of structural representation (e.g. full, partial)
      "representation" : "<string>", // The structural representation as a text string in a standard format
      "format" : { CodeableConcept }, // The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
      "document" : { Reference(DocumentReference) } // An attachment with the structural representation e.g. a structure graphic or AnIML file
    }]
  },
  "code" : [{ // Codes associated with the substance
    "code" : { CodeableConcept }, // The specific code
    "status" : { CodeableConcept }, // Status of the code assignment, for example 'provisional', 'approved'
    "statusDate" : "<dateTime>", // The date at which the code status was changed
    "note" : [{ Annotation }], // Any comment can be provided in this field
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "name" : [{ // Names applicable to this substance
    "name" : "<string>", // R!  The actual name
    "type" : { CodeableConcept }, // Name type e.g. 'systematic',  'scientific, 'brand'
    "status" : { CodeableConcept }, // The status of the name e.g. 'current', 'proposed'
    "preferred" : <boolean>, // If this is the preferred name for this substance
    "language" : [{ CodeableConcept }], // Human language that the name is written in
    "domain" : [{ CodeableConcept }], // The use context of this name e.g. as an active ingredient or as a food colour additive
    "jurisdiction" : [{ CodeableConcept }], // The jurisdiction where this name applies
    "synonym" : [{ Content as for SubstanceDefinition.name }], // A synonym of this particular name, by which the substance is also known
    "translation" : [{ Content as for SubstanceDefinition.name }], // A translation for this name into another human language
    "official" : [{ // Details of the official nature of this name
      "authority" : { CodeableConcept }, // Which authority uses this official name
      "status" : { CodeableConcept }, // The status of the official name, for example 'draft', 'active'
      "date" : "<dateTime>" // Date of official name change
    }],
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "relationship" : [{ // A link between this substance and another
    // substanceDefinition[x]: A pointer to another substance, as a resource or a representational code. One of these 2:
    "substanceDefinitionReference" : { Reference(SubstanceDefinition) },
    "substanceDefinitionCodeableConcept" : { CodeableConcept },
    "type" : { CodeableConcept }, // R!  For example "salt to parent", "active moiety"
    "isDefining" : <boolean>, // For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
    // amount[x]: 
      A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other. One of these 3:
    "amountQuantity" : { Quantity },
    "amountRatio" : { Ratio },
    "amountString" : "<string>",
    "ratioHighLimitAmount" : { Ratio }, // For use when the numeric has an uncertain range
    "comparator" : { CodeableConcept }, // An operator for the amount, for example "average", "approximately", "less than"
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "nucleicAcid" : { Reference(SubstanceNucleicAcid) }, // Data items specific to nucleic acids
  "polymer" : { Reference(SubstancePolymer) }, // Data items specific to polymers
  "protein" : { Reference(SubstanceProtein) }, // Data items specific to proteins
  "sourceMaterial" : { // Material or taxonomic/anatomical source
    "type" : { CodeableConcept }, // Classification of the origin of the raw material. e.g. cat hair is an Animal source type
    "genus" : { CodeableConcept }, // The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
    "species" : { CodeableConcept }, // The species of an organism e.g. the Latin epithet of the species of the plant/animal
    "part" : { CodeableConcept }, // An anatomical origin of the source material within an organism
    "countryOfOrigin" : [{ CodeableConcept }] // The country or countries where the material is harvested
  }
}

@prefix fhir: <http://hl7.org/fhir/> .


[ a fhir:SubstanceDefinition;
  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from Resource: .id, .meta, .implicitRules, and .language
  # from DomainResource: .text, .contained, .extension, and .modifierExtension
  fhir:identifier  ( [ Identifier ] ... ) ; # 0..* Identifier by which this substance is known
  fhir:version [ string ] ; # 0..1 A business level version identifier of the substance
  fhir:status [ CodeableConcept ] ; # 0..1 Status of substance within the catalogue e.g. active, retired
  fhir:classification  ( [ CodeableConcept ] ... ) ; # 0..* A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity
  fhir:domain [ CodeableConcept ] ; # 0..1 If the substance applies to human or veterinary use
  fhir:grade  ( [ CodeableConcept ] ... ) ; # 0..* The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
  fhir:description [ markdown ] ; # 0..1 Textual description of the substance
  fhir:informationSource  ( [ Reference(Citation) ] ... ) ; # 0..* Supporting literature
  fhir:note  ( [ Annotation ] ... ) ; # 0..* Textual comment about the substance's catalogue or registry record
  fhir:manufacturer  ( [ Reference(Organization) ] ... ) ; # 0..* The entity that creates, makes, produces or fabricates the substance
  fhir:supplier  ( [ Reference(Organization) ] ... ) ; # 0..* An entity that is the source for the substance. It may be different from the manufacturer
  fhir:moiety ( [ # 0..* Moiety, for structural modifications
    fhir:role [ CodeableConcept ] ; # 0..1 Role that the moiety is playing
    fhir:identifier [ Identifier ] ; # 0..1 Identifier by which this moiety substance is known
    fhir:name [ string ] ; # 0..1 Textual name for this moiety substance
    fhir:stereochemistry [ CodeableConcept ] ; # 0..1 Stereochemistry type
    fhir:opticalActivity [ CodeableConcept ] ; # 0..1 Optical activity type
    fhir:molecularFormula [ string ] ; # 0..1 Molecular formula for this moiety (e.g. with the Hill system)
    # amount[x] : 0..1 Quantitative value for this moiety. One of these 2
      fhir:amount [  a fhir:Quantity ; Quantity ]
      fhir:amount [  a fhir:string ; string ]
    fhir:measurementType [ CodeableConcept ] ; # 0..1 The measurement type of the quantitative value
  ] ... ) ;
  fhir:characterization ( [ # 0..* General specifications for this substance
    fhir:technique [ CodeableConcept ] ; # 0..1 The method used to find the characterization e.g. HPLC
    fhir:form [ CodeableConcept ] ; # 0..1 Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form
    fhir:description [ markdown ] ; # 0..1 The description or justification in support of the interpretation of the data file
    fhir:file  ( [ Attachment ] ... ) ; # 0..* The data produced by the analytical instrument or a pictorial representation of that data. Examples: a JCAMP, JDX, or ADX file, or a chromatogram or spectrum analysis
  ] ... ) ;
  fhir:property ( [ # 0..* General specifications for this substance
    fhir:type [ CodeableConcept ] ; # 1..1 A code expressing the type of property
    # value[x] : 0..1 A value for the property. One of these 5
      fhir:value [  a fhir:CodeableConcept ; CodeableConcept ]
      fhir:value [  a fhir:Quantity ; Quantity ]
      fhir:value [  a fhir:date ; date ]
      fhir:value [  a fhir:boolean ; boolean ]
      fhir:value [  a fhir:Attachment ; Attachment ]
  ] ... ) ;
  fhir:referenceInformation [ Reference(SubstanceReferenceInformation) ] ; # 0..1 General information detailing this substance
  fhir:molecularWeight ( [ # 0..* The average mass of a molecule of a compound
    fhir:method [ CodeableConcept ] ; # 0..1 The method by which the weight was determined
    fhir:type [ CodeableConcept ] ; # 0..1 Type of molecular weight e.g. exact, average, weight average
    fhir:amount [ Quantity ] ; # 1..1 Used to capture quantitative values for a variety of elements
  ] ... ) ;
  fhir:structure [ # 0..1 Structural information
    fhir:stereochemistry [ CodeableConcept ] ; # 0..1 Stereochemistry type
    fhir:opticalActivity [ CodeableConcept ] ; # 0..1 Optical activity type
    fhir:molecularFormula [ string ] ; # 0..1 An expression which states the number and type of atoms present in a molecule of a substance
    fhir:molecularFormulaByMoiety [ string ] ; # 0..1 Specified per moiety according to the Hill system
    fhir:molecularWeight [ See SubstanceDefinition.molecularWeight ] ; # 0..1 The molecular weight or weight range
    fhir:technique  ( [ CodeableConcept ] ... ) ; # 0..* The method used to find the structure e.g. X-ray, NMR
    fhir:sourceDocument  ( [ Reference(DocumentReference) ] ... ) ; # 0..* Source of information for the structure
    fhir:representation ( [ # 0..* A depiction of the structure of the substance
      fhir:type [ CodeableConcept ] ; # 0..1 The kind of structural representation (e.g. full, partial)
      fhir:representation [ string ] ; # 0..1 The structural representation as a text string in a standard format
      fhir:format [ CodeableConcept ] ; # 0..1 The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
      fhir:document [ Reference(DocumentReference) ] ; # 0..1 An attachment with the structural representation e.g. a structure graphic or AnIML file
    ] ... ) ;
  ] ;
  fhir:code ( [ # 0..* Codes associated with the substance
    fhir:code [ CodeableConcept ] ; # 0..1 The specific code
    fhir:status [ CodeableConcept ] ; # 0..1 Status of the code assignment, for example 'provisional', 'approved'
    fhir:statusDate [ dateTime ] ; # 0..1 The date at which the code status was changed
    fhir:note  ( [ Annotation ] ... ) ; # 0..* Any comment can be provided in this field
    fhir:source  ( [ Reference(DocumentReference) ] ... ) ; # 0..* Supporting literature
  ] ... ) ;
  fhir:name ( [ # 0..* Names applicable to this substance
    fhir:name [ string ] ; # 1..1 The actual name
    fhir:type [ CodeableConcept ] ; # 0..1 Name type e.g. 'systematic',  'scientific, 'brand'
    fhir:status [ CodeableConcept ] ; # 0..1 The status of the name e.g. 'current', 'proposed'
    fhir:preferred [ boolean ] ; # 0..1 If this is the preferred name for this substance
    fhir:language  ( [ CodeableConcept ] ... ) ; # 0..* Human language that the name is written in
    fhir:domain  ( [ CodeableConcept ] ... ) ; # 0..* The use context of this name e.g. as an active ingredient or as a food colour additive
    fhir:jurisdiction  ( [ CodeableConcept ] ... ) ; # 0..* The jurisdiction where this name applies
    fhir:synonym  ( [ See SubstanceDefinition.name ] ... ) ; # 0..* A synonym of this particular name, by which the substance is also known
    fhir:translation  ( [ See SubstanceDefinition.name ] ... ) ; # 0..* A translation for this name into another human language
    fhir:official ( [ # 0..* Details of the official nature of this name
      fhir:authority [ CodeableConcept ] ; # 0..1 Which authority uses this official name
      fhir:status [ CodeableConcept ] ; # 0..1 The status of the official name, for example 'draft', 'active'
      fhir:date [ dateTime ] ; # 0..1 Date of official name change
    ] ... ) ;
    fhir:source  ( [ Reference(DocumentReference) ] ... ) ; # 0..* Supporting literature
  ] ... ) ;
  fhir:relationship ( [ # 0..* A link between this substance and another
    # substanceDefinition[x] : 0..1 A pointer to another substance, as a resource or a representational code. One of these 2
      fhir:substanceDefinition [  a fhir:Reference ; Reference(SubstanceDefinition) ]
      fhir:substanceDefinition [  a fhir:CodeableConcept ; CodeableConcept ]
    fhir:type [ CodeableConcept ] ; # 1..1 For example "salt to parent", "active moiety"
    fhir:isDefining [ boolean ] ; # 0..1 For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
    # amount[x] : 0..1 A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other. One of these 3
      fhir:amount [  a fhir:Quantity ; Quantity ]
      fhir:amount [  a fhir:Ratio ; Ratio ]
      fhir:amount [  a fhir:string ; string ]
    fhir:ratioHighLimitAmount [ Ratio ] ; # 0..1 For use when the numeric has an uncertain range
    fhir:comparator [ CodeableConcept ] ; # 0..1 An operator for the amount, for example "average", "approximately", "less than"
    fhir:source  ( [ Reference(DocumentReference) ] ... ) ; # 0..* Supporting literature
  ] ... ) ;
  fhir:nucleicAcid [ Reference(SubstanceNucleicAcid) ] ; # 0..1 Data items specific to nucleic acids
  fhir:polymer [ Reference(SubstancePolymer) ] ; # 0..1 Data items specific to polymers
  fhir:protein [ Reference(SubstanceProtein) ] ; # 0..1 Data items specific to proteins
  fhir:sourceMaterial [ # 0..1 Material or taxonomic/anatomical source
    fhir:type [ CodeableConcept ] ; # 0..1 Classification of the origin of the raw material. e.g. cat hair is an Animal source type
    fhir:genus [ CodeableConcept ] ; # 0..1 The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
    fhir:species [ CodeableConcept ] ; # 0..1 The species of an organism e.g. the Latin epithet of the species of the plant/animal
    fhir:part [ CodeableConcept ] ; # 0..1 An anatomical origin of the source material within an organism
    fhir:countryOfOrigin  ( [ CodeableConcept ] ... ) ; # 0..* The country or countries where the material is harvested
  ] ;
]

Changes from both R4 and R4B

This resource did not exist in Release R4

See the Full Difference for further information

This analysis is available for R4 as XML or JSON and for R4B as XML or JSON.

Name	Flags	Card.	Type	Description & Constraints
SubstanceDefinition	TU		DomainResource	The detailed description of a substance, typically at a level beyond what is used for prescribing Elements defined in Ancestors: id, meta, implicitRules, language, text, contained, extension, modifierExtension
identifier	Σ	0..*	Identifier	Identifier by which this substance is known
version	Σ	0..1	string	A business level version identifier of the substance
status	Σ	0..1	CodeableConcept	Status of substance within the catalogue e.g. active, retired Binding: PublicationStatus (Preferred)
classification	Σ	0..*	CodeableConcept	A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity
domain	Σ	0..1	CodeableConcept	If the substance applies to human or veterinary use Binding: Medicinal Product Domain (Example)
grade	Σ	0..*	CodeableConcept	The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP) Binding: Substance Grade (Example)
description	Σ	0..1	markdown	Textual description of the substance
informationSource	Σ	0..*	Reference(Citation)	Supporting literature
note	Σ	0..*	Annotation	Textual comment about the substance's catalogue or registry record
manufacturer	Σ	0..*	Reference(Organization)	The entity that creates, makes, produces or fabricates the substance
supplier	Σ	0..*	Reference(Organization)	An entity that is the source for the substance. It may be different from the manufacturer
moiety	Σ	0..*	BackboneElement	Moiety, for structural modifications
role	Σ	0..1	CodeableConcept	Role that the moiety is playing
identifier	Σ	0..1	Identifier	Identifier by which this moiety substance is known
name	Σ	0..1	string	Textual name for this moiety substance
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type Binding: Stereochemistry (Example)
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type Binding: Optical Activity (Example)
molecularFormula	Σ	0..1	string	Molecular formula for this moiety (e.g. with the Hill system)
amount[x]	Σ	0..1		Quantitative value for this moiety
amountQuantity			Quantity
amountString			string
measurementType	Σ	0..1	CodeableConcept	The measurement type of the quantitative value Binding: Substance Amount Type (Example)
characterization	Σ	0..*	BackboneElement	General specifications for this substance
technique	Σ	0..1	CodeableConcept	The method used to find the characterization e.g. HPLC Binding: Structure Technique (Example)
form	Σ	0..1	CodeableConcept	Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form Binding: Substance Form (Example)
description	Σ	0..1	markdown	The description or justification in support of the interpretation of the data file
file	Σ	0..*	Attachment	The data produced by the analytical instrument or a pictorial representation of that data. Examples: a JCAMP, JDX, or ADX file, or a chromatogram or spectrum analysis
property	Σ	0..*	BackboneElement	General specifications for this substance
type	Σ	1..1	CodeableConcept	A code expressing the type of property Binding: Product Characteristic (Example)
value[x]	Σ	0..1		A value for the property
valueCodeableConcept			CodeableConcept
valueQuantity			Quantity
valueDate			date
valueBoolean			boolean
valueAttachment			Attachment
referenceInformation	Σ	0..1	Reference(SubstanceReferenceInformation)	General information detailing this substance
molecularWeight	Σ	0..*	BackboneElement	The average mass of a molecule of a compound
method	Σ	0..1	CodeableConcept	The method by which the weight was determined Binding: Weight Method (Example)
type	Σ	0..1	CodeableConcept	Type of molecular weight e.g. exact, average, weight average Binding: Weight Type (Example)
amount	Σ	1..1	Quantity	Used to capture quantitative values for a variety of elements
structure	Σ	0..1	BackboneElement	Structural information
stereochemistry	Σ	0..1	CodeableConcept	Stereochemistry type Binding: Stereochemistry (Example)
opticalActivity	Σ	0..1	CodeableConcept	Optical activity type Binding: Optical Activity (Example)
molecularFormula	Σ	0..1	string	An expression which states the number and type of atoms present in a molecule of a substance
molecularFormulaByMoiety	Σ	0..1	string	Specified per moiety according to the Hill system
molecularWeight	Σ	0..1	see molecularWeight	The molecular weight or weight range
technique	Σ	0..*	CodeableConcept	The method used to find the structure e.g. X-ray, NMR Binding: Structure Technique (Example)
sourceDocument	Σ	0..*	Reference(DocumentReference)	Source of information for the structure
representation	Σ	0..*	BackboneElement	A depiction of the structure of the substance
type	Σ	0..1	CodeableConcept	The kind of structural representation (e.g. full, partial) Binding: Substance Representation Type (Example)
representation	Σ	0..1	string	The structural representation as a text string in a standard format
format	Σ	0..1	CodeableConcept	The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format) Binding: Substance Representation Format (Example)
document	Σ	0..1	Reference(DocumentReference)	An attachment with the structural representation e.g. a structure graphic or AnIML file
code	Σ	0..*	BackboneElement	Codes associated with the substance
code	Σ	0..1	CodeableConcept	The specific code
status	Σ	0..1	CodeableConcept	Status of the code assignment, for example 'provisional', 'approved' Binding: PublicationStatus (Preferred)
statusDate	Σ	0..1	dateTime	The date at which the code status was changed
note	Σ	0..*	Annotation	Any comment can be provided in this field
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
name	Σ	0..*	BackboneElement	Names applicable to this substance
name	Σ	1..1	string	The actual name
type	Σ	0..1	CodeableConcept	Name type e.g. 'systematic', 'scientific, 'brand' Binding: Substance Name Type (Example)
status	Σ	0..1	CodeableConcept	The status of the name e.g. 'current', 'proposed' Binding: PublicationStatus (Preferred)
preferred	Σ	0..1	boolean	If this is the preferred name for this substance
language	Σ	0..*	CodeableConcept	Human language that the name is written in Binding: All Languages (Required) Additional Bindings Purpose Common Languages Starter Set
domain	Σ	0..*	CodeableConcept	The use context of this name e.g. as an active ingredient or as a food colour additive Binding: Substance Name Domain (Example)
jurisdiction	Σ	0..*	CodeableConcept	The jurisdiction where this name applies Binding: Jurisdiction ValueSet (Example)
synonym	Σ	0..*	see name	A synonym of this particular name, by which the substance is also known
translation	Σ	0..*	see name	A translation for this name into another human language
official	Σ	0..*	BackboneElement	Details of the official nature of this name
authority	Σ	0..1	CodeableConcept	Which authority uses this official name Binding: Substance Name Authority (Preferred)
status	Σ	0..1	CodeableConcept	The status of the official name, for example 'draft', 'active' Binding: PublicationStatus (Preferred)
date	Σ	0..1	dateTime	Date of official name change
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
relationship	Σ	0..*	BackboneElement	A link between this substance and another
substanceDefinition[x]	Σ	0..1		A pointer to another substance, as a resource or a representational code
substanceDefinitionReference			Reference(SubstanceDefinition)
substanceDefinitionCodeableConcept			CodeableConcept
type	Σ	1..1	CodeableConcept	For example "salt to parent", "active moiety" Binding: Substance Relationship Type (Example)
isDefining	Σ	0..1	boolean	For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
amount[x]	Σ	0..1		A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other
amountQuantity			Quantity
amountRatio			Ratio
amountString			string
ratioHighLimitAmount	Σ	0..1	Ratio	For use when the numeric has an uncertain range
comparator	Σ	0..1	CodeableConcept	An operator for the amount, for example "average", "approximately", "less than" Binding: Substance Amount Type (Example)
source	Σ	0..*	Reference(DocumentReference)	Supporting literature
nucleicAcid	Σ	0..1	Reference(SubstanceNucleicAcid)	Data items specific to nucleic acids
polymer	Σ	0..1	Reference(SubstancePolymer)	Data items specific to polymers
protein	Σ	0..1	Reference(SubstanceProtein)	Data items specific to proteins
sourceMaterial	Σ	0..1	BackboneElement	Material or taxonomic/anatomical source
type	Σ	0..1	CodeableConcept	Classification of the origin of the raw material. e.g. cat hair is an Animal source type Binding: Source Material Type (Example)
genus	Σ	0..1	CodeableConcept	The genus of an organism e.g. the Latin epithet of the plant/animal scientific name Binding: Source Material Genus (Example)
species	Σ	0..1	CodeableConcept	The species of an organism e.g. the Latin epithet of the species of the plant/animal Binding: Source Material Species (Example)
part	Σ	0..1	CodeableConcept	An anatomical origin of the source material within an organism Binding: Source Material Part (Example)
countryOfOrigin	Σ	0..*	CodeableConcept	The country or countries where the material is harvested Binding: Country ValueSet (Required)
Documentation for this format

See the Extensions for this resource

<SubstanceDefinition xmlns="http://hl7.org/fhir"> 
 <!-- from Resource: id, meta, implicitRules, and language -->
 <!-- from DomainResource: text, contained, extension, and modifierExtension -->
 <identifier><!-- 0..* Identifier Identifier by which this substance is known --></identifier>
 <version value="[string]"/><!-- 0..1 A business level version identifier of the substance -->
 <status><!-- 0..1 CodeableConcept Status of substance within the catalogue e.g. active, retired --></status>
 <classification><!-- 0..* CodeableConcept A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity --></classification>
 <domain><!-- 0..1 CodeableConcept If the substance applies to human or veterinary use --></domain>
 <grade><!-- 0..* CodeableConcept The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP) --></grade>
 <description value="[markdown]"/><!-- 0..1 Textual description of the substance -->
 <informationSource><!-- 0..* Reference(Citation) Supporting literature --></informationSource>
 <note><!-- 0..* Annotation Textual comment about the substance's catalogue or registry record --></note>
 <manufacturer><!-- 0..* Reference(Organization) The entity that creates, makes, produces or fabricates the substance --></manufacturer>
 <supplier><!-- 0..* Reference(Organization) An entity that is the source for the substance. It may be different from the manufacturer --></supplier>
 <moiety>  <!-- 0..* Moiety, for structural modifications -->
  <role><!-- 0..1 CodeableConcept Role that the moiety is playing --></role>
  <identifier><!-- 0..1 Identifier Identifier by which this moiety substance is known --></identifier>
  <name value="[string]"/><!-- 0..1 Textual name for this moiety substance -->
  <stereochemistry><!-- 0..1 CodeableConcept Stereochemistry type --></stereochemistry>
  <opticalActivity><!-- 0..1 CodeableConcept Optical activity type --></opticalActivity>
  <molecularFormula value="[string]"/><!-- 0..1 Molecular formula for this moiety (e.g. with the Hill system) -->
  <amount[x]><!-- 0..1 Quantity|string Quantitative value for this moiety --></amount[x]>
  <measurementType><!-- 0..1 CodeableConcept The measurement type of the quantitative value --></measurementType>
 </moiety>
 <characterization>  <!-- 0..* General specifications for this substance -->
  <technique><!-- 0..1 CodeableConcept The method used to find the characterization e.g. HPLC --></technique>
  <form><!-- 0..1 CodeableConcept Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form --></form>
  <description value="[markdown]"/><!-- 0..1 The description or justification in support of the interpretation of the data file -->
  <file><!-- 0..* Attachment The data produced by the analytical instrument or a pictorial representation of that data. Examples: a JCAMP, JDX, or ADX file, or a chromatogram or spectrum analysis --></file>
 </characterization>
 <property>  <!-- 0..* General specifications for this substance -->
  <type><!-- 1..1 CodeableConcept A code expressing the type of property --></type>
  <value[x]><!-- 0..1 CodeableConcept|Quantity|date|boolean|Attachment A value for the property --></value[x]>
 </property>
 <referenceInformation><!-- 0..1 Reference(SubstanceReferenceInformation) General information detailing this substance --></referenceInformation>
 <molecularWeight>  <!-- 0..* The average mass of a molecule of a compound -->
  <method><!-- 0..1 CodeableConcept The method by which the weight was determined --></method>
  <type><!-- 0..1 CodeableConcept Type of molecular weight e.g. exact, average, weight average --></type>
  <amount><!-- 1..1 Quantity Used to capture quantitative values for a variety of elements --></amount>
 </molecularWeight>
 <structure>  <!-- 0..1 Structural information -->
  <stereochemistry><!-- 0..1 CodeableConcept Stereochemistry type --></stereochemistry>
  <opticalActivity><!-- 0..1 CodeableConcept Optical activity type --></opticalActivity>
  <molecularFormula value="[string]"/><!-- 0..1 An expression which states the number and type of atoms present in a molecule of a substance -->
  <molecularFormulaByMoiety value="[string]"/><!-- 0..1 Specified per moiety according to the Hill system -->
  <molecularWeight><!-- 0..1 Content as for SubstanceDefinition.molecularWeight The molecular weight or weight range --></molecularWeight>
  <technique><!-- 0..* CodeableConcept The method used to find the structure e.g. X-ray, NMR --></technique>
  <sourceDocument><!-- 0..* Reference(DocumentReference) Source of information for the structure --></sourceDocument>
  <representation>  <!-- 0..* A depiction of the structure of the substance -->
   <type><!-- 0..1 CodeableConcept The kind of structural representation (e.g. full, partial) --></type>
   <representation value="[string]"/><!-- 0..1 The structural representation as a text string in a standard format -->
   <format><!-- 0..1 CodeableConcept The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format) --></format>
   <document><!-- 0..1 Reference(DocumentReference) An attachment with the structural representation e.g. a structure graphic or AnIML file --></document>
  </representation>
 </structure>
 <code>  <!-- 0..* Codes associated with the substance -->
  <code><!-- 0..1 CodeableConcept The specific code --></code>
  <status><!-- 0..1 CodeableConcept Status of the code assignment, for example 'provisional', 'approved' --></status>
  <statusDate value="[dateTime]"/><!-- 0..1 The date at which the code status was changed -->
  <note><!-- 0..* Annotation Any comment can be provided in this field --></note>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </code>
 <name>  <!-- 0..* Names applicable to this substance -->
  <name value="[string]"/><!-- 1..1 The actual name -->
  <type><!-- 0..1 CodeableConcept Name type e.g. 'systematic',  'scientific, 'brand' --></type>
  <status><!-- 0..1 CodeableConcept The status of the name e.g. 'current', 'proposed' --></status>
  <preferred value="[boolean]"/><!-- 0..1 If this is the preferred name for this substance -->
  <language><!-- 0..* CodeableConcept Human language that the name is written in --></language>
  <domain><!-- 0..* CodeableConcept The use context of this name e.g. as an active ingredient or as a food colour additive --></domain>
  <jurisdiction><!-- 0..* CodeableConcept The jurisdiction where this name applies --></jurisdiction>
  <synonym><!-- 0..* Content as for SubstanceDefinition.name A synonym of this particular name, by which the substance is also known --></synonym>
  <translation><!-- 0..* Content as for SubstanceDefinition.name A translation for this name into another human language --></translation>
  <official>  <!-- 0..* Details of the official nature of this name -->
   <authority><!-- 0..1 CodeableConcept Which authority uses this official name --></authority>
   <status><!-- 0..1 CodeableConcept The status of the official name, for example 'draft', 'active' --></status>
   <date value="[dateTime]"/><!-- 0..1 Date of official name change -->
  </official>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </name>
 <relationship>  <!-- 0..* A link between this substance and another -->
  <substanceDefinition[x]><!-- 0..1 Reference(SubstanceDefinition)|
    CodeableConcept A pointer to another substance, as a resource or a representational code --></substanceDefinition[x]>
  <type><!-- 1..1 CodeableConcept For example "salt to parent", "active moiety" --></type>
  <isDefining value="[boolean]"/><!-- 0..1 For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships -->
  <amount[x]><!-- 0..1 Quantity|Ratio|string A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other --></amount[x]>
  <ratioHighLimitAmount><!-- 0..1 Ratio For use when the numeric has an uncertain range --></ratioHighLimitAmount>
  <comparator><!-- 0..1 CodeableConcept An operator for the amount, for example "average", "approximately", "less than" --></comparator>
  <source><!-- 0..* Reference(DocumentReference) Supporting literature --></source>
 </relationship>
 <nucleicAcid><!-- 0..1 Reference(SubstanceNucleicAcid) Data items specific to nucleic acids --></nucleicAcid>
 <polymer><!-- 0..1 Reference(SubstancePolymer) Data items specific to polymers --></polymer>
 <protein><!-- 0..1 Reference(SubstanceProtein) Data items specific to proteins --></protein>
 <sourceMaterial>  <!-- 0..1 Material or taxonomic/anatomical source -->
  <type><!-- 0..1 CodeableConcept Classification of the origin of the raw material. e.g. cat hair is an Animal source type --></type>
  <genus><!-- 0..1 CodeableConcept The genus of an organism e.g. the Latin epithet of the plant/animal scientific name --></genus>
  <species><!-- 0..1 CodeableConcept The species of an organism e.g. the Latin epithet of the species of the plant/animal --></species>
  <part><!-- 0..1 CodeableConcept An anatomical origin of the source material within an organism --></part>
  <countryOfOrigin><!-- 0..* CodeableConcept The country or countries where the material is harvested --></countryOfOrigin>
 </sourceMaterial>
</SubstanceDefinition>

{
  "resourceType" : "SubstanceDefinition",
  // from Resource: id, meta, implicitRules, and language
  // from DomainResource: text, contained, extension, and modifierExtension
  "identifier" : [{ Identifier }], // Identifier by which this substance is known
  "version" : "<string>", // A business level version identifier of the substance
  "status" : { CodeableConcept }, // Status of substance within the catalogue e.g. active, retired
  "classification" : [{ CodeableConcept }], // A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity
  "domain" : { CodeableConcept }, // If the substance applies to human or veterinary use
  "grade" : [{ CodeableConcept }], // The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
  "description" : "<markdown>", // Textual description of the substance
  "informationSource" : [{ Reference(Citation) }], // Supporting literature
  "note" : [{ Annotation }], // Textual comment about the substance's catalogue or registry record
  "manufacturer" : [{ Reference(Organization) }], // The entity that creates, makes, produces or fabricates the substance
  "supplier" : [{ Reference(Organization) }], // An entity that is the source for the substance. It may be different from the manufacturer
  "moiety" : [{ // Moiety, for structural modifications
    "role" : { CodeableConcept }, // Role that the moiety is playing
    "identifier" : { Identifier }, // Identifier by which this moiety substance is known
    "name" : "<string>", // Textual name for this moiety substance
    "stereochemistry" : { CodeableConcept }, // Stereochemistry type
    "opticalActivity" : { CodeableConcept }, // Optical activity type
    "molecularFormula" : "<string>", // Molecular formula for this moiety (e.g. with the Hill system)
    // amount[x]: Quantitative value for this moiety. One of these 2:
    "amountQuantity" : { Quantity },
    "amountString" : "<string>",
    "measurementType" : { CodeableConcept } // The measurement type of the quantitative value
  }],
  "characterization" : [{ // General specifications for this substance
    "technique" : { CodeableConcept }, // The method used to find the characterization e.g. HPLC
    "form" : { CodeableConcept }, // Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form
    "description" : "<markdown>", // The description or justification in support of the interpretation of the data file
    "file" : [{ Attachment }] // The data produced by the analytical instrument or a pictorial representation of that data. Examples: a JCAMP, JDX, or ADX file, or a chromatogram or spectrum analysis
  }],
  "property" : [{ // General specifications for this substance
    "type" : { CodeableConcept }, // R!  A code expressing the type of property
    // value[x]: A value for the property. One of these 5:
    "valueCodeableConcept" : { CodeableConcept },
    "valueQuantity" : { Quantity },
    "valueDate" : "<date>",
    "valueBoolean" : <boolean>,
    "valueAttachment" : { Attachment }
  }],
  "referenceInformation" : { Reference(SubstanceReferenceInformation) }, // General information detailing this substance
  "molecularWeight" : [{ // The average mass of a molecule of a compound
    "method" : { CodeableConcept }, // The method by which the weight was determined
    "type" : { CodeableConcept }, // Type of molecular weight e.g. exact, average, weight average
    "amount" : { Quantity } // R!  Used to capture quantitative values for a variety of elements
  }],
  "structure" : { // Structural information
    "stereochemistry" : { CodeableConcept }, // Stereochemistry type
    "opticalActivity" : { CodeableConcept }, // Optical activity type
    "molecularFormula" : "<string>", // An expression which states the number and type of atoms present in a molecule of a substance
    "molecularFormulaByMoiety" : "<string>", // Specified per moiety according to the Hill system
    "molecularWeight" : { Content as for SubstanceDefinition.molecularWeight }, // The molecular weight or weight range
    "technique" : [{ CodeableConcept }], // The method used to find the structure e.g. X-ray, NMR
    "sourceDocument" : [{ Reference(DocumentReference) }], // Source of information for the structure
    "representation" : [{ // A depiction of the structure of the substance
      "type" : { CodeableConcept }, // The kind of structural representation (e.g. full, partial)
      "representation" : "<string>", // The structural representation as a text string in a standard format
      "format" : { CodeableConcept }, // The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
      "document" : { Reference(DocumentReference) } // An attachment with the structural representation e.g. a structure graphic or AnIML file
    }]
  },
  "code" : [{ // Codes associated with the substance
    "code" : { CodeableConcept }, // The specific code
    "status" : { CodeableConcept }, // Status of the code assignment, for example 'provisional', 'approved'
    "statusDate" : "<dateTime>", // The date at which the code status was changed
    "note" : [{ Annotation }], // Any comment can be provided in this field
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "name" : [{ // Names applicable to this substance
    "name" : "<string>", // R!  The actual name
    "type" : { CodeableConcept }, // Name type e.g. 'systematic',  'scientific, 'brand'
    "status" : { CodeableConcept }, // The status of the name e.g. 'current', 'proposed'
    "preferred" : <boolean>, // If this is the preferred name for this substance
    "language" : [{ CodeableConcept }], // Human language that the name is written in
    "domain" : [{ CodeableConcept }], // The use context of this name e.g. as an active ingredient or as a food colour additive
    "jurisdiction" : [{ CodeableConcept }], // The jurisdiction where this name applies
    "synonym" : [{ Content as for SubstanceDefinition.name }], // A synonym of this particular name, by which the substance is also known
    "translation" : [{ Content as for SubstanceDefinition.name }], // A translation for this name into another human language
    "official" : [{ // Details of the official nature of this name
      "authority" : { CodeableConcept }, // Which authority uses this official name
      "status" : { CodeableConcept }, // The status of the official name, for example 'draft', 'active'
      "date" : "<dateTime>" // Date of official name change
    }],
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "relationship" : [{ // A link between this substance and another
    // substanceDefinition[x]: A pointer to another substance, as a resource or a representational code. One of these 2:
    "substanceDefinitionReference" : { Reference(SubstanceDefinition) },
    "substanceDefinitionCodeableConcept" : { CodeableConcept },
    "type" : { CodeableConcept }, // R!  For example "salt to parent", "active moiety"
    "isDefining" : <boolean>, // For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
    // amount[x]: 
      A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other. One of these 3:
    "amountQuantity" : { Quantity },
    "amountRatio" : { Ratio },
    "amountString" : "<string>",
    "ratioHighLimitAmount" : { Ratio }, // For use when the numeric has an uncertain range
    "comparator" : { CodeableConcept }, // An operator for the amount, for example "average", "approximately", "less than"
    "source" : [{ Reference(DocumentReference) }] // Supporting literature
  }],
  "nucleicAcid" : { Reference(SubstanceNucleicAcid) }, // Data items specific to nucleic acids
  "polymer" : { Reference(SubstancePolymer) }, // Data items specific to polymers
  "protein" : { Reference(SubstanceProtein) }, // Data items specific to proteins
  "sourceMaterial" : { // Material or taxonomic/anatomical source
    "type" : { CodeableConcept }, // Classification of the origin of the raw material. e.g. cat hair is an Animal source type
    "genus" : { CodeableConcept }, // The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
    "species" : { CodeableConcept }, // The species of an organism e.g. the Latin epithet of the species of the plant/animal
    "part" : { CodeableConcept }, // An anatomical origin of the source material within an organism
    "countryOfOrigin" : [{ CodeableConcept }] // The country or countries where the material is harvested
  }
}

@prefix fhir: <http://hl7.org/fhir/> .


[ a fhir:SubstanceDefinition;
  fhir:nodeRole fhir:treeRoot; # if this is the parser root

  # from Resource: .id, .meta, .implicitRules, and .language
  # from DomainResource: .text, .contained, .extension, and .modifierExtension
  fhir:identifier  ( [ Identifier ] ... ) ; # 0..* Identifier by which this substance is known
  fhir:version [ string ] ; # 0..1 A business level version identifier of the substance
  fhir:status [ CodeableConcept ] ; # 0..1 Status of substance within the catalogue e.g. active, retired
  fhir:classification  ( [ CodeableConcept ] ... ) ; # 0..* A categorization, high level e.g. polymer or nucleic acid, or food, chemical, biological, or lower e.g. polymer linear or branch chain, or type of impurity
  fhir:domain [ CodeableConcept ] ; # 0..1 If the substance applies to human or veterinary use
  fhir:grade  ( [ CodeableConcept ] ... ) ; # 0..* The quality standard, established benchmark, to which substance complies (e.g. USP/NF, BP)
  fhir:description [ markdown ] ; # 0..1 Textual description of the substance
  fhir:informationSource  ( [ Reference(Citation) ] ... ) ; # 0..* Supporting literature
  fhir:note  ( [ Annotation ] ... ) ; # 0..* Textual comment about the substance's catalogue or registry record
  fhir:manufacturer  ( [ Reference(Organization) ] ... ) ; # 0..* The entity that creates, makes, produces or fabricates the substance
  fhir:supplier  ( [ Reference(Organization) ] ... ) ; # 0..* An entity that is the source for the substance. It may be different from the manufacturer
  fhir:moiety ( [ # 0..* Moiety, for structural modifications
    fhir:role [ CodeableConcept ] ; # 0..1 Role that the moiety is playing
    fhir:identifier [ Identifier ] ; # 0..1 Identifier by which this moiety substance is known
    fhir:name [ string ] ; # 0..1 Textual name for this moiety substance
    fhir:stereochemistry [ CodeableConcept ] ; # 0..1 Stereochemistry type
    fhir:opticalActivity [ CodeableConcept ] ; # 0..1 Optical activity type
    fhir:molecularFormula [ string ] ; # 0..1 Molecular formula for this moiety (e.g. with the Hill system)
    # amount[x] : 0..1 Quantitative value for this moiety. One of these 2
      fhir:amount [  a fhir:Quantity ; Quantity ]
      fhir:amount [  a fhir:string ; string ]
    fhir:measurementType [ CodeableConcept ] ; # 0..1 The measurement type of the quantitative value
  ] ... ) ;
  fhir:characterization ( [ # 0..* General specifications for this substance
    fhir:technique [ CodeableConcept ] ; # 0..1 The method used to find the characterization e.g. HPLC
    fhir:form [ CodeableConcept ] ; # 0..1 Describes the nature of the chemical entity and explains, for instance, whether this is a base or a salt form
    fhir:description [ markdown ] ; # 0..1 The description or justification in support of the interpretation of the data file
    fhir:file  ( [ Attachment ] ... ) ; # 0..* The data produced by the analytical instrument or a pictorial representation of that data. Examples: a JCAMP, JDX, or ADX file, or a chromatogram or spectrum analysis
  ] ... ) ;
  fhir:property ( [ # 0..* General specifications for this substance
    fhir:type [ CodeableConcept ] ; # 1..1 A code expressing the type of property
    # value[x] : 0..1 A value for the property. One of these 5
      fhir:value [  a fhir:CodeableConcept ; CodeableConcept ]
      fhir:value [  a fhir:Quantity ; Quantity ]
      fhir:value [  a fhir:date ; date ]
      fhir:value [  a fhir:boolean ; boolean ]
      fhir:value [  a fhir:Attachment ; Attachment ]
  ] ... ) ;
  fhir:referenceInformation [ Reference(SubstanceReferenceInformation) ] ; # 0..1 General information detailing this substance
  fhir:molecularWeight ( [ # 0..* The average mass of a molecule of a compound
    fhir:method [ CodeableConcept ] ; # 0..1 The method by which the weight was determined
    fhir:type [ CodeableConcept ] ; # 0..1 Type of molecular weight e.g. exact, average, weight average
    fhir:amount [ Quantity ] ; # 1..1 Used to capture quantitative values for a variety of elements
  ] ... ) ;
  fhir:structure [ # 0..1 Structural information
    fhir:stereochemistry [ CodeableConcept ] ; # 0..1 Stereochemistry type
    fhir:opticalActivity [ CodeableConcept ] ; # 0..1 Optical activity type
    fhir:molecularFormula [ string ] ; # 0..1 An expression which states the number and type of atoms present in a molecule of a substance
    fhir:molecularFormulaByMoiety [ string ] ; # 0..1 Specified per moiety according to the Hill system
    fhir:molecularWeight [ See SubstanceDefinition.molecularWeight ] ; # 0..1 The molecular weight or weight range
    fhir:technique  ( [ CodeableConcept ] ... ) ; # 0..* The method used to find the structure e.g. X-ray, NMR
    fhir:sourceDocument  ( [ Reference(DocumentReference) ] ... ) ; # 0..* Source of information for the structure
    fhir:representation ( [ # 0..* A depiction of the structure of the substance
      fhir:type [ CodeableConcept ] ; # 0..1 The kind of structural representation (e.g. full, partial)
      fhir:representation [ string ] ; # 0..1 The structural representation as a text string in a standard format
      fhir:format [ CodeableConcept ] ; # 0..1 The format of the representation e.g. InChI, SMILES, MOLFILE (note: not the physical file format)
      fhir:document [ Reference(DocumentReference) ] ; # 0..1 An attachment with the structural representation e.g. a structure graphic or AnIML file
    ] ... ) ;
  ] ;
  fhir:code ( [ # 0..* Codes associated with the substance
    fhir:code [ CodeableConcept ] ; # 0..1 The specific code
    fhir:status [ CodeableConcept ] ; # 0..1 Status of the code assignment, for example 'provisional', 'approved'
    fhir:statusDate [ dateTime ] ; # 0..1 The date at which the code status was changed
    fhir:note  ( [ Annotation ] ... ) ; # 0..* Any comment can be provided in this field
    fhir:source  ( [ Reference(DocumentReference) ] ... ) ; # 0..* Supporting literature
  ] ... ) ;
  fhir:name ( [ # 0..* Names applicable to this substance
    fhir:name [ string ] ; # 1..1 The actual name
    fhir:type [ CodeableConcept ] ; # 0..1 Name type e.g. 'systematic',  'scientific, 'brand'
    fhir:status [ CodeableConcept ] ; # 0..1 The status of the name e.g. 'current', 'proposed'
    fhir:preferred [ boolean ] ; # 0..1 If this is the preferred name for this substance
    fhir:language  ( [ CodeableConcept ] ... ) ; # 0..* Human language that the name is written in
    fhir:domain  ( [ CodeableConcept ] ... ) ; # 0..* The use context of this name e.g. as an active ingredient or as a food colour additive
    fhir:jurisdiction  ( [ CodeableConcept ] ... ) ; # 0..* The jurisdiction where this name applies
    fhir:synonym  ( [ See SubstanceDefinition.name ] ... ) ; # 0..* A synonym of this particular name, by which the substance is also known
    fhir:translation  ( [ See SubstanceDefinition.name ] ... ) ; # 0..* A translation for this name into another human language
    fhir:official ( [ # 0..* Details of the official nature of this name
      fhir:authority [ CodeableConcept ] ; # 0..1 Which authority uses this official name
      fhir:status [ CodeableConcept ] ; # 0..1 The status of the official name, for example 'draft', 'active'
      fhir:date [ dateTime ] ; # 0..1 Date of official name change
    ] ... ) ;
    fhir:source  ( [ Reference(DocumentReference) ] ... ) ; # 0..* Supporting literature
  ] ... ) ;
  fhir:relationship ( [ # 0..* A link between this substance and another
    # substanceDefinition[x] : 0..1 A pointer to another substance, as a resource or a representational code. One of these 2
      fhir:substanceDefinition [  a fhir:Reference ; Reference(SubstanceDefinition) ]
      fhir:substanceDefinition [  a fhir:CodeableConcept ; CodeableConcept ]
    fhir:type [ CodeableConcept ] ; # 1..1 For example "salt to parent", "active moiety"
    fhir:isDefining [ boolean ] ; # 0..1 For example where an enzyme strongly bonds with a particular substance, this is a defining relationship for that enzyme, out of several possible relationships
    # amount[x] : 0..1 A numeric factor for the relationship, e.g. that a substance salt has some percentage of active substance in relation to some other. One of these 3
      fhir:amount [  a fhir:Quantity ; Quantity ]
      fhir:amount [  a fhir:Ratio ; Ratio ]
      fhir:amount [  a fhir:string ; string ]
    fhir:ratioHighLimitAmount [ Ratio ] ; # 0..1 For use when the numeric has an uncertain range
    fhir:comparator [ CodeableConcept ] ; # 0..1 An operator for the amount, for example "average", "approximately", "less than"
    fhir:source  ( [ Reference(DocumentReference) ] ... ) ; # 0..* Supporting literature
  ] ... ) ;
  fhir:nucleicAcid [ Reference(SubstanceNucleicAcid) ] ; # 0..1 Data items specific to nucleic acids
  fhir:polymer [ Reference(SubstancePolymer) ] ; # 0..1 Data items specific to polymers
  fhir:protein [ Reference(SubstanceProtein) ] ; # 0..1 Data items specific to proteins
  fhir:sourceMaterial [ # 0..1 Material or taxonomic/anatomical source
    fhir:type [ CodeableConcept ] ; # 0..1 Classification of the origin of the raw material. e.g. cat hair is an Animal source type
    fhir:genus [ CodeableConcept ] ; # 0..1 The genus of an organism e.g. the Latin epithet of the plant/animal scientific name
    fhir:species [ CodeableConcept ] ; # 0..1 The species of an organism e.g. the Latin epithet of the species of the plant/animal
    fhir:part [ CodeableConcept ] ; # 0..1 An anatomical origin of the source material within an organism
    fhir:countryOfOrigin  ( [ CodeableConcept ] ... ) ; # 0..* The country or countries where the material is harvested
  ] ;
]

Changes from both R4 and R4B

This resource did not exist in Release R4

See the Full Difference for further information

This analysis is available for R4 as XML or JSON and for R4B as XML or JSON.