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15.11 Resource SubstanceProtein - Content

Biomedical Research and Regulation icon Work GroupMaturity Level: 0 Trial UseSecurity Category: Anonymous Compartments: No defined compartments

A SubstanceProtein is defined as a single unit of a linear amino acid sequence, or a combination of subunits that are either covalently linked or have a defined invariant stoichiometric relationship. This includes all synthetic, recombinant and purified SubstanceProteins of defined sequence, whether the use is therapeutic or prophylactic. This set of elements will be used to describe albumins, coagulation factors, cytokines, growth factors, peptide/SubstanceProtein hormones, enzymes, toxins, toxoids, recombinant vaccines, and immunomodulators.



For an overview of this resource and others in the Medication Definition domain, also see the module page

Structure

NameFlagsCard.TypeDescription & Constraintsdoco
.. SubstanceProtein TU DomainResource A SubstanceProtein is defined as a single unit of a linear amino acid sequence, or a combination of subunits that are either covalently linked or have a defined invariant stoichiometric relationship. This includes all synthetic, recombinant and purified SubstanceProteins of defined sequence, whether the use is therapeutic or prophylactic. This set of elements will be used to describe albumins, coagulation factors, cytokines, growth factors, peptide/SubstanceProtein hormones, enzymes, toxins, toxoids, recombinant vaccines, and immunomodulators

Elements defined in Ancestors: id, meta, implicitRules, language, text, contained, extension, modifierExtension
... sequenceType Σ 0..1 CodeableConcept The SubstanceProtein descriptive elements will only be used when a complete or partial amino acid sequence is available or derivable from a nucleic acid sequence
... numberOfSubunits Σ 0..1 integer Number of linear sequences of amino acids linked through peptide bonds. The number of subunits constituting the SubstanceProtein shall be described. It is possible that the number of subunits can be variable
... disulfideLinkage Σ 0..* string The disulphide bond between two cysteine residues either on the same subunit or on two different subunits shall be described. The position of the disulfide bonds in the SubstanceProtein shall be listed in increasing order of subunit number and position within subunit followed by the abbreviation of the amino acids involved. The disulfide linkage positions shall actually contain the amino acid Cysteine at the respective positions

.... subunit Σ 0..1 integer Index of primary sequences of amino acids linked through peptide bonds in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts
.... sequence Σ 0..1 string The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
.... length Σ 0..1 integer Length of linear sequences of amino acids contained in the subunit
.... sequenceAttachment Σ 0..1 Attachment The sequence information shall be provided enumerating the amino acids from N- to C-terminal end using standard single-letter amino acid codes. Uppercase shall be used for L-amino acids and lowercase for D-amino acids. Transcribed SubstanceProteins will always be described using the translated sequence; for synthetic peptide containing amino acids that are not represented with a single letter code an X should be used within the sequence. The modified amino acids will be distinguished by their position in the sequence
.... nTerminalModificationId Σ 0..1 Identifier Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
.... nTerminalModification Σ 0..1 string The name of the fragment modified at the N-terminal of the SubstanceProtein shall be specified
.... cTerminalModificationId Σ 0..1 Identifier Unique identifier for molecular fragment modification based on the ISO 11238 Substance ID
.... cTerminalModification Σ 0..1 string The modification at the C-terminal shall be specified

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Additional definitions: Master Definition XML + JSON, XML Schema/Schematron + JSON Schema, ShEx (for Turtle) + see the extensions, the spreadsheet version & the dependency analysis



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