FHIR CI-Build

This is the Continuous Integration Build of FHIR (will be incorrect/inconsistent at times).
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Biomedical Research and Regulation icon Work GroupMaturity Level: 0 Trial UseSecurity Category: Anonymous Compartments: No defined compartments

Detailed Descriptions for the elements in the SubstanceNucleicAcid resource.

SubstanceNucleicAcid
Element IdSubstanceNucleicAcid
Definition

Nucleic acids are defined by three distinct elements: the base, sugar and linkage. Individual substance/moiety IDs will be created for each of these elements. The nucleotide sequence will be always entered in the 5’-3’ direction.

Short DisplayNucleic acids are defined by three distinct elements: the base, sugar and linkage. Individual substance/moiety IDs will be created for each of these elements. The nucleotide sequence will be always entered in the 5’-3’ direction
Cardinality0..*
TypeDomainResource
Summaryfalse
SubstanceNucleicAcid.sequenceType
Element IdSubstanceNucleicAcid.sequenceType
Definition

The type of the sequence shall be specified based on a controlled vocabulary.

Short DisplayThe type of the sequence shall be specified based on a controlled vocabulary
Cardinality0..1
TypeCodeableConcept
Summarytrue
SubstanceNucleicAcid.numberOfSubunits
Element IdSubstanceNucleicAcid.numberOfSubunits
Definition

The number of linear sequences of nucleotides linked through phosphodiester bonds shall be described. Subunits would be strands of nucleic acids that are tightly associated typically through Watson-Crick base pairing. NOTE: If not specified in the reference source, the assumption is that there is 1 subunit.

Short DisplayThe number of linear sequences of nucleotides linked through phosphodiester bonds shall be described. Subunits would be strands of nucleic acids that are tightly associated typically through Watson-Crick base pairing. NOTE: If not specified in the reference source, the assumption is that there is 1 subunit
Cardinality0..1
Typeinteger
Summarytrue
SubstanceNucleicAcid.areaOfHybridisation
Element IdSubstanceNucleicAcid.areaOfHybridisation
Definition

The area of hybridisation shall be described if applicable for double stranded RNA or DNA. The number associated with the subunit followed by the number associated to the residue shall be specified in increasing order. The underscore “” shall be used as separator as follows: “Subunitnumber Residue”.

Short DisplayThe area of hybridisation shall be described if applicable for double stranded RNA or DNA. The number associated with the subunit followed by the number associated to the residue shall be specified in increasing order. The underscore “” shall be used as separator as follows: “Subunitnumber Residue”
Cardinality0..1
Typestring
Summarytrue
SubstanceNucleicAcid.oligoNucleotideType
Element IdSubstanceNucleicAcid.oligoNucleotideType
Definition

(TBC).

Short Display(TBC)
Cardinality0..1
TypeCodeableConcept
Summarytrue
SubstanceNucleicAcid.subunit
Element IdSubstanceNucleicAcid.subunit
Definition

Subunits are listed in order of decreasing length; sequences of the same length will be ordered by molecular weight; subunits that have identical sequences will be repeated multiple times.

Short DisplaySubunits are listed in order of decreasing length; sequences of the same length will be ordered by molecular weight; subunits that have identical sequences will be repeated multiple times
Cardinality0..*
Summarytrue
SubstanceNucleicAcid.subunit.subunit
Element IdSubstanceNucleicAcid.subunit.subunit
Definition

Index of linear sequences of nucleic acids in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts.

Short DisplayIndex of linear sequences of nucleic acids in order of decreasing length. Sequences of the same length will be ordered by molecular weight. Subunits that have identical sequences will be repeated and have sequential subscripts
Cardinality0..1
Typeinteger
Summarytrue
SubstanceNucleicAcid.subunit.sequence
Element IdSubstanceNucleicAcid.subunit.sequence
Definition

Actual nucleotide sequence notation from 5' to 3' end using standard single letter codes. In addition to the base sequence, sugar and type of phosphate or non-phosphate linkage should also be captured.

Short DisplayActual nucleotide sequence notation from 5' to 3' end using standard single letter codes. In addition to the base sequence, sugar and type of phosphate or non-phosphate linkage should also be captured
Cardinality0..1
Typestring
Summarytrue
SubstanceNucleicAcid.subunit.length
Element IdSubstanceNucleicAcid.subunit.length
Definition

The length of the sequence shall be captured.

Short DisplayThe length of the sequence shall be captured
Cardinality0..1
Typeinteger
Summarytrue
SubstanceNucleicAcid.subunit.sequenceAttachment
Element IdSubstanceNucleicAcid.subunit.sequenceAttachment
Definition

(TBC).

Short Display(TBC)
Cardinality0..1
TypeAttachment
Summarytrue
SubstanceNucleicAcid.subunit.fivePrime
Element IdSubstanceNucleicAcid.subunit.fivePrime
Definition

The nucleotide present at the 5’ terminal shall be specified based on a controlled vocabulary. Since the sequence is represented from the 5' to the 3' end, the 5’ prime nucleotide is the letter at the first position in the sequence. A separate representation would be redundant.

Short DisplayThe nucleotide present at the 5’ terminal shall be specified based on a controlled vocabulary. Since the sequence is represented from the 5' to the 3' end, the 5’ prime nucleotide is the letter at the first position in the sequence. A separate representation would be redundant
Cardinality0..1
TypeCodeableConcept
Summarytrue
SubstanceNucleicAcid.subunit.threePrime
Element IdSubstanceNucleicAcid.subunit.threePrime
Definition

The nucleotide present at the 3’ terminal shall be specified based on a controlled vocabulary. Since the sequence is represented from the 5' to the 3' end, the 5’ prime nucleotide is the letter at the last position in the sequence. A separate representation would be redundant.

Short DisplayThe nucleotide present at the 3’ terminal shall be specified based on a controlled vocabulary. Since the sequence is represented from the 5' to the 3' end, the 5’ prime nucleotide is the letter at the last position in the sequence. A separate representation would be redundant
Cardinality0..1
TypeCodeableConcept
Summarytrue
SubstanceNucleicAcid.subunit.linkage
Element IdSubstanceNucleicAcid.subunit.linkage
Definition

The linkages between sugar residues will also be captured.

Short DisplayThe linkages between sugar residues will also be captured
Cardinality0..*
Summarytrue
SubstanceNucleicAcid.subunit.linkage.connectivity
Element IdSubstanceNucleicAcid.subunit.linkage.connectivity
Definition

The entity that links the sugar residues together should also be captured for nearly all naturally occurring nucleic acid the linkage is a phosphate group. For many synthetic oligonucleotides phosphorothioate linkages are often seen. Linkage connectivity is assumed to be 3’-5’. If the linkage is either 3’-3’ or 5’-5’ this should be specified.

Short DisplayThe entity that links the sugar residues together should also be captured for nearly all naturally occurring nucleic acid the linkage is a phosphate group. For many synthetic oligonucleotides phosphorothioate linkages are often seen. Linkage connectivity is assumed to be 3’-5’. If the linkage is either 3’-3’ or 5’-5’ this should be specified
Cardinality0..1
Typestring
Summarytrue
SubstanceNucleicAcid.subunit.linkage.identifier
Element IdSubstanceNucleicAcid.subunit.linkage.identifier
Definition

Each linkage will be registered as a fragment and have an ID.

Short DisplayEach linkage will be registered as a fragment and have an ID
NoteThis is a business identifier, not a resource identifier (see discussion)
Cardinality0..1
TypeIdentifier
Summarytrue
SubstanceNucleicAcid.subunit.linkage.name
Element IdSubstanceNucleicAcid.subunit.linkage.name
Definition

Each linkage will be registered as a fragment and have at least one name. A single name shall be assigned to each linkage.

Short DisplayEach linkage will be registered as a fragment and have at least one name. A single name shall be assigned to each linkage
Cardinality0..1
Typestring
Summarytrue
SubstanceNucleicAcid.subunit.linkage.residueSite
Element IdSubstanceNucleicAcid.subunit.linkage.residueSite
Definition

Residues shall be captured as described in 5.3.6.8.3.

Short DisplayResidues shall be captured as described in 5.3.6.8.3
Cardinality0..1
Typestring
Summarytrue
SubstanceNucleicAcid.subunit.sugar
Element IdSubstanceNucleicAcid.subunit.sugar
Definition

5.3.6.8.1 Sugar ID (Mandatory).

Short Display5.3.6.8.1 Sugar ID (Mandatory)
Cardinality0..*
Summarytrue
SubstanceNucleicAcid.subunit.sugar.identifier
Element IdSubstanceNucleicAcid.subunit.sugar.identifier
Definition

The Substance ID of the sugar or sugar-like component that make up the nucleotide.

Short DisplayThe Substance ID of the sugar or sugar-like component that make up the nucleotide
NoteThis is a business identifier, not a resource identifier (see discussion)
Cardinality0..1
TypeIdentifier
Summarytrue
SubstanceNucleicAcid.subunit.sugar.name
Element IdSubstanceNucleicAcid.subunit.sugar.name
Definition

The name of the sugar or sugar-like component that make up the nucleotide.

Short DisplayThe name of the sugar or sugar-like component that make up the nucleotide
Cardinality0..1
Typestring
Summarytrue
SubstanceNucleicAcid.subunit.sugar.residueSite
Element IdSubstanceNucleicAcid.subunit.sugar.residueSite
Definition

The residues that contain a given sugar will be captured. The order of given residues will be captured in the 5‘-3‘direction consistent with the base sequences listed above.

Short DisplayThe residues that contain a given sugar will be captured. The order of given residues will be captured in the 5‘-3‘direction consistent with the base sequences listed above
Cardinality0..1
Typestring
Summarytrue