MII IG Kerndatensatz-Modul Molekulares Tumorboard, published by Medizininformatik-Initiative. This guide is not an authorized publication; it is the continuous build for version 2026.0.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/medizininformatik-initiative/kerndatensatzmodul-molekulares-tumorboard/ and changes regularly. See the Directory of published versions

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: Example In Situ Hybridization HER2/ERBB2 - XML Representation

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<Observation xmlns="http://hl7.org/fhir">
  <id value="PatientKimMusterperson-MolecularPathologyObs-FISH-0a-Her2neu-"/>
  <meta>
    <profile
             value="https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-insituhybridization-her2|2026.0.0"/>
  </meta>
  <text>
    <status value="generated"/>
    <div xmlns="http://www.w3.org/1999/xhtml"><p class="res-header-id"><b>Generated Narrative: Observation PatientKimMusterperson-MolecularPathologyObs-FISH-0a-Her2neu-</b></p><a name="PatientKimMusterperson-MolecularPathologyObs-FISH-0a-Her2neu-"> </a><a name="hcPatientKimMusterperson-MolecularPathologyObs-FISH-0a-Her2neu-"> </a><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px"/><p style="margin-bottom: 0px">Profile: <a href="StructureDefinition-mii-pr-mtb-insituhybridization-her2.html">MII PR MTB In Situ Hybridization HER2version: null2026.0.0)</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title="Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}">Labor</span>, <span title="Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}">A characterization of a given biomarker observation.</span></p><p><b>code</b>: <span title="Codes:{http://loinc.org 49683-6}, {http://snomed.info/sct 51864006}">ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH</span></p><p><b>subject</b>: <a href="Patient-PatientKimMusterperson.html">Kim Musterperson  (no stated gender), DoB: 1956-03-14</a></p><p><b>value</b>: 1.2/1</p><p><b>interpretation</b>: <span title="Codes:{http://snomed.info/sct 260385009}">Negative (qualifier value)</span></p><p><b>method</b>: <span title="Codes:{http://snomed.info/sct 1303773004}">Fluorescence in situ hybridization technique (qualifier value)</span></p><p><b>specimen</b>: <a href="Specimen-PatientKimMusterperson-AscitesSpecimen-2.html">Specimen: accessionIdentifier = Z230201/23; type = Ascitic fluid specimen (specimen)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 74860-8}">ERBB2 gene copy number/nucleus in Tissue by FISH</span></p><p><b>value</b>: 2.4 #</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 74861-6}">Chromosome 17 copy number/nucleus in Tissue by FISH</span></p><p><b>value</b>: 2 #</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title="Codes:{http://loinc.org 62361-1}">Cells counted [#]</span></p><p><b>value</b>: 50 #</p></blockquote></div>
  </text>
  <status value="final"/>
  <category>
    <coding>
      <system
              value="http://terminology.hl7.org/CodeSystem/observation-category"/>
      <code value="laboratory"/>
    </coding>
  </category>
  <category>
    <coding>
      <system
              value="http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"/>
      <code value="biomarker-category"/>
    </coding>
  </category>
  <code>
    <coding>
      <system value="http://loinc.org"/>
      <code value="49683-6"/>
      <display
               value="ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH"/>
    </coding>
    <coding>
      <system value="http://snomed.info/sct"/>
      <code value="51864006"/>
      <display
               value="Nucleic acid hybridization, function (observable entity)"/>
    </coding>
  </code>
  <subject>🔗 
    <reference value="Patient/PatientKimMusterperson"/>
  </subject>
  <valueRatio>
    <numerator>
      <value value="1.2"/>
    </numerator>
    <denominator>
      <value value="1"/>
    </denominator>
  </valueRatio>
  <interpretation>
    <coding>
      <system value="http://snomed.info/sct"/>
      <code value="260385009"/>
      <display value="Negative (qualifier value)"/>
    </coding>
  </interpretation>
  <method>
    <coding>
      <system value="http://snomed.info/sct"/>
      <code value="1303773004"/>
      <display
               value="Fluorescence in situ hybridization technique (qualifier value)"/>
    </coding>
  </method>
  <specimen>🔗 
    <reference value="Specimen/PatientKimMusterperson-AscitesSpecimen-2"/>
  </specimen>
  <component>
    <code>
      <coding>
        <system value="http://loinc.org"/>
        <code value="74860-8"/>
        <display value="ERBB2 gene copy number/nucleus in Tissue by FISH"/>
      </coding>
    </code>
    <valueQuantity>
      <value value="2.4"/>
      <unit value="#"/>
    </valueQuantity>
  </component>
  <component>
    <code>
      <coding>
        <system value="http://loinc.org"/>
        <code value="74861-6"/>
        <display value="Chromosome 17 copy number/nucleus in Tissue by FISH"/>
      </coding>
    </code>
    <valueQuantity>
      <value value="2"/>
      <unit value="#"/>
    </valueQuantity>
  </component>
  <component>
    <code>
      <coding>
        <system value="http://loinc.org"/>
        <code value="62361-1"/>
        <display value="Cells counted [#]"/>
      </coding>
    </code>
    <valueQuantity>
      <value value="50"/>
      <unit value="#"/>
    </valueQuantity>
  </component>
</Observation>