MII IG Kerndatensatz-Modul Molekulares Tumorboard, published by Medizininformatik-Initiative. This guide is not an authorized publication; it is the continuous build for version 2026.0.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/medizininformatik-initiative/kerndatensatzmodul-molekulares-tumorboard/ and changes regularly. See the Directory of published versions

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: Example In Situ Hybridization HER2/ERBB2 - JSON Representation

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{
  "resourceType" : "Observation",
  "id" : "PatientKimMusterperson-MolecularPathologyObs-FISH-0a-Her2neu-",
  "meta" : {
    "profile" : [
      🔗 "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-insituhybridization-her2|2026.0.0"
    ]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Observation PatientKimMusterperson-MolecularPathologyObs-FISH-0a-Her2neu-</b></p><a name=\"PatientKimMusterperson-MolecularPathologyObs-FISH-0a-Her2neu-\"> </a><a name=\"hcPatientKimMusterperson-MolecularPathologyObs-FISH-0a-Her2neu-\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mii-pr-mtb-insituhybridization-her2.html\">MII PR MTB In Situ Hybridization HER2version: null2026.0.0)</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Labor</span>, <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}\">A characterization of a given biomarker observation.</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 49683-6}, {http://snomed.info/sct 51864006}\">ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH</span></p><p><b>subject</b>: <a href=\"Patient-PatientKimMusterperson.html\">Kim Musterperson  (no stated gender), DoB: 1956-03-14</a></p><p><b>value</b>: 1.2/1</p><p><b>interpretation</b>: <span title=\"Codes:{http://snomed.info/sct 260385009}\">Negative (qualifier value)</span></p><p><b>method</b>: <span title=\"Codes:{http://snomed.info/sct 1303773004}\">Fluorescence in situ hybridization technique (qualifier value)</span></p><p><b>specimen</b>: <a href=\"Specimen-PatientKimMusterperson-AscitesSpecimen-2.html\">Specimen: accessionIdentifier = Z230201/23; type = Ascitic fluid specimen (specimen)</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 74860-8}\">ERBB2 gene copy number/nucleus in Tissue by FISH</span></p><p><b>value</b>: 2.4 #</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 74861-6}\">Chromosome 17 copy number/nucleus in Tissue by FISH</span></p><p><b>value</b>: 2 #</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 62361-1}\">Cells counted [#]</span></p><p><b>value</b>: 50 #</p></blockquote></div>"
  },
  "status" : "final",
  "category" : [
    {
      "coding" : [
        {
          "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
          "code" : "laboratory"
        }
      ]
    },
    {
      "coding" : [
        {
          "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
          "code" : "biomarker-category"
        }
      ]
    }
  ],
  "code" : {
    "coding" : [
      {
        "system" : "http://loinc.org",
        "code" : "49683-6",
        "display" : "ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH"
      },
      {
        "system" : "http://snomed.info/sct",
        "code" : "51864006",
        "display" : "Nucleic acid hybridization, function (observable entity)"
      }
    ]
  },
  "subject" : {
    🔗 "reference" : "Patient/PatientKimMusterperson"
  },
  "valueRatio" : {
    "numerator" : {
      "value" : 1.2
    },
    "denominator" : {
      "value" : 1
    }
  },
  "interpretation" : [
    {
      "coding" : [
        {
          "system" : "http://snomed.info/sct",
          "code" : "260385009",
          "display" : "Negative (qualifier value)"
        }
      ]
    }
  ],
  "method" : {
    "coding" : [
      {
        "system" : "http://snomed.info/sct",
        "code" : "1303773004",
        "display" : "Fluorescence in situ hybridization technique (qualifier value)"
      }
    ]
  },
  "specimen" : {
    🔗 "reference" : "Specimen/PatientKimMusterperson-AscitesSpecimen-2"
  },
  "component" : [
    {
      "code" : {
        "coding" : [
          {
            "system" : "http://loinc.org",
            "code" : "74860-8",
            "display" : "ERBB2 gene copy number/nucleus in Tissue by FISH"
          }
        ]
      },
      "valueQuantity" : {
        "value" : 2.4,
        "unit" : "#"
      }
    },
    {
      "code" : {
        "coding" : [
          {
            "system" : "http://loinc.org",
            "code" : "74861-6",
            "display" : "Chromosome 17 copy number/nucleus in Tissue by FISH"
          }
        ]
      },
      "valueQuantity" : {
        "value" : 2,
        "unit" : "#"
      }
    },
    {
      "code" : {
        "coding" : [
          {
            "system" : "http://loinc.org",
            "code" : "62361-1",
            "display" : "Cells counted [#]"
          }
        ]
      },
      "valueQuantity" : {
        "value" : 50,
        "unit" : "#"
      }
    }
  ]
}