value: cdc-opioid-guidance

system: PlanDefinitionType

code: eca-rule

display: ECA Rule

define "Subacute or Chronic Pain Opioid Analgesic with Ambulatory Misuse Potential Prescriptions":
  ( Common."Is Opioid Analgesic with Ambulatory Misuse Potential?"( ContextPrescriptions ) ) AmbulatoryOpioidPrescription
    where Routines."Is Subacute or Chronic Pain Prescription?"( AmbulatoryOpioidPrescription )

define "Patient Is Being Prescribed Opioid Analgesic with Ambulatory Misuse Potential":
  exists( "Subacute or Chronic Pain Opioid Analgesic with Ambulatory Misuse Potential Prescriptions" )

define "Patient Age Less Than 18":
  if (Config."Age Less than 18 Years Is Enabled") then
    AgeInYearsAt(Today()) < 18
  else
    false

define "Condition Positive for Sickle Cell":
      if (Config."Sickle Cell Check Enabled") then
        exists(
            Common."Positive Sickle Cell Condition"
        )  else
        false

// 3. Medications indicating end of life
    /* or exists (
      "Medications Indicating End of Life"
    ) */
define "US Core-Categorized Conditions":
  [Condition: category in "Encounter Diagnosis Condition Category"]
    union [Condition: category in "Problem List Condition Category"]
    union [Condition: category in "US Core Health Concern Condition Category"]

define "Conditions Indicating End Of Life Present":
  exists (
    Common."US Core-Categorized Conditions" LLEC
      where LLEC.code in Common."Limited life expectancy conditions"
        and LLEC.clinicalStatus in Common."Active Condition"
  )

define "Is Active Cancer Treatment?":
  if (Config."Active Cancer Treatment Encounters Condition Is Enabled") then
      "Has Two or More Encounters with Cancer Diagnosis During Encounter Period"
    else
      false

define "Conditions Including Cancer To Exclude Opioid Management Indicating End-Stage Disease Present":
  if (Config."End-Stage Disease Criteria Enabled") then
    exists (
      Common."US Core-Categorized Conditions" EOLC
        where EOLC.code in Common."Conditions likely terminal for opioid prescribing"
          and EOLC.clinicalStatus in Common."Active Condition"
    )
  else
    false

define "Is Opioid Review Useful?":
  not "Patient Age Less Than 18"
    and not "Condition Positive for Sickle Cell"
    and not "Conditions Indicating End Of Life Present"
    and not "Is Active Cancer Treatment?"
    and not "Conditions Including Cancer To Exclude Opioid Management Indicating End-Stage Disease Present"

// Constants
define "UDS Lookback Period":
  Interval[Today() - 12 months - 1 days, Today()]

define "All Opioid or Non-opioid UDS in Lookback Period":
  (
    [Observation: Common."All Drug Urine Screening"] Lab
      where date from Lab.effective in day of "UDS Lookback Period"
        and not (Lab.status.value in { 'unknown', 'entered-in-error', 'cancelled' })
  ) X sort by date from FHIRHelpers.ToDateTime(effective as FHIR.dateTime) desc

/*
@description: Determines whether an opioid review is appropriate for the patient and whether they had a UDS performed in the past year
*/
define "Inclusion Criteria For UDS Recommendation":
  Routines."Is Opioid Review Useful?"
    and not exists ("All Opioid or Non-opioid UDS in Lookback Period")

define "Conditions Indicating End of Life or With Limited Life Expectancy":
  (
    "US Core-Categorized Conditions" C
      where C.code in "Conditions likely terminal for opioid prescribing"
        and C.clinicalStatus in "Active Condition"
  )
  union
  (
    "US Core-Categorized Conditions" C
      where C.code in "Limited life expectancy conditions"
        and C.clinicalStatus in "Active Condition"
  )

define "Admitted/Referred/Discharged to Hospice Care":
  (
    if (Config."Hospice Findings Exclusion Enabled") then
      [Observation: code in "Hospice Finding Codes"] O
        where not (O.status.value in { 'unknown', 'entered-in-error', 'cancelled' })
    else
      {}
  )
  union
  (
    [Encounter] E
      where date from E.period.start 1 year or less on or before Today()
        and (
          if E.hospitalization.dischargeDisposition.coding is null
              or not exists (E.hospitalization.dischargeDisposition.coding)
            then false
          else E.hospitalization.dischargeDisposition in "Hospice Disposition"
        )
        and E.status.value in { 'planned', 'arrived', 'in-progress', 'finished', 'onleave' }
  )

define "End of Life Assessment":
    // 1. Conditions indicating end of life or with limited life expectancy
    exists (
      "Conditions Indicating End of Life or With Limited Life Expectancy"
    )
    // 2. Admitted/referred/discharged to hospice care
    or exists (
      "Admitted/Referred/Discharged to Hospice Care"
    )

define "Exclusion Criteria":
  Common."End of Life Assessment"

define "Is Perform Drug Screen Recommendation Applicable?":
  "Patient Is Being Prescribed Opioid Analgesic with Ambulatory Misuse Potential"
    and Rec10Common."Inclusion Criteria For UDS Recommendation"
    and not Rec10Common."Exclusion Criteria"

define "Amphetamine Simple Identifier": 'Amphetamine'

// Amphetamines
define "Amphetamine Screenings In Lookback Period":
  "All Opioid or Non-opioid UDS in Lookback Period" Lab
    where Lab.code in Common."Amphetamine Urine Tests"

define "Positive Amphetamine Screenings In Lookback Period":
  GetPositiveLabsInLookbackPeriod("Amphetamine Screenings In Lookback Period", true)

define "Negative Amphetamine Screenings In Lookback Period":
  GetNegativeLabsInLookbackPeriod("Amphetamine Screenings In Lookback Period", true)

define "Rx Lookback Period":
  Interval[Today() - 12 months - 31 days, Today()]

define "Normalize Rx In Lookback Period":
  Common."Get MedicationRequest Medication as Code"(
    [MedicationRequest: status in { 'active', 'completed', 'stopped' }] Rx
      where Rx.category in Common."Community"
        and Rx.intent = 'order'
        and Rx.authoredOn.value in day of "Rx Lookback Period"
  )

define "Amphetamine Rx In Lookback Period":
  "Normalize Rx In Lookback Period" Rx
      where Rx.medication in Common."Amphetamine Medications"

define "Barbiturate Simple Identifier": 'Barbiturate'

// Barbiturates
define "Barbiturate Screenings In Lookback Period":
  "All Opioid or Non-opioid UDS in Lookback Period" Lab
    where Lab.code in Common."Barbiturate Urine Tests"

define "Positive Barbiturate Screenings In Lookback Period":
  GetPositiveLabsInLookbackPeriod("Barbiturate Screenings In Lookback Period", true)

define "Negative Barbiturate Screenings In Lookback Period":
  GetNegativeLabsInLookbackPeriod("Barbiturate Screenings In Lookback Period", true)

define "Barbiturate Rx In Lookback Period":
  "Normalize Rx In Lookback Period" Rx
      where Rx.medication in Common."Barbiturate Medications"

define "Benzodiazepine Simple Identifier": 'Benzodiazepine'

// Benzodiazepines
define "Benzodiazepine Screenings In Lookback Period":
  "All Opioid or Non-opioid UDS in Lookback Period" Lab
    where Lab.code in Common."Benzodiazepine Urine Tests"

define "Positive Benzodiazepine Screenings In Lookback Period":
  GetPositiveLabsInLookbackPeriod("Benzodiazepine Screenings In Lookback Period", true)

define "Negative Benzodiazepine Screenings In Lookback Period":
  GetNegativeLabsInLookbackPeriod("Benzodiazepine Screenings In Lookback Period", true)

define "Benzodiazepine Rx In Lookback Period":
  "Normalize Rx In Lookback Period" Rx
      where Rx.medication in Common."Benzodiazepine medications"

define "Buprenorphine Simple Identifier": 'Buprenorphine'

// Buprenorphine
define "Buprenorphine Screenings In Lookback Period":
  "All Opioid or Non-opioid UDS in Lookback Period" Lab
    where Lab.code in Common."Buprenorphine Urine Tests"

define "Positive Buprenorphine Screenings In Lookback Period":
  GetPositiveLabsInLookbackPeriod("Buprenorphine Screenings In Lookback Period", true)

define "Negative Buprenorphine Screenings In Lookback Period":
  GetNegativeLabsInLookbackPeriod("Buprenorphine Screenings In Lookback Period", true)

define "Buprenorphine Rx In Lookback Period":
  "Normalize Rx In Lookback Period" Rx
      where Rx.medication in Common."Buprenorphine Medications"

define "Cannabinoid Simple Identifier": 'Cannabinoid'

// Cannabinoids
define "Cannabinoid Screenings In Lookback Period":
  if Config."Cannabinoid Urine Screening Check Enabled"
    then (
      "All Opioid or Non-opioid UDS in Lookback Period" Lab
        where Lab.code in Common."Cannabinoid Urine Tests"
    ) else null

define "Cannabinoid Urine Screening Check Enabled":
  false

define "Positive Cannabinoid Screenings In Lookback Period":
  GetPositiveLabsInLookbackPeriod("Cannabinoid Screenings In Lookback Period", Config."Cannabinoid Urine Screening Check Enabled")

define "Negative Cannabinoid Screenings In Lookback Period":
  GetNegativeLabsInLookbackPeriod("Cannabinoid Screenings In Lookback Period", Config."Cannabinoid Urine Screening Check Enabled")

define "Cocaine Simple Identifier": 'Cocaine'

// Cocaine
define "Cocaine Screenings In Lookback Period":
  "All Opioid or Non-opioid UDS in Lookback Period" Lab
    where Lab.code in Common."Cocaine Urine Tests"

define "Positive Cocaine Screenings In Lookback Period":
  GetPositiveLabsInLookbackPeriod("Cocaine Screenings In Lookback Period", true)

define "Negative Cocaine Screenings In Lookback Period":
  GetNegativeLabsInLookbackPeriod("Cocaine Screenings In Lookback Period", true)

define "Fentanyl Simple Identifier": 'Fentanyl'

// Fentanyl
define "Fentanyl Screenings In Lookback Period":
  if Config."Opiate Urine Screening Check Enabled"
  then (
    "All Opioid or Non-opioid UDS in Lookback Period" AllLabs
      where AllLabs.code in Common."Fentanyl Urine Tests"
  ) else null

// Recommendation 10
define "Opiate Urine Screening Check Enabled":
  true

define "Positive Fentanyl Screenings In Lookback Period":
  GetPositiveLabsInLookbackPeriod("Fentanyl Screenings In Lookback Period", Config."Opiate Urine Screening Check Enabled")

define "Negative Fentanyl Screenings In Lookback Period":
  GetNegativeLabsInLookbackPeriod("Fentanyl Screenings In Lookback Period", Config."Opiate Urine Screening Check Enabled")

define "Fentanyl Rx In Lookback Period":
  "Normalize Rx In Lookback Period" Rx
    where Rx.medication in Common."Fentanyl Medications"

define "Heroin Simple Identifier": 'Heroin (6-AM)'

// Heroin
define "Heroin Screenings In Lookback Period":
  "All Opioid or Non-opioid UDS in Lookback Period" Lab
    where Lab.code in Common."Heroin Urine Tests"

define "Positive Heroin Screenings In Lookback Period":
  GetPositiveLabsInLookbackPeriod("Heroin Screenings In Lookback Period", true)

define "Negative Heroin Screenings In Lookback Period":
  GetNegativeLabsInLookbackPeriod("Heroin Screenings In Lookback Period", true)

define "Methadone Simple Identifier": 'Methadone'

// Methadone
define "Methadone Screenings In Lookback Period":
  "All Opioid or Non-opioid UDS in Lookback Period" Lab
    where Lab.code in Common."Methadone Urine Tests"

define "Positive Methadone Screenings In Lookback Period":
  GetPositiveLabsInLookbackPeriod("Methadone Screenings In Lookback Period", true)

define "Negative Methadone Screenings In Lookback Period":
  GetNegativeLabsInLookbackPeriod("Methadone Screenings In Lookback Period", true)

define "Methadone Rx In Lookback Period":
  "Normalize Rx In Lookback Period" Rx
      where Rx.medication in Common."Methadone Medications"

define "Opiate Simple Identifier": 'Opiate'

// Opiates
define "Opiate Screenings In Lookback Period":
  if Config."Opiate Urine Screening Check Enabled"
    then (
      "All Opioid or Non-opioid UDS in Lookback Period" Lab
        where Lab.code in Common."General Opiate Urine Tests"
    ) else null

define "Positive Opiate Screenings In Lookback Period":
  GetPositiveLabsInLookbackPeriod("Opiate Screenings In Lookback Period", Config."Opiate Urine Screening Check Enabled")

define "Negative Opiate Screenings In Lookback Period":
  GetNegativeLabsInLookbackPeriod("Opiate Screenings In Lookback Period", Config."Opiate Urine Screening Check Enabled")

define "Opiate Rx In Lookback Period":
  "Normalize Rx In Lookback Period" Rx
      where Rx.medication in Common."Opiate Medications"

define "Oxycodone Simple Identifier": 'Oxycodone'

// Oxycodone
define "Oxycodone Screenings In Lookback Period":
  if Config."Opiate Urine Screening Check Enabled"
    then (
      "All Opioid or Non-opioid UDS in Lookback Period" Lab
        where Lab.code in Common."Oxycodone Urine Tests"
    ) else null

define "Positive Oxycodone Screenings In Lookback Period":
  GetPositiveLabsInLookbackPeriod("Oxycodone Screenings In Lookback Period", Config."Opiate Urine Screening Check Enabled")

define "Negative Oxycodone Screenings In Lookback Period":
  GetNegativeLabsInLookbackPeriod("Oxycodone Screenings In Lookback Period", Config."Opiate Urine Screening Check Enabled")

define "Oxycodone Rx In Lookback Period":
  "Normalize Rx In Lookback Period" Rx
      where Rx.medication in Common."Oxycodone Medications"

define "PCP Simple Identifier": 'Phencyclidine (PCP)'

// PCP
define "PCP Screenings In Lookback Period":
  "All Opioid or Non-opioid UDS in Lookback Period" AllLabs
    where AllLabs.code in Common."PCP Urine Tests"

define "Positive PCP Screenings In Lookback Period":
  GetPositiveLabsInLookbackPeriod("PCP Screenings In Lookback Period", true)

define "Negative PCP Screenings In Lookback Period":
  GetNegativeLabsInLookbackPeriod("PCP Screenings In Lookback Period", true)

// Details Logic
define "Unexpected Details":
  {
    CreateDetailWithPossibleUnexpectedNegative(
      "Amphetamine Simple Identifier", "Positive Amphetamine Screenings In Lookback Period", 
      "Negative Amphetamine Screenings In Lookback Period", "Amphetamine Rx In Lookback Period"
    ),
    CreateDetailWithPossibleUnexpectedNegative(
      "Barbiturate Simple Identifier", "Positive Barbiturate Screenings In Lookback Period", 
      "Negative Barbiturate Screenings In Lookback Period", "Barbiturate Rx In Lookback Period"
    ),
    CreateDetailWithPossibleUnexpectedNegative(
      "Benzodiazepine Simple Identifier", "Positive Benzodiazepine Screenings In Lookback Period", 
      "Negative Benzodiazepine Screenings In Lookback Period", "Benzodiazepine Rx In Lookback Period"
    ),
    CreateDetailWithPossibleUnexpectedNegative(
      "Buprenorphine Simple Identifier", "Positive Buprenorphine Screenings In Lookback Period", 
      "Negative Buprenorphine Screenings In Lookback Period", "Buprenorphine Rx In Lookback Period"
    ),
    CreateDetailWithoutPossibleUnexpectedNegative(
      "Cannabinoid Simple Identifier", "Positive Cannabinoid Screenings In Lookback Period", 
      "Negative Cannabinoid Screenings In Lookback Period"
    ),
    CreateDetailWithoutPossibleUnexpectedNegative(
      "Cocaine Simple Identifier", "Positive Cocaine Screenings In Lookback Period", 
      "Negative Cocaine Screenings In Lookback Period"
    ),
    CreateDetailWithPossibleUnexpectedNegative(
      "Fentanyl Simple Identifier", "Positive Fentanyl Screenings In Lookback Period", 
      "Negative Fentanyl Screenings In Lookback Period", "Fentanyl Rx In Lookback Period"
    ),
    CreateDetailWithoutPossibleUnexpectedNegative(
      "Heroin Simple Identifier", "Positive Heroin Screenings In Lookback Period", 
      "Negative Heroin Screenings In Lookback Period"
    ),
    CreateDetailWithPossibleUnexpectedNegative(
      "Methadone Simple Identifier", "Positive Methadone Screenings In Lookback Period", 
      "Negative Methadone Screenings In Lookback Period", "Methadone Rx In Lookback Period"
    ),
    CreateDetailWithPossibleUnexpectedNegative(
      "Opiate Simple Identifier", "Positive Opiate Screenings In Lookback Period", 
      "Negative Opiate Screenings In Lookback Period", "Opiate Rx In Lookback Period"
    ),
    CreateDetailWithPossibleUnexpectedNegative(
      "Oxycodone Simple Identifier", "Positive Oxycodone Screenings In Lookback Period", 
      "Negative Oxycodone Screenings In Lookback Period", "Oxycodone Rx In Lookback Period"
    ),
    CreateDetailWithoutPossibleUnexpectedNegative(
      "PCP Simple Identifier", "Positive PCP Screenings In Lookback Period", 
      "Negative PCP Screenings In Lookback Period"
    )
  }

define "Inclusion Criteria For Unexpected Results":
  AnyTrue(
    "Unexpected Details" Details
      return (exists Details.unexpectedPosDetails) or (exists Details.unexpectedNegDetails)
  )

define "Applicable Because of Unexpected Results":
  "Patient Is Being Prescribed Opioid Analgesic with Ambulatory Misuse Potential"
    and Rec10Common."Inclusion Criteria For Unexpected Results"
    and not Rec10Common."Exclusion Criteria"

define "Style Header":
  '<style>\r\n  .alert-body {\r\n    width: 670px;\r\n    font-family: segoe-ui, sans-serif;\r\n    background-color: #FEFFF1;\r\n  }\r\n\r\n  .details-table {\r\n    border-collapse:collapse;\r\n    border-style: ridge;\r\n    background-color: #FEFFF1;\r\n    padding: 2px;\r\n  }\r\n\r\n  .details-caption {\r\n    border-style: ridge;\r\n    border-bottom: none;\r\n    background-color: #FEFFF1;\r\n    padding: 2px;\r\n  }\r\n\r\n  .details-table-header {\r\n    border-style: ridge;\r\n    padding: 5px;\r\n  }\r\n\r\n  .details-table-cell {\r\n    border-style: ridge;\r\n    padding: 5px;\r\n  }\r\n\r\n  .details-table-footer-cell {\r\n    border-style: ridge;\r\n    padding: 5px;\r\n    font-size: small;\r\n  }\r\n\r\n  .details-table-cell-unexpected {\r\n    border-style: ridge;\r\n    padding: 5px;\r\n    color: red;\r\n    font-weight: bold;\r\n  }\r\n\r\n  .more-text {\r\n    position: relative;\r\n    margin-bottom: 2em;\r\n  }\r\n  \r\n  .more {\r\n    display:none;\r\n  }\r\n\r\n  #box .show-more:checked + .more {\r\n    display:block;\r\n  }\r\n<\/style>'

define "Unexpected Div Start":
  '<div class=\"alert-body\"><div><p>Patient may have <strong>unexpected urine toxicology test results<\/strong> in the past year.<\/p><\/div>'

define "Table Start":
  '<div><table class=\"details-table\"><caption class=\"details-caption\">Urine Toxicology Results<\/caption><tr><th class=\"details-table-header\">Substance<\/th>'

define "All Lab Dates in Lookback Period":
  (
    "All Opioid or Non-opioid UDS in Lookback Period" Lab
      return date from FHIRHelpers.ToDateTime(Lab.effective as FHIR.dateTime)
  ) X sort desc

define "Table Headers":
  "All Lab Dates in Lookback Period" LabDate
    return '<th class=\"details-table-header\">' + ToString(LabDate) + '<\/th>'

define "Generate Table Rows":
  "Unexpected Details" BOT
    let row: ToString(IndexOf("Unexpected Details", BOT) + 1)
    return '<tr>' + GetExpectedColumn(BOT.ingredient) + Combine(
      "All Lab Dates in Lookback Period" LabDate
        let col: ToString(IndexOf("All Lab Dates in Lookback Period", LabDate) + 2)
        return all (
          if BOT.unexpectedPosDetails.date contains LabDate
            then GetUnexpectedColumn('pos', row + ':' + col)
          else if BOT.unexpectedNegDetails.udsDate contains LabDate
            then GetUnexpectedColumn('neg', row + ':' + col)
          else if BOT.posDates contains LabDate
            then GetExpectedColumn('pos')
          else if BOT.negDates contains LabDate
            then GetExpectedColumn('neg')
          else GetExpectedColumn('n/a')
        )
    ) + '<\/tr>'

define "Generate Footer Rows":
  "Unexpected Details" BOT
      let row: ToString(IndexOf("Unexpected Details", BOT) + 1),
      colspan: Length("All Lab Dates in Lookback Period") + 1
      return Combine(
        "All Lab Dates in Lookback Period" LabDate
          let col: ToString(IndexOf("All Lab Dates in Lookback Period", LabDate) + 2)
          return all (
            if BOT.unexpectedPosDetails.date contains LabDate
              then singleton from (
                BOT.unexpectedPosDetails PosDetail
                  where PosDetail.date = LabDate
                    return '<tr>' + GetFooterColumn(colspan, row + ':' + col + ' - Possible unprescribed substance found: ' + PosDetail.udsDetail) + '<\/tr>'
              )
            else if BOT.unexpectedNegDetails.udsDate contains LabDate
              then singleton from (
                BOT.unexpectedNegDetails NegDetail
                  where NegDetail.udsDate = LabDate
                    return '<tr>' + GetFooterColumn(colspan, row + ':' + col + ' - Possible unexpected negative result found: prescribed ' + NegDetail.rxDetail + ' on ' + ToString(NegDetail.rxDate)) + '<\/tr>'
              )
            else ''
          )
      )

define "Table End":
  '<\/table><\/div>'

define "Details Table": 
  "Table Start" + Combine("Table Headers") 
    + '<tbody>' + Combine("Generate Table Rows") + '</tbody>' 
    + '<tfoot>' + Combine("Generate Footer Rows") + '<\/tfoot>' 
  + "Table End"

define "Details More Info":
  '<div id=\"box\">\r\n  <p>Note on false positives and unexpected negative results...<\/p>\r\n  <input type=\"checkbox\" class=\"show-more\"> Show more\r\n  <div class=\"more\">\r\n  <p>Positive results may be a false positives or could represent occasional use or possible substance use disorder.<br\/><br\/>For a review regarding interpreting possible false positive urine toxicology results, see <a target=\"_blank\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24986836\">http:\/\/pubmed.ncbi.nlm.nih.gov\/24986836<\/a>. It is unknown if the findings reported in this article can be extrapolated to other laboratory analyzers that were not used in the referenced studies.<br\/><br\/>For guidance regarding evaluating and addressing unexpected toxicology tests results, see <a target=\"_blank\" href=\"https:\/\/www.cdc.gov\/mmwr\/volumes\/71\/rr\/rr7103a1.htm#Recommendation10\">Recommendation 10 of the 22 CDC Clinical Practice Guideiline<\/a>.<\/p>\r\n  <p>An unexpectedly negative test may be due to diversion, intermittent use, aberrant drug use behavior, or other factors, including a false negative result. Clinicians should interpret this result in the context of the overall treatment plan.<\/p>\r\n  <\/div>\r\n<\/div>'

define "Div End": '<\/div>'

// HTML Generation
define "Get HTML Details":
  Common."Style Header" + "Unexpected Div Start" + "Details Table" + "Details More Info" + "Div End"

define "Detail":
  Rec10Common."Get HTML Details"

Documentation

• 2022 CDC Clinical Practice Guideline for Prescribing Opioids for Pain