Kenya National Cancer Control Programme (NCCP) FHIR Implementation Guide, published by Digital Health Agency (DHA), Kenya. This guide is not an authorized publication; it is the continuous build for version 0.1.0 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/IntelliSOFT-Consulting/nccpFHIRIG/ and changes regularly. See the Directory of published versions

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: Kenya OCM Protocol Markers Code System

Active as of 2026-06-04

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:CodeSystem ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "ocm-protocol-markers-cs"] ; # 
  fhir:language [ fhir:v "en"] ; # 
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: CodeSystem ocm-protocol-markers-cs</b></p><a name=\"ocm-protocol-markers-cs\"> </a><a name=\"hcocm-protocol-markers-cs\"> </a><p>This case-sensitive code system <code>https://nshr-uat.sha.go.ke/fhir/CodeSystem/ocm-protocol-markers-cs</code> defines the following codes:</p><table class=\"codes\"><tr><td style=\"white-space:nowrap\"><b>Code</b></td><td><b>Display</b></td><td><b>Definition</b></td></tr><tr><td style=\"white-space:nowrap\">HER2-POSITIVE<a name=\"ocm-protocol-markers-cs-HER2-POSITIVE\"> </a></td><td>HER2 Positive</td><td>HER2/neu overexpression or amplification detected.</td></tr><tr><td style=\"white-space:nowrap\">HER2-NEGATIVE<a name=\"ocm-protocol-markers-cs-HER2-NEGATIVE\"> </a></td><td>HER2 Negative</td><td>No HER2/neu overexpression or amplification.</td></tr><tr><td style=\"white-space:nowrap\">ER-POSITIVE<a name=\"ocm-protocol-markers-cs-ER-POSITIVE\"> </a></td><td>ER Positive</td><td>Oestrogen receptor positive.</td></tr><tr><td style=\"white-space:nowrap\">ER-NEGATIVE<a name=\"ocm-protocol-markers-cs-ER-NEGATIVE\"> </a></td><td>ER Negative</td><td>Oestrogen receptor negative.</td></tr><tr><td style=\"white-space:nowrap\">PR-POSITIVE<a name=\"ocm-protocol-markers-cs-PR-POSITIVE\"> </a></td><td>PR Positive</td><td>Progesterone receptor positive.</td></tr><tr><td style=\"white-space:nowrap\">PR-NEGATIVE<a name=\"ocm-protocol-markers-cs-PR-NEGATIVE\"> </a></td><td>PR Negative</td><td>Progesterone receptor negative.</td></tr><tr><td style=\"white-space:nowrap\">TRIPLE-NEGATIVE<a name=\"ocm-protocol-markers-cs-TRIPLE-NEGATIVE\"> </a></td><td>Triple Negative</td><td>ER-, PR-, HER2- breast cancer.</td></tr><tr><td style=\"white-space:nowrap\">KRAS-MUTANT<a name=\"ocm-protocol-markers-cs-KRAS-MUTANT\"> </a></td><td>KRAS Mutant</td><td>KRAS mutation detected.</td></tr><tr><td style=\"white-space:nowrap\">KRAS-WILD-TYPE<a name=\"ocm-protocol-markers-cs-KRAS-WILD-TYPE\"> </a></td><td>KRAS Wild-type</td><td>No KRAS mutation.</td></tr><tr><td style=\"white-space:nowrap\">BRAF-V600E<a name=\"ocm-protocol-markers-cs-BRAF-V600E\"> </a></td><td>BRAF V600E Mutant</td><td>BRAF V600E mutation detected.</td></tr><tr><td style=\"white-space:nowrap\">PD-L1-POSITIVE<a name=\"ocm-protocol-markers-cs-PD-L1-POSITIVE\"> </a></td><td>PD-L1 Positive</td><td>PD-L1 expression ≥1%.</td></tr><tr><td style=\"white-space:nowrap\">PD-L1-NEGATIVE<a name=\"ocm-protocol-markers-cs-PD-L1-NEGATIVE\"> </a></td><td>PD-L1 Negative</td><td>PD-L1 expression &lt;1%.</td></tr><tr><td style=\"white-space:nowrap\">MSI-HIGH<a name=\"ocm-protocol-markers-cs-MSI-HIGH\"> </a></td><td>MSI-High</td><td>Microsatellite instability high.</td></tr><tr><td style=\"white-space:nowrap\">MSI-LOW<a name=\"ocm-protocol-markers-cs-MSI-LOW\"> </a></td><td>MSI-Low / MSS</td><td>Microsatellite instability low or stable.</td></tr><tr><td style=\"white-space:nowrap\">EGFR-MUTANT<a name=\"ocm-protocol-markers-cs-EGFR-MUTANT\"> </a></td><td>EGFR Mutant</td><td>EGFR mutation detected.</td></tr><tr><td style=\"white-space:nowrap\">ALK-POSITIVE<a name=\"ocm-protocol-markers-cs-ALK-POSITIVE\"> </a></td><td>ALK Positive</td><td>ALK rearrangement detected.</td></tr><tr><td style=\"white-space:nowrap\">NOT-TESTED<a name=\"ocm-protocol-markers-cs-NOT-TESTED\"> </a></td><td>Not Tested</td><td>Biomarker testing not performed.</td></tr></table></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:url [
fhir:v "https://nshr-uat.sha.go.ke/fhir/CodeSystem/ocm-protocol-markers-cs"^^xsd:anyURI ;
fhir:l <https://nshr-uat.sha.go.ke/fhir/CodeSystem/ocm-protocol-markers-cs>
  ] ; # 
  fhir:version [ fhir:v "0.1.0"] ; # 
  fhir:name [ fhir:v "OCMProtocolMarkersCS"] ; # 
  fhir:title [ fhir:v "Kenya OCM Protocol Markers Code System"] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:experimental [ fhir:v false] ; # 
  fhir:date [ fhir:v "2026-06-04T14:49:30+00:00"^^xsd:dateTime] ; # 
  fhir:publisher [ fhir:v "Digital Health Agency (DHA), Kenya"] ; # 
  fhir:contact ( [
fhir:name [ fhir:v "Digital Health Agency (DHA), Kenya" ] ;
    ( fhir:telecom [
fhir:system [ fhir:v "url" ] ;
fhir:value [ fhir:v "https://dha.go.ke" ]     ] [
fhir:system [ fhir:v "email" ] ;
fhir:value [ fhir:v "info@dha.go.ke" ]     ] )
  ] [
fhir:name [ fhir:v "Digital Health Agency Kenya – FHIR Team" ] ;
    ( fhir:telecom [
fhir:system [ fhir:v "email" ] ;
fhir:value [ fhir:v "info@dha.go.ke" ] ;
fhir:use [ fhir:v "work" ]     ] [
fhir:system [ fhir:v "url" ] ;
fhir:value [ fhir:v "https://dha.go.ke" ] ;
fhir:use [ fhir:v "work" ]     ] )
  ] ) ; # 
  fhir:description [ fhir:v "Biomarker and molecular marker codes used for treatment protocol selection."] ; # 
  fhir:jurisdiction ( [
    ( fhir:coding [
fhir:system [
fhir:v "urn:iso:std:iso:3166"^^xsd:anyURI ;
fhir:l <urn:iso:std:iso:3166>       ] ;
fhir:code [ fhir:v "KE" ] ;
fhir:display [ fhir:v "Kenya" ]     ] )
  ] ) ; # 
  fhir:caseSensitive [ fhir:v true] ; # 
  fhir:content [ fhir:v "complete"] ; # 
  fhir:count [ fhir:v "17"^^xsd:nonNegativeInteger] ; # 
  fhir:concept ( [
fhir:code [ fhir:v "HER2-POSITIVE" ] ;
fhir:display [ fhir:v "HER2 Positive" ] ;
fhir:definition [ fhir:v "HER2/neu overexpression or amplification detected." ]
  ] [
fhir:code [ fhir:v "HER2-NEGATIVE" ] ;
fhir:display [ fhir:v "HER2 Negative" ] ;
fhir:definition [ fhir:v "No HER2/neu overexpression or amplification." ]
  ] [
fhir:code [ fhir:v "ER-POSITIVE" ] ;
fhir:display [ fhir:v "ER Positive" ] ;
fhir:definition [ fhir:v "Oestrogen receptor positive." ]
  ] [
fhir:code [ fhir:v "ER-NEGATIVE" ] ;
fhir:display [ fhir:v "ER Negative" ] ;
fhir:definition [ fhir:v "Oestrogen receptor negative." ]
  ] [
fhir:code [ fhir:v "PR-POSITIVE" ] ;
fhir:display [ fhir:v "PR Positive" ] ;
fhir:definition [ fhir:v "Progesterone receptor positive." ]
  ] [
fhir:code [ fhir:v "PR-NEGATIVE" ] ;
fhir:display [ fhir:v "PR Negative" ] ;
fhir:definition [ fhir:v "Progesterone receptor negative." ]
  ] [
fhir:code [ fhir:v "TRIPLE-NEGATIVE" ] ;
fhir:display [ fhir:v "Triple Negative" ] ;
fhir:definition [ fhir:v "ER-, PR-, HER2- breast cancer." ]
  ] [
fhir:code [ fhir:v "KRAS-MUTANT" ] ;
fhir:display [ fhir:v "KRAS Mutant" ] ;
fhir:definition [ fhir:v "KRAS mutation detected." ]
  ] [
fhir:code [ fhir:v "KRAS-WILD-TYPE" ] ;
fhir:display [ fhir:v "KRAS Wild-type" ] ;
fhir:definition [ fhir:v "No KRAS mutation." ]
  ] [
fhir:code [ fhir:v "BRAF-V600E" ] ;
fhir:display [ fhir:v "BRAF V600E Mutant" ] ;
fhir:definition [ fhir:v "BRAF V600E mutation detected." ]
  ] [
fhir:code [ fhir:v "PD-L1-POSITIVE" ] ;
fhir:display [ fhir:v "PD-L1 Positive" ] ;
fhir:definition [ fhir:v "PD-L1 expression ≥1%." ]
  ] [
fhir:code [ fhir:v "PD-L1-NEGATIVE" ] ;
fhir:display [ fhir:v "PD-L1 Negative" ] ;
fhir:definition [ fhir:v "PD-L1 expression <1%." ]
  ] [
fhir:code [ fhir:v "MSI-HIGH" ] ;
fhir:display [ fhir:v "MSI-High" ] ;
fhir:definition [ fhir:v "Microsatellite instability high." ]
  ] [
fhir:code [ fhir:v "MSI-LOW" ] ;
fhir:display [ fhir:v "MSI-Low / MSS" ] ;
fhir:definition [ fhir:v "Microsatellite instability low or stable." ]
  ] [
fhir:code [ fhir:v "EGFR-MUTANT" ] ;
fhir:display [ fhir:v "EGFR Mutant" ] ;
fhir:definition [ fhir:v "EGFR mutation detected." ]
  ] [
fhir:code [ fhir:v "ALK-POSITIVE" ] ;
fhir:display [ fhir:v "ALK Positive" ] ;
fhir:definition [ fhir:v "ALK rearrangement detected." ]
  ] [
fhir:code [ fhir:v "NOT-TESTED" ] ;
fhir:display [ fhir:v "Not Tested" ] ;
fhir:definition [ fhir:v "Biomarker testing not performed." ]
  ] ) . #