Genomics Reporting Implementation Guide, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 4.0.0-cibuild built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/genomics-reporting/ and changes regularly. See the Directory of published versions
: ROS1-Fusion-therapuTrial - TTL Representation
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@prefix fhir: <http://hl7.org/fhir/> .
@prefix loinc: <http://loinc.org/rdf#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
# - resource -------------------------------------------------------------------
<http://hl7.org/fhir/Observation/ROS1-Fusion-therapuTrial> a fhir:Observation ;
fhir:nodeRole fhir:treeRoot ;
fhir:Resource.id [ fhir:value "ROS1-Fusion-therapuTrial"] ;
fhir:Resource.meta [
fhir:Meta.profile [
fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication" ;
fhir:index 0 ;
fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/therapeutic-implication>
]
] ;
fhir:DomainResource.text [
fhir:Narrative.status [ fhir:value "extensions" ] ;
fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Observation ROS1-Fusion-therapuTrial</b></p><a name=\"ROS1-Fusion-therapuTrial\"> </a><a name=\"hcROS1-Fusion-therapuTrial\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-therapeutic-implication.html\">Therapeutic Implication</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Patient-somaticPatient.html\">Substance Junior Hamsburg (official) Male, DoB: 1987-09-01 ( Medical record number: 1234567 (use: temp, period: 2021-01-01 --> (ongoing)))</a></p><p><b>effective</b>: 2023-02-01</p><p><b>performer</b>: <a href=\"Practitioner-pathologistPractitioner.html\">Practitioner Test Dolin </a></p><p><b>derivedFrom</b>: <a href=\"Observation-ROS1-Fusion-var.html\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 81259-4}\">Associated phenotype</span></p><p><b>value</b>: <span title=\"Codes:{http://snomed.info/sct 254637007}\">Non-small cell lung cancer</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed</span></p><p><b>value</b>: <span title=\"Codes:\">Taletrectinib</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs associated-therapy}\">Associated Therapy</span></p><p><b>value</b>: <span title=\"Codes:{http://clinicaltrials.gov NCT04919811}\">A Single-Arm, Open-Label, Multicenter Phase 2 Study to Evaluate the Efficacy and Safety of Taletrectinib in Patients With Advanced or Metastatic ROS1 Positive NSCLC and Other Solid Tumors</span></p></blockquote><blockquote><p><b>component</b></p><p><b>Related artifact</b>: No display for RelatedArtifact (type: citation; url: https://www.cancer.net/cancer-types/lung-cancer-non-small-cell/types-treatment)</p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 93044-6}\">Level of evidence</span></p><p><b>value</b>: <span title=\"Codes:\">Tier I - Level A</span></p></blockquote></div>"
] ;
fhir:Observation.status [ fhir:value "final"] ;
fhir:Observation.category [
fhir:index 0 ;
fhir:CodeableConcept.coding [
fhir:index 0 ;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/observation-category" ] ;
fhir:Coding.code [ fhir:value "laboratory" ]
]
], [
fhir:index 1 ;
fhir:CodeableConcept.coding [
fhir:index 0 ;
fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ;
fhir:Coding.code [ fhir:value "GE" ]
]
] ;
fhir:Observation.code [
fhir:CodeableConcept.coding [
fhir:index 0 ;
fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ;
fhir:Coding.code [ fhir:value "therapeutic-implication" ]
]
] ;
fhir:Observation.subject [
fhir:link <http://hl7.org/fhir/Patient/somaticPatient> ;
fhir:Reference.reference [ fhir:value "Patient/somaticPatient" ]
] ;
fhir:Observation.effectiveDateTime [ fhir:value "2023-02-01"^^xsd:date] ;
fhir:Observation.performer [
fhir:index 0 ;
fhir:link <http://hl7.org/fhir/Practitioner/pathologistPractitioner> ;
fhir:Reference.reference [ fhir:value "Practitioner/pathologistPractitioner" ]
] ;
fhir:Observation.derivedFrom [
fhir:index 0 ;
fhir:link <http://hl7.org/fhir/Observation/ROS1-Fusion-var> ;
fhir:Reference.reference [ fhir:value "Observation/ROS1-Fusion-var" ]
] ;
fhir:Observation.component [
fhir:index 0 ;
fhir:Observation.component.code [
fhir:CodeableConcept.coding [
fhir:index 0 ;
a loinc:81259-4 ;
fhir:Coding.system [ fhir:value "http://loinc.org" ] ;
fhir:Coding.code [ fhir:value "81259-4" ]
]
] ;
fhir:Observation.component.valueCodeableConcept [
fhir:CodeableConcept.coding [
fhir:index 0 ;
a sct:254637007 ;
fhir:Coding.system [ fhir:value "http://snomed.info/sct" ] ;
fhir:Coding.code [ fhir:value "254637007" ] ;
fhir:Coding.display [ fhir:value "Non-small cell lung cancer (disorder)" ]
] ;
fhir:CodeableConcept.text [ fhir:value "Non-small cell lung cancer" ]
]
], [
fhir:index 1 ;
fhir:Observation.component.code [
fhir:CodeableConcept.coding [
fhir:index 0 ;
a loinc:51963-7 ;
fhir:Coding.system [ fhir:value "http://loinc.org" ] ;
fhir:Coding.code [ fhir:value "51963-7" ] ;
fhir:Coding.display [ fhir:value "Medication assessed" ]
]
] ;
fhir:Observation.component.valueCodeableConcept [
fhir:CodeableConcept.text [ fhir:value "Taletrectinib" ]
]
], [
fhir:index 2 ;
fhir:Observation.component.code [
fhir:CodeableConcept.coding [
fhir:index 0 ;
fhir:Coding.system [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs" ] ;
fhir:Coding.code [ fhir:value "associated-therapy" ] ;
fhir:Coding.display [ fhir:value "Associated Therapy" ]
]
] ;
fhir:Observation.component.valueCodeableConcept [
fhir:CodeableConcept.coding [
fhir:index 0 ;
fhir:Coding.system [ fhir:value "http://clinicaltrials.gov" ] ;
fhir:Coding.code [ fhir:value "NCT04919811" ] ;
fhir:Coding.display [ fhir:value "NCT04919811" ]
] ;
fhir:CodeableConcept.text [ fhir:value "A Single-Arm, Open-Label, Multicenter Phase 2 Study to Evaluate the Efficacy and Safety of Taletrectinib in Patients With Advanced or Metastatic ROS1 Positive NSCLC and Other Solid Tumors" ]
]
], [
fhir:index 3 ;
fhir:Element.extension [
fhir:index 0 ;
fhir:Extension.url [ fhir:value "http://hl7.org/fhir/StructureDefinition/workflow-relatedArtifact" ] ;
fhir:Extension.valueRelatedArtifact [
fhir:RelatedArtifact.type [ fhir:value "citation" ] ;
fhir:RelatedArtifact.url [ fhir:value "https://www.cancer.net/cancer-types/lung-cancer-non-small-cell/types-treatment" ]
]
] ;
fhir:Observation.component.code [
fhir:CodeableConcept.coding [
fhir:index 0 ;
a loinc:93044-6 ;
fhir:Coding.system [ fhir:value "http://loinc.org" ] ;
fhir:Coding.code [ fhir:value "93044-6" ] ;
fhir:Coding.display [ fhir:value "Level of evidence" ]
]
] ;
fhir:Observation.component.valueCodeableConcept [
fhir:CodeableConcept.text [ fhir:value "Tier I - Level A" ]
]
] .
<http://hl7.org/fhir/Patient/somaticPatient> a fhir:Patient .
<http://hl7.org/fhir/Practitioner/pathologistPractitioner> a fhir:Practitioner .
<http://hl7.org/fhir/Observation/ROS1-Fusion-var> a fhir:Observation .
# - ontology header ------------------------------------------------------------
<http://hl7.org/fhir/Observation/ROS1-Fusion-therapuTrial.ttl> a owl:Ontology ;
owl:imports fhir:fhir.ttl ;
owl:versionIRI <http://build.fhir.org/Observation/ROS1-Fusion-therapuTrial.ttl> .
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