Genomics Reporting Implementation Guide
4.0.0-cibuild - CI Build International flag

Genomics Reporting Implementation Guide, published by HL7 International / Clinical Genomics. This guide is not an authorized publication; it is the continuous build for version 4.0.0-cibuild built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/genomics-reporting/ and changes regularly. See the Directory of published versions

: somaticReport - TTL Representation

Page standards status: Informative

Raw ttl | Download


@prefix fhir: <http://hl7.org/fhir/> .
@prefix loinc: <http://loinc.org/rdf#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/DiagnosticReport/somaticReport> a fhir:DiagnosticReport ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:Resource.id [ fhir:value "somaticReport"] ;
  fhir:Resource.meta [
     fhir:Meta.profile [
       fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report" ;
       fhir:index 0 ;
       fhir:link <http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-report>
     ]
  ] ;
  fhir:DomainResource.text [
     fhir:Narrative.status [ fhir:value "generated" ] ;
     fhir:Narrative.div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: DiagnosticReport somaticReport</b></p><a name=\"somaticReport\"> </a><a name=\"hcsomaticReport\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-genomic-report.html\">Genomic Report</a></p></div><h2><span title=\"Codes:{http://loinc.org 51969-4}\">Genetic analysis report</span> (<span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetics</span>) </h2><table class=\"grid\"><tr><td>Relevant Time</td><td>2023-02-02</td></tr><tr><td>Performers</td><td> <a href=\"Practitioner-pathologistPractitioner.html\">Practitioner Test Dolin </a> <a href=\"Organization-performingOrganization.html\">Organization My Test Pathology Laboratories</a></td></tr><tr><td>Identifier</td><td> Accession ID/23-0000345</td></tr></table><p><b>Report Details</b></p><table class=\"grid\"><tr><td><b>Code</b></td><td><b>Value</b></td><td><b>Flags</b></td><td><b>Note</b></td><td><b>Relevant Time</b></td><td><b>Reported</b></td></tr><tr><td><a href=\"Observation-NOTCH1-uncertain-var.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-ZFHX3-uncertain-var.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-MSH2-del-var.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-NTHL1-snv-var.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-STAG2-insertion-var.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-ATR-insertion-var.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-EGFR-L858R-var.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-ROS1-Fusion-var.html\"><span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></a></td><td><span title=\"Codes:{http://loinc.org LA9633-4}\">Present</span></td><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-NOTCH1-significance.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-ZFHX3-significance.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-MSH2-del-disease.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-NTHL1-snv-disease.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-STAG2-insertion-significance.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-ATR-insertion-significance.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-EGFR-L858R-significance.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-ROS1-Fusion-disease.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs diagnostic-implication}\">Diagnostic Implication</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-ROS1-Fusion-therapuTrial.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-ROS1-Fusion-therapuDrug.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-EGFR-L858R-therapuDrug1.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-EGFR-L858R-therapuDrug2.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-TMB-therapuDrug.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-NOTCH1-uncertain-molc.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-ZFHX3-uncertain-molc.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-MSH2-del-molc.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-NTHL1-snv-molc.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-STAG2-insertion-molc.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-ATR-insertion-molc.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-EGFR-L858R-molc.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-ROS1-Fusion.html\"><span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs molecular-consequence}\">Molecular Consequence</span></a></td><td/><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-TMBExample.html\"><span title=\"Codes:{http://loinc.org 94076-7}\">Mutations/Megabase [# Ratio] in Tumor</span></a></td><td>29.8</td><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-MSIExample.html\"><span title=\"Codes:{http://loinc.org 81695-9}\">Microsatellite instability [Interpretation] in Cancer specimen Qualitative</span></a></td><td><span title=\"Codes:{http://loinc.org LA26203-2}\">MSI-H</span></td><td>Final</td><td/><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-PDL1Example.html\"><span title=\"Codes:{http://loinc.org 85147-7}\">PD-L1 by clone 22C3 in Tissue by Immune stain Report</span></a></td><td><span title=\"Codes:{http://loinc.org LA6576-8}\">Positive</span></td><td>Final</td><td><blockquote><div><p>5% tumor proportion score</p>\n</div></blockquote></td><td>2023-02-01</td><td/></tr><tr><td><a href=\"Observation-HLA-A-haplotype1.html\"><span title=\"Codes:{http://loinc.org 84414-2}\">Haplotype Name</span></a></td><td><span title=\"Codes:{http://www.ebi.ac.uk/ipd/imgt/hla A*24:02}\">HLA-A*24:02</span></td><td>Final</td><td/><td>2023-02-01</td><td>2023-02-01 00:00:00-0500</td></tr><tr><td><a href=\"Observation-HLA-A-haplotype2.html\"><span title=\"Codes:{http://loinc.org 84414-2}\">Haplotype Name</span></a></td><td><span title=\"Codes:{http://www.ebi.ac.uk/ipd/imgt/hla A*02:06}\">HLA-A*02:06</span></td><td>Final</td><td/><td>2023-02-01</td><td>2023-02-01 00:00:00-0500</td></tr><tr><td><a href=\"Observation-HLA-B-haplotype1.html\"><span title=\"Codes:{http://loinc.org 84414-2}\">Haplotype Name</span></a></td><td><span title=\"Codes:{http://www.ebi.ac.uk/ipd/imgt/hla B*35:01}\">HLA-B*35:01</span></td><td>Final</td><td/><td>2023-02-01</td><td>2023-02-01 00:00:00-0500</td></tr><tr><td><a href=\"Observation-HLA-B-haplotype2.html\"><span title=\"Codes:{http://loinc.org 84414-2}\">Haplotype Name</span></a></td><td><span title=\"Codes:{http://www.ebi.ac.uk/ipd/imgt/hla B*35:01}\">HLA-B*35:01</span></td><td>Final</td><td/><td>2023-02-01</td><td>2023-02-01 00:00:00-0500</td></tr><tr><td><a href=\"Observation-HLA-C-haplotype1.html\"><span title=\"Codes:{http://loinc.org 84414-2}\">Haplotype Name</span></a></td><td><span title=\"Codes:{http://www.ebi.ac.uk/ipd/imgt/hla C*03:03}\">HLA-C*03:03</span></td><td>Final</td><td/><td>2023-02-01</td><td>2023-02-01 00:00:00-0500</td></tr><tr><td><a href=\"Observation-HLA-C-haplotype2.html\"><span title=\"Codes:{http://loinc.org 84414-2}\">Haplotype Name</span></a></td><td><span title=\"Codes:{http://www.ebi.ac.uk/ipd/imgt/hla C*15:02}\">HLA-C*15:02</span></td><td>Final</td><td/><td>2023-02-01</td><td>2023-02-01 00:00:00-0500</td></tr></table><p>Patient is positive for Tier 1 / Level A variants, including variants with FDA-approved indications.</p><p><b>Coded Conclusions:</b></p><ul><li><span title=\"Codes:{http://loinc.org LA6576-8}\">Positive</span></li></ul></div>"
  ] ;
  fhir:DomainResource.extension [
     fhir:index 0 ;
     fhir:Extension.url [ fhir:value "http://hl7.org/fhir/uv/genomics-reporting/StructureDefinition/genomic-study-reference" ] ;
     fhir:Extension.valueReference [
       fhir:link <http://hl7.org/fhir/Procedure/somaticStudy> ;
       fhir:Reference.reference [ fhir:value "Procedure/somaticStudy" ] ;
       fhir:Reference.display [ fhir:value "somaticStudy" ]
     ]
  ] ;
  fhir:DiagnosticReport.identifier [
     fhir:index 0 ;
     fhir:Identifier.type [
       fhir:CodeableConcept.coding [
         fhir:index 0 ;
         fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0203" ] ;
         fhir:Coding.code [ fhir:value "ACSN" ] ;
         fhir:Coding.display [ fhir:value "Accession ID" ]
       ]
     ] ;
     fhir:Identifier.value [ fhir:value "23-0000345" ]
  ] ;
  fhir:DiagnosticReport.basedOn [
     fhir:index 0 ;
     fhir:link <http://hl7.org/fhir/ServiceRequest/somaticServiceRequest> ;
     fhir:Reference.reference [ fhir:value "ServiceRequest/somaticServiceRequest" ]
  ] ;
  fhir:DiagnosticReport.status [ fhir:value "final"] ;
  fhir:DiagnosticReport.category [
     fhir:index 0 ;
     fhir:CodeableConcept.coding [
       fhir:index 0 ;
       fhir:Coding.system [ fhir:value "http://terminology.hl7.org/CodeSystem/v2-0074" ] ;
       fhir:Coding.code [ fhir:value "GE" ] ;
       fhir:Coding.display [ fhir:value "Genetics" ]
     ]
  ] ;
  fhir:DiagnosticReport.code [
     fhir:CodeableConcept.coding [
       fhir:index 0 ;
       a loinc:51969-4 ;
       fhir:Coding.system [ fhir:value "http://loinc.org" ] ;
       fhir:Coding.code [ fhir:value "51969-4" ] ;
       fhir:Coding.display [ fhir:value "Genetic analysis report" ]
     ]
  ] ;
  fhir:DiagnosticReport.effectiveDateTime [ fhir:value "2023-02-02"^^xsd:date] ;
  fhir:DiagnosticReport.performer [
     fhir:index 0 ;
     fhir:link <http://hl7.org/fhir/Practitioner/pathologistPractitioner> ;
     fhir:Reference.reference [ fhir:value "Practitioner/pathologistPractitioner" ]
  ], [
     fhir:index 1 ;
     fhir:link <http://hl7.org/fhir/Organization/performingOrganization> ;
     fhir:Reference.reference [ fhir:value "Organization/performingOrganization" ]
  ] ;
  fhir:DiagnosticReport.resultsInterpreter [
     fhir:index 0 ;
     fhir:link <http://hl7.org/fhir/Practitioner/supervisorPractitioner> ;
     fhir:Reference.reference [ fhir:value "Practitioner/supervisorPractitioner" ]
  ], [
     fhir:index 1 ;
     fhir:link <http://hl7.org/fhir/Organization/performingOrganization> ;
     fhir:Reference.reference [ fhir:value "Organization/performingOrganization" ]
  ] ;
  fhir:DiagnosticReport.result [
     fhir:index 0 ;
     fhir:link <http://hl7.org/fhir/Observation/NOTCH1-uncertain-var> ;
     fhir:Reference.reference [ fhir:value "Observation/NOTCH1-uncertain-var" ]
  ], [
     fhir:index 1 ;
     fhir:link <http://hl7.org/fhir/Observation/ZFHX3-uncertain-var> ;
     fhir:Reference.reference [ fhir:value "Observation/ZFHX3-uncertain-var" ]
  ], [
     fhir:index 2 ;
     fhir:link <http://hl7.org/fhir/Observation/MSH2-del-var> ;
     fhir:Reference.reference [ fhir:value "Observation/MSH2-del-var" ]
  ], [
     fhir:index 3 ;
     fhir:link <http://hl7.org/fhir/Observation/NTHL1-snv-var> ;
     fhir:Reference.reference [ fhir:value "Observation/NTHL1-snv-var" ]
  ], [
     fhir:index 4 ;
     fhir:link <http://hl7.org/fhir/Observation/STAG2-insertion-var> ;
     fhir:Reference.reference [ fhir:value "Observation/STAG2-insertion-var" ]
  ], [
     fhir:index 5 ;
     fhir:link <http://hl7.org/fhir/Observation/ATR-insertion-var> ;
     fhir:Reference.reference [ fhir:value "Observation/ATR-insertion-var" ]
  ], [
     fhir:index 6 ;
     fhir:link <http://hl7.org/fhir/Observation/EGFR-L858R-var> ;
     fhir:Reference.reference [ fhir:value "Observation/EGFR-L858R-var" ]
  ], [
     fhir:index 7 ;
     fhir:link <http://hl7.org/fhir/Observation/ROS1-Fusion-var> ;
     fhir:Reference.reference [ fhir:value "Observation/ROS1-Fusion-var" ]
  ], [
     fhir:index 8 ;
     fhir:link <http://hl7.org/fhir/Observation/NOTCH1-significance> ;
     fhir:Reference.reference [ fhir:value "Observation/NOTCH1-significance" ]
  ], [
     fhir:index 9 ;
     fhir:link <http://hl7.org/fhir/Observation/ZFHX3-significance> ;
     fhir:Reference.reference [ fhir:value "Observation/ZFHX3-significance" ]
  ], [
     fhir:index 10 ;
     fhir:link <http://hl7.org/fhir/Observation/MSH2-del-disease> ;
     fhir:Reference.reference [ fhir:value "Observation/MSH2-del-disease" ]
  ], [
     fhir:index 11 ;
     fhir:link <http://hl7.org/fhir/Observation/NTHL1-snv-disease> ;
     fhir:Reference.reference [ fhir:value "Observation/NTHL1-snv-disease" ]
  ], [
     fhir:index 12 ;
     fhir:link <http://hl7.org/fhir/Observation/STAG2-insertion-significance> ;
     fhir:Reference.reference [ fhir:value "Observation/STAG2-insertion-significance" ]
  ], [
     fhir:index 13 ;
     fhir:link <http://hl7.org/fhir/Observation/ATR-insertion-significance> ;
     fhir:Reference.reference [ fhir:value "Observation/ATR-insertion-significance" ]
  ], [
     fhir:index 14 ;
     fhir:link <http://hl7.org/fhir/Observation/EGFR-L858R-significance> ;
     fhir:Reference.reference [ fhir:value "Observation/EGFR-L858R-significance" ]
  ], [
     fhir:index 15 ;
     fhir:link <http://hl7.org/fhir/Observation/ROS1-Fusion-disease> ;
     fhir:Reference.reference [ fhir:value "Observation/ROS1-Fusion-disease" ]
  ], [
     fhir:index 16 ;
     fhir:link <http://hl7.org/fhir/Observation/ROS1-Fusion-therapuTrial> ;
     fhir:Reference.reference [ fhir:value "Observation/ROS1-Fusion-therapuTrial" ]
  ], [
     fhir:index 17 ;
     fhir:link <http://hl7.org/fhir/Observation/ROS1-Fusion-therapuDrug> ;
     fhir:Reference.reference [ fhir:value "Observation/ROS1-Fusion-therapuDrug" ]
  ], [
     fhir:index 18 ;
     fhir:link <http://hl7.org/fhir/Observation/EGFR-L858R-therapuDrug1> ;
     fhir:Reference.reference [ fhir:value "Observation/EGFR-L858R-therapuDrug1" ]
  ], [
     fhir:index 19 ;
     fhir:link <http://hl7.org/fhir/Observation/EGFR-L858R-therapuDrug2> ;
     fhir:Reference.reference [ fhir:value "Observation/EGFR-L858R-therapuDrug2" ]
  ], [
     fhir:index 20 ;
     fhir:link <http://hl7.org/fhir/Observation/TMB-therapuDrug> ;
     fhir:Reference.reference [ fhir:value "Observation/TMB-therapuDrug" ]
  ], [
     fhir:index 21 ;
     fhir:link <http://hl7.org/fhir/Observation/NOTCH1-uncertain-molc> ;
     fhir:Reference.reference [ fhir:value "Observation/NOTCH1-uncertain-molc" ]
  ], [
     fhir:index 22 ;
     fhir:link <http://hl7.org/fhir/Observation/ZFHX3-uncertain-molc> ;
     fhir:Reference.reference [ fhir:value "Observation/ZFHX3-uncertain-molc" ]
  ], [
     fhir:index 23 ;
     fhir:link <http://hl7.org/fhir/Observation/MSH2-del-molc> ;
     fhir:Reference.reference [ fhir:value "Observation/MSH2-del-molc" ]
  ], [
     fhir:index 24 ;
     fhir:link <http://hl7.org/fhir/Observation/NTHL1-snv-molc> ;
     fhir:Reference.reference [ fhir:value "Observation/NTHL1-snv-molc" ]
  ], [
     fhir:index 25 ;
     fhir:link <http://hl7.org/fhir/Observation/STAG2-insertion-molc> ;
     fhir:Reference.reference [ fhir:value "Observation/STAG2-insertion-molc" ]
  ], [
     fhir:index 26 ;
     fhir:link <http://hl7.org/fhir/Observation/ATR-insertion-molc> ;
     fhir:Reference.reference [ fhir:value "Observation/ATR-insertion-molc" ]
  ], [
     fhir:index 27 ;
     fhir:link <http://hl7.org/fhir/Observation/EGFR-L858R-molc> ;
     fhir:Reference.reference [ fhir:value "Observation/EGFR-L858R-molc" ]
  ], [
     fhir:index 28 ;
     fhir:link <http://hl7.org/fhir/Observation/ROS1-Fusion> ;
     fhir:Reference.reference [ fhir:value "Observation/ROS1-Fusion" ]
  ], [
     fhir:index 29 ;
     fhir:link <http://hl7.org/fhir/Observation/TMBExample> ;
     fhir:Reference.reference [ fhir:value "Observation/TMBExample" ]
  ], [
     fhir:index 30 ;
     fhir:link <http://hl7.org/fhir/Observation/MSIExample> ;
     fhir:Reference.reference [ fhir:value "Observation/MSIExample" ]
  ], [
     fhir:index 31 ;
     fhir:link <http://hl7.org/fhir/Observation/PDL1Example> ;
     fhir:Reference.reference [ fhir:value "Observation/PDL1Example" ]
  ], [
     fhir:index 32 ;
     fhir:link <http://hl7.org/fhir/Observation/HLA-A-haplotype1> ;
     fhir:Reference.reference [ fhir:value "Observation/HLA-A-haplotype1" ]
  ], [
     fhir:index 33 ;
     fhir:link <http://hl7.org/fhir/Observation/HLA-A-haplotype2> ;
     fhir:Reference.reference [ fhir:value "Observation/HLA-A-haplotype2" ]
  ], [
     fhir:index 34 ;
     fhir:link <http://hl7.org/fhir/Observation/HLA-B-haplotype1> ;
     fhir:Reference.reference [ fhir:value "Observation/HLA-B-haplotype1" ]
  ], [
     fhir:index 35 ;
     fhir:link <http://hl7.org/fhir/Observation/HLA-B-haplotype2> ;
     fhir:Reference.reference [ fhir:value "Observation/HLA-B-haplotype2" ]
  ], [
     fhir:index 36 ;
     fhir:link <http://hl7.org/fhir/Observation/HLA-C-haplotype1> ;
     fhir:Reference.reference [ fhir:value "Observation/HLA-C-haplotype1" ]
  ], [
     fhir:index 37 ;
     fhir:link <http://hl7.org/fhir/Observation/HLA-C-haplotype2> ;
     fhir:Reference.reference [ fhir:value "Observation/HLA-C-haplotype2" ]
  ] ;
  fhir:DiagnosticReport.conclusion [ fhir:value "Patient is positive for Tier 1 / Level A variants, including variants with FDA-approved indications."] ;
  fhir:DiagnosticReport.conclusionCode [
     fhir:index 0 ;
     fhir:CodeableConcept.coding [
       fhir:index 0 ;
       a loinc:LA6576-8 ;
       fhir:Coding.system [ fhir:value "http://loinc.org" ] ;
       fhir:Coding.code [ fhir:value "LA6576-8" ] ;
       fhir:Coding.display [ fhir:value "Positive" ]
     ]
  ] .

<http://hl7.org/fhir/Procedure/somaticStudy> a fhir:Procedure .

<http://hl7.org/fhir/ServiceRequest/somaticServiceRequest> a fhir:ServiceRequest .

<http://hl7.org/fhir/Practitioner/pathologistPractitioner> a fhir:Practitioner .

<http://hl7.org/fhir/Organization/performingOrganization> a fhir:Organization .

<http://hl7.org/fhir/Practitioner/supervisorPractitioner> a fhir:Practitioner .

<http://hl7.org/fhir/Observation/NOTCH1-uncertain-var> a fhir:Observation .

<http://hl7.org/fhir/Observation/ZFHX3-uncertain-var> a fhir:Observation .

<http://hl7.org/fhir/Observation/MSH2-del-var> a fhir:Observation .

<http://hl7.org/fhir/Observation/NTHL1-snv-var> a fhir:Observation .

<http://hl7.org/fhir/Observation/STAG2-insertion-var> a fhir:Observation .

<http://hl7.org/fhir/Observation/ATR-insertion-var> a fhir:Observation .

<http://hl7.org/fhir/Observation/EGFR-L858R-var> a fhir:Observation .

<http://hl7.org/fhir/Observation/ROS1-Fusion-var> a fhir:Observation .

<http://hl7.org/fhir/Observation/NOTCH1-significance> a fhir:Observation .

<http://hl7.org/fhir/Observation/ZFHX3-significance> a fhir:Observation .

<http://hl7.org/fhir/Observation/MSH2-del-disease> a fhir:Observation .

<http://hl7.org/fhir/Observation/NTHL1-snv-disease> a fhir:Observation .

<http://hl7.org/fhir/Observation/STAG2-insertion-significance> a fhir:Observation .

<http://hl7.org/fhir/Observation/ATR-insertion-significance> a fhir:Observation .

<http://hl7.org/fhir/Observation/EGFR-L858R-significance> a fhir:Observation .

<http://hl7.org/fhir/Observation/ROS1-Fusion-disease> a fhir:Observation .

<http://hl7.org/fhir/Observation/ROS1-Fusion-therapuTrial> a fhir:Observation .

<http://hl7.org/fhir/Observation/ROS1-Fusion-therapuDrug> a fhir:Observation .

<http://hl7.org/fhir/Observation/EGFR-L858R-therapuDrug1> a fhir:Observation .

<http://hl7.org/fhir/Observation/EGFR-L858R-therapuDrug2> a fhir:Observation .

<http://hl7.org/fhir/Observation/TMB-therapuDrug> a fhir:Observation .

<http://hl7.org/fhir/Observation/NOTCH1-uncertain-molc> a fhir:Observation .

<http://hl7.org/fhir/Observation/ZFHX3-uncertain-molc> a fhir:Observation .

<http://hl7.org/fhir/Observation/MSH2-del-molc> a fhir:Observation .

<http://hl7.org/fhir/Observation/NTHL1-snv-molc> a fhir:Observation .

<http://hl7.org/fhir/Observation/STAG2-insertion-molc> a fhir:Observation .

<http://hl7.org/fhir/Observation/ATR-insertion-molc> a fhir:Observation .

<http://hl7.org/fhir/Observation/EGFR-L858R-molc> a fhir:Observation .

<http://hl7.org/fhir/Observation/ROS1-Fusion> a fhir:Observation .

<http://hl7.org/fhir/Observation/TMBExample> a fhir:Observation .

<http://hl7.org/fhir/Observation/MSIExample> a fhir:Observation .

<http://hl7.org/fhir/Observation/PDL1Example> a fhir:Observation .

<http://hl7.org/fhir/Observation/HLA-A-haplotype1> a fhir:Observation .

<http://hl7.org/fhir/Observation/HLA-A-haplotype2> a fhir:Observation .

<http://hl7.org/fhir/Observation/HLA-B-haplotype1> a fhir:Observation .

<http://hl7.org/fhir/Observation/HLA-B-haplotype2> a fhir:Observation .

<http://hl7.org/fhir/Observation/HLA-C-haplotype1> a fhir:Observation .

<http://hl7.org/fhir/Observation/HLA-C-haplotype2> a fhir:Observation .

# - ontology header ------------------------------------------------------------

<http://hl7.org/fhir/DiagnosticReport/somaticReport.ttl> a owl:Ontology ;
  owl:imports fhir:fhir.ttl ;
  owl:versionIRI <http://build.fhir.org/DiagnosticReport/somaticReport.ttl> .