Evidence Based Medicine on FHIR Implementation Guide
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Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 2.0.0-ballot built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: ComparativeEvidence: Mean difference in HbA1c between Surgery and Medical/Lifestyle groups in Dixon 2008 - TTL Representation

Active as of 2022-05-29

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:Evidence ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "47760"] ; # 
  fhir:meta [
fhir:versionId [ fhir:v "14" ] ;
fhir:lastUpdated [ fhir:v "2023-12-06T18:55:23.084Z"^^xsd:dateTime ] ;
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/comparative-evidence"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/uv/ebm/StructureDefinition/comparative-evidence>     ] [
fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/single-study-evidence"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/uv/ebm/StructureDefinition/single-study-evidence>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "extensions" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Evidence 47760</b></p><a name=\"47760\"> </a><a name=\"hc47760\"> </a><a name=\"47760-en-US\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 14; Last updated: 2023-12-06 18:55:23+0000</p><p style=\"margin-bottom: 0px\">Profiles: <a href=\"StructureDefinition-comparative-evidence.html\">ComparativeEvidence</a>, <a href=\"StructureDefinition-single-study-evidence.html\">SingleStudyEvidence</a></p></div><p><b>url</b>: <a href=\"Evidence-47760.html\">Evidence ComparativeEvidence: Mean difference in HbA1c between Surgery and Medical/Lifestyle groups in Dixon 2008</a></p><p><b>identifier</b>: FEvIR Object Identifier/47760, <a href=\"http://terminology.hl7.org/6.0.2/NamingSystem-uri.html\" title=\"As defined by RFC 3986 (http://www.ietf.org/rfc/rfc3986.txt)(with many schemes defined in many RFCs). For OIDs and UUIDs, use the URN form (urn:oid:(note: lowercase) and urn:uuid:). See http://www.ietf.org/rfc/rfc3001.txt and http://www.ietf.org/rfc/rfc4122.txt \r\n\r\nThis oid is used as an identifier II.root to indicate the the extension is an absolute URI (technically, an IRI). Typically, this is used for OIDs and GUIDs. Note that when this OID is used with OIDs and GUIDs, the II.extension should start with urn:oid or urn:uuid: \r\n\r\nNote that this OID is created to aid with interconversion between CDA and FHIR - FHIR uses urn:ietf:rfc:3986 as equivalent to this OID. URIs as identifiers appear more commonly in FHIR.\r\n\r\nThis OID may also be used in CD.codeSystem.\">Uniform Resource Identifier (URI)</a>/urn:oid:2.16.840.1.113883.4.642.40.44.22.19</p><p><b>version</b>: 2.0.0-ballot</p><p><b>name</b>: ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Dixon_2008</p><p><b>title</b>: ComparativeEvidence: Mean difference in HbA1c between Surgery and Medical/Lifestyle groups in Dixon 2008</p><p><b>status</b>: Active</p><p><b>date</b>: 2022-05-29 11:01:34+0000</p><p><b>publisher</b>: HL7 International / Clinical Decision Support</p><p><b>contact</b>: HL7 International / Clinical Decision Support: <a href=\"http://www.hl7.org/Special/committees/dss\">http://www.hl7.org/Special/committees/dss</a></p><p><b>author</b>: Brian S. Alper: </p><h3>UseContexts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Code</b></td><td><b>Value[x]</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"CodeSystem-179423.html#179423-evidence-communication\">Evidence Based Medicine on FHIR Implementation Guide Code System evidence-communication</a>: Evidence Communication</td><td><span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 ComparativeEvidence}\">ComparativeEvidence</span></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"CodeSystem-179423.html#179423-evidence-communication\">Evidence Based Medicine on FHIR Implementation Guide Code System evidence-communication</a>: Evidence Communication</td><td><span title=\"Codes:{https://fevir.net/resources/CodeSystem/179423 SingleStudyEvidence}\">SingleStudyEvidence</span></td></tr></table><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><blockquote><p><b>relatedArtifact</b></p><p><b>type</b>: Derived From</p><p><b>label</b>: data source</p><p><b>display</b>: Figure 2C</p><p><b>citation</b>: </p><div><p>Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations [Journal Article]. Contributors: Francesco Rubino, David M Nathan, Robert H Eckel, Philip R Schauer, K George M M Alberti, Paul Z Zimmet, Stefano Del Prato, Linong Ji, Shaukat M Sadikot, William H Herman, Stephanie A Amiel, Lee M Kaplan, Gaspar Taroncher-Oldenburg, David E Cummings, Delegates of the 2nd Diabetes Surgery Summit. In: Diabetes care, PMID 27222544. Published June 2016. Available at: https://pubmed.ncbi.nlm.nih.gov/27222544/.</p>\n</div><h3>Documents</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Url</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"https://diabetesjournals.org/care/article/39/6/861/29305/Metabolic-Surgery-in-the-Treatment-Algorithm-for\">https://diabetesjournals.org/care/article/39/6/861/29305/Metabolic-Surgery-in-the-Treatment-Algorithm-for</a></td></tr></table></blockquote><blockquote><p><b>relatedArtifact</b></p><p><b>type</b>: Cite As</p><p><b>citation</b>: </p><div><p>ComparativeEvidence: Mean difference in HbA1c between Surgery and Medical/Lifestyle groups in Dixon 2008 [Evidence]. Contributors: In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 47760. Revised 2022-05-29. Available at: https://fevir.net/resources/Evidence/47760. Computable resource at: https://fevir.net/resources/Evidence/47760.</p>\n</div></blockquote><p><b>description</b>: </p><div><p>Mean HbA1c at 24 months in Dixon 2008 was 6% in Surgery group (n = 30) and 7.2% in Medical/Lifestyle group (n = 30), mean difference -1.20% (95% CI -1.78% to -0.62%)</p>\n</div><blockquote><p><b>variableDefinition</b></p><p><b>org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code</b>: population</p><p><b>description</b>: </p><div><p>60 Patients with BMI&gt;30 and BMI&lt;40 and T2DM diagnosed in the last 2 years</p>\n</div><p><b>note</b>: population</p><p><b>observed</b>: Dixon 2008 Trial Enrollment Group</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code</b>: exposure</p><p><b>org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category</b>: no bariatric surgery</p><p><b>description</b>: </p><div><p>Laparoscopic Adjustable Gastric Banding LAGB gastric bypass vs. medical treatment (Conventional Diabetes Therapy)</p>\n</div><p><b>note</b>: exposure</p><p><b>intended</b>: <a href=\"EvidenceVariable-172427.html\">GroupAssignment: Bariatric Surgery vs. no bariatric surgery</a></p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code</b>: outcome</p><p><b>description</b>: </p><div><p>HbA1c at 24 months</p>\n</div><p><b>note</b>: outcome</p><p><b>observed</b>: <a href=\"EvidenceVariable-173246.html\">OutcomeVariable: HbA1c at 24 months</a></p></blockquote><p><b>synthesisType</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/synthesis-type NotApplicable}\">not applicable</span></p><p><b>studyDesign</b>: <span title=\"Codes:{https://fevir.net/resources/CodeSystem/181513 SEVCO:01003}\">randomized assignment</span></p><blockquote><p><b>statistic</b></p><p><b>description</b>: </p><div><p>mean difference -1.20% (95% CI -1.78% to -0.62%)</p>\n</div><p><b>note</b>: Mean HbA1c at 24 months in Dixon 2008 was 6% in Surgery group (n = 30) and 7.2% in Medical/Lifestyle group (n = 30)</p><p><b>statisticType</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/statistic-type 0000457}\">Mean Difference</span></p><p><b>quantity</b>: -1.2 %<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code% = '%')</span></p><h3>SampleSizes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>NumberOfParticipants</b></td><td><b>KnownDataCount</b></td></tr><tr><td style=\"display: none\">*</td><td>60</td><td>60</td></tr></table><h3>AttributeEstimates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Description</b></td><td><b>Type</b></td><td><b>Level</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td><div><p>95% CI -1.78% to -0.62%</p>\n</div></td><td><span title=\"Codes:{http://terminology.hl7.org/CodeSystem/attribute-estimate-type C53324}\">Confidence interval</span></td><td>0.95</td><td>-1.78--0.62 %</td></tr></table></blockquote></div>"
  ] ; # 
  fhir:url [ fhir:v "https://fevir.net/resources/Evidence/47760"^^xsd:anyURI] ; # 
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fhir:text [ fhir:v "FEvIR Object Identifier" ]     ] ;
fhir:system [ fhir:v "https://fevir.net"^^xsd:anyURI ] ;
fhir:value [ fhir:v "47760" ] ;
fhir:assigner [
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fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.40.44.22.19" ]
  ] ) ; # 
  fhir:version [ fhir:v "2.0.0-ballot"] ; # 
  fhir:name [ fhir:v "ComparativeEvidence_Mean_difference_in_HbA1c_between_Surgery_and_Medical_Lifestyle_groups_in_Dixon_2008"] ; # 
  fhir:title [ fhir:v "ComparativeEvidence: Mean difference in HbA1c between Surgery and Medical/Lifestyle groups in Dixon 2008"] ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:date [ fhir:v "2022-05-29T11:01:34.008Z"^^xsd:dateTime] ; # 
  fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; # 
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fhir:name [ fhir:v "HL7 International / Clinical Decision Support" ] ;
    ( fhir:telecom [
fhir:system [ fhir:v "url" ] ;
fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ]     ] )
  ] ) ; # 
  fhir:author ( [
fhir:name [ fhir:v "Brian S. Alper" ]
  ] ) ; # 
  fhir:useContext ( [
fhir:code [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "evidence-communication" ] ;
fhir:display [ fhir:v "Evidence Communication" ]     ] ;
fhir:value [
a fhir:CodeableConcept ;
      ( fhir:coding [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "ComparativeEvidence" ] ;
fhir:display [ fhir:v "ComparativeEvidence" ]       ] )     ]
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fhir:code [
fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "evidence-communication" ] ;
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fhir:value [
a fhir:CodeableConcept ;
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fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/179423"^^xsd:anyURI ] ;
fhir:code [ fhir:v "SingleStudyEvidence" ] ;
fhir:display [ fhir:v "SingleStudyEvidence" ]       ] )     ]
  ] ) ; # 
  fhir:copyright [ fhir:v "https://creativecommons.org/licenses/by-nc-sa/4.0/"] ; # 
  fhir:relatedArtifact ( [
fhir:type [ fhir:v "derived-from" ] ;
fhir:label [ fhir:v "data source" ] ;
fhir:display [ fhir:v "Figure 2C" ] ;
fhir:citation [ fhir:v "Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations [Journal Article]. Contributors: Francesco Rubino, David M Nathan, Robert H Eckel, Philip R Schauer, K George M M Alberti, Paul Z Zimmet, Stefano Del Prato, Linong Ji, Shaukat M Sadikot, William H Herman, Stephanie A Amiel, Lee M Kaplan, Gaspar Taroncher-Oldenburg, David E Cummings, Delegates of the 2nd Diabetes Surgery Summit. In: Diabetes care, PMID 27222544. Published June 2016. Available at: https://pubmed.ncbi.nlm.nih.gov/27222544/." ] ;
fhir:document [
fhir:url [ fhir:v "https://diabetesjournals.org/care/article/39/6/861/29305/Metabolic-Surgery-in-the-Treatment-Algorithm-for"^^xsd:anyURI ]     ]
  ] [
fhir:type [ fhir:v "cite-as" ] ;
fhir:citation [ fhir:v "ComparativeEvidence: Mean difference in HbA1c between Surgery and Medical/Lifestyle groups in Dixon 2008 [Evidence]. Contributors: In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 47760. Revised 2022-05-29. Available at: https://fevir.net/resources/Evidence/47760. Computable resource at: https://fevir.net/resources/Evidence/47760." ]
  ] ) ; # 
  fhir:description [ fhir:v "Mean HbA1c at 24 months in Dixon 2008 was 6% in Surgery group (n = 30) and 7.2% in Medical/Lifestyle group (n = 30), mean difference -1.20% (95% CI -1.78% to -0.62%)"] ; # 
  fhir:variableDefinition ( [
    ( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "population" ]     ] ) ;
fhir:description [ fhir:v "60 Patients with BMI>30 and BMI<40 and T2DM diagnosed in the last 2 years" ] ;
    ( fhir:note [
fhir:text [ fhir:v "population" ]     ] ) ;
fhir:observed [
fhir:type [ fhir:v "Group"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Dixon 2008 Trial Enrollment Group" ]     ]
  ] [
    ( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "exposure" ]     ] [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-comparator-category"^^xsd:anyURI ] ;
fhir:value [ fhir:v "no bariatric surgery" ]     ] ) ;
fhir:description [ fhir:v "Laparoscopic Adjustable Gastric Banding LAGB gastric bypass vs. medical treatment (Conventional Diabetes Therapy)" ] ;
    ( fhir:note [
fhir:text [ fhir:v "exposure" ]     ] ) ;
fhir:intended [
fhir:reference [ fhir:v "EvidenceVariable/172427" ] ;
fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
fhir:display [ fhir:v "GroupAssignment: Bariatric Surgery vs. no bariatric surgery" ]     ]
  ] [
    ( fhir:extension [
fhir:url [ fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/variable-definition-variable-role-code"^^xsd:anyURI ] ;
fhir:value [ fhir:v "outcome" ]     ] ) ;
fhir:description [ fhir:v "HbA1c at 24 months" ] ;
    ( fhir:note [
fhir:text [ fhir:v "outcome" ]     ] ) ;
fhir:observed [
fhir:reference [ fhir:v "EvidenceVariable/173246" ] ;
fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
fhir:display [ fhir:v "OutcomeVariable: HbA1c at 24 months" ]     ]
  ] ) ; # 
  fhir:synthesisType [
    ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/synthesis-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "NotApplicable" ] ;
fhir:display [ fhir:v "not applicable" ]     ] )
  ] ; # 
  fhir:studyDesign ( [
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fhir:system [ fhir:v "https://fevir.net/resources/CodeSystem/181513"^^xsd:anyURI ] ;
fhir:code [ fhir:v "SEVCO:01003" ] ;
fhir:display [ fhir:v "randomized assignment" ]     ] )
  ] ) ; # 
  fhir:statistic ( [
fhir:description [ fhir:v "mean difference -1.20% (95% CI -1.78% to -0.62%)" ] ;
    ( fhir:note [
fhir:text [ fhir:v "Mean HbA1c at 24 months in Dixon 2008 was 6% in Surgery group (n = 30) and 7.2% in Medical/Lifestyle group (n = 30)" ]     ] ) ;
fhir:statisticType [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/statistic-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "0000457" ] ;
fhir:display [ fhir:v "Mean Difference" ]       ] )     ] ;
fhir:quantity [
fhir:value [ fhir:v "-1.2"^^xsd:decimal ] ;
fhir:unit [ fhir:v "%" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "%" ]     ] ;
fhir:sampleSize [
fhir:numberOfParticipants [ fhir:v "60"^^xsd:nonNegativeInteger ] ;
fhir:knownDataCount [ fhir:v "60"^^xsd:nonNegativeInteger ]     ] ;
    ( fhir:attributeEstimate [
fhir:description [ fhir:v "95% CI -1.78% to -0.62%" ] ;
fhir:type [
        ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/attribute-estimate-type"^^xsd:anyURI ] ;
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fhir:display [ fhir:v "Confidence interval" ]         ] )       ] ;
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fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "%" ]         ]       ]     ] )
  ] ) . #