Evidence Based Medicine on FHIR Implementation Guide
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Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

Example Evidence: Mean Change in Blood Urea Nitrogen at 12 weeks for Candesartan in NCT03640312

version: 26; Last updated: 2025-08-18 13:22:42+0000

Profile: NonComparativeEvidence

ArtifactPublicationStatus: Active

url: https://fevir.net/resources/Evidence/367938

identifier: FEvIR Object Identifier/367938, FEvIR Linking Identifier/NCT03640312-otherOutcomeMeasure-5--OG001

name: NCT03640312_otherOutcomeMeasure_5_OG001

title: Mean Change in Blood Urea Nitrogen at 12 weeks for Candesartan in NCT03640312

citeAs:

Mean Change in Blood Urea Nitrogen at 12 weeks for Candesartan in NCT03640312 [Database Entry: FHIR Evidence Resource]. Contributors: Computable Publishing®: ClinicalTrials.gov-to-FEvIR Converter [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 367938. Revised 2025-08-18. Available at: https://fevir.net/resources/Evidence/367938. Computable resource at: https://fevir.net/resources/Evidence/367938#json.

status: Active

author: Computable Publishing®: ClinicalTrials.gov-to-FEvIR Converter:

publisher: Computable Publishing LLC

contact: support@computablepublishing.com

copyright:

https://creativecommons.org/licenses/by-nc-sa/4.0/

description:

This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide.

variableDefinition

description:

Candesartan

note: ,

Outcome Measure Population Description: Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.

Outcome Measure Denominator Units: Participants

variableRole: Population

observed: Patients randomized to the comparison arm took a once daily 8mg candesartan. Candesartan: Standard monotherapy of 8mg candesartan. Taken once daily for 12 weeks. (Identifier: ClinicalTrials.gov Outcome Measurement Group Id/OG001)

variableDefinition

variableRole: Outcome

observed: Mean Change in Blood Urea Nitrogen at 12 weeks - (NCT03640312)

statistic

statisticType: mean

quantity: -0.4 mg/dL

SampleSizes

-KnownDataCount
*30

AttributeEstimates

-TypeQuantity
*Standard Deviation7.11 mg/dL