Evidence Based Medicine on FHIR Implementation Guide
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Evidence Based Medicine on FHIR Implementation Guide, published by HL7 International / Clinical Decision Support. This guide is not an authorized publication; it is the continuous build for version 1.0.0-ballot2 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/HL7/ebm/ and changes regularly. See the Directory of published versions

: Mean Systolic Blood Pressure at 6 weeks for QUARTET LDQT in NCT03640312 - TTL Representation

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:Evidence ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "367905"] ; # 
  fhir:meta [
fhir:versionId [ fhir:v "26" ] ;
fhir:lastUpdated [ fhir:v "2025-08-18T13:22:42.074Z"^^xsd:dateTime ] ;
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/uv/ebm/StructureDefinition/non-comparative-evidence"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/uv/ebm/StructureDefinition/non-comparative-evidence>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "extensions" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Evidence 367905</b></p><a name=\"367905\"> </a><a name=\"hc367905\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">version: 26; Last updated: 2025-08-18 13:22:42+0000</p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-non-comparative-evidence.html\">NonComparativeEvidence</a></p></div><p><b>ArtifactPublicationStatus</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/cited-artifact-status-type active}\">Active</span></p><p><b>url</b>: <a href=\"https://fevir.net/resources/Evidence/367905\">https://fevir.net/resources/Evidence/367905</a></p><p><b>identifier</b>: FEvIR Object Identifier/367905, FEvIR Linking Identifier/NCT03640312-secondaryOutcomeMeasure-0--OG000</p><p><b>name</b>: NCT03640312_secondaryOutcomeMeasure_0_OG000</p><p><b>title</b>: Mean Systolic Blood Pressure at 6 weeks for QUARTET LDQT in NCT03640312</p><p><b>citeAs</b>: </p><div><p>Mean Systolic Blood Pressure at 6 weeks for QUARTET LDQT in NCT03640312 [Database Entry: FHIR Evidence Resource]. Contributors: Computable Publishing®: ClinicalTrials.gov-to-FEvIR Converter [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 367905. Revised 2025-08-18. Available at: https://fevir.net/resources/Evidence/367905. Computable resource at: https://fevir.net/resources/Evidence/367905#json.</p>\n</div><p><b>status</b>: Active</p><p><b>author</b>: Computable Publishing®: ClinicalTrials.gov-to-FEvIR Converter: </p><p><b>publisher</b>: Computable Publishing LLC</p><p><b>contact</b>: <a href=\"mailto:support@computablepublishing.com\">support@computablepublishing.com</a></p><p><b>copyright</b>: </p><div><p>https://creativecommons.org/licenses/by-nc-sa/4.0/</p>\n</div><p><b>description</b>: </p><div><p>This Evidence Resource is referenced in an example for the EBMonFHIR Implementation Guide.</p>\n</div><blockquote><p><b>variableDefinition</b></p><p><b>description</b>: </p><div><p>QUARTET LDQT</p>\n</div><p><b>note</b>: , </p><blockquote><div><p>Outcome Measure Population Description: Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol.</p>\n</div></blockquote><blockquote><div><p>Outcome Measure Denominator Units: Participants</p>\n</div></blockquote><p><b>variableRole</b>: Population</p><p><b>observed</b>: Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks. (Identifier: ClinicalTrials.gov Outcome Measurement Group Id/OG000)</p></blockquote><blockquote><p><b>variableDefinition</b></p><p><b>variableRole</b>: Outcome</p><p><b>observed</b>: <a href=\"EvidenceVariable-367883.html\">Mean Systolic Blood Pressure at 6 weeks -  (NCT03640312)</a></p></blockquote><blockquote><p><b>statistic</b></p><p><b>statisticType</b>: <span title=\"Codes:\">Least Squares Mean</span></p><p><b>quantity</b>: 122.37 mm Hg</p><h3>SampleSizes</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>KnownDataCount</b></td></tr><tr><td style=\"display: none\">*</td><td>32</td></tr></table><h3>AttributeEstimates</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Type</b></td><td><b>Range</b></td></tr><tr><td style=\"display: none\">*</td><td><span title=\"Codes:\">95% Confidence Interval</span></td><td>118.32-126.42 mm Hg</td></tr></table></blockquote></div>"^^rdf:XMLLiteral
  ] ; # 
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  fhir:title [ fhir:v "Mean Systolic Blood Pressure at 6 weeks for QUARTET LDQT in NCT03640312"] ; # 
  fhir:citeAs [ fhir:v "Mean Systolic Blood Pressure at 6 weeks for QUARTET LDQT in NCT03640312 [Database Entry: FHIR Evidence Resource]. Contributors: Computable Publishing®: ClinicalTrials.gov-to-FEvIR Converter [Authors/Creators]. In: Fast Evidence Interoperability Resources (FEvIR) Platform, FOI 367905. Revised 2025-08-18. Available at: https://fevir.net/resources/Evidence/367905. Computable resource at: https://fevir.net/resources/Evidence/367905#json."] ; # 
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fhir:description [ fhir:v "QUARTET LDQT" ] ;
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fhir:text [ fhir:v "Outcome Measure Population Description: Modified intent to treat whereby all those participants with data at any follow-up time point and baseline to contribute to analyses will be included in analyses according to arm to which they were randomized, regardless of adherence to the study protocol." ]     ] [
fhir:text [ fhir:v "Outcome Measure Denominator Units: Participants" ]     ] ) ;
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fhir:display [ fhir:v "Patients randomized to the intervention arm took a once daily ultra-low-dose quadruple combination therapy (QUARTET LDQT). The LDQT is an overencapsulated combination pill comprising four types of blood pressure lowering medications each at ¼ standard doses. QUARTET includes candesartan 2mg, amlodipine besylate 1.25mg, indapamide 0.625mg, and bisoprolol 2.5mg. The individual components are currently approved and marketed within the United States.\n\nQUARTET LDQT: Ultra-low-dose combination therapy comprising four different blood pressure lowering drugs at 1/4 dosages. Taken once daily for 12 weeks." ]     ]
  ] [
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fhir:display [ fhir:v "Mean Systolic Blood Pressure at 6 weeks -  (NCT03640312)" ]     ]
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  fhir:statistic ( [
fhir:statisticType [
fhir:text [ fhir:v "Least Squares Mean" ]     ] ;
fhir:quantity [
fhir:value [ fhir:v 122.37 ] ;
fhir:unit [ fhir:v "mm Hg" ]     ] ;
fhir:sampleSize [
fhir:knownDataCount [ fhir:v "32"^^xsd:nonNegativeInteger ]     ] ;
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fhir:text [ fhir:v "95% Confidence Interval" ]       ] ;
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fhir:value [ fhir:v 118.32 ] ;
fhir:unit [ fhir:v "mm Hg" ]         ] ;
fhir:high [
fhir:value [ fhir:v 126.42 ] ;
fhir:unit [ fhir:v "mm Hg" ]         ]       ]     ] )
  ] ) . #