Risk of fatal ICH with alteplase for stroke

@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<http://hl7.org/fhir/Evidence/example-stroke-alteplase-fatalICH> a fhir:Evidence ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "example-stroke-alteplase-fatalICH"] ; # 
  fhir:text [
     fhir:status [ fhir:v "generated" ] ;
     fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      \n      <p>\n        \"Risk of fatal ICH with alteplase for stroke\" is a univariate risk estimate.\n      </p>\n	\n    </div>"^^rdf:XMLLiteral
  ] ; # 
  fhir:extension ( [
     fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg"^^xsd:anyURI ] ;
     fhir:value [
       a fhir:code ;
       fhir:v "cds"
     ]
  ] ) ; # 
  fhir:url [ fhir:v "http://hl7.org/fhir/Evidence/example-stroke-alteplase-fatalICH"^^xsd:anyURI] ; # 
  fhir:identifier ( [
     fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ;
     fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.10.1" ]
  ] ) ; # 
  fhir:name [ fhir:v "RiskOfFatalICHWithAlteplaseForStroke"] ; # 
  fhir:title [ fhir:v "Risk of fatal ICH with alteplase for stroke"] ; # 
  fhir:status [ fhir:v "draft"] ; # 
  fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; # 
  fhir:contact ( [
     fhir:telecom ( [
       fhir:system [ fhir:v "url" ] ;
       fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ]
     ] )
  ] ) ; # 
  fhir:relatesTo ( [
     fhir:type [
       fhir:coding ( [
         fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/artifact-relationship-type"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "cites" ] ;
         fhir:display [ fhir:v "Cites" ]
       ] )
     ] ;
     fhir:target [
       a fhir:markdown ;
       fhir:v "Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. <b>Citation:</b> Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063 <b>URL:</b> https://doi.org/10.1016/S0140-6736(14)60584-5"
     ]
  ] ) ; # 
  fhir:description [ fhir:v "2.7% incidence of fatal intracranial hemorrhage within 7 days with alteplase in patients with acute ischemic stroke"] ; # 
  fhir:variableDefinition ( [
     fhir:variableRole [ fhir:v "population" ] ;
     fhir:observed [
       fhir:link <http://hl7.org/fhir/Group/Emberson-2014-IPD-MA-Alteplase-Cohort> ;
       fhir:reference [ fhir:v "Group/Emberson-2014-IPD-MA-Alteplase-Cohort" ] ;
       fhir:type [ fhir:v "Group"^^xsd:anyURI ] ;
       fhir:display [ fhir:v "Emberson 2014 IPD-MA Alteplase Cohort" ]
     ] ;
     fhir:intended [
       fhir:link <http://hl7.org/fhir/Group/AcuteIschemicStrokeTreatedWithAlteplase> ;
       fhir:reference [ fhir:v "Group/AcuteIschemicStrokeTreatedWithAlteplase" ] ;
       fhir:type [ fhir:v "Group"^^xsd:anyURI ] ;
       fhir:display [ fhir:v "adults with acute ischemic stroke treated with alteplase" ]
     ]
  ] [
     fhir:variableRole [ fhir:v "outcome" ] ;
     fhir:observed [
       fhir:link <http://hl7.org/fhir/EvidenceVariable/example-fatal-ICH-in-7-days> ;
       fhir:reference [ fhir:v "EvidenceVariable/example-fatal-ICH-in-7-days" ] ;
       fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
       fhir:display [ fhir:v "fatal ICH" ]
     ] ;
     fhir:intended [
       fhir:link <http://hl7.org/fhir/EvidenceVariable/example-fatal-ICH-in-7-days> ;
       fhir:reference [ fhir:v "EvidenceVariable/example-fatal-ICH-in-7-days" ] ;
       fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
       fhir:display [ fhir:v "fatal ICH" ]
     ]
  ] ) ; # 
  fhir:synthesisType ( [
     fhir:coding ( [
       fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/synthesis-type"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "IPD-MA" ] ;
       fhir:display [ fhir:v "individual patient data meta-analysis" ]
     ] )
  ] ) ; # 
  fhir:studyDesign ( [
     fhir:coding ( [
       fhir:system [ fhir:v "http://hl7.org/fhir/study-design"^^xsd:anyURI ] ;
       fhir:code [ fhir:v "SEVCO:01003" ] ;
       fhir:display [ fhir:v "randomized assignment" ]
     ] )
  ] ) ; # 
  fhir:statistic ( [
     fhir:statisticType [
       fhir:coding ( [
         fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/statistic-type"^^xsd:anyURI ] ;
         fhir:code [ fhir:v "C44256" ] ;
         fhir:display [ fhir:v "Proportion" ]
       ] )
     ] ;
     fhir:quantity [
       fhir:value [ fhir:v 0.026835741669 ]
     ] ;
     fhir:numberOfEvents [ fhir:v "91"^^xsd:nonNegativeInteger ] ;
     fhir:sampleSize [
       fhir:numberOfStudies [ fhir:v "9"^^xsd:nonNegativeInteger ] ;
       fhir:numberOfParticipants [ fhir:v "3391"^^xsd:nonNegativeInteger ]
     ]
  ] ) . # 

<http://hl7.org/fhir/Group/Emberson-2014-IPD-MA-Alteplase-Cohort> a fhir:Group .

<http://hl7.org/fhir/Group/AcuteIschemicStrokeTreatedWithAlteplase> a fhir:Group .

<http://hl7.org/fhir/EvidenceVariable/example-fatal-ICH-in-7-days> a fhir:EvidenceVariable .

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