FHIR CI-Build
Clinical ReasoningThis is the Continuous Integration Build of FHIR (will be incorrect/inconsistent at times).
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| Clinical Decision Support Work Group | Maturity Level: N/A | Standards Status: Informative | Compartments: No defined compartments |
Raw Turtle (+ also see Turtle/RDF Format Specification)
Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior
@prefix fhir: <http://hl7.org/fhir/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
# - resource -------------------------------------------------------------------
<http://hl7.org/fhir/Evidence/example-stroke-0-3-alteplase-vs-no-alteplase-mRS3-6> a fhir:Evidence ;
fhir:nodeRole fhir:treeRoot ;
fhir:id [ fhir:v "example-stroke-0-3-alteplase-vs-no-alteplase-mRS3-6"] ; #
fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n \n <p>\n \"Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior\" is a comparative effect estimate.\n </p>\n \n </div>"^^rdf:XMLLiteral
] ; #
fhir:extension ( [
fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg"^^xsd:anyURI ] ;
fhir:value [
a fhir:code ;
fhir:v "cds"
]
] ) ; #
fhir:url [ fhir:v "http://hl7.org/fhir/Evidence/example-stroke-0-3-alteplase-vs-no-alteplase-mRS3-6"^^xsd:anyURI] ; #
fhir:identifier ( [
fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ;
fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.10.5" ]
] ) ; #
fhir:name [ fhir:v "EffectOfAlteplaseVsNoAlteplaseOnMRS36At90DaysInStroke03HoursPrior"] ; #
fhir:title [ fhir:v "Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior"] ; #
fhir:status [ fhir:v "draft"] ; #
fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; #
fhir:contact ( [
fhir:telecom ( [
fhir:system [ fhir:v "url" ] ;
fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ]
] )
] ) ; #
fhir:relatesTo ( [
fhir:type [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/artifact-relationship-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "cites" ] ;
fhir:display [ fhir:v "Cites" ]
] )
] ;
fhir:target [
a fhir:markdown ;
fhir:v "Analysis 1.16 from Wardlaw 2014 <b>Citation:</b> Wardlaw JM, Murray V, Berge E, del Zoppo GJ. Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev. 2014 Jul 29(7):CD000213. PMID 25072528 <b>URL:</b> https://doi.org/10.1002/14651858.CD000213.pub3"
]
] ) ; #
fhir:description [ fhir:v "mRS 3-6 at 90 days Odds Ratio 0.65 for Alteplase vs. No Alteplase in patients with acute ischemic stroke 0-3 hours prior"] ; #
fhir:variableDefinition ( [
fhir:variableRole [ fhir:v "population" ] ;
fhir:observed [
fhir:link <http://hl7.org/fhir/EvidenceVariable/Wardlaw2014Analysis1.16.3EvidenceSet> ;
fhir:reference [ fhir:v "EvidenceVariable/Wardlaw2014Analysis1.16.3EvidenceSet" ] ;
fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Wardlaw 2014 Analysis 1.16.3 Evidence set" ]
] ;
fhir:intended [
fhir:link <http://hl7.org/fhir/Group/AcuteIschemicStroke0-3Hours> ;
fhir:reference [ fhir:v "Group/AcuteIschemicStroke0-3Hours" ] ;
fhir:type [ fhir:v "Group"^^xsd:anyURI ] ;
fhir:display [ fhir:v "stroke at 0-3 hours" ]
]
] [
fhir:variableRole [ fhir:v "outcome" ] ;
fhir:observed [
fhir:link <http://hl7.org/fhir/EvidenceVariable/example-mRS3-6-at-90days> ;
fhir:reference [ fhir:v "EvidenceVariable/example-mRS3-6-at-90days" ] ;
fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
fhir:display [ fhir:v "mRS 3-6 at 90 days" ]
] ;
fhir:intended [
fhir:link <http://hl7.org/fhir/EvidenceVariable/example-dead-or-dependent-90day> ;
fhir:reference [ fhir:v "EvidenceVariable/example-dead-or-dependent-90day" ] ;
fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Dead or functionally dependent at 90 days" ]
]
] [
fhir:variableRole [ fhir:v "exposure" ] ;
fhir:comparatorCategory [ fhir:v "No Alteplase" ] ;
fhir:observed [
fhir:link <http://hl7.org/fhir/EvidenceVariable/example-group-assignment-alteplase-for-stroke-vs-no-alteplase> ;
fhir:reference [ fhir:v "EvidenceVariable/example-group-assignment-alteplase-for-stroke-vs-no-alteplase" ] ;
fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ;
fhir:display [ fhir:v "Group Assignment: Alteplase for Stroke vs No Alteplase" ]
]
] ) ; #
fhir:synthesisType ( [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/synthesis-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "std-MA" ] ;
fhir:display [ fhir:v "summary data meta-analysis" ]
] )
] ) ; #
fhir:studyDesign ( [
fhir:coding ( [
fhir:system [ fhir:v "http://hl7.org/fhir/study-design"^^xsd:anyURI ] ;
fhir:code [ fhir:v "SEVCO:01003" ] ;
fhir:display [ fhir:v "randomized assignment" ]
] )
] ) ; #
fhir:statistic ( [
fhir:statisticType [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/statistic-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C16932" ] ;
fhir:display [ fhir:v "Odds Ratio" ]
] )
] ;
fhir:quantity [
fhir:value [ fhir:v 0.65 ]
] ;
fhir:numberOfEvents [ fhir:v "1137"^^xsd:nonNegativeInteger ] ;
fhir:sampleSize [
fhir:numberOfStudies [ fhir:v "6"^^xsd:nonNegativeInteger ] ;
fhir:numberOfParticipants [ fhir:v "1779"^^xsd:nonNegativeInteger ]
] ;
fhir:attributeEstimate ( [
fhir:description [ fhir:v "95% CI 0.54 to 0.80" ] ;
fhir:type [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/attribute-estimate-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C53324" ] ;
fhir:display [ fhir:v "Confidence interval" ]
] )
] ;
fhir:level [ fhir:v 0.95 ] ;
fhir:range [
fhir:low [
fhir:value [ fhir:v 0.54 ]
] ;
fhir:high [
fhir:value [ fhir:v 0.8 ]
]
]
] [
fhir:description [ fhir:v "P-value = 0.000023" ] ;
fhir:type [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/attribute-estimate-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C44185" ] ;
fhir:display [ fhir:v "P-value" ]
] )
] ;
fhir:quantity [
fhir:value [ fhir:v 0.000023 ]
]
] [
fhir:description [ fhir:v "Heterogeneity I-sq = 0.0%" ] ;
fhir:type [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/attribute-estimate-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "0000420" ] ;
fhir:display [ fhir:v "I-squared" ]
] )
] ;
fhir:quantity [
fhir:value [ fhir:v "0"^^xsd:decimal ] ;
fhir:unit [ fhir:v "%" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "%" ]
]
] )
] ) ; #
fhir:certainty ( [
fhir:description [ fhir:v "Moderate certainty due to risk of bias" ] ;
fhir:type [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/certainty-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Overall" ] ;
fhir:display [ fhir:v "Overall certainty" ]
] )
] ;
fhir:rating [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/certainty-rating"^^xsd:anyURI ] ;
fhir:code [ fhir:v "moderate" ] ;
fhir:display [ fhir:v "Moderate quality" ]
] )
] ;
fhir:subcomponent ( [
fhir:type [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/certainty-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "PublicationBias" ] ;
fhir:display [ fhir:v "Publication bias" ]
] )
] ;
fhir:rating [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/certainty-rating"^^xsd:anyURI ] ;
fhir:code [ fhir:v "no-concern" ] ;
fhir:display [ fhir:v "no serious concern" ]
] )
]
] [
fhir:type [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/certainty-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Inconsistency" ] ;
fhir:display [ fhir:v "Inconsistency" ]
] )
] ;
fhir:rating [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/certainty-rating"^^xsd:anyURI ] ;
fhir:code [ fhir:v "no-concern" ] ;
fhir:display [ fhir:v "no serious concern" ]
] )
]
] [
fhir:type [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/certainty-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Imprecision" ] ;
fhir:display [ fhir:v "Imprecision" ]
] )
] ;
fhir:rating [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/certainty-rating"^^xsd:anyURI ] ;
fhir:code [ fhir:v "no-concern" ] ;
fhir:display [ fhir:v "no serious concern" ]
] )
]
] [
fhir:type [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/certainty-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "Indirectness" ] ;
fhir:display [ fhir:v "Indirectness" ]
] )
] ;
fhir:rating [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/certainty-rating"^^xsd:anyURI ] ;
fhir:code [ fhir:v "no-concern" ] ;
fhir:display [ fhir:v "no serious concern" ]
] )
]
] [
fhir:note ( [
fhir:text [ fhir:v "results largely influenced by IST-3 trial which was unblinded and NINDS trial which had allocation concealment not stated and baseline imbalances" ]
] ) ;
fhir:type [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/certainty-type"^^xsd:anyURI ] ;
fhir:code [ fhir:v "RiskOfBias" ] ;
fhir:display [ fhir:v "Risk of bias" ]
] )
] ;
fhir:rating [
fhir:coding ( [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/certainty-rating"^^xsd:anyURI ] ;
fhir:code [ fhir:v "serious-concern" ] ;
fhir:display [ fhir:v "serious concern" ]
] )
]
] )
] ) . #
<http://hl7.org/fhir/EvidenceVariable/Wardlaw2014Analysis1.16.3EvidenceSet> a fhir:EvidenceVariable .
<http://hl7.org/fhir/Group/AcuteIschemicStroke0-3Hours> a fhir:Group .
<http://hl7.org/fhir/EvidenceVariable/example-mRS3-6-at-90days> a fhir:EvidenceVariable .
<http://hl7.org/fhir/EvidenceVariable/example-dead-or-dependent-90day> a fhir:EvidenceVariable .
<http://hl7.org/fhir/EvidenceVariable/example-group-assignment-alteplase-for-stroke-vs-no-alteplase> a fhir:EvidenceVariable .
# -------------------------------------------------------------------------------------
Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.
FHIR ®© HL7.org 2011+. FHIR R6 hl7.fhir.core#6.0.0-ballot3 generated on Thu, Oct 23, 2025 23:16+0000.
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