This is the Continuous Integration Build of FHIR (will be incorrect/inconsistent at times).
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Clinical Decision Support Work Group | Maturity Level: N/A | Standards Status: Informative | Compartments: No defined compartments |
Raw Turtle (+ also see Turtle/RDF Format Specification)
Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior
@prefix fhir: <http://hl7.org/fhir/> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . # - resource ------------------------------------------------------------------- [a fhir:Evidence ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "example-stroke-0-3-alteplase-vs-no-alteplase-mRS3-6"] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n \n <p>\n "Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior" is a comparative effect estimate.\n </p>\n \n </div>" ] ; # fhir:extension ( [ fhir:url [ fhir:v "http://hl7.org/fhir/StructureDefinition/structuredefinition-wg"^^xsd:anyURI ] ; fhir:value [ fhir:v "cds" ] ] ) ; # fhir:url [ fhir:v "http://hl7.org/fhir/Evidence/example-stroke-0-3-alteplase-vs-no-alteplase-mRS3-6"^^xsd:anyURI] ; # fhir:identifier ( [ fhir:system [ fhir:v "urn:ietf:rfc:3986"^^xsd:anyURI ] ; fhir:value [ fhir:v "urn:oid:2.16.840.1.113883.4.642.10.5" ] ] ) ; # fhir:name [ fhir:v "EffectOfAlteplaseVsNoAlteplaseOnMRS36At90DaysInStroke03HoursPrior"] ; # fhir:title [ fhir:v "Effect of Alteplase vs No alteplase on mRS 3-6 at 90 days in Stroke 0-3 hours prior"] ; # fhir:status [ fhir:v "draft"] ; # fhir:publisher [ fhir:v "HL7 International / Clinical Decision Support"] ; # fhir:contact ( [ fhir:telecom ( [ fhir:system [ fhir:v "url" ] ; fhir:value [ fhir:v "http://www.hl7.org/Special/committees/dss" ] ] ) ] ) ; # fhir:relatedArtifact ( [ fhir:type [ fhir:v "citation" ] ; fhir:label [ fhir:v "Wardlaw 2014" ] ; fhir:display [ fhir:v "Analysis 1.16 from Wardlaw 2014" ] ; fhir:citation [ fhir:v "Wardlaw JM, Murray V, Berge E, del Zoppo GJ. Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev. 2014 Jul 29(7):CD000213. PMID 25072528" ] ; fhir:document [ fhir:url [ fhir:v "https://doi.org/10.1002/14651858.CD000213.pub3"^^xsd:anyURI ] ] ] ) ; # fhir:description [ fhir:v "mRS 3-6 at 90 days Odds Ratio 0.65 for Alteplase vs. No Alteplase in patients with acute ischemic stroke 0-3 hours prior"] ; # fhir:variableDefinition ( [ fhir:variableRole [ fhir:v "population" ] ; fhir:observed [ fhir:reference [ fhir:v "EvidenceVariable/Wardlaw2014Analysis1.16.3EvidenceSet" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ; fhir:display [ fhir:v "Wardlaw 2014 Analysis 1.16.3 Evidence set" ] ] ; fhir:intended [ fhir:reference [ fhir:v "Group/AcuteIschemicStroke0-3Hours" ] ; fhir:type [ fhir:v "Group"^^xsd:anyURI ] ; fhir:display [ fhir:v "stroke at 0-3 hours" ] ] ] [ fhir:variableRole [ fhir:v "outcome" ] ; fhir:observed [ fhir:reference [ fhir:v "EvidenceVariable/example-mRS3-6-at-90days" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ; fhir:display [ fhir:v "mRS 3-6 at 90 days" ] ] ; fhir:intended [ fhir:reference [ fhir:v "EvidenceVariable/example-dead-or-dependent-90day" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ; fhir:display [ fhir:v "Dead or functionally dependent at 90 days" ] ] ] [ fhir:variableRole [ fhir:v "exposure" ] ; fhir:comparatorCategory [ fhir:v "No Alteplase" ] ; fhir:observed [ fhir:reference [ fhir:v "EvidenceVariable/example-group-assignment-alteplase-for-stroke-vs-no-alteplase" ] ; fhir:type [ fhir:v "EvidenceVariable"^^xsd:anyURI ] ; fhir:display [ fhir:v "Group Assignment: Alteplase for Stroke vs No Alteplase" ] ] ] ) ; # fhir:synthesisType [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/synthesis-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "std-MA" ] ; fhir:display [ fhir:v "summary data meta-analysis" ] ] ) ] ; # fhir:studyDesign ( [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/study-design"^^xsd:anyURI ] ; fhir:code [ fhir:v "SEVCO:01003" ] ; fhir:display [ fhir:v "randomized assignment" ] ] ) ] ) ; # fhir:statistic ( [ fhir:statisticType [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/statistic-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "C16932" ] ; fhir:display [ fhir:v "Odds Ratio" ] ] ) ] ; fhir:quantity [ fhir:value [ fhir:v "0.65"^^xsd:decimal ] ] ; fhir:numberOfEvents [ fhir:v "1137"^^xsd:nonNegativeInteger ] ; fhir:sampleSize [ fhir:numberOfStudies [ fhir:v "6"^^xsd:nonNegativeInteger ] ; fhir:numberOfParticipants [ fhir:v "1779"^^xsd:nonNegativeInteger ] ] ; fhir:attributeEstimate ( [ fhir:description [ fhir:v "95% CI 0.54 to 0.80" ] ; fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/attribute-estimate-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "C53324" ] ; fhir:display [ fhir:v "Confidence interval" ] ] ) ] ; fhir:level [ fhir:v "0.95"^^xsd:decimal ] ; fhir:range [ fhir:low [ fhir:value [ fhir:v "0.54"^^xsd:decimal ] ] ; fhir:high [ fhir:value [ fhir:v "0.8"^^xsd:decimal ] ] ] ] [ fhir:description [ fhir:v "P-value = 0.000023" ] ; fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/attribute-estimate-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "C44185" ] ; fhir:display [ fhir:v "P-value" ] ] ) ] ; fhir:quantity [ fhir:value [ fhir:v "0.000023"^^xsd:decimal ] ] ] [ fhir:description [ fhir:v "Heterogeneity I-sq = 0.0%" ] ; fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/attribute-estimate-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "0000420" ] ; fhir:display [ fhir:v "I-squared" ] ] ) ] ; fhir:quantity [ fhir:value [ fhir:v "0"^^xsd:decimal ] ; fhir:unit [ fhir:v "%" ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "%" ] ] ] ) ] ) ; # fhir:certainty ( [ fhir:description [ fhir:v "Moderate certainty due to risk of bias" ] ; fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/certainty-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "Overall" ] ; fhir:display [ fhir:v "Overall certainty" ] ] ) ] ; fhir:rating [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/certainty-rating"^^xsd:anyURI ] ; fhir:code [ fhir:v "moderate" ] ; fhir:display [ fhir:v "Moderate quality" ] ] ) ] ; fhir:subcomponent ( [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/certainty-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "PublicationBias" ] ; fhir:display [ fhir:v "Publication bias" ] ] ) ] ; fhir:rating [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/certainty-rating"^^xsd:anyURI ] ; fhir:code [ fhir:v "no-concern" ] ; fhir:display [ fhir:v "no serious concern" ] ] ) ] ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/certainty-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "Inconsistency" ] ; fhir:display [ fhir:v "Inconsistency" ] ] ) ] ; fhir:rating [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/certainty-rating"^^xsd:anyURI ] ; fhir:code [ fhir:v "no-concern" ] ; fhir:display [ fhir:v "no serious concern" ] ] ) ] ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/certainty-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "Imprecision" ] ; fhir:display [ fhir:v "Imprecision" ] ] ) ] ; fhir:rating [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/certainty-rating"^^xsd:anyURI ] ; fhir:code [ fhir:v "no-concern" ] ; fhir:display [ fhir:v "no serious concern" ] ] ) ] ] [ fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/certainty-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "Indirectness" ] ; fhir:display [ fhir:v "Indirectness" ] ] ) ] ; fhir:rating [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/certainty-rating"^^xsd:anyURI ] ; fhir:code [ fhir:v "no-concern" ] ; fhir:display [ fhir:v "no serious concern" ] ] ) ] ] [ fhir:note ( [ fhir:text [ fhir:v "results largely influenced by IST-3 trial which was unblinded and NINDS trial which had allocation concealment not stated and baseline imbalances" ] ] ) ; fhir:type [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/certainty-type"^^xsd:anyURI ] ; fhir:code [ fhir:v "RiskOfBias" ] ; fhir:display [ fhir:v "Risk of bias" ] ] ) ] ; fhir:rating [ fhir:coding ( [ fhir:system [ fhir:v "http://hl7.org/fhir/certainty-rating"^^xsd:anyURI ] ; fhir:code [ fhir:v "serious-concern" ] ; fhir:display [ fhir:v "serious concern" ] ] ) ] ] ) ] )] . # # -------------------------------------------------------------------------------------
Usage note: every effort has been made to ensure that the examples are correct and useful, but they are not a normative part of the specification.
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