HL7 FHIR Implementation Guide: Common Terminology Criteria (CTC) Adverse Events Release 1 - DRAFT
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HL7 FHIR Implementation Guide: Common Terminology Criteria (CTC) Adverse Events Release 1 - DRAFT, published by HL7 International Clinical Interoperability Council. This guide is not an authorized publication; it is the continuous build for version 0.0.1 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/standardhealth/fsh-ae/ and changes regularly. See the Directory of published versions

: ae-bundle-persona-2 - TTL Representation

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@prefix fhir: <http://hl7.org/fhir/> .
@prefix loinc: <https://loinc.org/rdf/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sct: <http://snomed.info/id/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

 a fhir:Bundle ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "ae-bundle-persona-2"] ; # 
  fhir:type [ fhir:v "collection"] ; # 
  fhir:entry ( [
fhir:fullUrl [ fhir:v "http://example.org/PatientPersona2"^^xsd:anyURI ] ;
    ( fhir:resource <http://example.org/PatientPersona2> )
  ] [
fhir:fullUrl [ fhir:v "http://example.org/ctc-adverse-event-anemia1-persona-2"^^xsd:anyURI ] ;
    ( fhir:resource <http://example.org/ctc-adverse-event-anemia1-persona-2> )
  ] [
fhir:fullUrl [ fhir:v "http://example.org/primary-cancer-condition-persona-2"^^xsd:anyURI ] ;
    ( fhir:resource <http://example.org/primary-cancer-condition-persona-2> )
  ] [
fhir:fullUrl [ fhir:v "http://example.org/medrequest-doxorubicin-persona-2"^^xsd:anyURI ] ;
    ( fhir:resource <http://example.org/medrequest-doxorubicin-persona-2> )
  ] [
fhir:fullUrl [ fhir:v "http://example.org/medadmin-doxorubicin-persona-2"^^xsd:anyURI ] ;
    ( fhir:resource <http://example.org/medadmin-doxorubicin-persona-2> )
  ] [
fhir:fullUrl [ fhir:v "http://example.org/diagnosticreport-cbc-201-1-persona2"^^xsd:anyURI ] ;
    ( fhir:resource <http://example.org/diagnosticreport-cbc-201-1-persona2> )
  ] [
fhir:fullUrl [ fhir:v "http://example.org/diagnosticreport-cbc-202-1-persona2"^^xsd:anyURI ] ;
    ( fhir:resource <http://example.org/diagnosticreport-cbc-202-1-persona2> )
  ] [
fhir:fullUrl [ fhir:v "http://example.org/encounter-ae1-evaluation-persona2"^^xsd:anyURI ] ;
    ( fhir:resource <http://example.org/encounter-ae1-evaluation-persona2> )
  ] ) . # 

<http://example.org/PatientPersona2> a fhir:Patient ;
  fhir:id [ fhir:v "PatientPersona2"] ; # 
  fhir:meta [
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-patient"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-patient>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Patient_PatientPersona2\"> </a><p><b>Generated Narrative: Patient</b><a name=\"PatientPersona2\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Patient &quot;PatientPersona2&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/us/mcode/2021May/StructureDefinition-mcode-cancer-patient.html\">Cancer Patient</a></p></div><p><b>identifier</b>: Medical Record Number/m456 (use: USUAL)</p><p><b>name</b>: Marsha C. </p><p><b>gender</b>: female</p><p><b>birthDate</b>: 1955-02-20</p><p><b>address</b>: 456 Smith Lane Anytown MA 12345 US </p><h3>Contacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Telecom</b></td></tr><tr><td style=\"display: none\">*</td><td>ph: 999-999-9999(HOME), <a href=\"mailto:marsha.c@example.com\">marsha.c@example.com</a></td></tr></table><h3>Communications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Language</b></td></tr><tr><td style=\"display: none\">*</td><td>English <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-ietf3066.html\">Tags for the Identification of Languages</a>#en-US &quot;English (Region=United States)&quot;)</span></td></tr></table></div>"
  ] ; # 
  fhir:identifier ( [
fhir:use [ fhir:v "usual" ] ;
fhir:type [
      ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ;
fhir:code [ fhir:v "MR" ] ;
fhir:display [ fhir:v "Medical Record Number" ]       ] )     ] ;
fhir:system [ fhir:v "http://hospital.example.org"^^xsd:anyURI ] ;
fhir:value [ fhir:v "m456" ]
  ] ) ; # 
  fhir:name ( [
fhir:family [ fhir:v "C." ] ;
    ( fhir:given [ fhir:v "Marsha" ] )
  ] ) ; # 
  fhir:gender [ fhir:v "female"] ; # 
  fhir:birthDate [ fhir:v "1955-02-20"^^xsd:date] ; # 
  fhir:address ( [
    ( fhir:line [ fhir:v "456 Smith Lane" ] ) ;
fhir:city [ fhir:v "Anytown" ] ;
fhir:state [ fhir:v "MA" ] ;
fhir:postalCode [ fhir:v "12345" ] ;
fhir:country [ fhir:v "US" ]
  ] ) ; # 
  fhir:contact ( [
    ( fhir:telecom [
fhir:system [ fhir:v "phone" ] ;
fhir:value [ fhir:v "999-999-9999" ] ;
fhir:use [ fhir:v "home" ]     ] [
fhir:system [ fhir:v "email" ] ;
fhir:value [ fhir:v "marsha.c@example.com" ]     ] )
  ] ) ; # 
  fhir:communication ( [
fhir:language [
      ( fhir:coding [
fhir:system [ fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ] ;
fhir:code [ fhir:v "en-US" ] ;
fhir:display [ fhir:v "English (Region=United States)" ]       ] ) ;
fhir:text [ fhir:v "English" ]     ]
  ] ) . # 

<http://example.org/ctc-adverse-event-anemia1-persona-2> a fhir:AdverseEvent ;
  fhir:id [ fhir:v "ctc-adverse-event-anemia1-persona-2"] ; # 
  fhir:meta [
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/ctc-adverse-event"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/us/ctcae/StructureDefinition/ctc-adverse-event>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "extensions" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"AdverseEvent_ctc-adverse-event-anemia1-persona-2\"> </a><p><b>Generated Narrative: AdverseEvent</b><a name=\"ctc-adverse-event-anemia1-persona-2\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource AdverseEvent &quot;ctc-adverse-event-anemia1-persona-2&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-ctc-adverse-event.html\">CTC Adverse Event</a></p></div><p><b>CTC Adverse Event Grade</b>: Moderate Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ctcae-grade-code-system.html\">CTCAE Grade Code System</a>#2)</span></p><p><b>Adverse Event Expectation</b>: Expected Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C41333)</span></p><p><b>Adverse Event Resolved Date</b>: 2020-12-21</p><p><b>actuality</b>: actual</p><p><b>event</b>: Hgb 9.0 per CBC results from 12/21/20 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (MedDRA Am Engl[20.0]#10002272 &quot;Anemia&quot;)</span></p><p><b>subject</b>: <a href=\"#Patient_PatientPersona2\">See above (Patient/PatientPersona2)</a></p><p><b>encounter</b>: <a href=\"#Encounter_encounter-ae1-evaluation-persona2\">See above (Encounter/encounter-ae1-evaluation-persona2)</a></p><p><b>recorder</b>: <a href=\"Practitioner-us-core-practitioner-nancy-oncology-nurse.html\">Practitioner/us-core-practitioner-nancy-oncology-nurse</a> &quot; NURSE&quot;</p><blockquote><p><b>suspectEntity</b></p><p><b>instance</b>: <a href=\"#MedicationAdministration_medadmin-doxorubicin-persona-2\">See above (MedicationAdministration/medadmin-doxorubicin-persona-2)</a></p><h3>Causalities</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>ProductRelatedness</b></td></tr><tr><td style=\"display: none\">*</td><td>probable</td></tr></table></blockquote><p><b>study</b>: <a href=\"ResearchStudy-clinical-trial-example-soc.html\">ResearchStudy/clinical-trial-example-soc</a></p></div>"
  ] ; # 
  fhir:extension ( [
fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/ctcae-grade"^^xsd:anyURI ] ;
fhir:value [
a fhir:CodeableConcept ;
      ( fhir:coding [
fhir:system [ fhir:v "http://hl7.org/fhir/us/ctcae/CodeSystem/ctcae-grade-code-system"^^xsd:anyURI ] ;
fhir:code [ fhir:v "2" ] ;
fhir:display [ fhir:v "Moderate Adverse Event" ]       ] )     ]
  ] [
fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/adverse-event-expectation"^^xsd:anyURI ] ;
fhir:value [
a fhir:CodeableConcept ;
      ( fhir:coding [
fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ;
fhir:code [ fhir:v "C41333" ] ;
fhir:display [ fhir:v "Expected Adverse Event" ]       ] )     ]
  ] [
fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/adverse-event-resolved-date"^^xsd:anyURI ] ;
fhir:value [ fhir:v "2020-12-21"^^xsd:date ]
  ] ) ; # 
  fhir:actuality [ fhir:v "actual"] ; # 
  fhir:event [
    ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/MDRAE"^^xsd:anyURI ] ;
fhir:version [ fhir:v "20.0" ] ;
fhir:code [ fhir:v "10002272" ] ;
fhir:display [ fhir:v "Anemia" ]     ] ) ;
fhir:text [ fhir:v "Hgb 9.0 per CBC results from 12/21/20" ]
  ] ; # 
  fhir:subject [
fhir:reference [ fhir:v "Patient/PatientPersona2" ]
  ] ; # 
  fhir:encounter [
fhir:reference [ fhir:v "Encounter/encounter-ae1-evaluation-persona2" ]
  ] ; # 
  fhir:recorder [
fhir:reference [ fhir:v "Practitioner/us-core-practitioner-nancy-oncology-nurse" ]
  ] ; # 
  fhir:suspectEntity ( [
fhir:instance [
fhir:reference [ fhir:v "MedicationAdministration/medadmin-doxorubicin-persona-2" ]     ] ;
    ( fhir:causality [
fhir:productRelatedness [ fhir:v "probable" ]     ] )
  ] ) ; # 
  fhir:study ( [
fhir:reference [ fhir:v "ResearchStudy/clinical-trial-example-soc" ]
  ] ) . # 

<http://example.org/primary-cancer-condition-persona-2> a fhir:Condition ;
  fhir:id [ fhir:v "primary-cancer-condition-persona-2"] ; # 
  fhir:meta [
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-primary-cancer-condition"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-primary-cancer-condition>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "extensions" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Condition_primary-cancer-condition-persona-2\"> </a><p><b>Generated Narrative: Condition</b><a name=\"primary-cancer-condition-persona-2\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Condition &quot;primary-cancer-condition-persona-2&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/us/mcode/2021May/StructureDefinition-mcode-primary-cancer-condition.html\">Primary Cancer Condition</a></p></div><p><b>Histology-Morphology-Behavior</b>: Invasive ductal carcinoma with an extensive intraductal component (morphologic abnormality) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#373395001)</span></p><p><b>clinicalStatus</b>: Active <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-condition-clinical.html\">Condition Clinical Status Codes</a>#active)</span></p><p><b>verificationStatus</b>: Confirmed <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-condition-ver-status.html\">ConditionVerificationStatus</a>#confirmed)</span></p><p><b>category</b>: Problem List Item <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-condition-category.html\">Condition Category Codes</a>#problem-list-item)</span></p><p><b>code</b>: Primary malignant neoplasm of female left breast (disorder) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#353431000119107)</span></p><p><b>subject</b>: <a href=\"#Patient_PatientPersona2\">See above (Patient/PatientPersona2)</a></p><p><b>onset</b>: 2020-09-25</p><p><b>asserter</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><h3>Stages</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Summary</b></td></tr><tr><td style=\"display: none\">*</td><td>3C <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (cancerstaging.org#3C)</span></td></tr></table></div>"
  ] ; # 
  fhir:extension ( [
fhir:url [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-histology-morphology-behavior"^^xsd:anyURI ] ;
fhir:value [
a fhir:CodeableConcept ;
      ( fhir:coding [
a sct:373395001 ;
fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ;
fhir:code [ fhir:v "373395001" ] ;
fhir:display [ fhir:v "Invasive ductal carcinoma with an extensive intraductal component (morphologic abnormality)" ]       ] )     ]
  ] ) ; # 
  fhir:clinicalStatus [
    ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/condition-clinical"^^xsd:anyURI ] ;
fhir:code [ fhir:v "active" ]     ] )
  ] ; # 
  fhir:verificationStatus [
    ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/condition-ver-status"^^xsd:anyURI ] ;
fhir:code [ fhir:v "confirmed" ]     ] )
  ] ; # 
  fhir:category ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/condition-category"^^xsd:anyURI ] ;
fhir:code [ fhir:v "problem-list-item" ]     ] )
  ] ) ; # 
  fhir:code [
    ( fhir:coding [
a sct:353431000119107 ;
fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ;
fhir:code [ fhir:v "353431000119107" ] ;
fhir:display [ fhir:v "Primary malignant neoplasm of female left breast (disorder)" ]     ] )
  ] ; # 
  fhir:subject [
fhir:reference [ fhir:v "Patient/PatientPersona2" ]
  ] ; # 
  fhir:onset [ fhir:v "2020-09-25"^^xsd:date] ; # 
  fhir:asserter [
fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ]
  ] ; # 
  fhir:stage ( [
fhir:summary [
      ( fhir:coding [
fhir:system [ fhir:v "http://cancerstaging.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "3C" ]       ] )     ]
  ] ) . # 

<http://example.org/medrequest-doxorubicin-persona-2> a fhir:MedicationRequest ;
  fhir:id [ fhir:v "medrequest-doxorubicin-persona-2"] ; # 
  fhir:meta [
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-related-medication-request"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-related-medication-request>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "extensions" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"MedicationRequest_medrequest-doxorubicin-persona-2\"> </a><p><b>Generated Narrative: MedicationRequest</b><a name=\"medrequest-doxorubicin-persona-2\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource MedicationRequest &quot;medrequest-doxorubicin-persona-2&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/us/mcode/2021May/StructureDefinition-mcode-cancer-related-medication-request.html\">Cancer-Related Medication Request</a></p></div><p><b>Treatment Intent</b>: Curative - procedure intent (qualifier value) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#373808002)</span></p><p><b>status</b>: active</p><p><b>intent</b>: order</p><p><b>category</b>: Outpatient <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-medicationrequest-category.html\">MedicationRequest Category Codes</a>#outpatient)</span></p><p><b>medication</b>: DOXOrubicin <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#3639)</span></p><p><b>subject</b>: <a href=\"#Patient_PatientPersona2\">See above (Patient/PatientPersona2)</a></p><p><b>authoredOn</b>: 2020-10-06</p><p><b>requester</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> &quot; ONCOLOGIST&quot;</p><p><b>reasonReference</b>: <a href=\"#Condition_primary-cancer-condition-persona-2\">See above (Condition/primary-cancer-condition-persona-2)</a></p><blockquote><p><b>dosageInstruction</b></p><p><b>text</b>: doxorubicin (60 mg/m² IV)</p><p><b>timing</b>: Starting 2018-04-01, Once</p><p><b>route</b>: Intravenous route (qualifier value) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#47625008)</span></p><blockquote><p><b>doseAndRate</b></p></blockquote><p><b>maxDosePerPeriod</b>: 1/3 week<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code wk = 'wk')</span></p></blockquote></div>"
  ] ; # 
  fhir:extension ( [
fhir:url [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-treatment-intent"^^xsd:anyURI ] ;
fhir:value [
a fhir:CodeableConcept ;
      ( fhir:coding [
a sct:373808002 ;
fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ;
fhir:code [ fhir:v "373808002" ] ;
fhir:display [ fhir:v "Curative - procedure intent (qualifier value)" ]       ] )     ]
  ] ) ; # 
  fhir:status [ fhir:v "active"] ; # 
  fhir:intent [ fhir:v "order"] ; # 
  fhir:category ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/medicationrequest-category"^^xsd:anyURI ] ;
fhir:code [ fhir:v "outpatient" ]     ] )
  ] ) ; # 
  fhir:medication [
a fhir:CodeableConcept ;
    ( fhir:coding [
fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ;
fhir:code [ fhir:v "3639" ] ;
fhir:display [ fhir:v "DOXOrubicin" ]     ] )
  ] ; # 
  fhir:subject [
fhir:reference [ fhir:v "Patient/PatientPersona2" ]
  ] ; # 
  fhir:authoredOn [ fhir:v "2020-10-06"^^xsd:date] ; # 
  fhir:requester [
fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ]
  ] ; # 
  fhir:reasonReference ( [
fhir:reference [ fhir:v "Condition/primary-cancer-condition-persona-2" ]
  ] ) ; # 
  fhir:dosageInstruction ( [
fhir:text [ fhir:v "doxorubicin (60 mg/m² IV)" ] ;
fhir:timing [
fhir:repeat [
fhir:bounds [
a fhir:Period ;
fhir:start [ fhir:v "2018-04-01"^^xsd:date ]         ]       ]     ] ;
fhir:route [
      ( fhir:coding [
a sct:47625008 ;
fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ;
fhir:code [ fhir:v "47625008" ] ;
fhir:display [ fhir:v "Intravenous route (qualifier value)" ]       ] )     ] ;
    ( fhir:doseAndRate [
fhir:rate [
a fhir:Quantity ;
fhir:value [ fhir:v "60"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg/m2" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mg/m2" ]       ]     ] ) ;
fhir:maxDosePerPeriod [
fhir:numerator [
fhir:value [ fhir:v "1"^^xsd:decimal ]       ] ;
fhir:denominator [
fhir:value [ fhir:v "3"^^xsd:decimal ] ;
fhir:unit [ fhir:v "week" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "wk" ]       ]     ]
  ] ) . # 

<http://example.org/medadmin-doxorubicin-persona-2> a fhir:MedicationAdministration ;
  fhir:id [ fhir:v "medadmin-doxorubicin-persona-2"] ; # 
  fhir:meta [
    ( fhir:profile [
fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-related-medication-administration"^^xsd:anyURI ;
fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-related-medication-administration>     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"MedicationAdministration_medadmin-doxorubicin-persona-2\"> </a><p><b>Generated Narrative: MedicationAdministration</b><a name=\"medadmin-doxorubicin-persona-2\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource MedicationAdministration &quot;medadmin-doxorubicin-persona-2&quot; </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/us/mcode/2021May/StructureDefinition-mcode-cancer-related-medication-administration.html\">Cancer-Related Medication Administration</a></p></div><p><b>status</b>: completed</p><p><b>category</b>: Outpatient <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-medicationrequest-category.html\">MedicationRequest Category Codes</a>#outpatient)</span></p><p><b>medication</b>: doxorubicin hydrochloride 20 MG per 10 ML Injection <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#1790099)</span></p><p><b>subject</b>: <a href=\"#Patient_PatientPersona2\">See above (Patient/PatientPersona2)</a></p><p><b>effective</b>: 2020-12-01</p><p><b>reasonReference</b>: <a href=\"#Condition_primary-cancer-condition-persona-2\">See above (Condition/primary-cancer-condition-persona-2)</a></p><p><b>request</b>: <a href=\"#MedicationRequest_medrequest-doxorubicin-persona-2\">See above (MedicationRequest/medrequest-doxorubicin-persona-2)</a></p><p><b>note</b>: doxorubicin (60 mg/m² IV), 105.96 mg in 50 ml 0.9% normal saline administered by continuous infusion. Patient tolerated infusion without side effects. (By Practitioner/us-core-practitioner-nancy-oncology-nurse @2020-12-01)</p><h3>Dosages</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Route</b></td><td><b>Dose</b></td></tr><tr><td style=\"display: none\">*</td><td>Intravenous route (qualifier value) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#47625008)</span></td><td>105.96 mg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code mg = 'mg')</span></td></tr></table></div>"
  ] ; # 
  fhir:status [ fhir:v "completed"] ; # 
  fhir:category [
    ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/medicationrequest-category"^^xsd:anyURI ] ;
fhir:code [ fhir:v "outpatient" ]     ] )
  ] ; # 
  fhir:medication [
a fhir:CodeableConcept ;
    ( fhir:coding [
fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ;
fhir:code [ fhir:v "1790099" ] ;
fhir:display [ fhir:v "doxorubicin hydrochloride 20 MG per 10 ML Injection" ]     ] )
  ] ; # 
  fhir:subject [
fhir:reference [ fhir:v "Patient/PatientPersona2" ]
  ] ; # 
  fhir:effective [ fhir:v "2020-12-01"^^xsd:date] ; # 
  fhir:reasonReference ( [
fhir:reference [ fhir:v "Condition/primary-cancer-condition-persona-2" ]
  ] ) ; # 
  fhir:request [
fhir:reference [ fhir:v "MedicationRequest/medrequest-doxorubicin-persona-2" ]
  ] ; # 
  fhir:note ( [
fhir:author [
a fhir:Reference ;
fhir:reference [ fhir:v "Practitioner/us-core-practitioner-nancy-oncology-nurse" ]     ] ;
fhir:time [ fhir:v "2020-12-01"^^xsd:date ] ;
fhir:text [ fhir:v "doxorubicin (60 mg/m² IV), 105.96 mg in 50 ml 0.9% normal saline administered by continuous infusion. Patient tolerated infusion without side effects." ]
  ] ) ; # 
  fhir:dosage [
fhir:route [
      ( fhir:coding [
a sct:47625008 ;
fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ;
fhir:code [ fhir:v "47625008" ] ;
fhir:display [ fhir:v "Intravenous route (qualifier value)" ]       ] )     ] ;
fhir:dose [
fhir:value [ fhir:v "105.96"^^xsd:decimal ] ;
fhir:unit [ fhir:v "mg" ] ;
fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "mg" ]     ]
  ] . # 

<http://example.org/diagnosticreport-cbc-201-1-persona2> a fhir:DiagnosticReport ;
  fhir:id [ fhir:v "201"] ; # 
  fhir:meta [
    ( fhir:tag [
fhir:system [ fhir:v "http://example.org/fhir/CodeSystem/workflow-codes"^^xsd:anyURI ] ;
fhir:code [ fhir:v "01" ] ;
fhir:display [ fhir:v "Needs Review" ]     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DiagnosticReport_201\"> </a><p><b>Generated Narrative: DiagnosticReport</b><a name=\"201\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource DiagnosticReport &quot;201&quot; </p><p style=\"margin-bottom: 0px\">Tag: <span title=\"{http://example.org/fhir/CodeSystem/workflow-codes http://example.org/fhir/CodeSystem/workflow-codes}\">http://example.org/fhir/CodeSystem/workflow-codes</span></p></div><p><b>identifier</b>: <code>http://acme.com/lab/reports</code>/5234342</p><p><b>status</b>: final</p><p><b>category</b>: Hematology <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html\">diagnosticServiceSectionId</a>#HM)</span></p><p><b>code</b>: Complete Blood Count <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#58410-2 &quot;CBC panel - Blood by Automated count&quot;)</span></p><p><b>subject</b>: <a href=\"#Patient_PatientPersona2\">See above (Patient/PatientPersona2)</a></p><p><b>effective</b>: 2020-12-21 08:30:00+1100</p><p><b>issued</b>: Dec 21, 2020, 12:45:33 AM</p><p><b>result</b>: </p><ul><li><a href=\"Observation-r201-1.html\">Observation/r201-1</a></li><li><a href=\"Observation-r201-2.html\">Observation/r201-2</a></li><li><a href=\"Observation-r201-3.html\">Observation/r201-3</a></li><li><a href=\"Observation-r201-4.html\">Observation/r201-4</a></li><li><a href=\"Observation-r201-5.html\">Observation/r201-5</a></li><li><a href=\"Observation-r201-6.html\">Observation/r201-6</a></li><li><a href=\"Observation-r201-7.html\">Observation/r201-7</a></li><li><a href=\"Observation-r201-8.html\">Observation/r201-8</a></li><li><a href=\"Observation-r201-9.html\">Observation/r201-9</a></li><li><a href=\"Observation-r201-10.html\">Observation/r201-10</a></li><li><a href=\"Observation-r201-11.html\">Observation/r201-11</a></li><li><a href=\"Observation-r201-12.html\">Observation/r201-12</a></li><li><a href=\"Observation-r201-13.html\">Observation/r201-13</a></li><li><a href=\"Observation-r201-14.html\">Observation/r201-14</a></li><li><a href=\"Observation-r201-15.html\">Observation/r201-15</a></li><li><a href=\"Observation-r201-16.html\">Observation/r201-16</a></li><li><a href=\"Observation-r201-17.html\">Observation/r201-17</a></li></ul></div>"
  ] ; # 
  fhir:identifier ( [
fhir:system [ fhir:v "http://acme.com/lab/reports"^^xsd:anyURI ] ;
fhir:value [ fhir:v "5234342" ]
  ] ) ; # 
  fhir:status [ fhir:v "final"] ; # 
  fhir:category ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ;
fhir:code [ fhir:v "HM" ]     ] )
  ] ) ; # 
  fhir:code [
    ( fhir:coding [
a loinc:58410-2 ;
fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "58410-2" ] ;
fhir:display [ fhir:v "CBC panel - Blood by Automated count" ]     ] ) ;
fhir:text [ fhir:v "Complete Blood Count" ]
  ] ; # 
  fhir:subject [
fhir:reference [ fhir:v "Patient/PatientPersona2" ]
  ] ; # 
  fhir:effective [ fhir:v "2020-12-21T08:30:00+11:00"^^xsd:dateTime] ; # 
  fhir:issued [ fhir:v "2020-12-21T11:45:33+11:00"^^xsd:dateTime] ; # 
  fhir:result ( [
fhir:reference [ fhir:v "Observation/r201-1" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-2" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-3" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-4" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-5" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-6" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-7" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-8" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-9" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-10" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-11" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-12" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-13" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-14" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-15" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-16" ]
  ] [
fhir:reference [ fhir:v "Observation/r201-17" ]
  ] ) . # 

<http://example.org/diagnosticreport-cbc-202-1-persona2> a fhir:DiagnosticReport ;
  fhir:id [ fhir:v "202"] ; # 
  fhir:meta [
    ( fhir:tag [
fhir:system [ fhir:v "http://example.org/fhir/CodeSystem/workflow-codes"^^xsd:anyURI ] ;
fhir:code [ fhir:v "01" ] ;
fhir:display [ fhir:v "Needs Review" ]     ] )
  ] ; # 
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"DiagnosticReport_202\"> </a><p><b>Generated Narrative: DiagnosticReport</b><a name=\"202\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource DiagnosticReport &quot;202&quot; </p><p style=\"margin-bottom: 0px\">Tag: <span title=\"{http://example.org/fhir/CodeSystem/workflow-codes http://example.org/fhir/CodeSystem/workflow-codes}\">http://example.org/fhir/CodeSystem/workflow-codes</span></p></div><p><b>identifier</b>: <code>http://acme.com/lab/reports</code>/5234342</p><p><b>status</b>: final</p><p><b>category</b>: Hematology <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v2-0074.html\">diagnosticServiceSectionId</a>#HM)</span></p><p><b>code</b>: Complete Blood Count <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://loinc.org/\">LOINC</a>#58410-2 &quot;CBC panel - Blood by Automated count&quot;)</span></p><p><b>subject</b>: <a href=\"#Patient_PatientPersona2\">See above (Patient/PatientPersona2)</a></p><p><b>effective</b>: 2020-12-29 08:30:00+1100</p><p><b>issued</b>: Dec 29, 2020, 12:45:33 AM</p><p><b>result</b>: </p><ul><li><a href=\"Observation-r202-1.html\">Observation/r202-1</a></li><li><a href=\"Observation-r202-2.html\">Observation/r202-2</a></li><li><a href=\"Observation-r202-3.html\">Observation/r202-3</a></li><li><a href=\"Observation-r202-4.html\">Observation/r202-4</a></li><li><a href=\"Observation-r202-5.html\">Observation/r202-5</a></li><li><a href=\"Observation-r202-6.html\">Observation/r202-6</a></li><li><a href=\"Observation-r202-7.html\">Observation/r202-7</a></li><li><a href=\"Observation-r202-8.html\">Observation/r202-8</a></li><li><a href=\"Observation-r202-9.html\">Observation/r202-9</a></li><li><a href=\"Observation-r202-10.html\">Observation/r202-10</a></li><li><a href=\"Observation-r202-11.html\">Observation/r202-11</a></li><li><a href=\"Observation-r202-12.html\">Observation/r202-12</a></li><li><a href=\"Observation-r202-13.html\">Observation/r202-13</a></li><li><a href=\"Observation-r202-14.html\">Observation/r202-14</a></li><li><a href=\"Observation-r202-15.html\">Observation/r202-15</a></li><li><a href=\"Observation-r202-16.html\">Observation/r202-16</a></li><li><a href=\"Observation-r202-17.html\">Observation/r202-17</a></li></ul></div>"
  ] ; # 
  fhir:identifier ( [
fhir:system [ fhir:v "http://acme.com/lab/reports"^^xsd:anyURI ] ;
fhir:value [ fhir:v "5234342" ]
  ] ) ; # 
  fhir:status [ fhir:v "final"] ; # 
  fhir:category ( [
    ( fhir:coding [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ] ;
fhir:code [ fhir:v "HM" ]     ] )
  ] ) ; # 
  fhir:code [
    ( fhir:coding [
a loinc:58410-2 ;
fhir:system [ fhir:v "http://loinc.org"^^xsd:anyURI ] ;
fhir:code [ fhir:v "58410-2" ] ;
fhir:display [ fhir:v "CBC panel - Blood by Automated count" ]     ] ) ;
fhir:text [ fhir:v "Complete Blood Count" ]
  ] ; # 
  fhir:subject [
fhir:reference [ fhir:v "Patient/PatientPersona2" ]
  ] ; # 
  fhir:effective [ fhir:v "2020-12-29T08:30:00+11:00"^^xsd:dateTime] ; # 
  fhir:issued [ fhir:v "2020-12-29T11:45:33+11:00"^^xsd:dateTime] ; # 
  fhir:result ( [
fhir:reference [ fhir:v "Observation/r202-1" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-2" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-3" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-4" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-5" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-6" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-7" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-8" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-9" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-10" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-11" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-12" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-13" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-14" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-15" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-16" ]
  ] [
fhir:reference [ fhir:v "Observation/r202-17" ]
  ] ) . # 

<http://example.org/encounter-ae1-evaluation-persona2> a fhir:Encounter ;
  fhir:id [ fhir:v "encounter-ae1-evaluation-persona2"] ; # 
  fhir:text [
fhir:status [ fhir:v "generated" ] ;
fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Encounter_encounter-ae1-evaluation-persona2\"> </a><p><b>Generated Narrative: Encounter</b><a name=\"encounter-ae1-evaluation-persona2\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Encounter &quot;encounter-ae1-evaluation-persona2&quot; </p></div><p><b>status</b>: finished</p><p><b>class</b>: ambulatory (Details: http://terminology.hl7.org/CodeSystem/v3-ActCode code AMB = 'ambulatory', stated as 'ambulatory')</p><p><b>subject</b>: <a href=\"#Patient_PatientPersona2\">See above (Patient/PatientPersona2)</a></p><p><b>period</b>: 2020-12-01 --&gt; 2020-12-01</p></div>"
  ] ; # 
  fhir:status [ fhir:v "finished"] ; # 
  fhir:class [
fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v3-ActCode"^^xsd:anyURI ] ;
fhir:code [ fhir:v "AMB" ] ;
fhir:display [ fhir:v "ambulatory" ]
  ] ; # 
  fhir:subject [
fhir:reference [ fhir:v "Patient/PatientPersona2" ]
  ] ; # 
  fhir:period [
fhir:start [ fhir:v "2020-12-01"^^xsd:date ] ;
fhir:end [ fhir:v "2020-12-01"^^xsd:date ]
  ] . #