HL7 FHIR Implementation Guide: Common Terminology Criteria (CTC) Adverse Events Release 1 - DRAFT
0.0.1 - DRAFT
HL7 FHIR Implementation Guide: Common Terminology Criteria (CTC) Adverse Events Release 1 - DRAFT, published by HL7 International Clinical Interoperability Council. This guide is not an authorized publication; it is the continuous build for version 0.0.1 built by the FHIR (HL7® FHIR® Standard) CI Build. This version is based on the current content of https://github.com/standardhealth/fsh-ae/ and changes regularly. See the Directory of published versions
@prefix fhir: <http://hl7.org/fhir/> . @prefix owl: <http://www.w3.org/2002/07/owl#> . @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> . @prefix sct: <http://snomed.info/id/> . @prefix xsd: <http://www.w3.org/2001/XMLSchema#> . # - resource ------------------------------------------------------------------- a fhir:Bundle ; fhir:nodeRole fhir:treeRoot ; fhir:id [ fhir:v "ae-bundle-kaitlyn-compass-trial"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-patient-bundle"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-patient-bundle> ] ) ] ; # fhir:type [ fhir:v "collection"] ; # fhir:entry ( [ fhir:fullUrl [ fhir:v "http://example.org/patient-example-kaitlyn-b"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/patient-example-kaitlyn-b> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/kaitlyn-primary-cancer-condition-ex1"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/kaitlyn-primary-cancer-condition-ex1> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/medication-request-example-kadcyla"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/medication-request-example-kadcyla> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/medication-request-example-tucatinib"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/medication-request-example-tucatinib> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/medication-administration-kadcyla"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/medication-administration-kadcyla> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/medication-administration-tucatinib"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/medication-administration-tucatinib> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/ctc-adverse-event-compass-ex1"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/ctc-adverse-event-compass-ex1> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/ctc-adverse-event-compass-ex1a"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/ctc-adverse-event-compass-ex1a> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/ctc-adverse-event-compass-ex1b"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/ctc-adverse-event-compass-ex1b> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/ctc-adverse-event-compass-ex2"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/ctc-adverse-event-compass-ex2> ) ] [ fhir:fullUrl [ fhir:v "http://example.org/clinical-trial-example-compass"^^xsd:anyURI ] ; ( fhir:resource <http://example.org/clinical-trial-example-compass> ) ] ) . # <http://example.org/patient-example-kaitlyn-b> a fhir:Patient ; fhir:id [ fhir:v "patient-example-kaitlyn-b"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-patient"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-patient> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Patient_patient-example-kaitlyn-b\"> </a><p><b>Generated Narrative: Patient</b><a name=\"patient-example-kaitlyn-b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Patient "patient-example-kaitlyn-b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/us/mcode/2021May/StructureDefinition-mcode-cancer-patient.html\">Cancer Patient</a></p></div><p><b>identifier</b>: Medical Record Number/m123 (use: USUAL)</p><p><b>name</b>: Kaitlyn Bounce </p><p><b>gender</b>: female</p><p><b>birthDate</b>: 1985-02-20</p><p><b>address</b>: 123 Main St Anytown 12345 US </p><h3>Contacts</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Telecom</b></td></tr><tr><td style=\"display: none\">*</td><td>ph: 545-123-4560(HOME), <a href=\"mailto:kaitlynb@example.com\">kaitlynb@example.com</a></td></tr></table><h3>Communications</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Language</b></td></tr><tr><td style=\"display: none\">*</td><td>English <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-ietf3066.html\">Tags for the Identification of Languages</a>#en-US "English (Region=United States)")</span></td></tr></table></div>" ] ; # fhir:identifier ( [ fhir:use [ fhir:v "usual" ] ; fhir:type [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v2-0203"^^xsd:anyURI ] ; fhir:code [ fhir:v "MR" ] ; fhir:display [ fhir:v "Medical Record Number" ] ] ) ] ; fhir:system [ fhir:v "http://hospital.example.org"^^xsd:anyURI ] ; fhir:value [ fhir:v "m123" ] ] ) ; # fhir:name ( [ fhir:family [ fhir:v "Bounce" ] ; ( fhir:given [ fhir:v "Kaitlyn" ] ) ] ) ; # fhir:gender [ fhir:v "female"] ; # fhir:birthDate [ fhir:v "1985-02-20"^^xsd:date] ; # fhir:address ( [ ( fhir:line [ fhir:v "123 Main St" ] ) ; fhir:city [ fhir:v "Anytown" ] ; fhir:postalCode [ fhir:v "12345" ] ; fhir:country [ fhir:v "US" ] ] ) ; # fhir:contact ( [ ( fhir:telecom [ fhir:system [ fhir:v "phone" ] ; fhir:value [ fhir:v "545-123-4560" ] ; fhir:use [ fhir:v "home" ] ] [ fhir:system [ fhir:v "email" ] ; fhir:value [ fhir:v "kaitlynb@example.com" ] ] ) ] ) ; # fhir:communication ( [ fhir:language [ ( fhir:coding [ fhir:system [ fhir:v "urn:ietf:bcp:47"^^xsd:anyURI ] ; fhir:code [ fhir:v "en-US" ] ; fhir:display [ fhir:v "English (Region=United States)" ] ] ) ; fhir:text [ fhir:v "English" ] ] ] ) . # <http://example.org/kaitlyn-primary-cancer-condition-ex1> a fhir:Condition ; fhir:id [ fhir:v "KaitlynPrimaryCancerConditionEx1"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-primary-cancer-condition"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-primary-cancer-condition> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"Condition_KaitlynPrimaryCancerConditionEx1\"> </a><p><b>Generated Narrative: Condition</b><a name=\"KaitlynPrimaryCancerConditionEx1\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource Condition "KaitlynPrimaryCancerConditionEx1" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/us/mcode/2021May/StructureDefinition-mcode-primary-cancer-condition.html\">Primary Cancer Condition</a></p></div><p><b>clinicalStatus</b>: Active <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-condition-clinical.html\">Condition Clinical Status Codes</a>#active)</span></p><p><b>verificationStatus</b>: Confirmed <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-condition-ver-status.html\">ConditionVerificationStatus</a>#confirmed)</span></p><p><b>category</b>: problem-list-item <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> ([not stated]#problem-list-item)</span></p><p><b>code</b>: Malignant neoplasm of female left breast (disorder) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#353431000119107)</span></p><p><b>subject</b>: <a href=\"#Patient_patient-example-kaitlyn-b\">See above (Patient/patient-example-kaitlyn-b)</a></p><p><b>onset</b>: 2019-05-01</p><p><b>asserter</b>: <a href=\"Practitioner-PractitionerExample1.html\">Practitioner/PractitionerExample1</a> " ANYDOC"</p></div>" ] ; # fhir:clinicalStatus [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/condition-clinical"^^xsd:anyURI ] ; fhir:code [ fhir:v "active" ] ; fhir:display [ fhir:v "Active" ] ] ) ] ; # fhir:verificationStatus [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/condition-ver-status"^^xsd:anyURI ] ; fhir:code [ fhir:v "confirmed" ] ; fhir:display [ fhir:v "Confirmed" ] ] ) ] ; # fhir:category ( [ ( fhir:coding [ fhir:code [ fhir:v "problem-list-item" ] ] ) ] ) ; # fhir:code [ ( fhir:coding [ a sct:353431000119107 ; fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ; fhir:code [ fhir:v "353431000119107" ] ; fhir:display [ fhir:v "Malignant neoplasm of female left breast (disorder)" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/patient-example-kaitlyn-b" ] ] ; # fhir:onset [ fhir:v "2019-05-01"^^xsd:date] ; # fhir:asserter [ fhir:reference [ fhir:v "Practitioner/PractitionerExample1" ] ] . # <http://example.org/medication-request-example-kadcyla> a fhir:MedicationRequest ; fhir:id [ fhir:v "medication-request-example-kadcyla"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-related-medication-request"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-related-medication-request> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"MedicationRequest_medication-request-example-kadcyla\"> </a><p><b>Generated Narrative: MedicationRequest</b><a name=\"medication-request-example-kadcyla\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource MedicationRequest "medication-request-example-kadcyla" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/us/mcode/2021May/StructureDefinition-mcode-cancer-related-medication-request.html\">Cancer-Related Medication Request</a></p></div><p><b>status</b>: active</p><p><b>intent</b>: order</p><p><b>medication</b>: KADCYLA <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#1371046)</span></p><p><b>subject</b>: <a href=\"#Patient_patient-example-kaitlyn-b\">See above (Patient/patient-example-kaitlyn-b)</a></p><p><b>authoredOn</b>: 2020-03-12</p><p><b>requester</b>: <a href=\"Practitioner-PractitionerExample1.html\">Practitioner/PractitionerExample1</a> " ANYDOC"</p><p><b>reasonReference</b>: <a href=\"#Condition_KaitlynPrimaryCancerConditionEx1\">See above (Condition/KaitlynPrimaryCancerConditionEx1)</a></p><blockquote><p><b>dosageInstruction</b></p><p><b>text</b>: Kadcyla IV at 3.6mg</p><p><b>timing</b>: Starting 2020-04-01, Once</p><p><b>route</b>: Intravenous route (qualifier value) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#47625008)</span></p><blockquote><p><b>doseAndRate</b></p></blockquote><p><b>maxDosePerAdministration</b>: 1</p></blockquote></div>" ] ; # fhir:status [ fhir:v "active"] ; # fhir:intent [ fhir:v "order"] ; # fhir:medication [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "1371046" ] ; fhir:display [ fhir:v "KADCYLA" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/patient-example-kaitlyn-b" ] ] ; # fhir:authoredOn [ fhir:v "2020-03-12"^^xsd:date] ; # fhir:requester [ fhir:reference [ fhir:v "Practitioner/PractitionerExample1" ] ] ; # fhir:reasonReference ( [ fhir:reference [ fhir:v "Condition/KaitlynPrimaryCancerConditionEx1" ] ] ) ; # fhir:dosageInstruction ( [ fhir:text [ fhir:v "Kadcyla IV at 3.6mg" ] ; fhir:timing [ fhir:repeat [ fhir:bounds [ a fhir:Period ; fhir:start [ fhir:v "2020-04-01"^^xsd:date ] ] ] ] ; fhir:route [ ( fhir:coding [ a sct:47625008 ; fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ; fhir:code [ fhir:v "47625008" ] ; fhir:display [ fhir:v "Intravenous route (qualifier value)" ] ] ) ] ; ( fhir:doseAndRate [ fhir:rate [ a fhir:Quantity ; fhir:value [ fhir:v "3.6"^^xsd:decimal ] ; fhir:unit [ fhir:v "mg" ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "mg" ] ] ] ) ; fhir:maxDosePerAdministration [ fhir:value [ fhir:v "1"^^xsd:decimal ] ] ] ) . # <http://example.org/medication-request-example-tucatinib> a fhir:MedicationRequest ; fhir:id [ fhir:v "medication-request-example-tucatinib"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-related-medication-request"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-related-medication-request> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"MedicationRequest_medication-request-example-tucatinib\"> </a><p><b>Generated Narrative: MedicationRequest</b><a name=\"medication-request-example-tucatinib\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource MedicationRequest "medication-request-example-tucatinib" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/us/mcode/2021May/StructureDefinition-mcode-cancer-related-medication-request.html\">Cancer-Related Medication Request</a></p></div><p><b>status</b>: active</p><p><b>intent</b>: order</p><p><b>medication</b>: tucatinib 150 MG Oral Tablet <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#2361290)</span></p><p><b>subject</b>: <a href=\"#Patient_patient-example-kaitlyn-b\">See above (Patient/patient-example-kaitlyn-b)</a></p><p><b>authoredOn</b>: 2020-03-12</p><p><b>requester</b>: <a href=\"Practitioner-PractitionerExample1.html\">Practitioner/PractitionerExample1</a> " ANYDOC"</p><p><b>reasonReference</b>: <a href=\"#Condition_KaitlynPrimaryCancerConditionEx1\">See above (Condition/KaitlynPrimaryCancerConditionEx1)</a></p><blockquote><p><b>dosageInstruction</b></p><p><b>text</b>: oral twice a day every day</p><p><b>timing</b>: Starting 2020-04-01, Once</p><p><b>route</b>: Oral route (qualifier value) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#26643006)</span></p><blockquote><p><b>doseAndRate</b></p></blockquote><p><b>maxDosePerAdministration</b>: 2</p></blockquote></div>" ] ; # fhir:status [ fhir:v "active"] ; # fhir:intent [ fhir:v "order"] ; # fhir:medication [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "2361290" ] ; fhir:display [ fhir:v "tucatinib 150 MG Oral Tablet" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/patient-example-kaitlyn-b" ] ] ; # fhir:authoredOn [ fhir:v "2020-03-12"^^xsd:date] ; # fhir:requester [ fhir:reference [ fhir:v "Practitioner/PractitionerExample1" ] ] ; # fhir:reasonReference ( [ fhir:reference [ fhir:v "Condition/KaitlynPrimaryCancerConditionEx1" ] ] ) ; # fhir:dosageInstruction ( [ fhir:text [ fhir:v "oral twice a day every day" ] ; fhir:timing [ fhir:repeat [ fhir:bounds [ a fhir:Period ; fhir:start [ fhir:v "2020-04-01"^^xsd:date ] ] ] ] ; fhir:route [ ( fhir:coding [ a sct:26643006 ; fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ; fhir:code [ fhir:v "26643006" ] ; fhir:display [ fhir:v "Oral route (qualifier value)" ] ] ) ] ; ( fhir:doseAndRate [ fhir:rate [ a fhir:Quantity ; fhir:value [ fhir:v "150"^^xsd:decimal ] ; fhir:unit [ fhir:v "MG" ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "MG" ] ] ] ) ; fhir:maxDosePerAdministration [ fhir:value [ fhir:v "2"^^xsd:decimal ] ] ] ) . # <http://example.org/medication-administration-kadcyla> a fhir:MedicationAdministration ; fhir:id [ fhir:v "medication-administration-kadcyla"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-related-medication-administration"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-related-medication-administration> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"MedicationAdministration_medication-administration-kadcyla\"> </a><p><b>Generated Narrative: MedicationAdministration</b><a name=\"medication-administration-kadcyla\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource MedicationAdministration "medication-administration-kadcyla" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/us/mcode/2021May/StructureDefinition-mcode-cancer-related-medication-administration.html\">Cancer-Related Medication Administration</a></p></div><p><b>status</b>: completed</p><p><b>medication</b>: KADCYLA <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#1371046)</span></p><p><b>subject</b>: <a href=\"#Patient_patient-example-kaitlyn-b\">See above (Patient/patient-example-kaitlyn-b)</a></p><p><b>effective</b>: 2020-04-01</p><h3>Performers</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Actor</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"Practitioner-practitioner-oncology-nurse-jane.html\">Practitioner/practitioner-oncology-nurse-jane</a> " NURSE"</td></tr></table><p><b>reasonReference</b>: <a href=\"#Condition_KaitlynPrimaryCancerConditionEx1\">See above (Condition/KaitlynPrimaryCancerConditionEx1)</a></p><p><b>request</b>: <a href=\"#MedicationRequest_medication-request-example-kadcyla\">See above (MedicationRequest/medication-request-example-kadcyla)</a></p><p><b>note</b>: 3.6mg administered by continuous infusion. Patient tolerated infusion without side effects. (By Practitioner/practitioner-oncology-nurse-jane @2020-04-01)</p><h3>Dosages</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Route</b></td><td><b>Dose</b></td></tr><tr><td style=\"display: none\">*</td><td>Intravenous route (qualifier value) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#47625008)</span></td><td>3.6 mg<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code mg = 'mg')</span></td></tr></table></div>" ] ; # fhir:status [ fhir:v "completed"] ; # fhir:medication [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "1371046" ] ; fhir:display [ fhir:v "KADCYLA" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/patient-example-kaitlyn-b" ] ] ; # fhir:effective [ fhir:v "2020-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:actor [ fhir:reference [ fhir:v "Practitioner/practitioner-oncology-nurse-jane" ] ] ] ) ; # fhir:reasonReference ( [ fhir:reference [ fhir:v "Condition/KaitlynPrimaryCancerConditionEx1" ] ] ) ; # fhir:request [ fhir:reference [ fhir:v "MedicationRequest/medication-request-example-kadcyla" ] ] ; # fhir:note ( [ fhir:author [ a fhir:Reference ; fhir:reference [ fhir:v "Practitioner/practitioner-oncology-nurse-jane" ] ] ; fhir:time [ fhir:v "2020-04-01"^^xsd:date ] ; fhir:text [ fhir:v "3.6mg administered by continuous infusion. Patient tolerated infusion without side effects." ] ] ) ; # fhir:dosage [ fhir:route [ ( fhir:coding [ a sct:47625008 ; fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ; fhir:code [ fhir:v "47625008" ] ; fhir:display [ fhir:v "Intravenous route (qualifier value)" ] ] ) ] ; fhir:dose [ fhir:value [ fhir:v "3.6"^^xsd:decimal ] ; fhir:unit [ fhir:v "mg" ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "mg" ] ] ] . # <http://example.org/medication-administration-tucatinib> a fhir:MedicationAdministration ; fhir:id [ fhir:v "medication-administration-tucatinib"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-related-medication-administration"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/mcode/StructureDefinition/mcode-cancer-related-medication-administration> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"MedicationAdministration_medication-administration-tucatinib\"> </a><p><b>Generated Narrative: MedicationAdministration</b><a name=\"medication-administration-tucatinib\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource MedicationAdministration "medication-administration-tucatinib" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"http://hl7.org/fhir/us/mcode/2021May/StructureDefinition-mcode-cancer-related-medication-administration.html\">Cancer-Related Medication Administration</a></p></div><p><b>status</b>: completed</p><p><b>medication</b>: tucatinib 150 MG Oral Tablet <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-rxNorm.html\">RxNorm</a>#2361290)</span></p><p><b>subject</b>: <a href=\"#Patient_patient-example-kaitlyn-b\">See above (Patient/patient-example-kaitlyn-b)</a></p><p><b>effective</b>: 2020-04-01</p><h3>Performers</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Actor</b></td></tr><tr><td style=\"display: none\">*</td><td><a href=\"Practitioner-practitioner-oncology-nurse-jane.html\">Practitioner/practitioner-oncology-nurse-jane</a> " NURSE"</td></tr></table><p><b>reasonReference</b>: <a href=\"#Condition_KaitlynPrimaryCancerConditionEx1\">See above (Condition/KaitlynPrimaryCancerConditionEx1)</a></p><p><b>request</b>: <a href=\"#MedicationRequest_medication-request-example-tucatinib\">See above (MedicationRequest/medication-request-example-tucatinib)</a></p><p><b>note</b>: Patient took 2 tablets (By Practitioner/practitioner-oncology-nurse-jane @2020-04-01)</p><h3>Dosages</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Route</b></td><td><b>Dose</b></td></tr><tr><td style=\"display: none\">*</td><td>Oral route (qualifier value) <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"https://browser.ihtsdotools.org/\">SNOMED CT</a>#26643006)</span></td><td>300 MG<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM code MG = 'MG')</span></td></tr></table></div>" ] ; # fhir:status [ fhir:v "completed"] ; # fhir:medication [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://www.nlm.nih.gov/research/umls/rxnorm"^^xsd:anyURI ] ; fhir:code [ fhir:v "2361290" ] ; fhir:display [ fhir:v "tucatinib 150 MG Oral Tablet" ] ] ) ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/patient-example-kaitlyn-b" ] ] ; # fhir:effective [ fhir:v "2020-04-01"^^xsd:date] ; # fhir:performer ( [ fhir:actor [ fhir:reference [ fhir:v "Practitioner/practitioner-oncology-nurse-jane" ] ] ] ) ; # fhir:reasonReference ( [ fhir:reference [ fhir:v "Condition/KaitlynPrimaryCancerConditionEx1" ] ] ) ; # fhir:request [ fhir:reference [ fhir:v "MedicationRequest/medication-request-example-tucatinib" ] ] ; # fhir:note ( [ fhir:author [ a fhir:Reference ; fhir:reference [ fhir:v "Practitioner/practitioner-oncology-nurse-jane" ] ] ; fhir:time [ fhir:v "2020-04-01"^^xsd:date ] ; fhir:text [ fhir:v "Patient took 2 tablets" ] ] ) ; # fhir:dosage [ fhir:route [ ( fhir:coding [ a sct:26643006 ; fhir:system [ fhir:v "http://snomed.info/sct"^^xsd:anyURI ] ; fhir:code [ fhir:v "26643006" ] ; fhir:display [ fhir:v "Oral route (qualifier value)" ] ] ) ] ; fhir:dose [ fhir:value [ fhir:v "300"^^xsd:decimal ] ; fhir:unit [ fhir:v "MG" ] ; fhir:system [ fhir:v "http://unitsofmeasure.org"^^xsd:anyURI ] ; fhir:code [ fhir:v "MG" ] ] ] . # <http://example.org/ctc-adverse-event-compass-ex1> a fhir:AdverseEvent ; fhir:id [ fhir:v "ctc-adverse-event-compass-ex1"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/ctc-adverse-event"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/ctcae/StructureDefinition/ctc-adverse-event> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "extensions" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"AdverseEvent_ctc-adverse-event-compass-ex1\"> </a><p><b>Generated Narrative: AdverseEvent</b><a name=\"ctc-adverse-event-compass-ex1\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource AdverseEvent "ctc-adverse-event-compass-ex1" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-ctc-adverse-event.html\">CTC Adverse Event</a></p></div><p><b>CTC Adverse Event Grade</b>: Mild Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ctcae-grade-code-system.html\">CTCAE Grade Code System</a>#1)</span></p><blockquote><p><b>Adverse Event Participant</b></p><blockquote><p><b>url</b></p><code>function</code></blockquote><p><b>value</b>: authenticator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-ParticipationType.html\">ParticipationType</a>#AUTHEN)</span></p><blockquote><p><b>url</b></p><code>actor</code></blockquote><p><b>value</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p></blockquote><p><b>Adverse Event Expectation</b>: Expected Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C41333)</span></p><p><b>actuality</b>: actual</p><p><b>event</b>: Alanine aminotransferase (ALT) increased at 50 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (MedDRA Am Engl[20.3]#10001551 "Alanine aminotransferase increased")</span></p><p><b>subject</b>: <a href=\"#Patient_patient-example-kaitlyn-b\">See above (Patient/patient-example-kaitlyn-b)</a></p><p><b>date</b>: 2020-04-22</p><p><b>seriousness</b>: Non-serious Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C41336)</span></p><p><b>outcome</b>: Ongoing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R4/codesystem-adverse-event-outcome.html\">AdverseEventOutcome</a>#ongoing)</span></p><p><b>recorder</b>: <a href=\"Practitioner-us-core-practitioner-nancy-oncology-nurse.html\">Practitioner/us-core-practitioner-nancy-oncology-nurse</a> " NURSE"</p><blockquote><p><b>suspectEntity</b></p><p><b>instance</b>: <a href=\"#MedicationAdministration_medication-administration-kadcyla\">See above (MedicationAdministration/medication-administration-kadcyla)</a></p><h3>Causalities</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Assessment</b></td></tr><tr><td style=\"display: none\">*</td><td>Adverse Event Probably Related to Intervention <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C53259)</span></td></tr></table></blockquote><blockquote><p><b>suspectEntity</b></p><p><b>instance</b>: <a href=\"#MedicationAdministration_medication-administration-tucatinib\">See above (MedicationAdministration/medication-administration-tucatinib)</a></p><h3>Causalities</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Assessment</b></td></tr><tr><td style=\"display: none\">*</td><td>Adverse Event Probably Related to Intervention <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C53259)</span></td></tr></table></blockquote><p><b>study</b>: <a href=\"#ResearchStudy_clinical-trial-example-compass\">See above (ResearchStudy/clinical-trial-example-compass)</a></p></div>" ] ; # fhir:extension ( [ fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/ctcae-grade"^^xsd:anyURI ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/us/ctcae/CodeSystem/ctcae-grade-code-system"^^xsd:anyURI ] ; fhir:code [ fhir:v "1" ] ] ) ] ] [ ( fhir:extension [ fhir:url [ fhir:v "function"^^xsd:anyURI ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v3-ParticipationType"^^xsd:anyURI ] ; fhir:code [ fhir:v "AUTHEN" ] ] ) ] ] [ fhir:url [ fhir:v "actor"^^xsd:anyURI ] ; fhir:value [ a fhir:Reference ; fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ] ) ; fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/adverse-event-participant"^^xsd:anyURI ] ] [ fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/adverse-event-expectation"^^xsd:anyURI ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C41333" ] ; fhir:display [ fhir:v "Expected Adverse Event" ] ] ) ] ] ) ; # fhir:actuality [ fhir:v "actual"] ; # fhir:event [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/MDRAE"^^xsd:anyURI ] ; fhir:version [ fhir:v "20.3" ] ; fhir:code [ fhir:v "10001551" ] ; fhir:display [ fhir:v "Alanine aminotransferase increased" ] ] ) ; fhir:text [ fhir:v "Alanine aminotransferase (ALT) increased at 50" ] ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/patient-example-kaitlyn-b" ] ] ; # fhir:date [ fhir:v "2020-04-22"^^xsd:date] ; # fhir:seriousness [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C41336" ] ; fhir:display [ fhir:v "Non-serious Adverse Event" ] ] ) ] ; # fhir:outcome [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/adverse-event-outcome"^^xsd:anyURI ] ; fhir:code [ fhir:v "ongoing" ] ] ) ] ; # fhir:recorder [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-nancy-oncology-nurse" ] ] ; # fhir:suspectEntity ( [ fhir:instance [ fhir:reference [ fhir:v "MedicationAdministration/medication-administration-kadcyla" ] ] ; ( fhir:causality [ fhir:assessment [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C53259" ] ] ) ; fhir:text [ fhir:v "Adverse Event Probably Related to Intervention" ] ] ] ) ] [ fhir:instance [ fhir:reference [ fhir:v "MedicationAdministration/medication-administration-tucatinib" ] ] ; ( fhir:causality [ fhir:assessment [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C53259" ] ] ) ; fhir:text [ fhir:v "Adverse Event Probably Related to Intervention" ] ] ] ) ] ) ; # fhir:study ( [ fhir:reference [ fhir:v "ResearchStudy/clinical-trial-example-compass" ] ] ) . # <http://example.org/ctc-adverse-event-compass-ex1a> a fhir:AdverseEvent ; fhir:id [ fhir:v "ctc-adverse-event-compass-ex1a"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/ctc-adverse-event"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/ctcae/StructureDefinition/ctc-adverse-event> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "extensions" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"AdverseEvent_ctc-adverse-event-compass-ex1a\"> </a><p><b>Generated Narrative: AdverseEvent</b><a name=\"ctc-adverse-event-compass-ex1a\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource AdverseEvent "ctc-adverse-event-compass-ex1a" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-ctc-adverse-event.html\">CTC Adverse Event</a></p></div><p><b>CTC Adverse Event Grade</b>: Severe Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ctcae-grade-code-system.html\">CTCAE Grade Code System</a>#3)</span></p><blockquote><p><b>Adverse Event Participant</b></p><blockquote><p><b>url</b></p><code>function</code></blockquote><p><b>value</b>: authenticator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-ParticipationType.html\">ParticipationType</a>#AUTHEN)</span></p><blockquote><p><b>url</b></p><code>actor</code></blockquote><p><b>value</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p></blockquote><p><b>Adverse Event Expectation</b>: Expected Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C41333)</span></p><p><b>actuality</b>: actual</p><p><b>event</b>: Alanine aminotransferase (ALT) increased to 200 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (MedDRA Am Engl[20.3]#10001551 "Alanine aminotransferase increased")</span></p><p><b>subject</b>: <a href=\"#Patient_patient-example-kaitlyn-b\">See above (Patient/patient-example-kaitlyn-b)</a></p><p><b>date</b>: 2020-05-13</p><p><b>seriousness</b>: Non-serious Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C41336)</span></p><p><b>outcome</b>: Ongoing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R4/codesystem-adverse-event-outcome.html\">AdverseEventOutcome</a>#ongoing)</span></p><p><b>recorder</b>: <a href=\"Practitioner-us-core-practitioner-nancy-oncology-nurse.html\">Practitioner/us-core-practitioner-nancy-oncology-nurse</a> " NURSE"</p><blockquote><p><b>suspectEntity</b></p><p><b>instance</b>: <a href=\"#MedicationAdministration_medication-administration-kadcyla\">See above (MedicationAdministration/medication-administration-kadcyla)</a></p><h3>Causalities</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Assessment</b></td></tr><tr><td style=\"display: none\">*</td><td>Adverse Event Probably Related to Intervention <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C53259)</span></td></tr></table></blockquote><blockquote><p><b>suspectEntity</b></p><p><b>instance</b>: <a href=\"#MedicationAdministration_medication-administration-tucatinib\">See above (MedicationAdministration/medication-administration-tucatinib)</a></p><h3>Causalities</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Assessment</b></td></tr><tr><td style=\"display: none\">*</td><td>Adverse Event Probably Related to Intervention <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C53259)</span></td></tr></table></blockquote><p><b>study</b>: <a href=\"#ResearchStudy_clinical-trial-example-compass\">See above (ResearchStudy/clinical-trial-example-compass)</a></p></div>" ] ; # fhir:extension ( [ fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/ctcae-grade"^^xsd:anyURI ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/us/ctcae/CodeSystem/ctcae-grade-code-system"^^xsd:anyURI ] ; fhir:code [ fhir:v "3" ] ] ) ] ] [ ( fhir:extension [ fhir:url [ fhir:v "function"^^xsd:anyURI ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v3-ParticipationType"^^xsd:anyURI ] ; fhir:code [ fhir:v "AUTHEN" ] ] ) ] ] [ fhir:url [ fhir:v "actor"^^xsd:anyURI ] ; fhir:value [ a fhir:Reference ; fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ] ) ; fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/adverse-event-participant"^^xsd:anyURI ] ] [ fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/adverse-event-expectation"^^xsd:anyURI ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C41333" ] ; fhir:display [ fhir:v "Expected Adverse Event" ] ] ) ] ] ) ; # fhir:actuality [ fhir:v "actual"] ; # fhir:event [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/MDRAE"^^xsd:anyURI ] ; fhir:version [ fhir:v "20.3" ] ; fhir:code [ fhir:v "10001551" ] ; fhir:display [ fhir:v "Alanine aminotransferase increased" ] ] ) ; fhir:text [ fhir:v "Alanine aminotransferase (ALT) increased to 200" ] ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/patient-example-kaitlyn-b" ] ] ; # fhir:date [ fhir:v "2020-05-13"^^xsd:date] ; # fhir:seriousness [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C41336" ] ; fhir:display [ fhir:v "Non-serious Adverse Event" ] ] ) ] ; # fhir:outcome [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/adverse-event-outcome"^^xsd:anyURI ] ; fhir:code [ fhir:v "ongoing" ] ] ) ] ; # fhir:recorder [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-nancy-oncology-nurse" ] ] ; # fhir:suspectEntity ( [ fhir:instance [ fhir:reference [ fhir:v "MedicationAdministration/medication-administration-kadcyla" ] ] ; ( fhir:causality [ fhir:assessment [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C53259" ] ] ) ; fhir:text [ fhir:v "Adverse Event Probably Related to Intervention" ] ] ] ) ] [ fhir:instance [ fhir:reference [ fhir:v "MedicationAdministration/medication-administration-tucatinib" ] ] ; ( fhir:causality [ fhir:assessment [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C53259" ] ] ) ; fhir:text [ fhir:v "Adverse Event Probably Related to Intervention" ] ] ] ) ] ) ; # fhir:study ( [ fhir:reference [ fhir:v "ResearchStudy/clinical-trial-example-compass" ] ] ) . # <http://example.org/ctc-adverse-event-compass-ex1b> a fhir:AdverseEvent ; fhir:id [ fhir:v "ctc-adverse-event-compass-ex1b"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/ctc-adverse-event"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/ctcae/StructureDefinition/ctc-adverse-event> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "extensions" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"AdverseEvent_ctc-adverse-event-compass-ex1b\"> </a><p><b>Generated Narrative: AdverseEvent</b><a name=\"ctc-adverse-event-compass-ex1b\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource AdverseEvent "ctc-adverse-event-compass-ex1b" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-ctc-adverse-event.html\">CTC Adverse Event</a></p></div><p><b>CTC Adverse Event Grade</b>: Mild Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ctcae-grade-code-system.html\">CTCAE Grade Code System</a>#1)</span></p><blockquote><p><b>Adverse Event Participant</b></p><blockquote><p><b>url</b></p><code>function</code></blockquote><p><b>value</b>: authenticator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-ParticipationType.html\">ParticipationType</a>#AUTHEN)</span></p><blockquote><p><b>url</b></p><code>actor</code></blockquote><p><b>value</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p></blockquote><p><b>Adverse Event Expectation</b>: Expected Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C41333)</span></p><p><b>Adverse Event Resolved Date</b>: 2020-06-10</p><p><b>actuality</b>: actual</p><p><b>event</b>: Alanine aminotransferase (ALT) decreased to 60 <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (MedDRA Am Engl[20.3]#10001551 "Alanine aminotransferase increased")</span></p><p><b>subject</b>: <a href=\"#Patient_patient-example-kaitlyn-b\">See above (Patient/patient-example-kaitlyn-b)</a></p><p><b>date</b>: 2020-05-20</p><p><b>seriousness</b>: Non-serious Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C41336)</span></p><p><b>outcome</b>: Resolved <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R4/codesystem-adverse-event-outcome.html\">AdverseEventOutcome</a>#resolved)</span></p><p><b>recorder</b>: <a href=\"Practitioner-us-core-practitioner-nancy-oncology-nurse.html\">Practitioner/us-core-practitioner-nancy-oncology-nurse</a> " NURSE"</p><blockquote><p><b>suspectEntity</b></p><p><b>instance</b>: <a href=\"#MedicationAdministration_medication-administration-kadcyla\">See above (MedicationAdministration/medication-administration-kadcyla)</a></p><h3>Causalities</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Assessment</b></td></tr><tr><td style=\"display: none\">*</td><td>Adverse Event Probably Related to Intervention <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C53259)</span></td></tr></table></blockquote><blockquote><p><b>suspectEntity</b></p><p><b>instance</b>: <a href=\"#MedicationAdministration_medication-administration-tucatinib\">See above (MedicationAdministration/medication-administration-tucatinib)</a></p><h3>Causalities</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Assessment</b></td></tr><tr><td style=\"display: none\">*</td><td>Adverse Event Probably Related to Intervention <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C53259)</span></td></tr></table></blockquote><p><b>study</b>: <a href=\"#ResearchStudy_clinical-trial-example-compass\">See above (ResearchStudy/clinical-trial-example-compass)</a></p></div>" ] ; # fhir:extension ( [ fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/ctcae-grade"^^xsd:anyURI ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/us/ctcae/CodeSystem/ctcae-grade-code-system"^^xsd:anyURI ] ; fhir:code [ fhir:v "1" ] ] ) ] ] [ ( fhir:extension [ fhir:url [ fhir:v "function"^^xsd:anyURI ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v3-ParticipationType"^^xsd:anyURI ] ; fhir:code [ fhir:v "AUTHEN" ] ] ) ] ] [ fhir:url [ fhir:v "actor"^^xsd:anyURI ] ; fhir:value [ a fhir:Reference ; fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ] ) ; fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/adverse-event-participant"^^xsd:anyURI ] ] [ fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/adverse-event-expectation"^^xsd:anyURI ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C41333" ] ; fhir:display [ fhir:v "Expected Adverse Event" ] ] ) ] ] [ fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/adverse-event-resolved-date"^^xsd:anyURI ] ; fhir:value [ fhir:v "2020-06-10"^^xsd:date ] ] ) ; # fhir:actuality [ fhir:v "actual"] ; # fhir:event [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/MDRAE"^^xsd:anyURI ] ; fhir:version [ fhir:v "20.3" ] ; fhir:code [ fhir:v "10001551" ] ; fhir:display [ fhir:v "Alanine aminotransferase increased" ] ] ) ; fhir:text [ fhir:v "Alanine aminotransferase (ALT) decreased to 60" ] ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/patient-example-kaitlyn-b" ] ] ; # fhir:date [ fhir:v "2020-05-20"^^xsd:date] ; # fhir:seriousness [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C41336" ] ; fhir:display [ fhir:v "Non-serious Adverse Event" ] ] ) ] ; # fhir:outcome [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/adverse-event-outcome"^^xsd:anyURI ] ; fhir:code [ fhir:v "resolved" ] ] ) ] ; # fhir:recorder [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-nancy-oncology-nurse" ] ] ; # fhir:suspectEntity ( [ fhir:instance [ fhir:reference [ fhir:v "MedicationAdministration/medication-administration-kadcyla" ] ] ; ( fhir:causality [ fhir:assessment [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C53259" ] ] ) ; fhir:text [ fhir:v "Adverse Event Probably Related to Intervention" ] ] ] ) ] [ fhir:instance [ fhir:reference [ fhir:v "MedicationAdministration/medication-administration-tucatinib" ] ] ; ( fhir:causality [ fhir:assessment [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C53259" ] ] ) ; fhir:text [ fhir:v "Adverse Event Probably Related to Intervention" ] ] ] ) ] ) ; # fhir:study ( [ fhir:reference [ fhir:v "ResearchStudy/clinical-trial-example-compass" ] ] ) . # <http://example.org/ctc-adverse-event-compass-ex2> a fhir:AdverseEvent ; fhir:id [ fhir:v "ctc-adverse-event-compass-ex2"] ; # fhir:meta [ ( fhir:profile [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/ctc-adverse-event"^^xsd:anyURI ; fhir:link <http://hl7.org/fhir/us/ctcae/StructureDefinition/ctc-adverse-event> ] ) ] ; # fhir:text [ fhir:status [ fhir:v "extensions" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"AdverseEvent_ctc-adverse-event-compass-ex2\"> </a><p><b>Generated Narrative: AdverseEvent</b><a name=\"ctc-adverse-event-compass-ex2\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource AdverseEvent "ctc-adverse-event-compass-ex2" </p><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-ctc-adverse-event.html\">CTC Adverse Event</a></p></div><p><b>CTC Adverse Event Grade</b>: Mild Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"CodeSystem-ctcae-grade-code-system.html\">CTCAE Grade Code System</a>#1)</span></p><blockquote><p><b>Adverse Event Participant</b></p><blockquote><p><b>url</b></p><code>function</code></blockquote><p><b>value</b>: authenticator <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-ParticipationType.html\">ParticipationType</a>#AUTHEN)</span></p><blockquote><p><b>url</b></p><code>actor</code></blockquote><p><b>value</b>: <a href=\"Practitioner-us-core-practitioner-owen-oncologist.html\">Practitioner/us-core-practitioner-owen-oncologist</a> " ONCOLOGIST"</p></blockquote><p><b>Adverse Event Expectation</b>: Expected Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C41333)</span></p><p><b>Adverse Event Resolved Date</b>: 2021-01-21</p><p><b>actuality</b>: actual</p><p><b>event</b>: Nausea <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (MedDRA Am Engl[20.3]#10028813)</span></p><p><b>subject</b>: <a href=\"#Patient_patient-example-kaitlyn-b\">See above (Patient/patient-example-kaitlyn-b)</a></p><p><b>date</b>: 2020-05-25</p><p><b>seriousness</b>: Non-serious Adverse Event <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C41336)</span></p><p><b>outcome</b>: Ongoing <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://hl7.org/fhir/R4/codesystem-adverse-event-outcome.html\">AdverseEventOutcome</a>#ongoing)</span></p><p><b>recorder</b>: <a href=\"Practitioner-us-core-practitioner-nancy-oncology-nurse.html\">Practitioner/us-core-practitioner-nancy-oncology-nurse</a> " NURSE"</p><blockquote><p><b>suspectEntity</b></p><p><b>instance</b>: <a href=\"#MedicationAdministration_medication-administration-kadcyla\">See above (MedicationAdministration/medication-administration-kadcyla)</a></p><h3>Causalities</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Assessment</b></td></tr><tr><td style=\"display: none\">*</td><td>Adverse Event Possibly Related to Intervention <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C53258)</span></td></tr></table></blockquote><blockquote><p><b>suspectEntity</b></p><p><b>instance</b>: <a href=\"#MedicationAdministration_medication-administration-tucatinib\">See above (MedicationAdministration/medication-administration-tucatinib)</a></p><h3>Causalities</h3><table class=\"grid\"><tr><td style=\"display: none\">-</td><td><b>Assessment</b></td></tr><tr><td style=\"display: none\">*</td><td>Adverse Event Probably Related to Intervention <span style=\"background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki\"> (<a href=\"http://terminology.hl7.org/5.3.0/CodeSystem-v3-nciThesaurus.html\">NCI Thesaurus</a>#C53259)</span></td></tr></table></blockquote><p><b>study</b>: <a href=\"#ResearchStudy_clinical-trial-example-compass\">See above (ResearchStudy/clinical-trial-example-compass)</a></p></div>" ] ; # fhir:extension ( [ fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/ctcae-grade"^^xsd:anyURI ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://hl7.org/fhir/us/ctcae/CodeSystem/ctcae-grade-code-system"^^xsd:anyURI ] ; fhir:code [ fhir:v "1" ] ] ) ] ] [ ( fhir:extension [ fhir:url [ fhir:v "function"^^xsd:anyURI ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/v3-ParticipationType"^^xsd:anyURI ] ; fhir:code [ fhir:v "AUTHEN" ] ] ) ] ] [ fhir:url [ fhir:v "actor"^^xsd:anyURI ] ; fhir:value [ a fhir:Reference ; fhir:reference [ fhir:v "Practitioner/us-core-practitioner-owen-oncologist" ] ] ] ) ; fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/adverse-event-participant"^^xsd:anyURI ] ] [ fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/adverse-event-expectation"^^xsd:anyURI ] ; fhir:value [ a fhir:CodeableConcept ; ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C41333" ] ; fhir:display [ fhir:v "Expected Adverse Event" ] ] ) ] ] [ fhir:url [ fhir:v "http://hl7.org/fhir/us/ctcae/StructureDefinition/adverse-event-resolved-date"^^xsd:anyURI ] ; fhir:value [ fhir:v "2021-01-21"^^xsd:date ] ] ) ; # fhir:actuality [ fhir:v "actual"] ; # fhir:event [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/MDRAE"^^xsd:anyURI ] ; fhir:version [ fhir:v "20.3" ] ; fhir:code [ fhir:v "10028813" ] ; fhir:display [ fhir:v "Nausea" ] ] ) ; fhir:text [ fhir:v "Nausea" ] ] ; # fhir:subject [ fhir:reference [ fhir:v "Patient/patient-example-kaitlyn-b" ] ] ; # fhir:date [ fhir:v "2020-05-25"^^xsd:date] ; # fhir:seriousness [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C41336" ] ; fhir:display [ fhir:v "Non-serious Adverse Event" ] ] ) ] ; # fhir:outcome [ ( fhir:coding [ fhir:system [ fhir:v "http://terminology.hl7.org/CodeSystem/adverse-event-outcome"^^xsd:anyURI ] ; fhir:code [ fhir:v "ongoing" ] ] ) ] ; # fhir:recorder [ fhir:reference [ fhir:v "Practitioner/us-core-practitioner-nancy-oncology-nurse" ] ] ; # fhir:suspectEntity ( [ fhir:instance [ fhir:reference [ fhir:v "MedicationAdministration/medication-administration-kadcyla" ] ] ; ( fhir:causality [ fhir:assessment [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C53258" ] ] ) ; fhir:text [ fhir:v "Adverse Event Possibly Related to Intervention" ] ] ] ) ] [ fhir:instance [ fhir:reference [ fhir:v "MedicationAdministration/medication-administration-tucatinib" ] ] ; ( fhir:causality [ fhir:assessment [ ( fhir:coding [ fhir:system [ fhir:v "http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl"^^xsd:anyURI ] ; fhir:code [ fhir:v "C53259" ] ] ) ; fhir:text [ fhir:v "Adverse Event Probably Related to Intervention" ] ] ] ) ] ) ; # fhir:study ( [ fhir:reference [ fhir:v "ResearchStudy/clinical-trial-example-compass" ] ] ) . # <http://example.org/clinical-trial-example-compass> a fhir:ResearchStudy ; fhir:id [ fhir:v "clinical-trial-example-compass"] ; # fhir:text [ fhir:status [ fhir:v "generated" ] ; fhir:div "<div xmlns=\"http://www.w3.org/1999/xhtml\"><a name=\"ResearchStudy_clinical-trial-example-compass\"> </a><p><b>Generated Narrative: ResearchStudy</b><a name=\"clinical-trial-example-compass\"> </a></p><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\">Resource ResearchStudy "clinical-trial-example-compass" </p></div><p><b>title</b>: Alliance COMPASS Trial A011801</p><p><b>status</b>: active</p></div>" ] ; # fhir:title [ fhir:v "Alliance COMPASS Trial A011801"] ; # fhir:status [ fhir:v "active"] . #
IG © 2021+ HL7 International Clinical Interoperability Council. Package hl7.fhir.us.ctcae#0.0.1 based on FHIR 4.0.1. Generated 2024-02-28
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