Id: ConversionFactors Url: Morphine Milligram Equivalent (MME) Conversion Factors for FHIR R4 Version: 3.0.0 Name: ConversionFactors Title: Morphine Milligram Equivalent (MME) Conversion Factors for FHIR R4 Status: active Experimental: false Type: system: http://terminology.hl7.org/CodeSystem/library-type code: logic-library Date: 2022-02-01 20:35:24+0000 Publisher: CDC / Security Risk Solutions, Inc. (SRS) Description: This library contains logic to expose configurable conversion factors for the MME calculation functionality provided by the OMTKLogic library. Knowledge Capability: shareable computable publishable executable Knowledge Representation Level: structured Use Context: code value display focus 182888003 Medication requested (situation) focus 82423001 Chronic pain (finding) Usage: NOTE: Do not use the calculated dose in MMEs to determine dosage for converting one opioid to another—the new opioid should be lower to avoid unintentional overdose caused by incomplete cross-tolerance and individual differences in opioid pharmacokinetics. Consult the medication label. Copyright: Copyright 2019+ Centers for Disease Control and Prevention (CDC) Last Review Date: 2020-09-26 Related Artifacts: Documentation Conversion Factors Conversion Factors References Nelson SJ, Zeng K, Kilbourne J, Powell T, Moore R. Normalized names for clinical drugs: RxNorm at 6 years. J Am Med Inform Assoc. 2011 Jul-Aug;18(4)441-8. doi: 10.1136/amiajnl-2011-000116. Epub 2011 Apr 21. PubMed PMID: 21515544; PubMed Central PMCID: PMC3128404. Full Text https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128404/ Schadow G, McDonald CJ. The Unified Code for Units of Measure. Regenstrief Institute, Inc. and the UCUM Organization, 2017. Version 2.1, Revision 442. http://unitsofmeasure.org http://unitsofmeasure.org Dowell D, Ragan KR, Jones CM, Baldwin GT, Chou R. CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States, 2022. MMWR Recomm Rep 2022;71(No. RR-3):1-95. DOI: http://dx.doi.org/10.15585/mmwr.rr7103a1 http://dx.doi.org/10.15585/mmwr.rr7103a1 Dependencies http://fhir.org/guides/cqf/common/Library/FHIR-ModelInfo|4.0.1 FHIR Helpers version: 4.0.1 CDCMMEClinicalConversionFactors version: 3.0.0 UsageContextType CDC MME Usage Context Codes Parameters: Name Type Min Max In/Out ErrorLevel string 0 1 In ConversionFactorSupplementName string 0 1 In Patient Patient 0 1 Out ConversionFactorSupplement CodeSystem 0 1 Out Data Requirements: Type Profile MS Code Filter Patient http://hl7.org/fhir/StructureDefinition/Patient Content: text/cql library ConversionFactors version '3.0.0' /* This library provides logic to determine the appropriate conversion factor to be used for calculating Morphine Milligram Equivalent (MME) for a given medication. The conversion factors are configurable using a CodeSystem supplement. This implementation guide contains one conversion factor table: CDCMMEClinicalConversionFactors The Clinical Conversion Factors table uses values from CDC guidance here: https://www.cdc.gov/drugoverdose/pdf/calculating_total_daily_dose-a.pdf The CodeSystem supplements are configured with 3 types of properties: * conversion-factor: Defines the conversion factor for a specific ingredient, when the conversion factor is the same for all dose forms and dose amounts for the ingredient. The value of this property will be the decimal representation of the conversion factor. * dose-form-conversion-factor: Defines the conversion factor for an ingredient when the conversion factor varies by the dose form of the medication. The value of this property will be a string of the form <dose-form-code>:<conversion-factor>[@<doses-per-day>], e.g. 970789:130, where '970789' is the RxNorm dose form code, and '130' is the decimal representation of the conversion factor. An example of a per-day conversion factor is fentanyl, 316987:7200@0.33333333, where 316987 is RxNorm dose form code, 7200 is the conversion factor, and 0.33333333 is the dosesPerDay, expressed as a decimal with a maximum of 8 digits after the decimal. * dose-range-conversion-factor: Defines the conversion factor for an ingredient when the conversion factor varies by the overall dose of the medication. The value of this property will be a string of the form <low-value>-<high-value>:<conversion-factor>, e.g. 1-20:4. Note that the low-value or high-value may be a wildcard '*' to indicate the range continues (e.g. '61-*:12' indicates the range is 61 or greater). For a given ingredient, only one of 'dose-form' or 'dose-range' will be present, with or without an ingredient-specific conversion factor. The properties together will enable a unique conversion factor to be determined if the input is within the expected range. If the input is outside the expected range, and there is no ingredient-specific conversion-factor specified, implementations should indicate a conversion factor could not be determined from the supplied information. All conversion factors supplied in these supplements are in 'mg/d'. */ using FHIR version '4.0.1' include FHIRHelpers version '4.0.1' include CDCMMEClinicalConversionFactors version '3.0.0' called CDCMMEClinicalConversionFactors codesystem "Usage Context Type": 'http://terminology.hl7.org/CodeSystem/usage-context-type' codesystem "CDC MME Usage Context Codes": 'http://fhir.org/guides/cdc/opioid-mme-r4/CodeSystem/CDCMMEUsageContextCodes' code "Task Usage Context": 'task' from "Usage Context Type" code "MME Calculation": 'mme-calculation' from "CDC MME Usage Context Codes" parameter ErrorLevel String default 'Trace' /* If this parameter is supplied, it specifies the name of the code system supplement to be used to supply conversion factors for the calculator. If this parameter is not provided, the _single_ CodeSystem with a task usage context code of "mme-calculation" from the CDCMMEUsageContextCodes code system will be used to provide conversion factors. If neither of these configurations is available, the hard-coded conversion factors in GetConversionFactor will be used. The hard-coded conversion factors use the clinical conversion factors only. */ parameter ConversionFactorSupplementName String default 'CDCMMEClinicalConversionFactors' context Patient /* Returns the conversion factor for the given ingredient CDC Guidance: https://www.cdc.gov/drugoverdose/pdf/calculating_total_daily_dose-a.pdf |Opioid (strength in mg except where noted) |MME Conversion Factor*| |-----------------------------------------------|----------------------| |Codeine | 0.15 | |Fentanyl, transdermal patch (MCG/HR) | 2.4 | |Hydrocodone | 1 | |Hydromorphone | 4 | |Methadone | | | 1-20 mg/d | 4 | | 21-40 mg/d | 8 | | 41-60 mg/d | 10 | | 61-80+ mg/d | 12 | | Morphine | 1 | | Oxycodone | 1.5 | | Oxymorphone | 3 | */ define function GetConversionFactor(ingredientCode System.Code, dailyDose System.Quantity, doseFormCode System.Code, dosesPerDay System.Decimal): Coalesce( LookupConversionFactor(ingredientCode, dailyDose, doseFormCode, dosesPerDay), case ToInteger(ingredientCode.code) when 2670 then 0.15 /* Codeine */ when 4337 then ( /* Fentanyl */ case when ToInteger(doseFormCode.code) = 316987 then (0.33333333 / dosesPerDay) * 7200 /* Transdermal system */ else Message(null, true, 'OMTKLogic.GetConversionFactor.UnknownDoseForm', ErrorLevel, 'Unknown dose form code ' & doseFormCode.code) end ) when 5489 then 1 /* Hydrocodone */ when 3423 then 4 /* Hydromorphone */ when 6813 then ( /* Methadone */ case when dailyDose.value between 1 and 20 then 4 when dailyDose.value between 21 and 40 then 8 when dailyDose.value between 41 and 60 then 10 when dailyDose.value >= 61 then 12 when dailyDose is null or dailyDose.value is null then Message(null, true, 'OMTKLogic.GetConversionFactor.DailyDoseNull', ErrorLevel, 'Daily dose is required to determine methadone conversion factor') else Message(null, dailyDose.value < 1, 'OMTKLogic.GetConversionFactor.DailyDoseLessThanOne', ErrorLevel, 'Daily dose less than 1') end ) when 7052 then 1 /* Morphine */ when 7804 then 1.5 /* Oxycodone */ when 7814 then 3 /* Oxymorphone */ else Message(null, true, 'OMTKLogic.GetConversionFactor.UnknownIngredientCode', ErrorLevel, 'Unknown ingredient code: ' & ingredientCode.code) end ) /* The use of the CDCMMEClinicalConversionFactors is a workaround for the fact that we can't retrieve the formally defined CodeSystem resource (https://fhir.org/guides/cdc/opioid-mme-r4/CodeSystem-CDCMMEClinicalConversionFactors.html) from the FHIR server */ define ConversionFactorSupplement: CDCMMEClinicalConversionFactors."CDCMMEClinicalConversionFactorsCodeSystem" C where C.supplements.value = 'http://www.nlm.nih.gov/research/umls/rxnorm' and ( C.name.value = ConversionFactorSupplementName or exists ( C.useContext UC where UC.code ~ "Task Usage Context" and UC.value ~ "MME Calculation" ) ) /* Converts a range value boundary to a Decimal (or null for a wildcard) */ define function ToRangeValue(value System.String): if value = '*' then null else ToDecimal(value) /* Converts the property value of a dose-range-conversion-factor property to the dose range <low-value>-<high-value>:<conversion-factor> Note that low-value and/or high-value may be wildcards '*' */ define function ToDoseRange(propertyValue FHIR.string): ({ : }) X let rangeValues: Split(Split(propertyValue.value, ':')[0], '-') return Interval[ToRangeValue(rangeValues[0]), ToRangeValue(rangeValues[1])] /* Converts the property value of a dose-range-conversion-factor property to the conversion factor <low-value>-<high-value>:<conversion-factor> */ define function ToDoseRangeConversionFactor(propertyValue FHIR.string): ToDecimal(Split(propertyValue.value, ':')[1]) /* Converts the property value of a dose-form-conversion-factor property to the dose form <dose-form-code>:<conversion-factor> */ define function ToDoseForm(propertyValue FHIR.string): Split(propertyValue.value, ':')[0] /* Converts the property value of a dose-form-conversion-factor property to the conversion factor <dose-form-code>:<conversion-factor>[@doses-per-day] */ define function ToDoseFormConversionFactor(propertyValue FHIR.string, dosesPerDay System.Decimal): if PositionOf('@', propertyValue.value) > 0 then ToDoseFormDosesPerDayConversionFactor(propertyValue, dosesPerDay) else ToDecimal(Split(propertyValue.value, ':')[1]) /* Converts the property value of a dose-form-conversion-factor property to the conversion factor if the property includes a doses-per-day value */ define function ToDoseFormDosesPerDayConversionFactor(propertyValue FHIR.string, dosesPerDay System.Decimal): propertyValue P let components: Split(P.value, '@') return (ToDecimal(components[1]) / dosesPerDay) * ToDecimal(Split(components[0], ':')[1]) /* Returns the conversion factor for a conversion-factor property NOTE: These functions are used to avoid use of _is_ and _as_ */ define function ToConversionFactor(propertyValue FHIR.decimal): propertyValue.value /* Looks up the conversion factor for the given ingredient, daily dose, and dose form from the configured conversion factor supplement, if available. If no conversion factor supplement is configured, returns null */ define function LookupConversionFactor(ingredientCode System.Code, dailyDose System.Quantity, doseFormCode System.Code, dosesPerDay System.Decimal): ConversionFactorSupplement CFS let ingredientConcept: singleton from (CFS."concept" C where C.code.value = ingredientCode.code), conversionFactor: singleton from (ingredientConcept.property P where P.code.value = 'conversion-factor'), doseFormConversionFactors: (ingredientConcept.property P where P.code.value = 'dose-form-conversion-factor'), doseRangeConversionFactors: (ingredientConcept.property P where P.code.value = 'dose-range-conversion-factor') return Coalesce ( case when exists (doseRangeConversionFactors) then singleton from ( doseRangeConversionFactors DRCF where dailyDose.value in ToDoseRange(DRCF.value) return ToDoseRangeConversionFactor(DRCF.value) ) when exists (doseFormConversionFactors) then singleton from ( doseFormConversionFactors DFCF where doseFormCode.code = ToDoseForm(DFCF.value) return ToDoseFormConversionFactor(DFCF.value, dosesPerDay) ) else null end, ToConversionFactor(conversionFactor.value) ) Content: application/elm+xml Encoded data (175480 characters) Content: application/elm+json Encoded data (337040 characters)
Morphine Milligram Equivalent (MME) Conversion Factors for FHIR R4
CDC / Security Risk Solutions, Inc. (SRS)
This library contains logic to expose configurable conversion factors for the MME calculation functionality provided by the OMTKLogic library.
NOTE: Do not use the calculated dose in MMEs to determine dosage for converting one opioid to another—the new opioid should be lower to avoid unintentional overdose caused by incomplete cross-tolerance and individual differences in opioid pharmacokinetics. Consult the medication label.
Copyright 2019+ Centers for Disease Control and Prevention (CDC)
This product uses publicly available data courtesy of the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.
Nelson SJ, Zeng K, Kilbourne J, Powell T, Moore R. Normalized names for clinical drugs: RxNorm at 6 years. J Am Med Inform Assoc. 2011 Jul-Aug;18(4)441-8. doi: 10.1136/amiajnl-2011-000116. Epub 2011 Apr 21. PubMed PMID: 21515544; PubMed Central PMCID: PMC3128404. [Full Text](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128404/)
This product includes all or a portion of the UCUM table, UCUM codes, and UCUM definitions or is derived from it, subject to a license from Regenstrief Institute, Inc. and The UCUM Organization. Your use of the UCUM table, UCUM codes, UCUM definitions also is subject to this license, a copy of which is available at http://unitsofmeasure.org The current complete UCUM table, UCUM Specification are available for download at http://unitsofmeasure.org The UCUM table and UCUM codes are copyright © 1995-2009, Regenstrief Institute, Inc. and the Unified Codes for Units of Measures (UCUM) Organization. All rights reserved.
Schadow G, McDonald CJ. The Unified Code for Units of Measure. Regenstrief Institute, Inc. and the UCUM Organization, 2017. Version 2.1, Revision 442. http://unitsofmeasure.org
CDC Clinical Practice Guideline for Prescribing Opioids for Pain
CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States, 2022
Dowell D, Ragan KR, Jones CM, Baldwin GT, Chou R. CDC Clinical Practice Guideline for Prescribing Opioids for Pain — United States, 2022. MMWR Recomm Rep 2022;71(No. RR-3):1-95. DOI: http://dx.doi.org/10.15585/mmwr.rr7103a1