@startuml references-mtb-timeline

' Timeline/workflow layout - zigzag through the process
skinparam linetype ortho
skinparam nodesep 60
skinparam ranksep 100
skinparam packageStyle rectangle
skinparam shadowing false
skinparam arrow {
    Color #555555
    Thickness 1.5
}

!$colors = {"CarePlan": "#6a6cf8", "Claim": "#f26f6f", "ClaimResponse": "#a4b1f7", "ClinicalImpression": "#69f683", "Condition": "#6d7198", "DiagnosticReport": "#fa92bb", "MedicationRequest": "#ba6bf9", "MedicationStatement": "#74f8dc", "Observation": "#fbca69", "Procedure": "#70a68c", "RequestGroup": "#fee0b0", "ResearchStudy": "#d96ac5", "ServiceRequest": "#a3c16d"}

legend top left
    **MTB Workflow Timeline**
    |Color|Type|
    |<$colors.DiagnosticReport>|DiagnosticReport|<$colors.ClinicalImpression>|ClinicalImpression|
    |<$colors.Condition>|Condition|<$colors.Observation>|Observation|
    |<$colors.Procedure>|Procedure|<$colors.CarePlan>|CarePlan|
    |<$colors.MedicationRequest>|MedicationRequest|<$colors.RequestGroup>|RequestGroup|
    |<$colors.ServiceRequest>|ServiceRequest|<$colors.ResearchStudy>|ResearchStudy|
    |<$colors.Claim>|Claim|<$colors.ClaimResponse>|ClaimResponse|
endlegend

' =============== PHASE 1: Diagnostic Input (Left) ===============
package "**Phase 1: Diagnostics**" as phase1 {
    object "NGS Bericht" as NGS $colors.DiagnosticReport
    object "Molecular Path.\nReport" as MolPath $colors.DiagnosticReport
}

' =============== PHASE 2: NGS Details (Right, down) ===============
package "**Phase 2: NGS Analysis**" as phase2 {
    object "Varianten &\nBiomarker" as Var $colors.Observation
    object "Genomic Study" as GS $colors.Procedure
    object "Genomic Analysis" as GA $colors.Procedure
    object "Therapeutische\nImplikation" as TI $colors.Observation
    object "Diagnostische\nImplikation" as DI $colors.Observation
}

' =============== PHASE 3: Episode & Diagnosis (Left, down) ===============
package "**Phase 3: MTB Episode**" as phase3 {
    object "**Behandlungsepisode**" as Episode $colors.ClinicalImpression {
        ==Core Entity==
    }
    object "**Diagnose Primärtumor**" as Diag $colors.Condition {
        ==Main Problem==
    }
    object "Consent" as Consent $colors.Observation
    object "Vortherapie" as Vorth $colors.Procedure
}

' =============== PHASE 4: Diagnosis Details (Right, down) ===============
package "**Phase 4: Diagnosis Details**" as phase4 {
    object "Tumorausbreitung" as TA $colors.Observation
    object "WHO Grad ZNS" as WHO $colors.Observation
    object "Oncotree" as OT $colors.Observation
    object "Mol. Path.\nInhalte" as MPI $colors.Observation
}

' =============== PHASE 5: Treatment Planning (Left, down) ===============
package "**Phase 5: Treatment Plan**" as phase5 {
    object "**Therapieplan**" as TP $colors.CarePlan {
        ==Treatment Plan==
    }
    object "Therapieempfehlung" as TE $colors.MedicationRequest
    object "Kombi-Therapie" as TK $colors.RequestGroup
}

' =============== PHASE 6: Service Requests (Right, down) ===============
package "**Phase 6: Service Requests**" as phase6 {
    object "Humangenetische\nBeratung" as HG $colors.ServiceRequest
    object "Histologie\nEvaluation" as HE $colors.ServiceRequest
    object "Biopsie" as Bio $colors.ServiceRequest
    object "Studieneinschluss" as SE $colors.ServiceRequest
    object "Tumorzellgehalt" as TZG $colors.Observation
    object "Studie" as St $colors.ResearchStudy
}

' =============== PHASE 7: Follow-Up (Left, down) ===============
package "**Phase 7: Follow-Up**" as phase7 {
    object "Follow-Up Episode" as FU $colors.ClinicalImpression
    object "Systemische\nTherapie" as SysT $colors.Procedure
    object "Response" as Resp $colors.Observation
}

' =============== PHASE 8: Cost Claims (Right, down) ===============
package "**Phase 8: Cost Management**" as phase8 {
    object "Antrag\nKostenübernahme" as Claim $colors.Claim
    object "Antwort\nKostenübernahme" as ClaimResp $colors.ClaimResponse
}

' ============== LAYOUT HINTS ==============
' Zigzag: left-right-left-right pattern
phase1 -[hidden]right- phase2
phase2 -[hidden]down- phase3
phase3 -[hidden]right- phase4
phase4 -[hidden]down- phase5
phase5 -[hidden]right- phase6
phase6 -[hidden]down- phase7
phase7 -[hidden]right- phase8

' ============== RELATIONSHIPS ==============

' Phase 1 -> Phase 2: Diagnostic reports produce results
NGS -down-> Var : result
NGS -down-> GS : extension
NGS -down-> GA : extension
NGS -down-> TI : result
NGS -down-> DI : result
GS -right-> GA : extension:\ngenomic-study-analysis
Var -down-> TI : derivedFrom
Var -down-> DI : derivedFrom

' Phase 1 -> Phase 3: Reports feed into episode
NGS -down-> Episode : investigation
MolPath -down-> Episode : investigation

' Phase 2 -> Phase 3: Implikationen point to diagnosis
TI -down-> Diag : focus
DI -down-> Diag : focus

' Phase 3: Episode internal relationships
Episode -right-> Diag : problem
Episode -right-> Consent : supportingInfo
Episode -right-> Vorth : supportingInfo

' Phase 3 -> Phase 4: Diagnosis details
Diag -down-> TA : stage
Diag -down-> WHO : stage
Diag -down-> OT : stage

' Phase 1 -> Phase 4: Mol Path details
MolPath -down-> MPI : result

' Phase 3 -> Phase 5: Episode to Treatment Plan
Episode -down-> TP : supportingInfo
Vorth -down-> TP : basedOn

' Phase 5: Treatment plan internal
TP -right-> TE : activity
TP -right-> TK : activity
TK -up-> TE : action.resource
TE -up-> Diag : reasonReference

' Phase 5 -> Phase 6: Treatment plan to service requests
TP -down-> HG : activity
TP -down-> HE : activity
TP -down-> Bio : activity
TP -down-> SE : activity
Bio -right-> TZG : reasonReference
HE -right-> TZG : reasonReference
SE -up-> Diag : reasonReference
SE -right-> St : supportingInfo

' Phase 3 -> Phase 7: Episode to Follow-up
Episode -down-> FU : previous (via Follow-Up)

' Phase 5 -> Phase 7: Treatment recommendation to therapy
TE -down-> SysT : basedOn
SysT -right-> Resp : partOf (via Response)
Resp -up-> Diag : focus

' Phase 7 -> Phase 8: Follow-up to cost claims
ClaimResp -left-> Claim : request
Claim -up-> Claim : related.claim

@enduml