Profile: MII_PR_MTB_IMMUNOHISTOCHEMISTRY_HER2
Parent: MII_PR_MTB_Immunohistochemistry // 
Id: mii-pr-mtb-immunohistochemistry-her2
Title: "MII PR MTB Immunohistochemistry"
Description: "Immunhistrchemistry report"
* insert PR_Header

* code.coding ^slicing.discriminator.type = #value
* code.coding ^slicing.discriminator.path = "system"
* code.coding ^slicing.rules = #open
* code.coding ^slicing.description = "Slices for the coding"
* code.coding ^slicing.ordered = false
* code.coding contains LNC 1..1 MS
* code.coding[LNC] = $LNC#18474-7 "HER2 Ag [Presence] in Tissue by Immune stain"
* valueCodeableConcept.coding.system = $LNC
* valueCodeableConcept.coding.code from http://loinc.org/vs/LL4396-9 //
* valueCodeableConcept.coding ^short =  "0|1+|2+|3+|Indeterminate"
* component[gene-studied].valueCodeableConcept = $HGNC#HGNC:2064 "ERBB2"
//* component[protein-studied].valueCodeableConcept = $UNIPROT#P04626 "Receptor tyrosine-protein kinase erbB-2"
* component[biomarker-category].valueCodeableConcept.coding = #immuneStain // alternative: protein



Profile: MII_PR_MTB_INSITUHYBRIDIZATION_HER2
Parent: MII_PR_MTB_Molekularer_Biomarker // copy of CG STU3profile
Id: mii-pr-mtb-insituhybridization-her2
Title: "MII PR MTB In Situ Hybridization"
Description: "In Situ Hybridization report"
* insert PR_Header
* code.coding = $LNC#31150-6 "ERBB2 gene duplication [Presence] in Tissue by FISH"
* valueCodeableConcept.coding.system = $LNC
* valueCodeableConcept.coding.code from http://loinc.org/vs/LL360-9-9 //
* component[gene-studied].valueCodeableConcept = $HGNC#HGNC:2064 "ERBB2"
//* component[protein-studied].valueCodeableConcept = $UNIPROT#P04626 "Receptor tyrosine-protein kinase erbB-2"
* component[biomarker-category].valueCodeableConcept.coding.code = #inSituHybridization //new code for method, otherwise 
/* additional optional components from (LOINC Panel)
74885-5	ERBB2 gene (HER2) duplication associated observations panel - Tissue by FISH			
 31150-6	ERBB2 gene duplication [Presence] in Tissue by FISH	 --> this is already valueCodeableConcept		
 49683-6	ERBB2 gene copy number/Chromosome 17 copy number in Tissue by FISH		e.g. valueRatio ( valueQuantitiy 6.0
 74860-8	ERBB2 gene copy number/nucleus in Tissue by FISH			{#}
 74861-6	Chromosome 17 copy number/nucleus in Tissue by FISH			{#}
 62361-1	Cells counted [#]			{#}
 19147-8	Referral lab test reference range
 */


Profile: MII_PR_MTB_BIOMARKER_HER2_STATUS
Parent: MII_PR_MTB_Molekularer_Biomarker // copy of CG STU3profile --> or is this a diagnostic / therapeutic implication?
Id: mii-pr-mtb-biomarker-her2-status
Title: "MII PR Biomarker Her2 Status"
Description: "..."
* insert PR_Header
* code.coding = $LNC#48676-1 "HER2 [Interpretation] in Tissue"
* valueCodeableConcept.coding.system = $LNC
* valueCodeableConcept.coding.code from http://loinc.org/vs/LL3593-2 //Pos|Weak pos|Neg -> maybe also Her2low as explicit response option in self-defined value set

* component[gene-studied].valueCodeableConcept = $HGNC#HGNC:2064 "ERBB2"
//* component[protein-studied].valueCodeableConcept = $UNIPROT#P04626 "Receptor tyrosine-protein kinase erbB-2"
* component[biomarker-category].valueCodeableConcept.coding.code = #molgen  //derived Biomarker or implication?