@prefix fhir: <http://hl7.org/fhir/> .
@prefix loinc: <https://loinc.org/rdf/> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

# - resource -------------------------------------------------------------------

<https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/Observation/mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1> a fhir:Observation ;
  fhir:nodeRole fhir:treeRoot ;
  fhir:id [ fhir:v "mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1"] ; # 
  fhir:meta [
     fhir:profile ( [
       fhir:v "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapeutische-implikation|2026.0.1"^^xsd:anyURI ;
       fhir:l <https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapeutische-implikation?version=2026.0.1>
     ] )
  ] ; # 
  fhir:text [
     fhir:status [ fhir:v "extensions" ] ;
     fhir:div [ fhir:v "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Observation mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1</b></p><a name=\"mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1\"> </a><a name=\"hcmii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mii-pr-mtb-therapeutische-implikation.html\">MII PR MTB Therapeutische Implikationversion: null2026.0.1)</a></p></div><p><b>MII EX MTB Empfehlung Evidenzgraduierung</b>: <span title=\"Codes:{https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad m3}\">m3</span></p><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetik</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Patient-PatientKimMusterperson.html\">Kim Musterperson  (no stated gender), DoB: 1956-03-14</a></p><p><b>derivedFrom</b>: <a href=\"Observation-mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1.html\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs conclusion-string}\">Conclusion Text</span></p><p><b>value</b>: Ausweislich praeklinischer Daten liegt ein Ansprechen auf MEK-Inhibition nahe (PMID: 31209687, EL m3).</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://fhir.de/CodeSystem/bfarm/atc L01EE}\">Mitogen-aktivierte Proteinkinase (MEK)-Inhibitoren</span></p></blockquote></div>"^^rdf:XMLLiteral ]
  ] ; # 
  fhir:extension ( [
     fhir:url [
       fhir:v "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung"^^xsd:anyURI ;
       fhir:l <https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung>
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         fhir:system [
           fhir:v "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad"^^xsd:anyURI ;
           fhir:l <https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad>
         ] ;
         fhir:code [ fhir:v "m3" ]
       ] )
     ]
  ] ) ; # 
  fhir:status [ fhir:v "final"] ; # 
  fhir:category ( [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://terminology.hl7.org/CodeSystem/observation-category"^^xsd:anyURI ;
         fhir:l <http://terminology.hl7.org/CodeSystem/observation-category>
       ] ;
       fhir:code [ fhir:v "laboratory" ] ;
       fhir:display [ fhir:v "Laboratory" ]
     ] )
  ] [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://terminology.hl7.org/CodeSystem/v2-0074"^^xsd:anyURI ;
         fhir:l <http://terminology.hl7.org/CodeSystem/v2-0074>
       ] ;
       fhir:code [ fhir:v "GE" ]
     ] )
  ] ) ; # 
  fhir:code [
     fhir:coding ( [
       fhir:system [
         fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
         fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
       ] ;
       fhir:code [ fhir:v "therapeutic-implication" ] ;
       fhir:display [ fhir:v "Therapeutic Implication" ]
     ] )
  ] ; # 
  fhir:subject [
     fhir:l <https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/Patient/PatientKimMusterperson> ;
     fhir:reference [ fhir:v "Patient/PatientKimMusterperson" ]
  ] ; # 
  fhir:derivedFrom ( [
     fhir:l <https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1> ;
     fhir:reference [ fhir:v "Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1" ]
  ] ) ; # 
  fhir:component ( [
     fhir:code [
       fhir:coding ( [
         fhir:system [
           fhir:v "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs"^^xsd:anyURI ;
           fhir:l <http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs>
         ] ;
         fhir:code [ fhir:v "conclusion-string" ]
       ] )
     ] ;
     fhir:value [
       a fhir:String ;
       fhir:v "Ausweislich praeklinischer Daten liegt ein Ansprechen auf MEK-Inhibition nahe (PMID: 31209687, EL m3)."
     ]
  ] [
     fhir:code [
       fhir:coding ( [
         a loinc:51963-7 ;
         fhir:system [
           fhir:v "http://loinc.org"^^xsd:anyURI ;
           fhir:l <http://loinc.org>
         ] ;
         fhir:code [ fhir:v "51963-7" ] ;
         fhir:display [ fhir:v "Medication assessed [ID]" ]
       ] )
     ] ;
     fhir:value [
       a fhir:CodeableConcept ;
       fhir:coding ( [
         fhir:system [
           fhir:v "http://fhir.de/CodeSystem/bfarm/atc"^^xsd:anyURI ;
           fhir:l <http://fhir.de/CodeSystem/bfarm/atc>
         ] ;
         fhir:code [ fhir:v "L01EE" ] ;
         fhir:display [ fhir:v "Mitogen-aktivierte Proteinkinase (MEK)-Inhibitoren" ]
       ] )
     ]
  ] ) . # 

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