{
  "resourceType" : "Observation",
  "id" : "mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1",
  "meta" : {
    "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-therapeutische-implikation|2026.0.1"]
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  "text" : {
    "status" : "extensions",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Observation mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1</b></p><a name=\"mii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1\"> </a><a name=\"hcmii-exa-mtb-kim-musterperson-TherapeutischeImplikation-PIK3R1\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mii-pr-mtb-therapeutische-implikation.html\">MII PR MTB Therapeutische Implikationversion: null2026.0.1)</a></p></div><p><b>MII EX MTB Empfehlung Evidenzgraduierung</b>: <span title=\"Codes:{https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad m3}\">m3</span></p><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetik</span></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs therapeutic-implication}\">Therapeutic Implication</span></p><p><b>subject</b>: <a href=\"Patient-PatientKimMusterperson.html\">Kim Musterperson  (no stated gender), DoB: 1956-03-14</a></p><p><b>derivedFrom</b>: <a href=\"Observation-mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1.html\">Observation Genetic variant assessment</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs conclusion-string}\">Conclusion Text</span></p><p><b>value</b>: Ausweislich praeklinischer Daten liegt ein Ansprechen auf MEK-Inhibition nahe (PMID: 31209687, EL m3).</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 51963-7}\">Medication assessed [ID]</span></p><p><b>value</b>: <span title=\"Codes:{http://fhir.de/CodeSystem/bfarm/atc L01EE}\">Mitogen-aktivierte Proteinkinase (MEK)-Inhibitoren</span></p></blockquote></div>"
  },
  "extension" : [{
    "url" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-ex-mtb-empfehlung-evidenzgraduierung",
    "valueCodeableConcept" : {
      "coding" : [{
        "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-empfehlung-evidenzgrad",
        "code" : "m3"
      }]
    }
  }],
  "status" : "final",
  "category" : [{
    "coding" : [{
      "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
      "code" : "laboratory",
      "display" : "Laboratory"
    }]
  },
  {
    "coding" : [{
      "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
      "code" : "GE"
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  }],
  "code" : {
    "coding" : [{
      "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
      "code" : "therapeutic-implication",
      "display" : "Therapeutic Implication"
    }]
  },
  "subject" : {
    "reference" : "Patient/PatientKimMusterperson"
  },
  "derivedFrom" : [{
    "reference" : "Observation/mii-exa-mtb-kim-musterperson-EinfacheVariante-PIK3R1"
  }],
  "component" : [{
    "code" : {
      "coding" : [{
        "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
        "code" : "conclusion-string"
      }]
    },
    "valueString" : "Ausweislich praeklinischer Daten liegt ein Ansprechen auf MEK-Inhibition nahe (PMID: 31209687, EL m3)."
  },
  {
    "code" : {
      "coding" : [{
        "system" : "http://loinc.org",
        "code" : "51963-7",
        "display" : "Medication assessed [ID]"
      }]
    },
    "valueCodeableConcept" : {
      "coding" : [{
        "system" : "http://fhir.de/CodeSystem/bfarm/atc",
        "code" : "L01EE",
        "display" : "Mitogen-aktivierte Proteinkinase (MEK)-Inhibitoren"
      }]
    }
  }]
}