{
  "resourceType" : "Observation",
  "id" : "MII-EXA-MTB-HRD-Score-1",
  "meta" : {
    "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-hrd-score|2026.0.1"]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Observation MII-EXA-MTB-HRD-Score-1</b></p><a name=\"MII-EXA-MTB-HRD-Score-1\"> </a><a name=\"hcMII-EXA-MTB-HRD-Score-1\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mii-pr-mtb-hrd-score.html\">MII PR MTB HRD Scoreversion: null2026.0.1)</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetik</span>, <span title=\"Codes:{http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs biomarker-category}\">A characterization of a given biomarker observation.</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 107286-7}\">Homologous recombination deficiency status analysis [Presence] in Tissue by Molecular genetics method</span></p><p><b>subject</b>: <a href=\"https://simplifier.net/resolve?scope=de.basisprofil.r4@1.5.4&amp;canonical=http://fhir.org/packages/de.basisprofil.r4/Patient/example\">Patient/example</a></p><p><b>encounter</b>: <a href=\"https://simplifier.net/resolve?scope=de.basisprofil.r4@1.5.4&amp;canonical=http://fhir.org/packages/de.basisprofil.r4/Encounter/example\">Encounter/example</a></p><p><b>performer</b>: <a href=\"https://simplifier.net/resolve?scope=de.basisprofil.r4@1.5.4&amp;canonical=http://fhir.org/packages/de.basisprofil.r4/Practitioner/example\">Practitioner/example</a></p><p><b>value</b>: 43</p><p><b>interpretation</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v3-ObservationInterpretation H}\">High</span></p><p><b>specimen</b>: <a href=\"https://simplifier.net/resolve?scope=de.basisprofil.r4@1.5.4&amp;canonical=http://fhir.org/packages/de.basisprofil.r4/Specimen/example\">Specimen/example</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html C18016}\">Loss of Heterozygosity</span></p><p><b>value</b>: 14</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html C129774}\">Telomeric Allelic Imbalance Region</span></p><p><b>value</b>: 12</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html C120466}\">Large-Scale State Transition</span></p><p><b>value</b>: 17</p></blockquote></div>"
  },
  "status" : "final",
  "category" : [{
    "coding" : [{
      "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
      "code" : "laboratory",
      "display" : "Laboratory"
    }]
  },
  {
    "coding" : [{
      "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
      "code" : "GE"
    }]
  },
  {
    "coding" : [{
      "system" : "http://hl7.org/fhir/uv/genomics-reporting/CodeSystem/tbd-codes-cs",
      "code" : "biomarker-category"
    }]
  }],
  "code" : {
    "coding" : [{
      "system" : "http://loinc.org",
      "code" : "107286-7",
      "display" : "Homologous recombination deficiency status analysis [Presence] in Tissue by Molecular genetics method"
    }]
  },
  "subject" : {
    "reference" : "Patient/example"
  },
  "encounter" : {
    "reference" : "Encounter/example"
  },
  "performer" : [{
    "reference" : "Practitioner/example"
  }],
  "valueInteger" : 43,
  "interpretation" : [{
    "coding" : [{
      "system" : "http://terminology.hl7.org/CodeSystem/v3-ObservationInterpretation",
      "code" : "H",
      "display" : "High"
    }]
  }],
  "specimen" : {
    "reference" : "Specimen/example"
  },
  "component" : [{
    "code" : {
      "coding" : [{
        "system" : "https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html",
        "code" : "C18016",
        "display" : "Loss of Heterozygosity"
      }]
    },
    "valueInteger" : 14
  },
  {
    "code" : {
      "coding" : [{
        "system" : "https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html",
        "code" : "C129774",
        "display" : "Telomeric Allelic Imbalance Region"
      }]
    },
    "valueInteger" : 12
  },
  {
    "code" : {
      "coding" : [{
        "system" : "https://nih-ncpi.github.io/ncpi-fhir-ig/CodeSystem-ncit.html",
        "code" : "C120466",
        "display" : "Large-Scale State Transition"
      }]
    },
    "valueInteger" : 17
  }]
}