{
  "resourceType" : "Observation",
  "id" : "MII-EXA-MTB-DNA-Fusion-1",
  "meta" : {
    "profile" : ["https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/StructureDefinition/mii-pr-mtb-dna-fusion|2026.0.1"]
  },
  "text" : {
    "status" : "generated",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\"><p class=\"res-header-id\"><b>Generated Narrative: Observation MII-EXA-MTB-DNA-Fusion-1</b></p><a name=\"MII-EXA-MTB-DNA-Fusion-1\"> </a><a name=\"hcMII-EXA-MTB-DNA-Fusion-1\"> </a><div style=\"display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%\"><p style=\"margin-bottom: 0px\"/><p style=\"margin-bottom: 0px\">Profile: <a href=\"StructureDefinition-mii-pr-mtb-dna-fusion.html\">MII PR MTB DNA Fusionversion: null2026.0.1)</a></p></div><p><b>status</b>: Final</p><p><b>category</b>: <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/observation-category laboratory}\">Laboratory</span>, <span title=\"Codes:{http://terminology.hl7.org/CodeSystem/v2-0074 GE}\">Genetik</span></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 69548-6}\">Genetic variant assessment</span></p><p><b>subject</b>: <a href=\"https://simplifier.net/resolve?scope=de.basisprofil.r4@1.5.4&amp;canonical=http://fhir.org/packages/de.basisprofil.r4/Patient/example\">Patient/example</a></p><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker five-prime-chromosome}\">Five Prime Chromosome</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA21255-7}\">Chromosome 2</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker three-prime-chromosome}\">Three Prime Chromosome</span></p><p><b>value</b>: <span title=\"Codes:{http://loinc.org LA21258-1}\">Chromosome 5</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker five-prime-position}\">Five Prime Position</span></p><p><b>value</b>: 12345678-12345680</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker three-prime-position}\">Three Prime Position</span></p><p><b>value</b>: 87654321-87654323</p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker five-prime-gene}\">Five Prime Gene</span></p><p><b>value</b>: <span title=\"Codes:\">BRCA1</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker three-prime-gene}\">Three Prime Gene</span></p><p><b>value</b>: <span title=\"Codes:\">RET</span></p></blockquote><blockquote><p><b>component</b></p><p><b>code</b>: <span title=\"Codes:{http://loinc.org 82121-5}\">Allelic read depth</span></p><p><b>value</b>: 150 Number of reported reads<span style=\"background: LightGoldenRodYellow\"> (Details: UCUM  code1 = '1')</span></p></blockquote></div>"
  },
  "status" : "final",
  "category" : [{
    "coding" : [{
      "system" : "http://terminology.hl7.org/CodeSystem/observation-category",
      "code" : "laboratory",
      "display" : "Laboratory"
    }]
  },
  {
    "coding" : [{
      "system" : "http://terminology.hl7.org/CodeSystem/v2-0074",
      "code" : "GE"
    }]
  }],
  "code" : {
    "coding" : [{
      "system" : "http://loinc.org",
      "code" : "69548-6",
      "display" : "Genetic variant assessment"
    }]
  },
  "subject" : {
    "reference" : "Patient/example"
  },
  "component" : [{
    "code" : {
      "coding" : [{
        "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker",
        "code" : "five-prime-chromosome"
      }]
    },
    "valueCodeableConcept" : {
      "coding" : [{
        "system" : "http://loinc.org",
        "code" : "LA21255-7",
        "display" : "Chromosome 2"
      }]
    }
  },
  {
    "code" : {
      "coding" : [{
        "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker",
        "code" : "three-prime-chromosome"
      }]
    },
    "valueCodeableConcept" : {
      "coding" : [{
        "system" : "http://loinc.org",
        "code" : "LA21258-1",
        "display" : "Chromosome 5"
      }]
    }
  },
  {
    "code" : {
      "coding" : [{
        "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker",
        "code" : "five-prime-position"
      }]
    },
    "valueRange" : {
      "low" : {
        "value" : 12345678
      },
      "high" : {
        "value" : 12345680
      }
    }
  },
  {
    "code" : {
      "coding" : [{
        "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker",
        "code" : "three-prime-position"
      }]
    },
    "valueRange" : {
      "low" : {
        "value" : 87654321
      },
      "high" : {
        "value" : 87654323
      }
    }
  },
  {
    "code" : {
      "coding" : [{
        "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker",
        "code" : "five-prime-gene"
      }]
    },
    "valueCodeableConcept" : {
      "coding" : [{
        "code" : "HGNC:1100",
        "display" : "BRCA1"
      }]
    }
  },
  {
    "code" : {
      "coding" : [{
        "system" : "https://www.medizininformatik-initiative.de/fhir/ext/modul-mtb/CodeSystem/mii-cs-mtb-molekulare-biomarker",
        "code" : "three-prime-gene"
      }]
    },
    "valueCodeableConcept" : {
      "coding" : [{
        "code" : "HGNC:9967",
        "display" : "RET"
      }]
    }
  },
  {
    "code" : {
      "coding" : [{
        "system" : "http://loinc.org",
        "code" : "82121-5"
      }]
    },
    "valueQuantity" : {
      "value" : 150,
      "unit" : "Number of reported reads",
      "system" : "http://unitsofmeasure.org",
      "code" : "1"
    }
  }]
}