// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson
InstanceOf: MII_PR_Person_Patient
Usage: #example
* birthDate = 1956-03-14
* name.family = "Musterperson"
* name.given = "Kim"

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-Procedure-1
InstanceOf: MII_PR_Prozedur_Procedure
Usage: #example  
Description: "10.06.2021 CT Abdomen mit KM"
* status = #completed
* subject = Reference(PatientKimMusterperson)
* code.coding = $OPS#3-222 "Computertomographie des Abdomens mit Kontrastmittel"
* code.coding.version = "2024"
* performedDateTime = 2021-06-10

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-PrimaryDiagnosis-2
InstanceOf: MII_PR_MTB_Diagnose_Primaertumor
Usage: #example
Description: "bestätigte Primärdiagnose"
* extension[Feststellungsdatum].valueDateTime = 2021-06-10
* recordedDate = 2021-06-10
* subject = Reference(PatientKimMusterperson)
* clinicalStatus = #active
* verificationStatus.coding[condition-ver-status] = $condition-ver-status#unconfirmed
* verificationStatus.coding[primaertumorDiagnosesicherung] = $mii-cs-onko-primaertumor-diagnosesicherung#2
* code.coding  = $ICD10GM#C48.2 "Bösartige Neubildung des Retroperitoneums und Peritoneums - Peritoneum, nicht näher bezeichnet"
* bodySite = $ICDO3#C56.9 "Ovar"

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-Diagnosis-1
InstanceOf: MII_PR_MTB_Diagnose_Primaertumor
Usage: #example
Description: "Diagnose Primärtumor"
* recordedDate = 2021-06-10
* subject = Reference(PatientKimMusterperson)
* clinicalStatus = $condition-ver-status#active
* verificationStatus.coding[primaertumorDiagnosesicherung] = $mii-cs-onko-primaertumor-diagnosesicherung#2 "klinische Diagnostik"
* code.coding  = $ICD10GM#C48.2 "Bösartige Neubildung des Retroperitoneums und Peritoneums - Peritoneum, nicht näher bezeichnet"
* bodySite = $ICDO3#C56.9 "Ovar"
* extension[Feststellungsdatum].valueDateTime = 2021-05-09 

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-Procedure-2
InstanceOf: MII_PR_Prozedur_Procedure
Usage: #example  
Description: "15.06.2021 Aszitespunktion"
* status = #completed
* subject = Reference(PatientKimMusterperson)
* code.coding = $OPS#1-853.2 "Aszitespunktion"
* performedDateTime = 2021-06-15

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-Procedure-3
InstanceOf: MII_PR_Prozedur_Procedure
Usage: #example  
Description: "22.06.2021 CT Thorax: kein Hinweis auf Metastasen."
* status = #completed
* subject = Reference(PatientKimMusterperson)
* code.coding = $OPS#1-853.2 "CT Thorax"
* performedDateTime = 2021-06-22

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-Tumorkonferenz-1
InstanceOf: MII_PR_Onko_Tumorkonferenz
Usage: #example  
Description: "."
* subject = Reference(PatientKimMusterperson)
* status = #completed
* intent = #plan
* category.coding = $mii-cs-onko-therapieplanung-typ#praeth "prätherapeutische Tumorkonferenz (Festlegung der Therapiestrategie)" 
* created = 2021-06-25
* addresses = Reference(PatientKimMusterperson-Diagnosis-1)
* activity[0].detail.code = $mii-cs-onko-therapie-typ#CH "Chemotherapie"
* activity[0].detail.status = #completed
* activity[0].detail.statusReason = $mii-cs-onko-therapieabweichung#N
* activity[1].detail.code = $mii-cs-onko-therapie-typ#OP
* activity[1].detail.status = #completed
* activity[1].detail.statusReason = $mii-cs-onko-therapieabweichung#N

// NOTE: Changed Onko Systemische Therapie -> MTB Systemische Therapie
// TODO: Merge two different profile for MTB systemic therapy
Instance: PatientKimMusterperson-SystemicTherapy-1
InstanceOf: MII_PR_MTB_Systemische_Vortherapie
Usage: #example
Description: "."
* subject = Reference(PatientKimMusterperson)
* status = #completed
* category = $SCT#18629005
* code.coding = $OPS#8-54 "Chemotherapie"
* extension[Intention].valueCodeableConcept = $mii-cs-onko-intention#K
* extension[StellungZurOp].valueCodeableConcept = $mii-cs-onko-therapie-stellungzurop#N "neoadjuvant"
* performedPeriod.start = 2021-07-05
* performedPeriod.end = 2021-09-05
* basedOn = Reference(PatientKimMusterperson-Tumorkonferenz-1)

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-SystemicTherapyMedication-1a
InstanceOf: MII_PR_Onko_Systemische_Therapie_Medikation
Usage: #example
Description: "."
* subject = Reference(PatientKimMusterperson)
* status = #recorded 
* effectivePeriod.start = 2021-07-05  
* effectivePeriod.end = 2021-09-05
* medicationCodeableConcept.coding[atcClassDe][0] = $ATC_DE#L01CD01 "Paclitaxel"
* partOf[+] = Reference(PatientKimMusterperson-SystemicTherapy-1)
* note.text = "CarboTax"

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-SystemicTherapyMedication-1b
InstanceOf: MII_PR_Onko_Systemische_Therapie_Medikation
Usage: #example
Description: "."
* subject = Reference(PatientKimMusterperson)
* status = #recorded 
* effectivePeriod.start = 2021-07-05  
* effectivePeriod.end = 2021-09-05
* medicationCodeableConcept.coding[atcClassDe][0] = $ATC_DE#L01XA02 "Carboplatin"
* partOf[+] = Reference(PatientKimMusterperson-SystemicTherapy-1)
* note.text = "CarboTax"

Instance: PatientKimMusterperson-Tumorkonferenz-2
InstanceOf: MII_PR_Onko_Tumorkonferenz
Usage: #example  
Description: "."
* subject = Reference(PatientKimMusterperson)
* status = #completed
* intent = #plan
* category.coding = $mii-cs-onko-therapieplanung-typ#praeth "prätherapeutische Tumorkonferenz (Festlegung der Therapiestrategie" 
* created = 2021-09-16
* addresses = Reference(PatientKimMusterperson-Diagnosis-1)
* activity[0].detail.code = $mii-cs-onko-therapie-typ#OP
* activity[0].detail.status = #completed
* activity[0].detail.statusReason = $mii-cs-onko-therapieabweichung#N 

// TODO: Erweiterung Szenario Onkologie - Plausibilität prüfen
// NOTE: Umgang mit Procedure.partOf klären
Instance: PatientKimMusterperson-EpisodeOfCare
InstanceOf: MII_PR_MTB_Behandlungsepisode
Usage: #example
Description: "TBD"
* patient = Reference(PatientKimMusterperson)
* period.start = 2022-03-01
* diagnosis = Reference(PatientKimMusterperson-PrimaryDiagnosis-2)
* extension[Vortherapie].extension[Prozedur] = Reference(PatientKimMusterperson-Procedure-4)
* extension[Vortherapie].extension[Prozedur] = Reference(PatientKimMusterperson-Procedure-4a)
* extension[Vortherapie].extension[Prozedur] = Reference(PatientKimMusterperson-Procedure-4b)
* extension[Vortherapie].extension[Prozedur] = Reference(PatientKimMusterperson-Procedure-4c)
* extension[Vortherapie].extension[Prozedur] = Reference(PatientKimMusterperson-Procedure-4d)

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-Procedure-4
InstanceOf: MII_PR_Prozedur_Procedure
Usage: #example  
Description: "30.09.2021 OP Intervalldebulking mittels Längsschnittlaparotomie, Tumorresektion mittels Hysterektomie, bilateraler Adnexektomie, und atpyischer Lebersegmentresektion (Seg. II und V). Postoperativ: R0."
* status = #completed
* subject = Reference(PatientKimMusterperson)
* performedDateTime = 2021-09-30
* outcome = $mii-cs-onko-residualstatus#R0

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-Procedure-4a
InstanceOf: MII_PR_Prozedur_Procedure
Usage: #example  
Description: "30.09.2021 OP Intervalldebulking mittels Längsschnittlaparotomie, Tumorresektion mittels Hysterektomie, bilateraler Adnexektomie, und atpyischer Lebersegmentresektion (Seg. II und V). Postoperativ: R0."
* status = #completed
* subject = Reference(PatientKimMusterperson)
* category = $SCT#387713003 "Operationen"
* code.coding = $OPS#5-547.0 "Resektion von Gewebe ohne sichere Organzuordnung - intraperitoneal"
* performedDateTime = 2021-09-30
* partOf = Reference(PatientKimMusterperson-Procedure-4)
* outcome = $mii-cs-onko-residualstatus#R0

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-Procedure-4b
InstanceOf: MII_PR_Prozedur_Procedure
Usage: #example  
Description: "30.09.2021 OP Intervalldebulking mittels Längsschnittlaparotomie, Tumorresektion mittels Hysterektomie, bilateraler Adnexektomie, und atpyischer Lebersegmentresektion (Seg. II und V). Postoperativ: R0."
* status = #completed
* subject = Reference(PatientKimMusterperson)
* category = $SCT#387713003 "Operationen"
* code.coding = $OPS#5-683 "Hysterektomie"
* performedDateTime = 2021-09-30
* partOf = Reference(PatientKimMusterperson-Procedure-4)
* outcome = $mii-cs-onko-residualstatus#R0

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-Procedure-4c
InstanceOf: MII_PR_Prozedur_Procedure
Usage: #example  
Description: "30.09.2021 OP Intervalldebulking mittels Längsschnittlaparotomie, Tumorresektion mittels Hysterektomie, bilateraler Adnexektomie, und atpyischer Lebersegmentresektion (Seg. II und V). Postoperativ: R0."
* status = #completed
* subject = Reference(PatientKimMusterperson)
* category = $SCT#387713003 "Operationen"
* code.coding = $OPS#5-661 "bilaterale Adnexektomie / Salpingektomie"
* performedDateTime = 2021-09-30
* partOf = Reference(PatientKimMusterperson-Procedure-4)
* outcome = $mii-cs-onko-residualstatus#R0

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-Procedure-4d
InstanceOf: MII_PR_Prozedur_Procedure
Usage: #example  
Description: "30.09.2021 OP Intervalldebulking mittels Längsschnittlaparotomie, Tumorresektion mittels Hysterektomie, bilateraler Adnexektomie, und atpyischer Lebersegmentresektion (Seg. II und V). Postoperativ: R0."
* status = #completed
* subject = Reference(PatientKimMusterperson)
* category = $SCT#387713003 "Operationen"
* code.coding = $OPS#5-501 "atypische Lebersegmentresektion"
* performedDateTime = 2021-09-30
* partOf = Reference(PatientKimMusterperson-Procedure-4)
* outcome = $mii-cs-onko-residualstatus#R0

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-PathoReport-1
InstanceOf: MII_PR_Patho_Report
Usage: #example  
Description: "Pathoreport incl. Immunhistochemie"
* subject = Reference(PatientKimMusterperson)
* status = #complete
* code.coding = $LNC#22034-3 "Pathology Report Cancer Narrative"
* conclusion = "Histologie: Resektat vom 30.09.2021: Neoplasie des Ovars (Z.n. neoadjuvanter Therapie) (ICD-10-C56) Ovar o.n.A. (ICD-O-C56.9) Untersuchungsmaterial: Resektat WHO-Typ: Seröses Adenokarzinom (ICD-O M-8441/3) Lokale Tumorausbreitung: Ovartumor links mit einer max. Größe von 2,2 cm und tumorinfiltrierter Kapsel mit Nachweis von Tumorzellen auf der Ovaroberfläche, Anteil vitaler Tumorzellen von ca. 80 %. UICC-Klassifikation (8. Auflage): ypT3c. pM1b (HEP) L1. V0. Pn0 FIGO: IVB"

// NOTE: Changed InstanceOf
Instance: PatientKimMusterperson-Specimen-1
InstanceOf: MII_PR_Onko_Specimen
Usage: #example  
Description: "Tumorresektat Primärtumor"
* subject = Reference(PatientKimMusterperson)
* identifier.value = "12345678"
* collection.collectedDateTime = 2021-09-30 

Instance: TNM-Klassifikation-Observation-2
InstanceOf: MII_PR_Onko_TNM_Klassifikation
Usage: #example  
Description: "."
* status = #final
* subject = Reference(PatientKimMusterperson)
* code.coding = $SCT#399588009 "Pathologic TNM stage grouping"
* effectiveDateTime = 2021-06-22
* method = $mii-cs-onko-tnm-version#8 "8. Auflage"
* partOf = Reference(PatientKimMusterperson-Procedure-4)

Instance: TNM-T-Observation-2
InstanceOf: MII_PR_Onko_TNM_T_Kategorie
Usage: #example  
Description: "Lokale Tumorausbreitung: Ovartumor links mit einer max. Größe von 2,2 cm und tumorinfiltrierter Kapsel mit Nachweis von Tumorzellen auf der Ovaroberfläche, Anteil vitaler Tumorzellen von ca. 80 %."
* status = #final
* subject = Reference(PatientKimMusterperson)
* code.extension[cpPraefix].valueCodeableConcept = $UICC#p
* code.coding = $SCT#384625004 "pT category (observable entity)"
* effectiveDateTime = 2021-06-22
* method = $mii-cs-onko-tnm-version#8 "8. Auflage"
* partOf = Reference(PatientKimMusterperson-Procedure-4)
* valueCodeableConcept.coding = $UICC#T3c

Instance: TNM-M-Observation-2
InstanceOf: MII_PR_Onko_TNM_M_Kategorie
Usage: #example  
Description: "."
* status = #final
* subject = Reference(PatientKimMusterperson)
* code.extension[cpPraefix].valueCodeableConcept = $UICC#p
* code.coding = $SCT#371497001 "pM category (observable entity)"
* effectiveDateTime = 2021-06-22
* method = $mii-cs-onko-tnm-version#8 "8. Auflage"
* partOf = Reference(PatientKimMusterperson-Procedure-4)
* valueCodeableConcept.coding = $UICC#M1b

Instance: TNM-y-Symbol-Observation-2
InstanceOf: MII_PR_Onko_TNM_y_Symbol
Usage: #example  
Description: "."
* status = #final
* subject = Reference(PatientKimMusterperson)
* code.coding = $LNC#101658-3
* effectiveDateTime = 2021-06-22
* method = $mii-cs-onko-tnm-version#8 "8. Auflage"
* partOf = Reference(PatientKimMusterperson-Procedure-4)
* valueCodeableConcept.coding = $SCT#421755005

Instance: TNM-Pn-Observation-2
InstanceOf: MII_PR_Onko_TNM_Pn_Kategorie
Usage: #example  
Description: "."
* status = #final
* subject = Reference(PatientKimMusterperson)
* code.coding = $SCT#371513001
* effectiveDateTime = 2021-06-22
* method = $mii-cs-onko-tnm-version#8 "8. Auflage"
* partOf = Reference(PatientKimMusterperson-Procedure-4)
* valueCodeableConcept.coding = $UICC#Pn0

Instance: TNM-L-Observation-2
InstanceOf: MII_PR_Onko_TNM_L_Kategorie
Usage: #example  
Description: "."
* status = #final
* subject = Reference(PatientKimMusterperson)
* code.coding = $SCT#395715009
* effectiveDateTime = 2021-06-22
* method = $mii-cs-onko-tnm-version#8 "8. Auflage"
* partOf = Reference(PatientKimMusterperson-Procedure-4)
* valueCodeableConcept.coding = $UICC#L1

Instance: TNM-V-Observation-2
InstanceOf: MII_PR_Onko_TNM_L_Kategorie
Usage: #example  
Description: "."
* status = #final
* subject = Reference(PatientKimMusterperson)
* code.coding = $SCT#371493002
* effectiveDateTime = 2021-06-22
* method = $mii-cs-onko-tnm-version#8 "8. Auflage"
* partOf = Reference(PatientKimMusterperson-Procedure-4)
* valueCodeableConcept.coding = $UICC#V0

Instance: PatientKimMusterperson-Tumorkonferenz-3
InstanceOf: MII_PR_Onko_Tumorkonferenz
Usage: #example  
Description: "."
* subject = Reference(PatientKimMusterperson)
* status = #completed
* intent = #plan
* category.coding = $mii-cs-onko-therapieplanung-typ#postop "Posttherapeutische Tumorkonferenz" 
* created = 2021-10-25
* replaces = Reference(PatientKimMusterperson-Tumorkonferenz-2)
* addresses = Reference(PatientKimMusterperson-PrimaryDiagnosis-2)
* activity[0].detail.code = $mii-cs-onko-therapie-typ#CH
* activity[0].detail.status = #completed
* activity[0].detail.statusReason = $mii-cs-onko-therapieabweichung#N

Instance: PatientKimMusterperson-SystemicTherapy-2
InstanceOf: MII_PR_Onko_Systemische_Therapie
Usage: #example
Description: "."
* subject = Reference(PatientKimMusterperson)
* status = #completed
* code.coding = $OPS#8-54 "Chemotherapie"
* extension[Intention].valueCodeableConcept = $mii-cs-onko-intention#K
* extension[StellungZurOp].valueCodeableConcept = $mii-cs-onko-therapie-stellungzurop#A "adjuvant"
* performedPeriod.start = 2021-11-08
* performedPeriod.end = 2022-01-09

Instance: PatientKimMusterperson-SystemicTherapyMedication-2a
InstanceOf: MII_PR_Onko_Systemische_Therapie_Medikation
Usage: #example
Description: "."
* subject = Reference(PatientKimMusterperson)
* status = #completed
* effectivePeriod.start = 2021-11-08  
* effectivePeriod.end = 2022-01-09
* medicationCodeableConcept.coding[atcClassDe][0] = $ATC_DE#L01BC05 "Gemcitabin"
* partOf = Reference(PatientKimMusterperson-SystemicTherapy-2)
* note.text = "Gem-Carbo"

Instance: PatientKimMusterperson-SystemicTherapyMedication-2b
InstanceOf: MII_PR_Onko_Systemische_Therapie_Medikation
Usage: #example
Description: "."
* subject = Reference(PatientKimMusterperson)
* status = #completed
* effectivePeriod.start = 2021-11-08  
* effectivePeriod.end = 2022-01-09
* medicationCodeableConcept.coding[atcClassDe][0] = $ATC_DE#L01XA02 "Carboplatin"
* partOf = Reference(PatientKimMusterperson-SystemicTherapy-2)
* note.text = "Gem-Carbo"

Instance: PatientKimMusterperson-Verlauf-2022-01-22
InstanceOf: MII_PR_Onko_Verlauf
Usage: #example
Description: "."
* subject = Reference(PatientKimMusterperson)
* status = #final
* effectiveDateTime = 2022-01-22
* focus = Reference(PatientKimMusterperson-PrimaryDiagnosis-2)
* code.coding = $SCT#396432002 "Status of regression of tumor (observable entity)"
* valueCodeableConcept.coding = $mii-cs-onko-verlauf-gesamtbeurteilung#V "Vollremission (complete remission, CR)" 
* component[Tumor_Verlauf].code.coding = $SCT#277062004 "Status des Residualtumors"
* component[Tumor_Verlauf].valueCodeableConcept = $mii-cs-onko-verlauf-primaertumor#T "Tumorreste (Residualtumor)"
* component[Fernmetastasen_Verlauf].code.coding = $SCT#399608002 "Status of distant metastasis (observable entity)"
* component[Fernmetastasen_Verlauf].valueCodeableConcept = $mii-cs-onko-verlauf-fernmetastasen#K "Keine Fernmetastasen nachweisbar"

Instance: PatientKimMusterperson-Tumorkonferenz-4
InstanceOf: MII_PR_Onko_Tumorkonferenz
Usage: #example  
Description: "."
* subject = Reference(PatientKimMusterperson)
* status = #in-progress
* intent = #plan
* category.coding = $mii-cs-onko-therapieplanung-typ#postop "posttherapeutische Tumorkonferenz (manche Tumoren werden nicht operiert)" 
* created = 2022-01-20
* replaces = Reference(PatientKimMusterperson-Tumorkonferenz-3)
* addresses = Reference(PatientKimMusterperson-PrimaryDiagnosis-2)
* activity[0].detail.code = $mii-cs-onko-therapie-typ#ZS
* activity[0].detail.status = #active 
* activity[0].detail.statusReason = $mii-cs-onko-therapieabweichung#U "unbekannt"
* description = "Erhaltungstherapie mit Niraparib bei BRCAwt"

Instance: PatientKimMusterperson-SystemicTherapy-3
InstanceOf: MII_PR_MTB_Systemische_Vortherapie
Usage: #example
Description: "."
* subject = Reference(PatientKimMusterperson)
* status = #completed
* code.coding = $OPS#8-54 "Chemotherapie"
* extension[Intention].valueCodeableConcept = $mii-cs-onko-intention#K
* extension[StellungZurOp].valueCodeableConcept = $mii-cs-onko-therapie-stellungzurop#A "adjuvant"
* performedPeriod.start = 2022-01-25

Instance: PatientKimMusterperson-SystemicTherapyMedication-3
InstanceOf: MII_PR_Onko_Systemische_Therapie_Medikation
Usage: #example
Description: "."
* subject = Reference(PatientKimMusterperson)
* status = #completed
* effectivePeriod.start = 2022-01-25  
* medicationCodeableConcept.coding[atcClassDe][0] = $ATC_DE#L01XK02  "Niraparib"
* partOf = Reference(PatientKimMusterperson-SystemicTherapy-3)
* note.text = "Niraparib"