Substitution occurred or is permitted with another bioequivalent and therapeutically equivalent product.

Substitution occurred or is permitted with another product that is a:

• pharmaceutical alternative containing the same active ingredient but is formulated with different salt, ester
• pharmaceutical equivalent that has the same active ingredient, strength, dosage form and route of administration

Examples:

• Pharmaceutical alternative: Erythromycin Ethylsuccinate for Erythromycin Stearate
• Pharmaceutical equivalent: Lisonpril for Zestril

Substitution occurred or is permitted between equivalent Brands but not Generics

Examples:

• Zestril for Prinivil
• Coumadin for Jantoven

Substitution occurred or is permitted between equivalent Generics but not Brands

Examples:

• Lisnopril (Lupin Corp) for Lisnopril (Wockhardt Corp)

Substitution occurred or is permitted with another product having the same therapeutic objective and safety profile.

Examples:

• ranitidine for Tagamet

Substitution occurred or is permitted between therapeutically equivalent Brands but not Generics

Examples:

• Zantac for Tagamet

Substitution occurred or is permitted between therapeutically equivalent Generics but not Brands

Examples:

• Ranitidine for cimetidine

This substitution was performed or is permitted based on formulary guidelines.